TY  - JOUR
AU  - Marjanović, Zaklina S
AU  - Grebenc, T
AU  - Marković, M
AU  - Glisić, Aleksa
AU  - Milenković, M.
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1366
AB  - Marjanovic, Z(1), Grebenc, T(2), Markovic, M(3), Glisic, A(4), and Milenkovic, M(5) (2010) Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula Sydowia 62 (1) 67-87 Little is known on the diversity and distribution of truffles at the Balkan Peninsula A first detailed study of hypogeous fungi in Serbia has been started at 1992 To extend the knowledge on European truffles and their natural habitats, data on their diversity in Serbia, and to some extent in Montenegro and FYRO Macedonia are summarised within this paper Twelve species of the genus Tuber, including five varieties of T rufum Pico, are recorded and their habitats briefly described Four species are reported for the Balkan Peninsula for the first time In addition, parts of ribosomal DNA (ITS regions) of 46 specimens are sequenced and analysed to confirm the morphological determinations ITS sequences of specimens morphologically identified as Tuber fulgens Quel are reported for the first time A phylogeny based on ITS sequences of the Balkan truffles and additional 29 records from the GenBank is calculated The results are discussed towards expanding the information on distribution as well as ecological and molecular diversification of Tuber spp in Europe
T2  - Sydowia
T1  - Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula
IS  - 1
VL  - 62
EP  - 87
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1366
ER  - 

@article{
author = "Marjanović, Zaklina S and Grebenc, T and Marković, M and Glisić, Aleksa and Milenković, M.",
year = "2010",
abstract = "Marjanovic, Z(1), Grebenc, T(2), Markovic, M(3), Glisic, A(4), and Milenkovic, M(5) (2010) Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula Sydowia 62 (1) 67-87 Little is known on the diversity and distribution of truffles at the Balkan Peninsula A first detailed study of hypogeous fungi in Serbia has been started at 1992 To extend the knowledge on European truffles and their natural habitats, data on their diversity in Serbia, and to some extent in Montenegro and FYRO Macedonia are summarised within this paper Twelve species of the genus Tuber, including five varieties of T rufum Pico, are recorded and their habitats briefly described Four species are reported for the Balkan Peninsula for the first time In addition, parts of ribosomal DNA (ITS regions) of 46 specimens are sequenced and analysed to confirm the morphological determinations ITS sequences of specimens morphologically identified as Tuber fulgens Quel are reported for the first time A phylogeny based on ITS sequences of the Balkan truffles and additional 29 records from the GenBank is calculated The results are discussed towards expanding the information on distribution as well as ecological and molecular diversification of Tuber spp in Europe",
journal = "Sydowia",
title = "Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula",
number = "1",
volume = "62",
pages = "87",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1366"
}

Marjanović, Z. S., Grebenc, T., Marković, M., Glisić, A.,& Milenković, M.. (2010). Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula. in Sydowia, 62(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1366

Marjanović ZS, Grebenc T, Marković M, Glisić A, Milenković M. Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula. in Sydowia. 2010;62(1):null-87.
https://hdl.handle.net/21.15107/rcub_ibiss_1366 .

Marjanović, Zaklina S, Grebenc, T, Marković, M, Glisić, Aleksa, Milenković, M., "Ecological specificities and molecular diversity of truffles (genus Tuber) originating from mid-west of the Balkan Peninsula" in Sydowia, 62, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1366 .

TY  - JOUR
AU  - Harhaji-Trajković, Ljubica
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Stojanović, Ivana D.
AU  - Momčilović, Miljana
AU  - Tufegdžić, Srđan J
AU  - Maksimović, Vuk M
AU  - Marjanović, Zaklina S
AU  - Stošić-Grujičić, Stanislava
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1487
AB  - Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.
T2  - Nutrition and Cancer-An International Journal
T1  - Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo
IS  - 5
VL  - 61
EP  - 707
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1487
ER  - 

@article{
author = "Harhaji-Trajković, Ljubica and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Stojanović, Ivana D. and Momčilović, Miljana and Tufegdžić, Srđan J and Maksimović, Vuk M and Marjanović, Zaklina S and Stošić-Grujičić, Stanislava",
year = "2009",
abstract = "Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.",
journal = "Nutrition and Cancer-An International Journal",
title = "Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo",
number = "5",
volume = "61",
pages = "707",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1487"
}

Harhaji-Trajković, L., Mijatović, S., Maksimović-Ivanić, D., Stojanović, I. D., Momčilović, M., Tufegdžić, S. J., Maksimović, V. M., Marjanović, Z. S.,& Stošić-Grujičić, S.. (2009). Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo. in Nutrition and Cancer-An International Journal, 61(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1487

Harhaji-Trajković L, Mijatović S, Maksimović-Ivanić D, Stojanović ID, Momčilović M, Tufegdžić SJ, Maksimović VM, Marjanović ZS, Stošić-Grujičić S. Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo. in Nutrition and Cancer-An International Journal. 2009;61(5):null-707.
https://hdl.handle.net/21.15107/rcub_ibiss_1487 .

Harhaji-Trajković, Ljubica, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Stojanović, Ivana D., Momčilović, Miljana, Tufegdžić, Srđan J, Maksimović, Vuk M, Marjanović, Zaklina S, Stošić-Grujičić, Stanislava, "Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo" in Nutrition and Cancer-An International Journal, 61, no. 5 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1487 .

TY  - JOUR
AU  - Harhaji-Trajković, Ljubica
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Stojanović, Ivana D.
AU  - Momčilović, Miljana
AU  - Maksimović, Vuk M.
AU  - Tufegdžić, Srđan J.
AU  - Marjanović, Zaklina S.
AU  - Mostarica-Stojković, Marija B.
AU  - Vučinić, Zeljko B.
AU  - Stošić-Grujičić, Stanislava
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1531
AB  - Numerous studies have shown immunostimulatory and anti-tumor effects of water and standardized aqueous ethanol extracts derived from the medicinal mushroom, Coriolus versicolor, but the biological activity of methanol extracts has not been examined so far. In the present study we investigated the anti-tumor effect of C versicolor methanol extract (which contains terpenoids and poly-phenols) on B16 mouse melanoma cells both in vitro and in vivo. In vitro treatment of the cells with the methanol extract (25-1600 mu g/ml) reduced melanoma cell viability in it dose-dependent manner. Furthermore, in the presence of the methanol extract (200 mu g/ml, concentration IC50) the proliferation of B16 cells was arrested in the G(0)/G(1) phase of the cell cycle, followed by both apoptotic and secondary necrotic cell death. In vivo methanol extract treatment (i.p. 50 mg/kg, for 14 days) inhibited tumor growth in C57BL/6 mice inoculated with syngeneic B16 tumor cells. Moreover, peritoneal macrophages collected 21 days after tumor implantation from methanol extract-treated animals exerted stronger tumoristatic activity ex vivo than macrophages from control melanoma-bearing rnice. Taken together, our results demonstrate that C. versicolor methanol extract exerts pronounced anti-melanoma activity, both directly through antiproliferative and cytotoxic effects on tumor cells and indirectly through promotion of macrophage anti-tumor activity. (c) 2008 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study
IS  - 5
VL  - 46
DO  - 10.1016/j.fct.2008.01.027
SP  - 1825
EP  - 1833
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1531
ER  - 

@article{
author = "Harhaji-Trajković, Ljubica and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Stojanović, Ivana D. and Momčilović, Miljana and Maksimović, Vuk M. and Tufegdžić, Srđan J. and Marjanović, Zaklina S. and Mostarica-Stojković, Marija B. and Vučinić, Zeljko B. and Stošić-Grujičić, Stanislava",
year = "2008",
abstract = "Numerous studies have shown immunostimulatory and anti-tumor effects of water and standardized aqueous ethanol extracts derived from the medicinal mushroom, Coriolus versicolor, but the biological activity of methanol extracts has not been examined so far. In the present study we investigated the anti-tumor effect of C versicolor methanol extract (which contains terpenoids and poly-phenols) on B16 mouse melanoma cells both in vitro and in vivo. In vitro treatment of the cells with the methanol extract (25-1600 mu g/ml) reduced melanoma cell viability in it dose-dependent manner. Furthermore, in the presence of the methanol extract (200 mu g/ml, concentration IC50) the proliferation of B16 cells was arrested in the G(0)/G(1) phase of the cell cycle, followed by both apoptotic and secondary necrotic cell death. In vivo methanol extract treatment (i.p. 50 mg/kg, for 14 days) inhibited tumor growth in C57BL/6 mice inoculated with syngeneic B16 tumor cells. Moreover, peritoneal macrophages collected 21 days after tumor implantation from methanol extract-treated animals exerted stronger tumoristatic activity ex vivo than macrophages from control melanoma-bearing rnice. Taken together, our results demonstrate that C. versicolor methanol extract exerts pronounced anti-melanoma activity, both directly through antiproliferative and cytotoxic effects on tumor cells and indirectly through promotion of macrophage anti-tumor activity. (c) 2008 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study",
number = "5",
volume = "46",
doi = "10.1016/j.fct.2008.01.027",
pages = "1825-1833",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1531"
}

Harhaji-Trajković, L., Mijatović, S., Maksimović-Ivanić, D., Stojanović, I. D., Momčilović, M., Maksimović, V. M., Tufegdžić, S. J., Marjanović, Z. S., Mostarica-Stojković, M. B., Vučinić, Z. B.,& Stošić-Grujičić, S.. (2008). Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study. in Food and Chemical Toxicology
Elsevier., 46(5), 1825-1833.
https://doi.org/10.1016/j.fct.2008.01.027
https://hdl.handle.net/21.15107/rcub_ibiss_1531

Harhaji-Trajković L, Mijatović S, Maksimović-Ivanić D, Stojanović ID, Momčilović M, Maksimović VM, Tufegdžić SJ, Marjanović ZS, Mostarica-Stojković MB, Vučinić ZB, Stošić-Grujičić S. Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study. in Food and Chemical Toxicology. 2008;46(5):1825-1833.
doi:10.1016/j.fct.2008.01.027
https://hdl.handle.net/21.15107/rcub_ibiss_1531 .

Harhaji-Trajković, Ljubica, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Stojanović, Ivana D., Momčilović, Miljana, Maksimović, Vuk M., Tufegdžić, Srđan J., Marjanović, Zaklina S., Mostarica-Stojković, Marija B., Vučinić, Zeljko B., Stošić-Grujičić, Stanislava, "Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study" in Food and Chemical Toxicology, 46, no. 5 (2008):1825-1833,
https://doi.org/10.1016/j.fct.2008.01.027 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1531 .