TY  - JOUR
AU  - Bajić, Aleksandar
AU  - Spasić, Mihajlo
AU  - Anđus, Pavle R
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasojević, Ivan B
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/959
AB  - The effects of H2O2 are widely studied in cell cultures and other in vitro systems. However, such investigations are performed with the assumption that H2O2 concentration is constant, which may not properly reflect in vivo settings, particularly in redox-turbulent microenvironments such as mitochondria. Here we introduced and tested a novel concept of fluctuating oxidative stress. We treated C6 astroglial cells and primary astrocytes with H2O2, using three regimes of exposure - continuous, as well as fluctuating at low or high rate, and evaluated mitochondrial membrane potential and other parameters of mitochondrial activity - respiration, reducing capacity, and superoxide production, as well as intracellular ATP, intracellular calcium, and NF-kappa B activation. When compared to continuous exposure, fluctuating H2O2 induced a pronounced hyperpolarization in mitochondria, whereas the activity of electron transport chain appears not to be significantly affected. H2O2 provoked a decrease of ATP level and an increase of intracellular calcium concentration, independently of the regime of treatment. However, fluctuating H2O2 induced a specific pattern of large-amplitude fluctuations of calcium concentration. An impact on NF kappa B activation was observed for high rate fluctuations, whereas continuous and low rate fluctuating oxidative stress did not provoke significant effects. Presented results outline the (patho)physiological relevance of redox fluctuations.
T2  - Plos One
T1  - Fluctuating vs. Continuous Exposure to H2O2: The Effects on Mitochondrial Membrane Potential, Intracellular Calcium, and NF-kappa B in Astroglia
IS  - 10
VL  - 8
SP  - 111
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_959
ER  - 

@article{
author = "Bajić, Aleksandar and Spasić, Mihajlo and Anđus, Pavle R and Savić, Danijela and Parabučki, Ana B. and Nikolić-Kokić, Aleksandra and Spasojević, Ivan B",
year = "2013",
abstract = "The effects of H2O2 are widely studied in cell cultures and other in vitro systems. However, such investigations are performed with the assumption that H2O2 concentration is constant, which may not properly reflect in vivo settings, particularly in redox-turbulent microenvironments such as mitochondria. Here we introduced and tested a novel concept of fluctuating oxidative stress. We treated C6 astroglial cells and primary astrocytes with H2O2, using three regimes of exposure - continuous, as well as fluctuating at low or high rate, and evaluated mitochondrial membrane potential and other parameters of mitochondrial activity - respiration, reducing capacity, and superoxide production, as well as intracellular ATP, intracellular calcium, and NF-kappa B activation. When compared to continuous exposure, fluctuating H2O2 induced a pronounced hyperpolarization in mitochondria, whereas the activity of electron transport chain appears not to be significantly affected. H2O2 provoked a decrease of ATP level and an increase of intracellular calcium concentration, independently of the regime of treatment. However, fluctuating H2O2 induced a specific pattern of large-amplitude fluctuations of calcium concentration. An impact on NF kappa B activation was observed for high rate fluctuations, whereas continuous and low rate fluctuating oxidative stress did not provoke significant effects. Presented results outline the (patho)physiological relevance of redox fluctuations.",
journal = "Plos One",
title = "Fluctuating vs. Continuous Exposure to H2O2: The Effects on Mitochondrial Membrane Potential, Intracellular Calcium, and NF-kappa B in Astroglia",
number = "10",
volume = "8",
pages = "111-na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_959"
}

Bajić, A., Spasić, M., Anđus, P. R., Savić, D., Parabučki, A. B., Nikolić-Kokić, A.,& Spasojević, I. B.. (2013). Fluctuating vs. Continuous Exposure to H2O2: The Effects on Mitochondrial Membrane Potential, Intracellular Calcium, and NF-kappa B in Astroglia. in Plos One, 8(10), 111-na.
https://hdl.handle.net/21.15107/rcub_ibiss_959

Bajić A, Spasić M, Anđus PR, Savić D, Parabučki AB, Nikolić-Kokić A, Spasojević IB. Fluctuating vs. Continuous Exposure to H2O2: The Effects on Mitochondrial Membrane Potential, Intracellular Calcium, and NF-kappa B in Astroglia. in Plos One. 2013;8(10):111-na.
https://hdl.handle.net/21.15107/rcub_ibiss_959 .

Bajić, Aleksandar, Spasić, Mihajlo, Anđus, Pavle R, Savić, Danijela, Parabučki, Ana B., Nikolić-Kokić, Aleksandra, Spasojević, Ivan B, "Fluctuating vs. Continuous Exposure to H2O2: The Effects on Mitochondrial Membrane Potential, Intracellular Calcium, and NF-kappa B in Astroglia" in Plos One, 8, no. 10 (2013):111-na,
https://hdl.handle.net/21.15107/rcub_ibiss_959 .

TY  - JOUR
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Bjelobaba, Ivana
AU  - Dačić, Sanja
AU  - Božić, Iva D.
AU  - Parabučki, Ana B.
AU  - Nedeljković, Nadezda N
AU  - Peković, Sanja
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana B
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1167
AB  - Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Microglia and astrocytes represent two related cell types involved in the brain pathology in EAE. Accumulations of hypertrophic reactive astrocytes, intensely stained with glial fibrillary acidic protein (GFAP), which also expressed vimentin, are prominent features of EAE lesions. Recent studies from our laboratory reported that ribavirin attenuated the disease process in EAE by reducing clinical and histological manifestations. EAE was induced in genetically susceptible Dark Agouti rats with syngeneic spinal cord homogenate in complete Freund's adjuvant. Real time PCR and immunohistochemistry were used for determination of GFAP and vimentin gene and tissue expression. We have observed the increased gene and tissue expression of GFAP and vimentin in EAE rats. Ribavirin treatment significantly decreased the number of reactive astrocytes at the peak of disease. At the end of the disease, we have observed reactive GFAP(+) and vimentin(+) astrocytes in both immunized and ribavirin-treated groups, accompanied by increased level of GFAP mRNA. The present study indicates that ribavirin may have the ability to attenuate astrocyte proliferation and glial scaring at the peak of the disease and modulate the astroglial response to EAE during the time-course of the disease.
T2  - Journal of Pharmacological Sciences
T1  - The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis
IS  - 3
VL  - 119
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1167
ER  - 

@article{
author = "Lavrnja, Irena and Savić, Danijela and Bjelobaba, Ivana and Dačić, Sanja and Božić, Iva D. and Parabučki, Ana B. and Nedeljković, Nadezda N and Peković, Sanja and Rakić, Ljubisav and Stojiljković, Mirjana B",
year = "2012",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Microglia and astrocytes represent two related cell types involved in the brain pathology in EAE. Accumulations of hypertrophic reactive astrocytes, intensely stained with glial fibrillary acidic protein (GFAP), which also expressed vimentin, are prominent features of EAE lesions. Recent studies from our laboratory reported that ribavirin attenuated the disease process in EAE by reducing clinical and histological manifestations. EAE was induced in genetically susceptible Dark Agouti rats with syngeneic spinal cord homogenate in complete Freund's adjuvant. Real time PCR and immunohistochemistry were used for determination of GFAP and vimentin gene and tissue expression. We have observed the increased gene and tissue expression of GFAP and vimentin in EAE rats. Ribavirin treatment significantly decreased the number of reactive astrocytes at the peak of disease. At the end of the disease, we have observed reactive GFAP(+) and vimentin(+) astrocytes in both immunized and ribavirin-treated groups, accompanied by increased level of GFAP mRNA. The present study indicates that ribavirin may have the ability to attenuate astrocyte proliferation and glial scaring at the peak of the disease and modulate the astroglial response to EAE during the time-course of the disease.",
journal = "Journal of Pharmacological Sciences",
title = "The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis",
number = "3",
volume = "119",
pages = "232",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1167"
}

Lavrnja, I., Savić, D., Bjelobaba, I., Dačić, S., Božić, I. D., Parabučki, A. B., Nedeljković, N. N., Peković, S., Rakić, L.,& Stojiljković, M. B.. (2012). The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. in Journal of Pharmacological Sciences, 119(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1167

Lavrnja I, Savić D, Bjelobaba I, Dačić S, Božić ID, Parabučki AB, Nedeljković NN, Peković S, Rakić L, Stojiljković MB. The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. in Journal of Pharmacological Sciences. 2012;119(3):null-232.
https://hdl.handle.net/21.15107/rcub_ibiss_1167 .

Lavrnja, Irena, Savić, Danijela, Bjelobaba, Ivana, Dačić, Sanja, Božić, Iva D., Parabučki, Ana B., Nedeljković, Nadezda N, Peković, Sanja, Rakić, Ljubisav, Stojiljković, Mirjana B, "The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis" in Journal of Pharmacological Sciences, 119, no. 3 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1167 .

TY  - JOUR
AU  - Brkić, Predrag D
AU  - Stojiljković, Mirjana B
AU  - Jovanović, Tomislav S
AU  - Dačić, Sanja
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Bjelobaba, Ivana
AU  - Rakić, Ljubisav
AU  - Peković, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1146
AB  - Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), Control+HBO (CHBO), Sham controls (S), Sham control+HBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, Lesion+HBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60 minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries.
T2  - Brain Injury
T1  - Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats
IS  - 10
VL  - 26
SP  - 961
EP  - 1284
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1146
ER  - 

@article{
author = "Brkić, Predrag D and Stojiljković, Mirjana B and Jovanović, Tomislav S and Dačić, Sanja and Lavrnja, Irena and Savić, Danijela and Parabučki, Ana B. and Bjelobaba, Ivana and Rakić, Ljubisav and Peković, Sanja",
year = "2012",
abstract = "Objective: To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex. Methods: The experimental paradigm implies the following groups: Control animals (C), Control+HBO (CHBO), Sham controls (S), Sham control+HBO (SHBO), Lesion group (L), right sensorimotor cortex was removed by suction, Lesion+HBO (LHBO). Hyperbaric protocol: pressure applied 2.5 atmospheres absolute, for 60 minutes, once a day for 10 days. A beam walking test and grip strength meter were used to evaluate the recovery of motor functions. Expression profiles of growth-associated protein 43 (GAP43) and synaptophysin (SYP) were detected using immunohistochemistry. Results: The LHBO group achieved statistically superior scores in the beam walking test compared to the L group. Additionally, the recovery of muscle strength of the affected hindpaw was significantly enhanced after HBO treatment. Hyperbaric oxygenation induced over-expression of GAP43 and SYP in the neurons surrounding the lesion site. Conclusions: Data presented suggest that hyperbaric oxygen therapy can intensify neuroplastic responses by promoting axonal sprouting and synapse remodelling, which contributes to the recovery of locomotor performances in rats. This provides the perspective for implementation of HBO in clinical strategies for treating traumatic brain injuries.",
journal = "Brain Injury",
title = "Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats",
number = "10",
volume = "26",
pages = "961-1284",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1146"
}

Brkić, P. D., Stojiljković, M. B., Jovanović, T. S., Dačić, S., Lavrnja, I., Savić, D., Parabučki, A. B., Bjelobaba, I., Rakić, L.,& Peković, S.. (2012). Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. in Brain Injury, 26(10), 961-1284.
https://hdl.handle.net/21.15107/rcub_ibiss_1146

Brkić PD, Stojiljković MB, Jovanović TS, Dačić S, Lavrnja I, Savić D, Parabučki AB, Bjelobaba I, Rakić L, Peković S. Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. in Brain Injury. 2012;26(10):961-1284.
https://hdl.handle.net/21.15107/rcub_ibiss_1146 .

Brkić, Predrag D, Stojiljković, Mirjana B, Jovanović, Tomislav S, Dačić, Sanja, Lavrnja, Irena, Savić, Danijela, Parabučki, Ana B., Bjelobaba, Ivana, Rakić, Ljubisav, Peković, Sanja, "Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats" in Brain Injury, 26, no. 10 (2012):961-1284,
https://hdl.handle.net/21.15107/rcub_ibiss_1146 .

TY  - JOUR
AU  - Parabučki, Ana B.
AU  - Božić, Iva D.
AU  - Bjelobaba, Ivana
AU  - Lavrnja, Irena
AU  - Brkić, Predrag D
AU  - Jovanović, Tomislav S
AU  - Savić, Danijela
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1072
AB  - Aim To evaluate the effect of hyperbaric oxygen therapy (HBOT) on superoxide dismutase 2 (SOD2) expression pattern after the cortical stab injury (CSI). Methods CSI was performed on 88 male Wistar rats, divided into control, sham, lesioned, and HBO groups. HBOT protocol was the following: pressure applied was 2.5 absolute atmospheres, for 60 minutes, once a day for consecutive 3 or 10 days. The pattern of SOD2 expression and cellular localization was analyzed using real-time polymerase chain reaction, Western blot, and double-label fluorescence immunohistochemistry. Neurons undergoing degeneration were visualized with Fluoro-Jade (R) B. Results CSI induced significant transient increase in SOD2 protein levels at day 3 post injury, which was followed by a reduction toward control levels at post-injury day 10. At the same time points, mRNA levels for SOD2 in the injured cortex were down-regulated. Exposure to HBO for 3 days considerably down-regulated SOD2 protein levels in the injured cortex, while after 10 days of HBOT an up-regulation of SOD2 was observed. HBOT significantly increased mRNA levels for SOD2 at both time points compared to the corresponding L group, but they were still lower than in controls. Double immunofluorescence staining revealed that 3 days after CSI, up-regulation of SOD2 was mostly due to an increased expression in reactive astrocytes surrounding the lesion site. HBOT attenuated SOD2 expression both in neuronal and astroglial cells. Fluoro-Jade (R) B labeling showed that HBOT significantly decreased the number of degenerating neurons in the injured cortex. Conclusion HBOT alters SOD2 protein and mRNA levels after brain injury in a time-dependent manner.
T2  - Croatian Medical Journal
T1  - Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats
IS  - 6
VL  - 53
SP  - 217
EP  - 597
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1072
ER  - 

@article{
author = "Parabučki, Ana B. and Božić, Iva D. and Bjelobaba, Ivana and Lavrnja, Irena and Brkić, Predrag D and Jovanović, Tomislav S and Savić, Danijela and Stojiljković, Mirjana B and Peković, Sanja",
year = "2012",
abstract = "Aim To evaluate the effect of hyperbaric oxygen therapy (HBOT) on superoxide dismutase 2 (SOD2) expression pattern after the cortical stab injury (CSI). Methods CSI was performed on 88 male Wistar rats, divided into control, sham, lesioned, and HBO groups. HBOT protocol was the following: pressure applied was 2.5 absolute atmospheres, for 60 minutes, once a day for consecutive 3 or 10 days. The pattern of SOD2 expression and cellular localization was analyzed using real-time polymerase chain reaction, Western blot, and double-label fluorescence immunohistochemistry. Neurons undergoing degeneration were visualized with Fluoro-Jade (R) B. Results CSI induced significant transient increase in SOD2 protein levels at day 3 post injury, which was followed by a reduction toward control levels at post-injury day 10. At the same time points, mRNA levels for SOD2 in the injured cortex were down-regulated. Exposure to HBO for 3 days considerably down-regulated SOD2 protein levels in the injured cortex, while after 10 days of HBOT an up-regulation of SOD2 was observed. HBOT significantly increased mRNA levels for SOD2 at both time points compared to the corresponding L group, but they were still lower than in controls. Double immunofluorescence staining revealed that 3 days after CSI, up-regulation of SOD2 was mostly due to an increased expression in reactive astrocytes surrounding the lesion site. HBOT attenuated SOD2 expression both in neuronal and astroglial cells. Fluoro-Jade (R) B labeling showed that HBOT significantly decreased the number of degenerating neurons in the injured cortex. Conclusion HBOT alters SOD2 protein and mRNA levels after brain injury in a time-dependent manner.",
journal = "Croatian Medical Journal",
title = "Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats",
number = "6",
volume = "53",
pages = "217-597",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1072"
}

Parabučki, A. B., Božić, I. D., Bjelobaba, I., Lavrnja, I., Brkić, P. D., Jovanović, T. S., Savić, D., Stojiljković, M. B.,& Peković, S.. (2012). Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats. in Croatian Medical Journal, 53(6), 217-597.
https://hdl.handle.net/21.15107/rcub_ibiss_1072

Parabučki AB, Božić ID, Bjelobaba I, Lavrnja I, Brkić PD, Jovanović TS, Savić D, Stojiljković MB, Peković S. Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats. in Croatian Medical Journal. 2012;53(6):217-597.
https://hdl.handle.net/21.15107/rcub_ibiss_1072 .

Parabučki, Ana B., Božić, Iva D., Bjelobaba, Ivana, Lavrnja, Irena, Brkić, Predrag D, Jovanović, Tomislav S, Savić, Danijela, Stojiljković, Mirjana B, Peković, Sanja, "Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats" in Croatian Medical Journal, 53, no. 6 (2012):217-597,
https://hdl.handle.net/21.15107/rcub_ibiss_1072 .

TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Parabučki, Ana B.
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Dačić, Sanja
AU  - Peković, Sanja
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Nedeljković, Nadezda N
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1289
AB  - Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.
T2  - Journal of Neuroscience Research
T1  - Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury
IS  - 6
VL  - 89
EP  - 873
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1289
ER  - 

@article{
author = "Bjelobaba, Ivana and Parabučki, Ana B. and Lavrnja, Irena and Savić, Danijela and Dačić, Sanja and Peković, Sanja and Rakić, Ljubisa M and Stojiljković, Mirjana B and Nedeljković, Nadezda N",
year = "2011",
abstract = "Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.",
journal = "Journal of Neuroscience Research",
title = "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury",
number = "6",
volume = "89",
pages = "873",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1289"
}

Bjelobaba, I., Parabučki, A. B., Lavrnja, I., Savić, D., Dačić, S., Peković, S., Rakić, L. M., Stojiljković, M. B.,& Nedeljković, N. N.. (2011). Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research, 89(6).
https://hdl.handle.net/21.15107/rcub_ibiss_1289

Bjelobaba I, Parabučki AB, Lavrnja I, Savić D, Dačić S, Peković S, Rakić LM, Stojiljković MB, Nedeljković NN. Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research. 2011;89(6):null-873.
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

Bjelobaba, Ivana, Parabučki, Ana B., Lavrnja, Irena, Savić, Danijela, Dačić, Sanja, Peković, Sanja, Rakić, Ljubisa M, Stojiljković, Mirjana B, Nedeljković, Nadezda N, "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury" in Journal of Neuroscience Research, 89, no. 6 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

TY  - CONF
AU  - Parabučki, Ana B.
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
AU  - Nedeljković, Nadezda N
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1263
C3  - Glia
T1  - Pannexin-1 Upregulation in Cultured Astrocytes Is Induced By Scratch Wound
IS  - null
VL  - 59
EP  - S147
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1263
ER  - 

@conference{
author = "Parabučki, Ana B. and Bjelobaba, Ivana and Savić, Danijela and Stojiljković, Mirjana B and Peković, Sanja and Nedeljković, Nadezda N",
year = "2011",
journal = "Glia",
title = "Pannexin-1 Upregulation in Cultured Astrocytes Is Induced By Scratch Wound",
number = "null",
volume = "59",
pages = "S147",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1263"
}

Parabučki, A. B., Bjelobaba, I., Savić, D., Stojiljković, M. B., Peković, S.,& Nedeljković, N. N.. (2011). Pannexin-1 Upregulation in Cultured Astrocytes Is Induced By Scratch Wound. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1263

Parabučki AB, Bjelobaba I, Savić D, Stojiljković MB, Peković S, Nedeljković NN. Pannexin-1 Upregulation in Cultured Astrocytes Is Induced By Scratch Wound. in Glia. 2011;59(null):null-S147.
https://hdl.handle.net/21.15107/rcub_ibiss_1263 .

Parabučki, Ana B., Bjelobaba, Ivana, Savić, Danijela, Stojiljković, Mirjana B, Peković, Sanja, Nedeljković, Nadezda N, "Pannexin-1 Upregulation in Cultured Astrocytes Is Induced By Scratch Wound" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1263 .

TY  - CONF
AU  - Dačić, Sanja
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Božić, Iva D.
AU  - Bjelobaba, Ivana
AU  - Laketa, Danijela
AU  - Nedeljković, Nadezda N
AU  - Rakić, Ljubisa M
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1262
C3  - Glia
T1  - Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation
IS  - null
VL  - 59
EP  - S52
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1262
ER  - 

@conference{
author = "Dačić, Sanja and Stojiljković, Mirjana B and Lavrnja, Irena and Savić, Danijela and Parabučki, Ana B. and Božić, Iva D. and Bjelobaba, Ivana and Laketa, Danijela and Nedeljković, Nadezda N and Rakić, Ljubisa M and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation",
number = "null",
volume = "59",
pages = "S52",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1262"
}

Dačić, S., Stojiljković, M. B., Lavrnja, I., Savić, D., Parabučki, A. B., Božić, I. D., Bjelobaba, I., Laketa, D., Nedeljković, N. N., Rakić, L. M.,& Peković, S.. (2011). Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1262

Dačić S, Stojiljković MB, Lavrnja I, Savić D, Parabučki AB, Božić ID, Bjelobaba I, Laketa D, Nedeljković NN, Rakić LM, Peković S. Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia. 2011;59(null):null-S52.
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

Dačić, Sanja, Stojiljković, Mirjana B, Lavrnja, Irena, Savić, Danijela, Parabučki, Ana B., Božić, Iva D., Bjelobaba, Ivana, Laketa, Danijela, Nedeljković, Nadezda N, Rakić, Ljubisa M, Peković, Sanja, "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

TY  - CONF
AU  - Božić, Iva D.
AU  - Gađanski, Ivana
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Dačić, Sanja
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1261
C3  - Glia
T1  - Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury
IS  - null
VL  - 59
EP  - S101
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1261
ER  - 

@conference{
author = "Božić, Iva D. and Gađanski, Ivana and Lavrnja, Irena and Parabučki, Ana B. and Dačić, Sanja and Bjelobaba, Ivana and Savić, Danijela and Rakić, Ljubisa M and Stojiljković, Mirjana B and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury",
number = "null",
volume = "59",
pages = "S101",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1261"
}

Božić, I. D., Gađanski, I., Lavrnja, I., Parabučki, A. B., Dačić, S., Bjelobaba, I., Savić, D., Rakić, L. M., Stojiljković, M. B.,& Peković, S.. (2011). Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1261

Božić ID, Gađanski I, Lavrnja I, Parabučki AB, Dačić S, Bjelobaba I, Savić D, Rakić LM, Stojiljković MB, Peković S. Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia. 2011;59(null):null-S101.
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

Božić, Iva D., Gađanski, Ivana, Lavrnja, Irena, Parabučki, Ana B., Dačić, Sanja, Bjelobaba, Ivana, Savić, Danijela, Rakić, Ljubisa M, Stojiljković, Mirjana B, Peković, Sanja, "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

TY  - CONF
AU  - Savić, Danijela
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Dačić, Sanja
AU  - Bjelobaba, Ivana
AU  - Nedeljković, Nadezda N
AU  - Herdegen, T
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1264
C3  - Glia
T1  - In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation
IS  - null
VL  - 59
EP  - S149
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1264
ER  - 

@conference{
author = "Savić, Danijela and Stojiljković, Mirjana B and Lavrnja, Irena and Parabučki, Ana B. and Dačić, Sanja and Bjelobaba, Ivana and Nedeljković, Nadezda N and Herdegen, T and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation",
number = "null",
volume = "59",
pages = "S149",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1264"
}

Savić, D., Stojiljković, M. B., Lavrnja, I., Parabučki, A. B., Dačić, S., Bjelobaba, I., Nedeljković, N. N., Herdegen, T.,& Peković, S.. (2011). In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1264

Savić D, Stojiljković MB, Lavrnja I, Parabučki AB, Dačić S, Bjelobaba I, Nedeljković NN, Herdegen T, Peković S. In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation. in Glia. 2011;59(null):null-S149.
https://hdl.handle.net/21.15107/rcub_ibiss_1264 .

Savić, Danijela, Stojiljković, Mirjana B, Lavrnja, Irena, Parabučki, Ana B., Dačić, Sanja, Bjelobaba, Ivana, Nedeljković, Nadezda N, Herdegen, T, Peković, Sanja, "In Vitro Effect of Ribavirin and Tiazofurin on Microglial Response To Inflammation" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1264 .

TY  - JOUR
AU  - Clarner, T
AU  - Parabučki, Ana B.
AU  - Beyer, Christian
AU  - Kipp, M
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1280
AB  - Corticosteroids (CS) are effective in the treatment of many brain disorders, such as multiple sclerosis (MS) or traumatic brain injury. This has been scrutinised in different experimental animal models. However, neither the mechanisms, nor the site of CS action are fully understood. Short-term high-dose CS treatment improves MS symptoms and severity of clinical disability during an acute inflammatory exacerbation of disease. In the present study, we analysed the influence of CS on the expression of cellular and molecular markers of spontaneous endogenous remyelination in the toxic non-immune cuprizone animal model at early (9 days) and intermediate (21 days) remyelination, as well as steroidal effects in primary astrocytes and oligodendrocyte progenitor cultures. Dexamethasone (Dex) and methylprednisolone (MP) induced a higher expression of the differentiation markers myelin basic protein and proteolipid protein (PLP) in cultured oligodendrocyte progenitor cells (OPC). CS exposure of primary cultured astrocytes resulted in a greater expression of those genes involved in OPC proliferation [fibroblast growth factor 2 (FGF2) and platelet-derived growth factor (PDGF)-alpha alpha] and a reduced expression of the pro-maturation factor insulin-like growth factor 1. Pro-maturating effects of CS were completely blocked by FGF2 and PDGF-alpha alpha co-application in OPC cultures. MP treatment in vivo resulted in a reduced recovery of PLP-staining intensity, whereas the re-population of the demyelinated corpus callosum with adenomatous polyposis coli-expressing oligodendrocytes was not affected. The numbers of brain intrinsic inflammatory cells, microglia and astrocytes during remyelination were similar in placebo and MP-treated animals. Our findings suggest that treatment with CS might have, in addition to the well-known benefical effects on inflammatory processes, a negative influence on remyelination.
T2  - Journal of Neuroendocrinology
T1  - Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice
IS  - 7
VL  - 23
EP  - 611
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1280
ER  - 

@article{
author = "Clarner, T and Parabučki, Ana B. and Beyer, Christian and Kipp, M",
year = "2011",
abstract = "Corticosteroids (CS) are effective in the treatment of many brain disorders, such as multiple sclerosis (MS) or traumatic brain injury. This has been scrutinised in different experimental animal models. However, neither the mechanisms, nor the site of CS action are fully understood. Short-term high-dose CS treatment improves MS symptoms and severity of clinical disability during an acute inflammatory exacerbation of disease. In the present study, we analysed the influence of CS on the expression of cellular and molecular markers of spontaneous endogenous remyelination in the toxic non-immune cuprizone animal model at early (9 days) and intermediate (21 days) remyelination, as well as steroidal effects in primary astrocytes and oligodendrocyte progenitor cultures. Dexamethasone (Dex) and methylprednisolone (MP) induced a higher expression of the differentiation markers myelin basic protein and proteolipid protein (PLP) in cultured oligodendrocyte progenitor cells (OPC). CS exposure of primary cultured astrocytes resulted in a greater expression of those genes involved in OPC proliferation [fibroblast growth factor 2 (FGF2) and platelet-derived growth factor (PDGF)-alpha alpha] and a reduced expression of the pro-maturation factor insulin-like growth factor 1. Pro-maturating effects of CS were completely blocked by FGF2 and PDGF-alpha alpha co-application in OPC cultures. MP treatment in vivo resulted in a reduced recovery of PLP-staining intensity, whereas the re-population of the demyelinated corpus callosum with adenomatous polyposis coli-expressing oligodendrocytes was not affected. The numbers of brain intrinsic inflammatory cells, microglia and astrocytes during remyelination were similar in placebo and MP-treated animals. Our findings suggest that treatment with CS might have, in addition to the well-known benefical effects on inflammatory processes, a negative influence on remyelination.",
journal = "Journal of Neuroendocrinology",
title = "Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice",
number = "7",
volume = "23",
pages = "611",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1280"
}

Clarner, T., Parabučki, A. B., Beyer, C.,& Kipp, M.. (2011). Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice. in Journal of Neuroendocrinology, 23(7).
https://hdl.handle.net/21.15107/rcub_ibiss_1280

Clarner T, Parabučki AB, Beyer C, Kipp M. Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice. in Journal of Neuroendocrinology. 2011;23(7):null-611.
https://hdl.handle.net/21.15107/rcub_ibiss_1280 .

Clarner, T, Parabučki, Ana B., Beyer, Christian, Kipp, M, "Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice" in Journal of Neuroendocrinology, 23, no. 7 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1280 .

TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Savić, Danijela
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
AU  - Nedeljković, Nadezda N
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1341
AB  - The ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), an enzyme involved in degradation of extracellular adenosine triphosphate (ATP), is expressed on nerve fibers in different brain regions, including cortex. Here we studied the expression and role of this enzyme after unilateral cortical stab injury in rats. In cortical sections of control rats, NTPDase3 immunoreactivity was associated with two types of fibers: thin processes, occasionally with small mushroom-like protrusions and slightly thicker fibers with more pronounced and more frequent varicosities, whereas immunopositive neuronal perycaria were never observed. Although NTPDase3-positive thin processes and thicker fibers, by general appearance, size and shape, could be dendrites and axons, respectively, they were never immunopositive for microtubule associated protein-2 or neurofilament H subunit. Cortical stab injury induced rapid (within 4 hours) focal varicose swelling that evolved over time to prominent beading of NTPDase3-positive fibers. The NTPDase3-positive fibers in all experimental groups also abundantly express NTPDase1, ecto-5'-nucleotidase and P2X2 receptor channels. Because the brain injury causes a massive ATP release, it is reasonable to conclude that purinoreceptors and ectonucleotidases play an important role in the process of neuritic beading. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
T2  - Neuroscience
T1  - The Cortical Stab Injury Induces Beading of Fibers Expressing Ecto-Nucleoside Triphosphate Diphosphohydrolase 3
IS  - 1
VL  - 170
EP  - 116
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1341
ER  - 

@article{
author = "Bjelobaba, Ivana and Lavrnja, Irena and Parabučki, Ana B. and Savić, Danijela and Stojiljković, Mirjana B and Peković, Sanja and Nedeljković, Nadezda N",
year = "2010",
abstract = "The ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), an enzyme involved in degradation of extracellular adenosine triphosphate (ATP), is expressed on nerve fibers in different brain regions, including cortex. Here we studied the expression and role of this enzyme after unilateral cortical stab injury in rats. In cortical sections of control rats, NTPDase3 immunoreactivity was associated with two types of fibers: thin processes, occasionally with small mushroom-like protrusions and slightly thicker fibers with more pronounced and more frequent varicosities, whereas immunopositive neuronal perycaria were never observed. Although NTPDase3-positive thin processes and thicker fibers, by general appearance, size and shape, could be dendrites and axons, respectively, they were never immunopositive for microtubule associated protein-2 or neurofilament H subunit. Cortical stab injury induced rapid (within 4 hours) focal varicose swelling that evolved over time to prominent beading of NTPDase3-positive fibers. The NTPDase3-positive fibers in all experimental groups also abundantly express NTPDase1, ecto-5'-nucleotidase and P2X2 receptor channels. Because the brain injury causes a massive ATP release, it is reasonable to conclude that purinoreceptors and ectonucleotidases play an important role in the process of neuritic beading. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.",
journal = "Neuroscience",
title = "The Cortical Stab Injury Induces Beading of Fibers Expressing Ecto-Nucleoside Triphosphate Diphosphohydrolase 3",
number = "1",
volume = "170",
pages = "116",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1341"
}

Bjelobaba, I., Lavrnja, I., Parabučki, A. B., Savić, D., Stojiljković, M. B., Peković, S.,& Nedeljković, N. N.. (2010). The Cortical Stab Injury Induces Beading of Fibers Expressing Ecto-Nucleoside Triphosphate Diphosphohydrolase 3. in Neuroscience, 170(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1341

Bjelobaba I, Lavrnja I, Parabučki AB, Savić D, Stojiljković MB, Peković S, Nedeljković NN. The Cortical Stab Injury Induces Beading of Fibers Expressing Ecto-Nucleoside Triphosphate Diphosphohydrolase 3. in Neuroscience. 2010;170(1):null-116.
https://hdl.handle.net/21.15107/rcub_ibiss_1341 .

Bjelobaba, Ivana, Lavrnja, Irena, Parabučki, Ana B., Savić, Danijela, Stojiljković, Mirjana B, Peković, Sanja, Nedeljković, Nadezda N, "The Cortical Stab Injury Induces Beading of Fibers Expressing Ecto-Nucleoside Triphosphate Diphosphohydrolase 3" in Neuroscience, 170, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1341 .

TY  - CONF
AU  - Nedeljković, Nadezda N
AU  - Bjelobaba, Ivana
AU  - Parabučki, Ana B.
AU  - Lavrnja, Irena
AU  - Peković, Sanja
AU  - Stojiljković, Mirjana B
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1374
C3  - Purinergic Signalling
T1  - Ecto-5 '-nucleotidase (e-5NT) switches from neurons to astrocytes after cortical stab injury in rat
IS  - null
VL  - 6
EP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1374
ER  - 

@conference{
author = "Nedeljković, Nadezda N and Bjelobaba, Ivana and Parabučki, Ana B. and Lavrnja, Irena and Peković, Sanja and Stojiljković, Mirjana B",
year = "2010",
journal = "Purinergic Signalling",
title = "Ecto-5 '-nucleotidase (e-5NT) switches from neurons to astrocytes after cortical stab injury in rat",
number = "null",
volume = "6",
pages = "77",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1374"
}

Nedeljković, N. N., Bjelobaba, I., Parabučki, A. B., Lavrnja, I., Peković, S.,& Stojiljković, M. B.. (2010). Ecto-5 '-nucleotidase (e-5NT) switches from neurons to astrocytes after cortical stab injury in rat. in Purinergic Signalling, 6(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1374

Nedeljković NN, Bjelobaba I, Parabučki AB, Lavrnja I, Peković S, Stojiljković MB. Ecto-5 '-nucleotidase (e-5NT) switches from neurons to astrocytes after cortical stab injury in rat. in Purinergic Signalling. 2010;6(null):null-77.
https://hdl.handle.net/21.15107/rcub_ibiss_1374 .

Nedeljković, Nadezda N, Bjelobaba, Ivana, Parabučki, Ana B., Lavrnja, Irena, Peković, Sanja, Stojiljković, Mirjana B, "Ecto-5 '-nucleotidase (e-5NT) switches from neurons to astrocytes after cortical stab injury in rat" in Purinergic Signalling, 6, no. null (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1374 .