TY  - JOUR
AU  - Kasalović, Marijana P.
AU  - Dimić, Dušan
AU  - Jelača, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B.
AU  - Schreiner, Simon H. F.
AU  - Rüffer, Tobias
AU  - Pantelić, Nebojša Đ.
AU  - Kaluđerović, Goran N.
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6626
AB  - A novel trimethyltin(IV) complex (Me3SnL), derived from 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoate ligand, has been synthesized and characterized by elemental microanalysis, UV/Vis spectrophotometry, FT-IR and multinuclear (1H, 13C and 119Sn) NMR spectroscopies. Furthermore, the structure of the ligand precursor HL was solved using SC-XRD (single-crystal X-ray diffraction). The prediction of UV/Vis and NMR spectra by quantum-chemical methods was performed and compared to experimental findings. The protein binding affinity of Me3SnL towards BSA was determined by spectrofluorometric titration and subsequent molecular docking simulations. Me3SnL has been evaluated for its in vitro anticancer activity against three human cell lines, MCF-7 (breast adenocarcinoma), A375 (melanoma) and HCT116 (colorectal carcinoma), and three mouse tumor cell lines, 4T1 (breast carcinoma), B16 (melanoma) and CT26 (colon carcinoma), using MTT and CV assays. The strong inhibition of A375 cell proliferation, ROS/RNS upregulation and robust lipid peroxidation lead to autophagic cell death upon treatment with Me3SnL.
PB  - Basel: MDPI
T2  - Pharmaceuticals
T1  - Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells
IS  - 3
VL  - 17
DO  - 10.3390/ph17030372
SP  - 372
ER  - 

@article{
author = "Kasalović, Marijana P. and Dimić, Dušan and Jelača, Sanja and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Zmejkovski, Bojana B. and Schreiner, Simon H. F. and Rüffer, Tobias and Pantelić, Nebojša Đ. and Kaluđerović, Goran N.",
year = "2024",
abstract = "A novel trimethyltin(IV) complex (Me3SnL), derived from 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoate ligand, has been synthesized and characterized by elemental microanalysis, UV/Vis spectrophotometry, FT-IR and multinuclear (1H, 13C and 119Sn) NMR spectroscopies. Furthermore, the structure of the ligand precursor HL was solved using SC-XRD (single-crystal X-ray diffraction). The prediction of UV/Vis and NMR spectra by quantum-chemical methods was performed and compared to experimental findings. The protein binding affinity of Me3SnL towards BSA was determined by spectrofluorometric titration and subsequent molecular docking simulations. Me3SnL has been evaluated for its in vitro anticancer activity against three human cell lines, MCF-7 (breast adenocarcinoma), A375 (melanoma) and HCT116 (colorectal carcinoma), and three mouse tumor cell lines, 4T1 (breast carcinoma), B16 (melanoma) and CT26 (colon carcinoma), using MTT and CV assays. The strong inhibition of A375 cell proliferation, ROS/RNS upregulation and robust lipid peroxidation lead to autophagic cell death upon treatment with Me3SnL.",
publisher = "Basel: MDPI",
journal = "Pharmaceuticals",
title = "Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells",
number = "3",
volume = "17",
doi = "10.3390/ph17030372",
pages = "372"
}

Kasalović, M. P., Dimić, D., Jelača, S., Maksimović-Ivanić, D., Mijatović, S., Zmejkovski, B. B., Schreiner, S. H. F., Rüffer, T., Pantelić, N. Đ.,& Kaluđerović, G. N.. (2024). Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells. in Pharmaceuticals
Basel: MDPI., 17(3), 372.
https://doi.org/10.3390/ph17030372

Kasalović MP, Dimić D, Jelača S, Maksimović-Ivanić D, Mijatović S, Zmejkovski BB, Schreiner SHF, Rüffer T, Pantelić NĐ, Kaluđerović GN. Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells. in Pharmaceuticals. 2024;17(3):372.
doi:10.3390/ph17030372 .

Kasalović, Marijana P., Dimić, Dušan, Jelača, Sanja, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Zmejkovski, Bojana B., Schreiner, Simon H. F., Rüffer, Tobias, Pantelić, Nebojša Đ., Kaluđerović, Goran N., "Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells" in Pharmaceuticals, 17, no. 3 (2024):372,
https://doi.org/10.3390/ph17030372 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Kaluderovic, Milena R.
AU  - Mojić, Marija
AU  - Zmejkovski, Bojana B.
AU  - Hey-Hawkins, Evamarie
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1916
AB  - (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.
T2  - European Journal of Pharmacology
T1  - Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions
VL  - 760
DO  - 10.1016/j.ejphar.2015.04.012
SP  - 136
EP  - 144
ER  - 

@article{
author = "Bulatović, Mirna Z. and Kaluderovic, Milena R. and Mojić, Marija and Zmejkovski, Bojana B. and Hey-Hawkins, Evamarie and Vidaković, Melita and Grdović, Nevena and Kaluđerović, Goran N. and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2015",
abstract = "(O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
   num(IV), {[}PtCl4(iBu(2)eddp)]. shows an improved pharmacological
   profile in comparison to cisplatin. This is manifested through
   accelerated dying process led by necrotic cell death, reflected through
   mitochondrial collapse, strong ATP depletion and reactive oxygen species
   production. Loss of mitochondrial potential was further followed with
   intensive apoptosis that finalized with DNA fragmentation.
   Different dynamic of tumoricidal action could be partly ascribed to less
   affected repair mechanisms in comparison to cisplatin. Importantly,
   {[}PtCl4(iBu(2)eddp)] did not induce necrosis in primary fibroblasts
   suggesting different intracellular response of normal vs. tumor cells.
   This selectivity toward malignant phenotype is further confirmed by
   retained tumoricidal potential in hypoxic conditions, while cisplatin
   became completely inefficient. (C) 2015 Published by Elsevier B.V.",
journal = "European Journal of Pharmacology",
title = "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions",
volume = "760",
doi = "10.1016/j.ejphar.2015.04.012",
pages = "136-144"
}

Bulatović, M. Z., Kaluderovic, M. R., Mojić, M., Zmejkovski, B. B., Hey-Hawkins, E., Vidaković, M., Grdović, N., Kaluđerović, G. N., Mijatović, S.,& Maksimović-Ivanić, D.. (2015). Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology, 760, 136-144.
https://doi.org/10.1016/j.ejphar.2015.04.012

Bulatović MZ, Kaluderovic MR, Mojić M, Zmejkovski BB, Hey-Hawkins E, Vidaković M, Grdović N, Kaluđerović GN, Mijatović S, Maksimović-Ivanić D. Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions. in European Journal of Pharmacology. 2015;760:136-144.
doi:10.1016/j.ejphar.2015.04.012 .

Bulatović, Mirna Z., Kaluderovic, Milena R., Mojić, Marija, Zmejkovski, Bojana B., Hey-Hawkins, Evamarie, Vidaković, Melita, Grdović, Nevena, Kaluđerović, Goran N., Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Improved in vitro antitumor potential of
 (O,O'-Diisobutyl-ethylenediamine-N,N'-di-3-propionate)tetrachloridoplati
 num(IV) complex under normoxic and hypoxic conditions" in European Journal of Pharmacology, 760 (2015):136-144,
https://doi.org/10.1016/j.ejphar.2015.04.012 . .