TY  - JOUR
AU  - Milošević-Zlatanović, Svetlana
AU  - Vukov, Tanja
AU  - Stamenković, Srđan
AU  - Jovanović, Marija
AU  - Tomašević Kolarov, Nataša
PY  - 2018
UR  - https://frontiersinzoology.biomedcentral.com/articles/10.1186/s12983-018-0283-8
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6161383
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3217
AB  - Background As a small artiodactyl, the roe deer (Capreolus capreolus L.) is characterized by biological plasticity and great adaptability demonstrated by their survival under a wide variety of environmental conditions. In order to depict patterns of phenotypic variation of roe deer body this study aims to quantify variation during ontogenetic development and determine how sex-specific reproductive investment and non-uniform habitat differences relate to phenotypic variation and do these differential investments mold the patterns of phenotypic variation through modular organisation. Results Patterns of phenotypic correlation among body traits change during the ontogeny of roe deer, with differential influence of sex and habitat type. Modularity was found to be a feature of closed habitats with trunk+forelimbs+hindlimbs as the best supported integration/modularity hypothesis for both sexes. The indices of integration and evolvability vary with habitat type, age and sex where increased integration is followed by decreased evolvability. Conclusion This is the first study that quantifies patterns of correlation in the roe deer body and finds pronounced changes in correlation structure during ontogeny affected by sex and habitat type. The correlation structure of the roe deer body is developmentally written over the course of ontogeny but we do not exclude the influence of function on ontogenetic changes. Modularity arises with the onset of reproduction (subadults not being modular) and is differentially expressed in males and females from different habitats. Both adult males and females show modularity in primordial, closed habitats. Overall, all these findings are important as they provide support to the idea that modularity can evolve at the population level and change fast within a species.
T2  - Frontiers in Zoology
T1  - The modular organization of roe deer (Capreolus capreolus) body during ontogeny: the effects of sex and habitat.
IS  - 1
VL  - 15
DO  - 10.1186/s12983-018-0283-8
SP  - 37
ER  - 

@article{
author = "Milošević-Zlatanović, Svetlana and Vukov, Tanja and Stamenković, Srđan and Jovanović, Marija and Tomašević Kolarov, Nataša",
year = "2018",
abstract = "Background As a small artiodactyl, the roe deer (Capreolus capreolus L.) is characterized by biological plasticity and great adaptability demonstrated by their survival under a wide variety of environmental conditions. In order to depict patterns of phenotypic variation of roe deer body this study aims to quantify variation during ontogenetic development and determine how sex-specific reproductive investment and non-uniform habitat differences relate to phenotypic variation and do these differential investments mold the patterns of phenotypic variation through modular organisation. Results Patterns of phenotypic correlation among body traits change during the ontogeny of roe deer, with differential influence of sex and habitat type. Modularity was found to be a feature of closed habitats with trunk+forelimbs+hindlimbs as the best supported integration/modularity hypothesis for both sexes. The indices of integration and evolvability vary with habitat type, age and sex where increased integration is followed by decreased evolvability. Conclusion This is the first study that quantifies patterns of correlation in the roe deer body and finds pronounced changes in correlation structure during ontogeny affected by sex and habitat type. The correlation structure of the roe deer body is developmentally written over the course of ontogeny but we do not exclude the influence of function on ontogenetic changes. Modularity arises with the onset of reproduction (subadults not being modular) and is differentially expressed in males and females from different habitats. Both adult males and females show modularity in primordial, closed habitats. Overall, all these findings are important as they provide support to the idea that modularity can evolve at the population level and change fast within a species.",
journal = "Frontiers in Zoology",
title = "The modular organization of roe deer (Capreolus capreolus) body during ontogeny: the effects of sex and habitat.",
number = "1",
volume = "15",
doi = "10.1186/s12983-018-0283-8",
pages = "37"
}

Milošević-Zlatanović, S., Vukov, T., Stamenković, S., Jovanović, M.,& Tomašević Kolarov, N.. (2018). The modular organization of roe deer (Capreolus capreolus) body during ontogeny: the effects of sex and habitat.. in Frontiers in Zoology, 15(1), 37.
https://doi.org/10.1186/s12983-018-0283-8

Milošević-Zlatanović S, Vukov T, Stamenković S, Jovanović M, Tomašević Kolarov N. The modular organization of roe deer (Capreolus capreolus) body during ontogeny: the effects of sex and habitat.. in Frontiers in Zoology. 2018;15(1):37.
doi:10.1186/s12983-018-0283-8 .

Milošević-Zlatanović, Svetlana, Vukov, Tanja, Stamenković, Srđan, Jovanović, Marija, Tomašević Kolarov, Nataša, "The modular organization of roe deer (Capreolus capreolus) body during ontogeny: the effects of sex and habitat." in Frontiers in Zoology, 15, no. 1 (2018):37,
https://doi.org/10.1186/s12983-018-0283-8 . .

TY  - JOUR
AU  - Adžić, Marija
AU  - Stevanović, Ivana
AU  - Josipović, Nataša
AU  - Laketa, Danijela
AU  - Lavrnja, Irena
AU  - Bjelobaba, Ivana
AU  - Božić, Iva
AU  - Jovanović, Marija
AU  - Milošević, Milena
AU  - Nedeljković, Nadežda
PY  - 2017
UR  - http://doi.wiley.com/10.1002/jnr.23950
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2560
AB  - It is widely accepted that adenosine triphosphate (ATP) acts as a universal danger-associated molecular pattern with several known mechanisms for immune cell activation. In the central nervous system, ATP activates microglia and astrocytes and induces a neuroinflammatory response. The aim of the present study was to describe responses of isolated astrocytes to increasing concentrations of ATP (5 µM to 1 mM), which were intended to mimic graded intensity of the extracellular stimulus. The results show that ATP induces graded activation response of astrocytes in terms of the cell proliferation, stellation, shape remodeling, and underlying actin and GFAP filament rearrangement, although the changes occurred without an apparent increase in GFAP and actin protein expression. On the other hand, ATP in the range of applied concentrations did not evoke IL-1β release from cultured astrocytes, nor did it modify the release from LPS and LPS+IFN-γ–primed astrocytes. ATP did not promote astrocyte migration in the wound-healing assay, nor did it increase production of reactive oxygen and nitrogen species and lipid peroxidation. Instead, ATP strengthened the antioxidative defense of astrocytes by inducing Cu/ZnSOD and MnSOD activities and by increasing their glutathione content. Our current results suggest that although ATP triggers several attributes of activated astrocytic phenotype with a magnitude that increases with the concentration, it is not sufficient to induce full-blown reactive phenotype of astrocytes in vitro. © 2016 Wiley Periodicals, Inc.
T2  - Journal of Neuroscience Research
T1  - Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro
IS  - 4
VL  - 95
DO  - 10.1002/jnr.23950
SP  - 1053
EP  - 1066
ER  - 

@article{
author = "Adžić, Marija and Stevanović, Ivana and Josipović, Nataša and Laketa, Danijela and Lavrnja, Irena and Bjelobaba, Ivana and Božić, Iva and Jovanović, Marija and Milošević, Milena and Nedeljković, Nadežda",
year = "2017",
abstract = "It is widely accepted that adenosine triphosphate (ATP) acts as a universal danger-associated molecular pattern with several known mechanisms for immune cell activation. In the central nervous system, ATP activates microglia and astrocytes and induces a neuroinflammatory response. The aim of the present study was to describe responses of isolated astrocytes to increasing concentrations of ATP (5 µM to 1 mM), which were intended to mimic graded intensity of the extracellular stimulus. The results show that ATP induces graded activation response of astrocytes in terms of the cell proliferation, stellation, shape remodeling, and underlying actin and GFAP filament rearrangement, although the changes occurred without an apparent increase in GFAP and actin protein expression. On the other hand, ATP in the range of applied concentrations did not evoke IL-1β release from cultured astrocytes, nor did it modify the release from LPS and LPS+IFN-γ–primed astrocytes. ATP did not promote astrocyte migration in the wound-healing assay, nor did it increase production of reactive oxygen and nitrogen species and lipid peroxidation. Instead, ATP strengthened the antioxidative defense of astrocytes by inducing Cu/ZnSOD and MnSOD activities and by increasing their glutathione content. Our current results suggest that although ATP triggers several attributes of activated astrocytic phenotype with a magnitude that increases with the concentration, it is not sufficient to induce full-blown reactive phenotype of astrocytes in vitro. © 2016 Wiley Periodicals, Inc.",
journal = "Journal of Neuroscience Research",
title = "Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro",
number = "4",
volume = "95",
doi = "10.1002/jnr.23950",
pages = "1053-1066"
}

Adžić, M., Stevanović, I., Josipović, N., Laketa, D., Lavrnja, I., Bjelobaba, I., Božić, I., Jovanović, M., Milošević, M.,& Nedeljković, N.. (2017). Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro. in Journal of Neuroscience Research, 95(4), 1053-1066.
https://doi.org/10.1002/jnr.23950

Adžić M, Stevanović I, Josipović N, Laketa D, Lavrnja I, Bjelobaba I, Božić I, Jovanović M, Milošević M, Nedeljković N. Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro. in Journal of Neuroscience Research. 2017;95(4):1053-1066.
doi:10.1002/jnr.23950 .

Adžić, Marija, Stevanović, Ivana, Josipović, Nataša, Laketa, Danijela, Lavrnja, Irena, Bjelobaba, Ivana, Božić, Iva, Jovanović, Marija, Milošević, Milena, Nedeljković, Nadežda, "Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro" in Journal of Neuroscience Research, 95, no. 4 (2017):1053-1066,
https://doi.org/10.1002/jnr.23950 . .