TY  - JOUR
AU  - Milošević, Verica
AU  - Brkić, B
AU  - Velkovski, SD
AU  - Sekulić, Milka I.
AU  - Lovren, Mirjana B.
AU  - Starcević, V
AU  - Severs, Walter B
PY  - 1998
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1859
AB  - This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells), Male rats received three i.c.v. injections (1 mu g/5 mu l) of SRIH-14 or SRIH-28 every second day, Blood samples were collected for hormone assays and pituitaries were removed for histological and morphometric evaluation 5 days after the last i.c.v. treatment, Compared to control animals, SRIH treatment decreased (p < 0.05) pituitary weight and all morphometric measurements obtained in GH and PRL cells, Concentrations of serum growth hormone (GH) and prolactin (PRL) in both SRIH-treated groups were also lower (p < 0.05) than in control rats, These findings suggest that centrally administered somatostatin is specifically involved in the control of growth and secretory activity of GH and PRL cells, Thus, pharmacological manipulation of SRIH receptors reached from cerebrospinal fluid may alter systemic effects of GH and PRL.
T2  - Pharmacology
T1  - Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin
IS  - 1
VL  - 57
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1859
ER  - 

@article{
author = "Milošević, Verica and Brkić, B and Velkovski, SD and Sekulić, Milka I. and Lovren, Mirjana B. and Starcević, V and Severs, Walter B",
year = "1998",
abstract = "This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells), Male rats received three i.c.v. injections (1 mu g/5 mu l) of SRIH-14 or SRIH-28 every second day, Blood samples were collected for hormone assays and pituitaries were removed for histological and morphometric evaluation 5 days after the last i.c.v. treatment, Compared to control animals, SRIH treatment decreased (p < 0.05) pituitary weight and all morphometric measurements obtained in GH and PRL cells, Concentrations of serum growth hormone (GH) and prolactin (PRL) in both SRIH-treated groups were also lower (p < 0.05) than in control rats, These findings suggest that centrally administered somatostatin is specifically involved in the control of growth and secretory activity of GH and PRL cells, Thus, pharmacological manipulation of SRIH receptors reached from cerebrospinal fluid may alter systemic effects of GH and PRL.",
journal = "Pharmacology",
title = "Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin",
number = "1",
volume = "57",
pages = "34",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1859"
}

Milošević, V., Brkić, B., Velkovski, S., Sekulić, M. I., Lovren, M. B., Starcević, V.,& Severs, W. B.. (1998). Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin. in Pharmacology, 57(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1859

Milošević V, Brkić B, Velkovski S, Sekulić MI, Lovren MB, Starcević V, Severs WB. Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin. in Pharmacology. 1998;57(1):null-34.
https://hdl.handle.net/21.15107/rcub_ibiss_1859 .

Milošević, Verica, Brkić, B, Velkovski, SD, Sekulić, Milka I., Lovren, Mirjana B., Starcević, V, Severs, Walter B, "Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin" in Pharmacology, 57, no. 1 (1998),
https://hdl.handle.net/21.15107/rcub_ibiss_1859 .

TY  - CONF
AU  - Dergović, D
AU  - Micić, M
AU  - Zivković, I
AU  - Koezević, J
AU  - Milosević, V
AU  - Starcević, V
PY  - 1998
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1864
C3  - European Journal of Neuroscience
T1  - The thymic monoaminergic innervation after centrally applied somatostatin in young rats
IS  - null
VL  - 10
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1864
ER  - 

@conference{
author = "Dergović, D and Micić, M and Zivković, I and Koezević, J and Milosević, V and Starcević, V",
year = "1998",
journal = "European Journal of Neuroscience",
title = "The thymic monoaminergic innervation after centrally applied somatostatin in young rats",
number = "null",
volume = "10",
pages = "232",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1864"
}

Dergović, D., Micić, M., Zivković, I., Koezević, J., Milosević, V.,& Starcević, V.. (1998). The thymic monoaminergic innervation after centrally applied somatostatin in young rats. in European Journal of Neuroscience, 10(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1864

Dergović D, Micić M, Zivković I, Koezević J, Milosević V, Starcević V. The thymic monoaminergic innervation after centrally applied somatostatin in young rats. in European Journal of Neuroscience. 1998;10(null):null-232.
https://hdl.handle.net/21.15107/rcub_ibiss_1864 .

Dergović, D, Micić, M, Zivković, I, Koezević, J, Milosević, V, Starcević, V, "The thymic monoaminergic innervation after centrally applied somatostatin in young rats" in European Journal of Neuroscience, 10, no. null (1998),
https://hdl.handle.net/21.15107/rcub_ibiss_1864 .

TY  - CONF
AU  - Micić, M
AU  - Dergović, D
AU  - Zivković, I
AU  - Knežević, J
AU  - Milosević, V
AU  - Starcević, V
PY  - 1998
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1863
C3  - European Journal of Neuroscience
T1  - The thymic cholinergic innervation of young rats centrally treated with somatostatin
IS  - null
VL  - 10
EP  - 229
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1863
ER  - 

@conference{
author = "Micić, M and Dergović, D and Zivković, I and Knežević, J and Milosević, V and Starcević, V",
year = "1998",
journal = "European Journal of Neuroscience",
title = "The thymic cholinergic innervation of young rats centrally treated with somatostatin",
number = "null",
volume = "10",
pages = "229",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1863"
}

Micić, M., Dergović, D., Zivković, I., Knežević, J., Milosević, V.,& Starcević, V.. (1998). The thymic cholinergic innervation of young rats centrally treated with somatostatin. in European Journal of Neuroscience, 10(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1863

Micić M, Dergović D, Zivković I, Knežević J, Milosević V, Starcević V. The thymic cholinergic innervation of young rats centrally treated with somatostatin. in European Journal of Neuroscience. 1998;10(null):null-229.
https://hdl.handle.net/21.15107/rcub_ibiss_1863 .

Micić, M, Dergović, D, Zivković, I, Knežević, J, Milosević, V, Starcević, V, "The thymic cholinergic innervation of young rats centrally treated with somatostatin" in European Journal of Neuroscience, 10, no. null (1998),
https://hdl.handle.net/21.15107/rcub_ibiss_1863 .

TY  - JOUR
AU  - Milošević, Verica
AU  - Brkić, B
AU  - Velkovski, S
AU  - Lovren, Mirjana B.
AU  - Sekulić, Milka I.
AU  - Starcević, V
PY  - 1997
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1878
AB  - The effects of the intracerebroventricular (i.c.v.) administration of somatostatin (SRIF-14) on zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex and an the blood concentrations of adrenocorticotropic hormone (ACTH), prolactin (PRL), growth hormone (GH), aldosterone, cortisol, progesterone and estradiol in male rats were studied. Each experimental animal was given three 1 mu g doses of SRIF-14 dissolved in 5 mu L saline by i.c.v. route every second day. Controls were treated in the same way with the same volume of saline. The rats were sacrificed by decapitation five days after the last SRIF-14 dose. The left adrenal gland of each animal was dissected and prepared for histological and morphometric analyses. Blood samples were collected for hormone level determinations. SRIF-14 led to a significant reduction (p < 0.05) of the absolute volume of the adrenal gland and of the volume of the cortex and ZG in comparison with the controls. Total number and volume of ZG cells and their nuclei was also significantly reduced (p < 0.05) in SRIF-14-treated rats as compared to the controls. There were no significant changes in morphometric parameters of ZF and ZR. At the same time, a significant decrease (p < 0.05) of aldosterone, GH, and PRL levels were observed, while the concentration of ACTH, cortisol, progesterone, and estradiol were almost unaltered in comparison with control values. It can be concluded that centrally applied SRIF-14 inhibits both the secretory activity and growth of adrenal ZG cells only, while insignificantly affecting ZF and ZR cells.
T2  - Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry
T1  - The effects of centrally applied somatostatin on the adrenal cortex of male rats
IS  - 2
VL  - 16
EP  - 94
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1878
ER  - 

@article{
author = "Milošević, Verica and Brkić, B and Velkovski, S and Lovren, Mirjana B. and Sekulić, Milka I. and Starcević, V",
year = "1997",
abstract = "The effects of the intracerebroventricular (i.c.v.) administration of somatostatin (SRIF-14) on zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex and an the blood concentrations of adrenocorticotropic hormone (ACTH), prolactin (PRL), growth hormone (GH), aldosterone, cortisol, progesterone and estradiol in male rats were studied. Each experimental animal was given three 1 mu g doses of SRIF-14 dissolved in 5 mu L saline by i.c.v. route every second day. Controls were treated in the same way with the same volume of saline. The rats were sacrificed by decapitation five days after the last SRIF-14 dose. The left adrenal gland of each animal was dissected and prepared for histological and morphometric analyses. Blood samples were collected for hormone level determinations. SRIF-14 led to a significant reduction (p < 0.05) of the absolute volume of the adrenal gland and of the volume of the cortex and ZG in comparison with the controls. Total number and volume of ZG cells and their nuclei was also significantly reduced (p < 0.05) in SRIF-14-treated rats as compared to the controls. There were no significant changes in morphometric parameters of ZF and ZR. At the same time, a significant decrease (p < 0.05) of aldosterone, GH, and PRL levels were observed, while the concentration of ACTH, cortisol, progesterone, and estradiol were almost unaltered in comparison with control values. It can be concluded that centrally applied SRIF-14 inhibits both the secretory activity and growth of adrenal ZG cells only, while insignificantly affecting ZF and ZR cells.",
journal = "Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry",
title = "The effects of centrally applied somatostatin on the adrenal cortex of male rats",
number = "2",
volume = "16",
pages = "94",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1878"
}

Milošević, V., Brkić, B., Velkovski, S., Lovren, M. B., Sekulić, M. I.,& Starcević, V.. (1997). The effects of centrally applied somatostatin on the adrenal cortex of male rats. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 16(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1878

Milošević V, Brkić B, Velkovski S, Lovren MB, Sekulić MI, Starcević V. The effects of centrally applied somatostatin on the adrenal cortex of male rats. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry. 1997;16(2):null-94.
https://hdl.handle.net/21.15107/rcub_ibiss_1878 .

Milošević, Verica, Brkić, B, Velkovski, S, Lovren, Mirjana B., Sekulić, Milka I., Starcević, V, "The effects of centrally applied somatostatin on the adrenal cortex of male rats" in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 16, no. 2 (1997),
https://hdl.handle.net/21.15107/rcub_ibiss_1878 .