TY  - JOUR
AU  - Pešić, Vesna
AU  - Veskov, Rosica
AU  - Petković, Branka
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana
PY  - 2003
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0197458002002324?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3812
AB  - Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10- imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age. The following age groups of animals were considered: 28-30 postnatal day (PND)-old rats (peripubertal), 48-50 PND-old (pubertal), 3-month-old (adults), 12-month-old (middle-aged) and 24-month-old (aged). The motor response was measured by an automated animal activity measuring system. The obtained results showed that: (1) in contrast to AMPH, MK-801 induced more pronounced increases of both locomotor and stereotypic activities in peripubertal and pubertal than in adult and aged rats; (2) AMPH induced the same locomotor and stereotypic activity increase in pubertal, adult and middle-aged rats; (3) both AMPH and MK-801 led to a senescence-related decrease of motor activity. These data suggest that the balance of the glutamatergic and dopaminergic systems changes during aging. Such a change is important in understanding schizophrenia and the motor system decline observed in the later stages of life.
PB  - Elsevier Science Inc
T2  - Neurobiology of Aging
T1  - Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats
IS  - 5
VL  - 24
DO  - 10.1016/S0197-4580(02)00232-4
SP  - 715
EP  - 723
ER  - 

@article{
author = "Pešić, Vesna and Veskov, Rosica and Petković, Branka and Rakić, Ljubisav and Stojiljković, Mirjana",
year = "2003",
abstract = "Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10- imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age. The following age groups of animals were considered: 28-30 postnatal day (PND)-old rats (peripubertal), 48-50 PND-old (pubertal), 3-month-old (adults), 12-month-old (middle-aged) and 24-month-old (aged). The motor response was measured by an automated animal activity measuring system. The obtained results showed that: (1) in contrast to AMPH, MK-801 induced more pronounced increases of both locomotor and stereotypic activities in peripubertal and pubertal than in adult and aged rats; (2) AMPH induced the same locomotor and stereotypic activity increase in pubertal, adult and middle-aged rats; (3) both AMPH and MK-801 led to a senescence-related decrease of motor activity. These data suggest that the balance of the glutamatergic and dopaminergic systems changes during aging. Such a change is important in understanding schizophrenia and the motor system decline observed in the later stages of life.",
publisher = "Elsevier Science Inc",
journal = "Neurobiology of Aging",
title = "Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats",
number = "5",
volume = "24",
doi = "10.1016/S0197-4580(02)00232-4",
pages = "715-723"
}

Pešić, V., Veskov, R., Petković, B., Rakić, L.,& Stojiljković, M.. (2003). Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. in Neurobiology of Aging
Elsevier Science Inc., 24(5), 715-723.
https://doi.org/10.1016/S0197-4580(02)00232-4

Pešić V, Veskov R, Petković B, Rakić L, Stojiljković M. Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. in Neurobiology of Aging. 2003;24(5):715-723.
doi:10.1016/S0197-4580(02)00232-4 .

Pešić, Vesna, Veskov, Rosica, Petković, Branka, Rakić, Ljubisav, Stojiljković, Mirjana, "Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats" in Neurobiology of Aging, 24, no. 5 (2003):715-723,
https://doi.org/10.1016/S0197-4580(02)00232-4 . .

TY  - JOUR
AU  - Pešić, Vesna
AU  - Petković, Branka
AU  - Milanović, Desanka
AU  - Tomić, Mirko
AU  - Veskov, Rosica
AU  - Rakić, Ljubisav
PY  - 2003
UR  - https://www.sciencedirect.com/science/article/pii/S0166432803001426?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3811
AB  - The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.
PB  - Elsevier
T2  - Behavioural Brain Research
T1  - Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine
IS  - 1-2
VL  - 147
DO  - 10.1016/S0166-4328(03)00142-6
SP  - 211
EP  - 215
ER  - 

@article{
author = "Pešić, Vesna and Petković, Branka and Milanović, Desanka and Tomić, Mirko and Veskov, Rosica and Rakić, Ljubisav",
year = "2003",
abstract = "The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.",
publisher = "Elsevier",
journal = "Behavioural Brain Research",
title = "Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine",
number = "1-2",
volume = "147",
doi = "10.1016/S0166-4328(03)00142-6",
pages = "211-215"
}

Pešić, V., Petković, B., Milanović, D., Tomić, M., Veskov, R.,& Rakić, L.. (2003). Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine. in Behavioural Brain Research
Elsevier., 147(1-2), 211-215.
https://doi.org/10.1016/S0166-4328(03)00142-6

Pešić V, Petković B, Milanović D, Tomić M, Veskov R, Rakić L. Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine. in Behavioural Brain Research. 2003;147(1-2):211-215.
doi:10.1016/S0166-4328(03)00142-6 .

Pešić, Vesna, Petković, Branka, Milanović, Desanka, Tomić, Mirko, Veskov, Rosica, Rakić, Ljubisav, "Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine" in Behavioural Brain Research, 147, no. 1-2 (2003):211-215,
https://doi.org/10.1016/S0166-4328(03)00142-6 . .