Stilinović, Nebojša

Link to this page

Authority KeyName Variants
289fa95c-fd3a-4fa6-8259-b992a858ccaa
  • Stilinović, Nebojša (2)
Projects

Author's Bibliography

Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus

Sekulić, Slobodan; Stilinović, Nebojša; Baturan, Branislava; Krsman, Anita; Tešić, Igor; Vejnović, Aleksandra; Petrović, Đorđe; Nikolašević, Željka; Mijavec, Anna; Pešić, Vesna; Petković, Branka

(Lausanne: Frontiers Media SA, 2023)

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Stilinović, Nebojša
AU  - Baturan, Branislava
AU  - Krsman, Anita
AU  - Tešić, Igor
AU  - Vejnović, Aleksandra
AU  - Petrović, Đorđe
AU  - Nikolašević, Željka
AU  - Mijavec, Anna
AU  - Pešić, Vesna
AU  - Petković, Branka
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6057
AB  - Background: Breech presentation (BP) results from at random filling of the intrauterine cavity, with an equal probability for a BP or cephalic presentation (CP). Each fetus in BP has its "pair" in CP randomly assumed CP. Direct comparison of BP and CP makes bias to less expressed differences between these two groups. It is therefore necessary to subtract the number of fetuses/newborns from the CP set that are identical to the number of fetuses/newborns in the BP set, with identical characteristics, and add this group to the BP set before comparing them to the rest of the CP fetuses/newborns in the matching process. Methods: The procedure encompasses nine variables in pregnancies with a congenitally malformed uterus (CMU) identified at the Department of Obstetrics (1985-2014): gestational age, birth mass, birth length, head circumference, shoulders circumference, umbilical length, placental weight, newborn mass/newborn length ratio, and newborn mass/placental mass ratio. Firstly, the probability of BP was determined and its relation to gestational age, physical characteristics, and previous presentations. Then direct comparison as well as case-control matching of the CP and BP were performed. Case-control matching was based on either a single specific variable (M1) or all combined variables (M2). Findings: 462 deliveries were identified with CMU. In 81 cases of multiparity, a fetal presentation was found to be an independent event regardless of the previous presentation, gestational age, and newborn physical characteristics. In four types of CMU with 337 deliveries (Bicornuate, Didelphys, Unicornuate, Arcuate), 9 variables with 36 instances of comparison were observed. M1 in 10 instances and M2 in 6 instances showed a statistically significant lower value of breech/random presentation compared with CP. CP have lower value in 2 instances in M1 and 1 in M2. Statistically significant differences were absent without the matching process. Interpretations: The study confirms the maximum probability for the BP is 50%. The case-control matching procedure shows that it is able to detect the difference between the breech/random presentation and CP, while the classic method of direct comparison was unable to detect any differences. The outcome of the breech/random presentation in CMU should be evaluated with the described case-control matching procedure.
PB  - Lausanne: Frontiers Media SA
T2  - Frontiers in Medicine
T1  - Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus
VL  - 10
DO  - 10.3389/fmed.2023.1160229
SP  - 1160229
ER  - 
@article{
author = "Sekulić, Slobodan and Stilinović, Nebojša and Baturan, Branislava and Krsman, Anita and Tešić, Igor and Vejnović, Aleksandra and Petrović, Đorđe and Nikolašević, Željka and Mijavec, Anna and Pešić, Vesna and Petković, Branka",
year = "2023",
abstract = "Background: Breech presentation (BP) results from at random filling of the intrauterine cavity, with an equal probability for a BP or cephalic presentation (CP). Each fetus in BP has its "pair" in CP randomly assumed CP. Direct comparison of BP and CP makes bias to less expressed differences between these two groups. It is therefore necessary to subtract the number of fetuses/newborns from the CP set that are identical to the number of fetuses/newborns in the BP set, with identical characteristics, and add this group to the BP set before comparing them to the rest of the CP fetuses/newborns in the matching process. Methods: The procedure encompasses nine variables in pregnancies with a congenitally malformed uterus (CMU) identified at the Department of Obstetrics (1985-2014): gestational age, birth mass, birth length, head circumference, shoulders circumference, umbilical length, placental weight, newborn mass/newborn length ratio, and newborn mass/placental mass ratio. Firstly, the probability of BP was determined and its relation to gestational age, physical characteristics, and previous presentations. Then direct comparison as well as case-control matching of the CP and BP were performed. Case-control matching was based on either a single specific variable (M1) or all combined variables (M2). Findings: 462 deliveries were identified with CMU. In 81 cases of multiparity, a fetal presentation was found to be an independent event regardless of the previous presentation, gestational age, and newborn physical characteristics. In four types of CMU with 337 deliveries (Bicornuate, Didelphys, Unicornuate, Arcuate), 9 variables with 36 instances of comparison were observed. M1 in 10 instances and M2 in 6 instances showed a statistically significant lower value of breech/random presentation compared with CP. CP have lower value in 2 instances in M1 and 1 in M2. Statistically significant differences were absent without the matching process. Interpretations: The study confirms the maximum probability for the BP is 50%. The case-control matching procedure shows that it is able to detect the difference between the breech/random presentation and CP, while the classic method of direct comparison was unable to detect any differences. The outcome of the breech/random presentation in CMU should be evaluated with the described case-control matching procedure.",
publisher = "Lausanne: Frontiers Media SA",
journal = "Frontiers in Medicine",
title = "Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus",
volume = "10",
doi = "10.3389/fmed.2023.1160229",
pages = "1160229"
}
Sekulić, S., Stilinović, N., Baturan, B., Krsman, A., Tešić, I., Vejnović, A., Petrović, Đ., Nikolašević, Ž., Mijavec, A., Pešić, V.,& Petković, B.. (2023). Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus. in Frontiers in Medicine
Lausanne: Frontiers Media SA., 10, 1160229.
https://doi.org/10.3389/fmed.2023.1160229
Sekulić S, Stilinović N, Baturan B, Krsman A, Tešić I, Vejnović A, Petrović Đ, Nikolašević Ž, Mijavec A, Pešić V, Petković B. Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus. in Frontiers in Medicine. 2023;10:1160229.
doi:10.3389/fmed.2023.1160229 .
Sekulić, Slobodan, Stilinović, Nebojša, Baturan, Branislava, Krsman, Anita, Tešić, Igor, Vejnović, Aleksandra, Petrović, Đorđe, Nikolašević, Željka, Mijavec, Anna, Pešić, Vesna, Petković, Branka, "Corrected evaluation of the breech presentation outcome based on etiology of this presentation in congenitally malformed uterus" in Frontiers in Medicine, 10 (2023):1160229,
https://doi.org/10.3389/fmed.2023.1160229 . .

Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses

Čapo, Ivan; Milenković, Ivan; Čapo, Nataša; Stilinović, Nebojša; Vukmirović, Saša; Teofilovic, Branislava; Petković, Branka; Sekulić, Slobodan

(Serbian Biological Society, 2020)

TY  - JOUR
AU  - Čapo, Ivan
AU  - Milenković, Ivan
AU  - Čapo, Nataša
AU  - Stilinović, Nebojša
AU  - Vukmirović, Saša
AU  - Teofilovic, Branislava
AU  - Petković, Branka
AU  - Sekulić, Slobodan
PY  - 2020
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46642000041C
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4102
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6035
AB  - The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses
IS  - 4
VL  - 72
DO  - 10.2298/ABS200619041C
SP  - 473
EP  - 482
ER  - 
@article{
author = "Čapo, Ivan and Milenković, Ivan and Čapo, Nataša and Stilinović, Nebojša and Vukmirović, Saša and Teofilovic, Branislava and Petković, Branka and Sekulić, Slobodan",
year = "2020",
abstract = "The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses",
number = "4",
volume = "72",
doi = "10.2298/ABS200619041C",
pages = "473-482"
}
Čapo, I., Milenković, I., Čapo, N., Stilinović, N., Vukmirović, S., Teofilovic, B., Petković, B.,& Sekulić, S.. (2020). Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences
Serbian Biological Society., 72(4), 473-482.
https://doi.org/10.2298/ABS200619041C
Čapo I, Milenković I, Čapo N, Stilinović N, Vukmirović S, Teofilovic B, Petković B, Sekulić S. Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences. 2020;72(4):473-482.
doi:10.2298/ABS200619041C .
Čapo, Ivan, Milenković, Ivan, Čapo, Nataša, Stilinović, Nebojša, Vukmirović, Saša, Teofilovic, Branislava, Petković, Branka, Sekulić, Slobodan, "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses" in Archives of Biological Sciences, 72, no. 4 (2020):473-482,
https://doi.org/10.2298/ABS200619041C . .