Milenković, Ivan

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  • Milenković, Ivan (5)
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Author's Bibliography

Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens

Milanović, Slobodan; Milenković, Ivan; Lazarević, Jelica; Todosijević, Marina; Ljujić, Jovana; Mitić, Zorica; Nikolić, Biljana; Marin, Petar; Tešević, Vele

(Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade, 2024)

TY  - DATA
AU  - Milanović, Slobodan
AU  - Milenković, Ivan
AU  - Lazarević, Jelica
AU  - Todosijević, Marina
AU  - Ljujić, Jovana
AU  - Mitić, Zorica
AU  - Nikolić, Biljana
AU  - Marin, Petar
AU  - Tešević, Vele
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6490
AB  - We provide one excel (with five sheets) and 5 csv files. The data in the excel file is the same as the one provided in the 5 csv files. Data file named 'raw data.xlsx' is consisted of 5 sheets containing raw data on all analyzed traits in the manuscript for the spongy moth and Phytophthora sp. The first sheet named 'RDC' contains data on relative deterrence coefficients of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils. The second sheet named 'ADC' contains data on absolute deterrence coefficients of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils. The third sheet named 'RCR' contains data on the relative consumption rate of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils, and control treatment. The forth sheet named ‘RGR’ contains data on relative growth rate of gypsy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils, and control treatment. The fifth sheet named ‘Ir’ contains data on the antimicrobial activity of three concentrations of Calocedrus decurrens and Cupressus arizonica essential oils against Phytophthora × cambivora, P. plurivora and P. quercina expressed as inhibition rate of mycelial growth.
PB  - Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade
T1  - Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6490
ER  - 
@misc{
author = "Milanović, Slobodan and Milenković, Ivan and Lazarević, Jelica and Todosijević, Marina and Ljujić, Jovana and Mitić, Zorica and Nikolić, Biljana and Marin, Petar and Tešević, Vele",
year = "2024",
abstract = "We provide one excel (with five sheets) and 5 csv files. The data in the excel file is the same as the one provided in the 5 csv files. Data file named 'raw data.xlsx' is consisted of 5 sheets containing raw data on all analyzed traits in the manuscript for the spongy moth and Phytophthora sp. The first sheet named 'RDC' contains data on relative deterrence coefficients of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils. The second sheet named 'ADC' contains data on absolute deterrence coefficients of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils. The third sheet named 'RCR' contains data on the relative consumption rate of spongy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils, and control treatment. The forth sheet named ‘RGR’ contains data on relative growth rate of gypsy moth larvae exposed to three different concentrations of Calocedrus decurrens and Cupressus arizonica essential oils, and control treatment. The fifth sheet named ‘Ir’ contains data on the antimicrobial activity of three concentrations of Calocedrus decurrens and Cupressus arizonica essential oils against Phytophthora × cambivora, P. plurivora and P. quercina expressed as inhibition rate of mycelial growth.",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade",
title = "Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6490"
}
Milanović, S., Milenković, I., Lazarević, J., Todosijević, M., Ljujić, J., Mitić, Z., Nikolić, B., Marin, P.,& Tešević, V.. (2024). Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens. 
Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade..
https://hdl.handle.net/21.15107/rcub_ibiss_6490
Milanović S, Milenković I, Lazarević J, Todosijević M, Ljujić J, Mitić Z, Nikolić B, Marin P, Tešević V. Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens. 2024;.
https://hdl.handle.net/21.15107/rcub_ibiss_6490 .
Milanović, Slobodan, Milenković, Ivan, Lazarević, Jelica, Todosijević, Marina, Ljujić, Jovana, Mitić, Zorica, Nikolić, Biljana, Marin, Petar, Tešević, Vele, "Biological activity of two coniferous essential oils against spongy moth larvae and Phytophthora root pathogens" (2024),
https://hdl.handle.net/21.15107/rcub_ibiss_6490 .

Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem

Dimitrijević, Dunja; Boranijašević, Sanja; Lavrnja, Irena; Adžić, Marija; Dragić, Milorad; Stekić, Anđela; Mihajlović, Katarina; Milenković, Ivan; Laketa, Danijela

(Belgrade: Serbian Neuroscience Society, 2023)

TY  - CONF
AU  - Dimitrijević, Dunja
AU  - Boranijašević, Sanja
AU  - Lavrnja, Irena
AU  - Adžić, Marija
AU  - Dragić, Milorad
AU  - Stekić, Anđela
AU  - Mihajlović, Katarina
AU  - Milenković, Ivan
AU  - Laketa, Danijela
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5983
AB  - In preterm infants, insufficient exposure to endogenous glucocorticoids often leads to fatal complications. Therefore, synthetic glucocorticoids (sGC) are commonly applied to pregnant women at risk of preterm delivery between the 24th and 34th week of gestation. Despite the risk of adverse neurodevelopmental effects, repeat courses are frequently given. In the auditory system, the repeated sGC treatment prolonged neural transmission time and increased auditory thresholds in Wistar rats. Purinergic signaling plays an important role in the development of the auditory system.
We investigated the effects of repeated antenatal treatment with sGC on the components of the purinergic system in the developing auditory brainstem, at postnatal days (PD) 8,14, and 20 (pre-, post-hearing onset, and juvenile stage, respectively). Pregnant C57BL/6 dams received 0.4 mg/kg dexamethasone (DEX) s.c., at gestation days (GD) 15-17 (repeated course - 3DEX), mimicking clinical treatment for three consecutive weeks. In a single treatment (1 DEX), dams received DEX at GD 15, then saline at GD16 and 17. The control group (Sh) received saline. After treatment with 3DEX, a sharp decrease in immunoreactivity for A1 receptors and P2Y1 mRNA expression was observed (in PD8-20 and PD8, respectively). Although treatment effects were not detected for P2X2 receptor, we observed a developmental increase in its mRNA expression. P2X3 receptor, as well as CD73, CD39, and NTPDase2, exhibited stable expression.
In conclusion, repeated antenatal DEX treatment induced changes in A1 and P2Y1 receptors expression in the developing auditory brainstem, suggesting adverse neurodevelopmental effects, urging for evaluation of the current protocols for antenatal sGC treatment.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
T1  - Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem
SP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5983
ER  - 
@conference{
author = "Dimitrijević, Dunja and Boranijašević, Sanja and Lavrnja, Irena and Adžić, Marija and Dragić, Milorad and Stekić, Anđela and Mihajlović, Katarina and Milenković, Ivan and Laketa, Danijela",
year = "2023",
abstract = "In preterm infants, insufficient exposure to endogenous glucocorticoids often leads to fatal complications. Therefore, synthetic glucocorticoids (sGC) are commonly applied to pregnant women at risk of preterm delivery between the 24th and 34th week of gestation. Despite the risk of adverse neurodevelopmental effects, repeat courses are frequently given. In the auditory system, the repeated sGC treatment prolonged neural transmission time and increased auditory thresholds in Wistar rats. Purinergic signaling plays an important role in the development of the auditory system.
We investigated the effects of repeated antenatal treatment with sGC on the components of the purinergic system in the developing auditory brainstem, at postnatal days (PD) 8,14, and 20 (pre-, post-hearing onset, and juvenile stage, respectively). Pregnant C57BL/6 dams received 0.4 mg/kg dexamethasone (DEX) s.c., at gestation days (GD) 15-17 (repeated course - 3DEX), mimicking clinical treatment for three consecutive weeks. In a single treatment (1 DEX), dams received DEX at GD 15, then saline at GD16 and 17. The control group (Sh) received saline. After treatment with 3DEX, a sharp decrease in immunoreactivity for A1 receptors and P2Y1 mRNA expression was observed (in PD8-20 and PD8, respectively). Although treatment effects were not detected for P2X2 receptor, we observed a developmental increase in its mRNA expression. P2X3 receptor, as well as CD73, CD39, and NTPDase2, exhibited stable expression.
In conclusion, repeated antenatal DEX treatment induced changes in A1 and P2Y1 receptors expression in the developing auditory brainstem, suggesting adverse neurodevelopmental effects, urging for evaluation of the current protocols for antenatal sGC treatment.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia",
title = "Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem",
pages = "64",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5983"
}
Dimitrijević, D., Boranijašević, S., Lavrnja, I., Adžić, M., Dragić, M., Stekić, A., Mihajlović, K., Milenković, I.,& Laketa, D.. (2023). Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society., 64.
https://hdl.handle.net/21.15107/rcub_ibiss_5983
Dimitrijević D, Boranijašević S, Lavrnja I, Adžić M, Dragić M, Stekić A, Mihajlović K, Milenković I, Laketa D. Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem. in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. 2023;:64.
https://hdl.handle.net/21.15107/rcub_ibiss_5983 .
Dimitrijević, Dunja, Boranijašević, Sanja, Lavrnja, Irena, Adžić, Marija, Dragić, Milorad, Stekić, Anđela, Mihajlović, Katarina, Milenković, Ivan, Laketa, Danijela, "Developmental effects of repeated antenatal synthetic glucocorticoid treatment on purinergic signaling in the auditory brainstem" in Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia (2023):64,
https://hdl.handle.net/21.15107/rcub_ibiss_5983 .

Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses

Čapo, Ivan; Milenković, Ivan; Čapo, Nataša; Stilinović, Nebojša; Vukmirović, Saša; Teofilovic, Branislava; Petković, Branka; Sekulić, Slobodan

(Serbian Biological Society, 2020)

TY  - JOUR
AU  - Čapo, Ivan
AU  - Milenković, Ivan
AU  - Čapo, Nataša
AU  - Stilinović, Nebojša
AU  - Vukmirović, Saša
AU  - Teofilovic, Branislava
AU  - Petković, Branka
AU  - Sekulić, Slobodan
PY  - 2020
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46642000041C
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4102
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6035
AB  - The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses
IS  - 4
VL  - 72
DO  - 10.2298/ABS200619041C
SP  - 473
EP  - 482
ER  - 
@article{
author = "Čapo, Ivan and Milenković, Ivan and Čapo, Nataša and Stilinović, Nebojša and Vukmirović, Saša and Teofilovic, Branislava and Petković, Branka and Sekulić, Slobodan",
year = "2020",
abstract = "The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses",
number = "4",
volume = "72",
doi = "10.2298/ABS200619041C",
pages = "473-482"
}
Čapo, I., Milenković, I., Čapo, N., Stilinović, N., Vukmirović, S., Teofilovic, B., Petković, B.,& Sekulić, S.. (2020). Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences
Serbian Biological Society., 72(4), 473-482.
https://doi.org/10.2298/ABS200619041C
Čapo I, Milenković I, Čapo N, Stilinović N, Vukmirović S, Teofilovic B, Petković B, Sekulić S. Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences. 2020;72(4):473-482.
doi:10.2298/ABS200619041C .
Čapo, Ivan, Milenković, Ivan, Čapo, Nataša, Stilinović, Nebojša, Vukmirović, Saša, Teofilovic, Branislava, Petković, Branka, Sekulić, Slobodan, "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses" in Archives of Biological Sciences, 72, no. 4 (2020):473-482,
https://doi.org/10.2298/ABS200619041C . .

Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar

Milanović, Slobodan; Lazarević, Jelica; Karadžić, Dragan; Milenković, Ivan; Jankovsky, Libor; Vuleta, Ana

(Blackwell Publishing Ltd, 2015)

TY  - JOUR
AU  - Milanović, Slobodan
AU  - Lazarević, Jelica
AU  - Karadžić, Dragan
AU  - Milenković, Ivan
AU  - Jankovsky, Libor
AU  - Vuleta, Ana
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3961
AB  - 1. Globally, vast areas of forest are currently threatened by Lymantria dispar
L. and Phytophthora species, which cause widespread declines and cascading ecological
impacts. One important aim of evolutionary and ecological studies is to understand their
interactions.
2. The present study tests whether Quercus rubra L. trees naturally infected with P.
plurivora T. Jung & T.I. Burgess or free of infection are more suitable for L. dispar
herbivory, and if relationships between L. dispar performance and herbivory may vary
depending on whether trees are infected or free of infection.
3. In choice tests, the consumed area of leaves from trees infected by P. plurivora was
four times larger than that from non-infected trees, probably because the increased values
of N, soluble protein, and water content observed in the leaves of infected trees enhanced
acceptability. Although larval performance was better in Phytophthora-infected trees,
relationships between larval performance and defoliation did not significantly interact
with the health status of trees.
4. The present results suggest that the impact of P. plurivora on natural and managed
ecosystems may generate a positive feedback loop for oak decline. The link between the
behavioural and physiological responses of L. dispar to infected trees and the population
growth in nature deserves further investigation.
PB  - Blackwell Publishing Ltd
T2  - Ecological Entomology
T1  - Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar
IS  - 4
VL  - 40
DO  - 10.1111/een.12193
SP  - 479
EP  - 482
ER  - 
@article{
author = "Milanović, Slobodan and Lazarević, Jelica and Karadžić, Dragan and Milenković, Ivan and Jankovsky, Libor and Vuleta, Ana",
year = "2015",
abstract = "1. Globally, vast areas of forest are currently threatened by Lymantria dispar
L. and Phytophthora species, which cause widespread declines and cascading ecological
impacts. One important aim of evolutionary and ecological studies is to understand their
interactions.
2. The present study tests whether Quercus rubra L. trees naturally infected with P.
plurivora T. Jung & T.I. Burgess or free of infection are more suitable for L. dispar
herbivory, and if relationships between L. dispar performance and herbivory may vary
depending on whether trees are infected or free of infection.
3. In choice tests, the consumed area of leaves from trees infected by P. plurivora was
four times larger than that from non-infected trees, probably because the increased values
of N, soluble protein, and water content observed in the leaves of infected trees enhanced
acceptability. Although larval performance was better in Phytophthora-infected trees,
relationships between larval performance and defoliation did not significantly interact
with the health status of trees.
4. The present results suggest that the impact of P. plurivora on natural and managed
ecosystems may generate a positive feedback loop for oak decline. The link between the
behavioural and physiological responses of L. dispar to infected trees and the population
growth in nature deserves further investigation.",
publisher = "Blackwell Publishing Ltd",
journal = "Ecological Entomology",
title = "Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar",
number = "4",
volume = "40",
doi = "10.1111/een.12193",
pages = "479-482"
}
Milanović, S., Lazarević, J., Karadžić, D., Milenković, I., Jankovsky, L.,& Vuleta, A.. (2015). Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar. in Ecological Entomology
Blackwell Publishing Ltd., 40(4), 479-482.
https://doi.org/10.1111/een.12193
Milanović S, Lazarević J, Karadžić D, Milenković I, Jankovsky L, Vuleta A. Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar. in Ecological Entomology. 2015;40(4):479-482.
doi:10.1111/een.12193 .
Milanović, Slobodan, Lazarević, Jelica, Karadžić, Dragan, Milenković, Ivan, Jankovsky, Libor, Vuleta, Ana, "Belowground infections of the invasive Phytophthora plurivora pathogen enhance the suitability of red oak leaves to the generalist herbivore Lymantria dispar" in Ecological Entomology, 40, no. 4 (2015):479-482,
https://doi.org/10.1111/een.12193 . .
21
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Molecular basis of brain injury and repair

Peković, Sanja; Dacić, Sanja; Nedeljković, Nadežda; Bjelobaba, Ivana; Filipović, Radmila; Milenković, Ivan; Lavrnja, Irena; Savić, Danijela; Jovanović, Saša; Rakić, Ljubisav; Stojiljković, Mirjana

(Kerala, India: Research Signpost, 2006)

TY  - CHAP
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Nedeljković, Nadežda
AU  - Bjelobaba, Ivana
AU  - Filipović, Radmila
AU  - Milenković, Ivan
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Jovanović, Saša
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5871
AB  - Injury to the central nervous system (CNS) is one of the leading causes of death and invalidity among all people below the age of 45 for which there are no specific treatments. The insight into the molecular pathophysiology of brain dysfunctions after the injury will provide indications for new effective therapeutic approaches that will limit damage, slow cell death and promote repair. The aim of this review is to highlight molecular mechanisms underlining primary and secondary injury. The initial impact or primary injury induces elevation of extracellular concentration of neurotransmitters leading to changes in electrical properties of neuronal membrane, net influx of Ca2+ and activation of diverse cellular signaling pathways. To restore neuronal homeostasis, the activities and expression of a variety of enzymes involved in control of extracellular concentration of biogenic amines and purine nucleotides/nucleosides, as well as the membrane potential are altered. The CNS has a limited capacity of self-repair. However, there are indications that the neonatal brain has a greater capacity for recovery than adult brain. The well known pathological hallmark of CNS injury is formation of the glial scar, the major impediment to axonal regeneration. Recently, it was shown that treatment with the purine nucleoside analogues attenuates and delays the process of reactive gliosis, and thus may be a useful approach for improving neurological recovery from head injury.
PB  - Kerala, India: Research Signpost
T2  - Neurobiological studies – From genes to behavior 2006
T1  - Molecular basis of brain injury and repair
SP  - 143
EP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5871
ER  - 
@inbook{
author = "Peković, Sanja and Dacić, Sanja and Nedeljković, Nadežda and Bjelobaba, Ivana and Filipović, Radmila and Milenković, Ivan and Lavrnja, Irena and Savić, Danijela and Jovanović, Saša and Rakić, Ljubisav and Stojiljković, Mirjana",
year = "2006",
abstract = "Injury to the central nervous system (CNS) is one of the leading causes of death and invalidity among all people below the age of 45 for which there are no specific treatments. The insight into the molecular pathophysiology of brain dysfunctions after the injury will provide indications for new effective therapeutic approaches that will limit damage, slow cell death and promote repair. The aim of this review is to highlight molecular mechanisms underlining primary and secondary injury. The initial impact or primary injury induces elevation of extracellular concentration of neurotransmitters leading to changes in electrical properties of neuronal membrane, net influx of Ca2+ and activation of diverse cellular signaling pathways. To restore neuronal homeostasis, the activities and expression of a variety of enzymes involved in control of extracellular concentration of biogenic amines and purine nucleotides/nucleosides, as well as the membrane potential are altered. The CNS has a limited capacity of self-repair. However, there are indications that the neonatal brain has a greater capacity for recovery than adult brain. The well known pathological hallmark of CNS injury is formation of the glial scar, the major impediment to axonal regeneration. Recently, it was shown that treatment with the purine nucleoside analogues attenuates and delays the process of reactive gliosis, and thus may be a useful approach for improving neurological recovery from head injury.",
publisher = "Kerala, India: Research Signpost",
journal = "Neurobiological studies – From genes to behavior 2006",
booktitle = "Molecular basis of brain injury and repair",
pages = "143-165",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5871"
}
Peković, S., Dacić, S., Nedeljković, N., Bjelobaba, I., Filipović, R., Milenković, I., Lavrnja, I., Savić, D., Jovanović, S., Rakić, L.,& Stojiljković, M.. (2006). Molecular basis of brain injury and repair. in Neurobiological studies – From genes to behavior 2006
Kerala, India: Research Signpost., 143-165.
https://hdl.handle.net/21.15107/rcub_ibiss_5871
Peković S, Dacić S, Nedeljković N, Bjelobaba I, Filipović R, Milenković I, Lavrnja I, Savić D, Jovanović S, Rakić L, Stojiljković M. Molecular basis of brain injury and repair. in Neurobiological studies – From genes to behavior 2006. 2006;:143-165.
https://hdl.handle.net/21.15107/rcub_ibiss_5871 .
Peković, Sanja, Dacić, Sanja, Nedeljković, Nadežda, Bjelobaba, Ivana, Filipović, Radmila, Milenković, Ivan, Lavrnja, Irena, Savić, Danijela, Jovanović, Saša, Rakić, Ljubisav, Stojiljković, Mirjana, "Molecular basis of brain injury and repair" in Neurobiological studies – From genes to behavior 2006 (2006):143-165,
https://hdl.handle.net/21.15107/rcub_ibiss_5871 .
5