TY  - JOUR
AU  - Miljković, Đorđe
AU  - Momčilović, Miljana
AU  - Stanojević, Zeljka S
AU  - Rasić, Dejan M
AU  - Mostarica-Stojković, Marija B
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1279
AB  - Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis. Dark Agouti rats immunized with spinal cord homogenate (SCH) and carbonyl iron (CI), as an adjuvant, develop severe hyperacute form of EAE. They succumb to EAE earlier and have higher clinical scores and lethality rate in comparison to counterparts immunized with SCH + complete Freund's adjuvant. There is no difference in the number of cells or in histological presentation of the CNS infiltrates of rats immunized with the two adjuvants. However, there are more granulocytes, NK and NKT cells, and less CD4(+) T cells in the spinal cord infiltrates of SCH + CI-immunized animals. Nitric oxide (NO)-generating enzyme inducible NO synthase have higher expression in spinal cord of SCH + CI-immunized rats, and this corresponds to more intensive nitrotyrosine formation in the CNS tissue of these rats. Abundant infiltration of granulocytes and NK cells into the CNS and excessive generation of peroxynitrite within the CNS of SCH + CI-immunized rats might account for the severe neurological deficits induced by immunization with CI. These factors should be closely examined in the fulminant forms of multiple sclerosis and acute disseminated encephalomyelitis, as they could represent a promising targets for therapy.
T2  - Journal of Neurochemistry
T1  - It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction
IS  - 2
VL  - 118
EP  - 214
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1279
ER  - 

@article{
author = "Miljković, Đorđe and Momčilović, Miljana and Stanojević, Zeljka S and Rasić, Dejan M and Mostarica-Stojković, Marija B",
year = "2011",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis. Dark Agouti rats immunized with spinal cord homogenate (SCH) and carbonyl iron (CI), as an adjuvant, develop severe hyperacute form of EAE. They succumb to EAE earlier and have higher clinical scores and lethality rate in comparison to counterparts immunized with SCH + complete Freund's adjuvant. There is no difference in the number of cells or in histological presentation of the CNS infiltrates of rats immunized with the two adjuvants. However, there are more granulocytes, NK and NKT cells, and less CD4(+) T cells in the spinal cord infiltrates of SCH + CI-immunized animals. Nitric oxide (NO)-generating enzyme inducible NO synthase have higher expression in spinal cord of SCH + CI-immunized rats, and this corresponds to more intensive nitrotyrosine formation in the CNS tissue of these rats. Abundant infiltration of granulocytes and NK cells into the CNS and excessive generation of peroxynitrite within the CNS of SCH + CI-immunized rats might account for the severe neurological deficits induced by immunization with CI. These factors should be closely examined in the fulminant forms of multiple sclerosis and acute disseminated encephalomyelitis, as they could represent a promising targets for therapy.",
journal = "Journal of Neurochemistry",
title = "It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction",
number = "2",
volume = "118",
pages = "214",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1279"
}

Miljković, Đ., Momčilović, M., Stanojević, Z. S., Rasić, D. M.,& Mostarica-Stojković, M. B.. (2011). It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction. in Journal of Neurochemistry, 118(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1279

Miljković Đ, Momčilović M, Stanojević ZS, Rasić DM, Mostarica-Stojković MB. It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction. in Journal of Neurochemistry. 2011;118(2):null-214.
https://hdl.handle.net/21.15107/rcub_ibiss_1279 .

Miljković, Đorđe, Momčilović, Miljana, Stanojević, Zeljka S, Rasić, Dejan M, Mostarica-Stojković, Marija B, "It is still not for the old iron: adjuvant effects of carbonyl iron in experimental autoimmune encephalomyelitis induction" in Journal of Neurochemistry, 118, no. 2 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1279 .