TY  - CONF
AU  - Perović, Tatjana
AU  - Kostić, Marina
AU  - Lazović, Biljana
AU  - Džamić, Ana
AU  - Ćirić, Ana
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4920
AB  - Within the project of bilateral cooperation between Montenegro and Serbia, a project 
called ‘Biocontrol of phytopathogenic fungus by natural products from subtropical 
plants order Rosales’ is being implemented. Natural plant extracts are an alternative 
to synthetic fungicides or as an additional way to reduce their use. The choice and 
application of plant extracts depends on their functional characteristics, availability, 
cost-effectiveness and their impact on phyto-pathogens.
The project is focused on researching the biological properties of extracts of two 
subtropical plants from Montenegro: Celtis australis and Ziziphus jujuba, that previously 
were not recognised for this purpose.
Four extracts of Z. jujuba obtained from dried fruits (using various solvents: methanol, 
water, dichloromethane and n-butanol), and methanolic extracts prepared from leaves 
and unripe mesocarps of C. australis, were evaluated for their phenolic compounds 
composition as well as antimicrobial and cytotoxic properties. Both species extracts 
were rich in phenolic compounds.
Results showed that all of Z. jujuba extracts possess antibacterial/antifungal activity 
against seven tested bacterial species (belonging to human infectious agents and 
food contaminants) and fungi (four clinical isolates of dermatomycetes and six 
phytopathogens). The extracts showed very high antimicrobial potential, slightly weaker 
in the aqueous extract. No difference in antifungal potential according to the origin of 
the extracts was shown.
Extracts of Celtis australis contain various bioactive constituents and possess higher 
antifungal potential than ‘Previcur’, which is a commercial systemic fungicide used in 
controling production of vegetable seedling. 
Therefore, both species extracts represent potential, Z. jujuba as source of new 
compounds with antimicrobial activity, while extracts of Celtis australiscan has a potential 
for application in agriculture as an alternative to the syntethic fungicides.
Worth mentioning is that the examined extracts are natural biodegradable fungicides 
which enable a more efficient control of pathogenic bacteria and fungi.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade
C3  - The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia
T1  - Antimicrobial potential of subtropcal species from Montenegro
SP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4920
ER  - 

@conference{
author = "Perović, Tatjana and Kostić, Marina and Lazović, Biljana and Džamić, Ana and Ćirić, Ana",
year = "2021",
abstract = "Within the project of bilateral cooperation between Montenegro and Serbia, a project 
called ‘Biocontrol of phytopathogenic fungus by natural products from subtropical 
plants order Rosales’ is being implemented. Natural plant extracts are an alternative 
to synthetic fungicides or as an additional way to reduce their use. The choice and 
application of plant extracts depends on their functional characteristics, availability, 
cost-effectiveness and their impact on phyto-pathogens.
The project is focused on researching the biological properties of extracts of two 
subtropical plants from Montenegro: Celtis australis and Ziziphus jujuba, that previously 
were not recognised for this purpose.
Four extracts of Z. jujuba obtained from dried fruits (using various solvents: methanol, 
water, dichloromethane and n-butanol), and methanolic extracts prepared from leaves 
and unripe mesocarps of C. australis, were evaluated for their phenolic compounds 
composition as well as antimicrobial and cytotoxic properties. Both species extracts 
were rich in phenolic compounds.
Results showed that all of Z. jujuba extracts possess antibacterial/antifungal activity 
against seven tested bacterial species (belonging to human infectious agents and 
food contaminants) and fungi (four clinical isolates of dermatomycetes and six 
phytopathogens). The extracts showed very high antimicrobial potential, slightly weaker 
in the aqueous extract. No difference in antifungal potential according to the origin of 
the extracts was shown.
Extracts of Celtis australis contain various bioactive constituents and possess higher 
antifungal potential than ‘Previcur’, which is a commercial systemic fungicide used in 
controling production of vegetable seedling. 
Therefore, both species extracts represent potential, Z. jujuba as source of new 
compounds with antimicrobial activity, while extracts of Celtis australiscan has a potential 
for application in agriculture as an alternative to the syntethic fungicides.
Worth mentioning is that the examined extracts are natural biodegradable fungicides 
which enable a more efficient control of pathogenic bacteria and fungi.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade",
journal = "The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia",
title = "Antimicrobial potential of subtropcal species from Montenegro",
pages = "24",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4920"
}

Perović, T., Kostić, M., Lazović, B., Džamić, A.,& Ćirić, A.. (2021). Antimicrobial potential of subtropcal species from Montenegro. in The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia
Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade., 24.
https://hdl.handle.net/21.15107/rcub_ibiss_4920

Perović T, Kostić M, Lazović B, Džamić A, Ćirić A. Antimicrobial potential of subtropcal species from Montenegro. in The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia. 2021;:24.
https://hdl.handle.net/21.15107/rcub_ibiss_4920 .

Perović, Tatjana, Kostić, Marina, Lazović, Biljana, Džamić, Ana, Ćirić, Ana, "Antimicrobial potential of subtropcal species from Montenegro" in The 3rd Annual Conference of the Pan-Balkan Alliance of Natural Products and Drug Discovery Associations (PANDA); 2021 Nov 1; Belgrade, Serbia (2021):24,
https://hdl.handle.net/21.15107/rcub_ibiss_4920 .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Lazović, B.
AU  - Glamočlija, Jasmina
AU  - Kataranovski, Milena
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S1156523318301239?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3247
AB  - Aspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. This review represents a concise view of cellular and humoral participants in an immune response to Aspergillus gained mostly from rodent models of aspergillosis. The survey of immune defense mechanisms was given, including the role of innate immune cells (macrophages, neutrophils, monocytes, eosinophils, innate-like lymphocytes) and receptors in antifungal response, the significance of dendritic cells in activation of specific adaptive T cell-mediated immune responses and the regulatory mechanisms of excessive response. Insight into innate immune defense mechanisms gained using non-vertebrate models of infections with Aspergillus sp. was given as well. The contribution of animal models to the current knowledge of immune mechanisms of resistance or susceptibility to these fungi was stressed and the significance of data gained from these models in forming the basis for the design of therapeutic strategies in prevention and/or treatment of aspergillosis was pointed out.
T2  - Journal de Mycologie Médicale
T1  - Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.
IS  - 1
VL  - 29
DO  - 10.1016/j.mycmed.2019.01.006
SP  - 84
EP  - 96
ER  - 

@article{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Lazović, B. and Glamočlija, Jasmina and Kataranovski, Milena",
year = "2019",
abstract = "Aspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. This review represents a concise view of cellular and humoral participants in an immune response to Aspergillus gained mostly from rodent models of aspergillosis. The survey of immune defense mechanisms was given, including the role of innate immune cells (macrophages, neutrophils, monocytes, eosinophils, innate-like lymphocytes) and receptors in antifungal response, the significance of dendritic cells in activation of specific adaptive T cell-mediated immune responses and the regulatory mechanisms of excessive response. Insight into innate immune defense mechanisms gained using non-vertebrate models of infections with Aspergillus sp. was given as well. The contribution of animal models to the current knowledge of immune mechanisms of resistance or susceptibility to these fungi was stressed and the significance of data gained from these models in forming the basis for the design of therapeutic strategies in prevention and/or treatment of aspergillosis was pointed out.",
journal = "Journal de Mycologie Médicale",
title = "Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.",
number = "1",
volume = "29",
doi = "10.1016/j.mycmed.2019.01.006",
pages = "84-96"
}

Mirkov, I., Popov Aleksandrov, A., Lazović, B., Glamočlija, J.,& Kataranovski, M.. (2019). Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.. in Journal de Mycologie Médicale, 29(1), 84-96.
https://doi.org/10.1016/j.mycmed.2019.01.006

Mirkov I, Popov Aleksandrov A, Lazović B, Glamočlija J, Kataranovski M. Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections.. in Journal de Mycologie Médicale. 2019;29(1):84-96.
doi:10.1016/j.mycmed.2019.01.006 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Lazović, B., Glamočlija, Jasmina, Kataranovski, Milena, "Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections." in Journal de Mycologie Médicale, 29, no. 1 (2019):84-96,
https://doi.org/10.1016/j.mycmed.2019.01.006 . .