TY  - JOUR
AU  - Savić, Danka
AU  - Knežević, Goran
AU  - Matić, Gordana
AU  - Damjanović, Svetozar
PY  - 2018
UR  - http://www.psyneuen-journal.com/article/S0306-4530(18)30088-X/fulltext
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3034
AB  - BACKGROUND Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. RESULTS The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder - personality trait Disintegration. CONCLUSIONS According to our project results, DHEAS is the second putative biomarker for trauma-related disorders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.
T2  - Psychoneuroendocrinology
T1  - PTSD and depressive symptoms are linked to DHEAS via personality.
VL  - 92
DO  - 10.1016/j.psyneuen.2018.03.017
SP  - 29
EP  - 33
ER  - 

@article{
author = "Savić, Danka and Knežević, Goran and Matić, Gordana and Damjanović, Svetozar",
year = "2018",
abstract = "BACKGROUND Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. RESULTS The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder - personality trait Disintegration. CONCLUSIONS According to our project results, DHEAS is the second putative biomarker for trauma-related disorders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.",
journal = "Psychoneuroendocrinology",
title = "PTSD and depressive symptoms are linked to DHEAS via personality.",
volume = "92",
doi = "10.1016/j.psyneuen.2018.03.017",
pages = "29-33"
}

Savić, D., Knežević, G., Matić, G.,& Damjanović, S.. (2018). PTSD and depressive symptoms are linked to DHEAS via personality.. in Psychoneuroendocrinology, 92, 29-33.
https://doi.org/10.1016/j.psyneuen.2018.03.017

Savić D, Knežević G, Matić G, Damjanović S. PTSD and depressive symptoms are linked to DHEAS via personality.. in Psychoneuroendocrinology. 2018;92:29-33.
doi:10.1016/j.psyneuen.2018.03.017 .

Savić, Danka, Knežević, Goran, Matić, Gordana, Damjanović, Svetozar, "PTSD and depressive symptoms are linked to DHEAS via personality." in Psychoneuroendocrinology, 92 (2018):29-33,
https://doi.org/10.1016/j.psyneuen.2018.03.017 . .

TY  - CHAP
AU  - Matić, Gordana
AU  - Vojnović-Milutinović, Danijela
AU  - Elaković, Ivana
AU  - Brkljačić, Jelena
AU  - Savić, Danka
PY  - 2016
UR  - http://link.springer.com/10.1007/978-3-319-08359-9_3
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2628
AB  - This chapter summarizes current research on glucocorticoid receptor (GR) functional alterations associated with trauma exposure, posttraumatic stress disorder (PTSD) psychopathology, and resilience and vulnerability to PTSD. Special attention is paid to hormone-binding activity of the receptor, the level of its expression, its ratio to mineralocorticoid receptor (MR), and the interactions of corticosteroid receptors with heat shock protein chaperones, Hsp90 and Hsp70. Determinations of GR number (Bmax) and assessments of lymphocyte sensitivity to glucocorticoids in trauma-exposed individuals with and without PTSD have yielded rather inconsistent results. The contribution of most other factors determining tissue responsiveness to glucocorticoid hormones to PTSD pathophysiology is currently under investigation. Thus, increased GR protein level in peripheral lymphocytes from current and lifetime PTSD patients in comparison to trauma-exposed non-PTSD individuals (trauma controls) appeared to be a possible correlate of vulnerability to PTSD. Besides, PTSD patients displayed the lowest and trauma controls the highest fractional occupancy of the GR, suggesting that the receptor redox status may be a factor contributing to vulnerability/resilience to PTSD. Estimates of the GR hormone-binding potency (Bmax/KD ratio) and of strength of correlation between Bmax and KD pointed to deterioration of glucocorticoid signaling in the lymphocytes as a characteristic of PTSD patients. Lymphocyte MR protein level, MR/GR ratio, and Hsp90 and Hsp70 levels were found to be unaffected by traumatic events and past or current PTSD symptoms. However, the association of GR and Hsp90 expression levels appeared as a candidate marker of trauma exposure, while that of MR and Hsp70 levels of vulnerability to PTSD.
PB  - Springer International Publishing
T2  - Comprehensive Guide to Post-Traumatic Stress Disorders
T1  - Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD
DO  - 10.1007/978-3-319-08359-9_3
SP  - 961
EP  - 978
ER  - 

@inbook{
editor = "Martin, Colin R., Preedy, Victor R., Patel, Vinood B.",
author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Elaković, Ivana and Brkljačić, Jelena and Savić, Danka",
year = "2016",
abstract = "This chapter summarizes current research on glucocorticoid receptor (GR) functional alterations associated with trauma exposure, posttraumatic stress disorder (PTSD) psychopathology, and resilience and vulnerability to PTSD. Special attention is paid to hormone-binding activity of the receptor, the level of its expression, its ratio to mineralocorticoid receptor (MR), and the interactions of corticosteroid receptors with heat shock protein chaperones, Hsp90 and Hsp70. Determinations of GR number (Bmax) and assessments of lymphocyte sensitivity to glucocorticoids in trauma-exposed individuals with and without PTSD have yielded rather inconsistent results. The contribution of most other factors determining tissue responsiveness to glucocorticoid hormones to PTSD pathophysiology is currently under investigation. Thus, increased GR protein level in peripheral lymphocytes from current and lifetime PTSD patients in comparison to trauma-exposed non-PTSD individuals (trauma controls) appeared to be a possible correlate of vulnerability to PTSD. Besides, PTSD patients displayed the lowest and trauma controls the highest fractional occupancy of the GR, suggesting that the receptor redox status may be a factor contributing to vulnerability/resilience to PTSD. Estimates of the GR hormone-binding potency (Bmax/KD ratio) and of strength of correlation between Bmax and KD pointed to deterioration of glucocorticoid signaling in the lymphocytes as a characteristic of PTSD patients. Lymphocyte MR protein level, MR/GR ratio, and Hsp90 and Hsp70 levels were found to be unaffected by traumatic events and past or current PTSD symptoms. However, the association of GR and Hsp90 expression levels appeared as a candidate marker of trauma exposure, while that of MR and Hsp70 levels of vulnerability to PTSD.",
publisher = "Springer International Publishing",
journal = "Comprehensive Guide to Post-Traumatic Stress Disorders",
booktitle = "Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD",
doi = "10.1007/978-3-319-08359-9_3",
pages = "961-978"
}

Martin, C. R., Preedy, V. R., Patel, V. B., Matić, G., Vojnović-Milutinović, D., Elaković, I., Brkljačić, J.,& Savić, D.. (2016). Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD. in Comprehensive Guide to Post-Traumatic Stress Disorders
Springer International Publishing., 961-978.
https://doi.org/10.1007/978-3-319-08359-9_3

Martin CR, Preedy VR, Patel VB, Matić G, Vojnović-Milutinović D, Elaković I, Brkljačić J, Savić D. Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD. in Comprehensive Guide to Post-Traumatic Stress Disorders. 2016;:961-978.
doi:10.1007/978-3-319-08359-9_3 .

Martin, Colin R., Preedy, Victor R., Patel, Vinood B., Matić, Gordana, Vojnović-Milutinović, Danijela, Elaković, Ivana, Brkljačić, Jelena, Savić, Danka, "Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD" in Comprehensive Guide to Post-Traumatic Stress Disorders (2016):961-978,
https://doi.org/10.1007/978-3-319-08359-9_3 . .