TY  - JOUR
AU  - Radovanović, Tijana
AU  - Gavrilović, Branka
AU  - Petrović, Tamara
AU  - Despotović, Svetlana
AU  - Gavrić, Jelena
AU  - Kijanović, Ana
AU  - Mirč, Marko
AU  - Tomašević Kolarov, Nataša
AU  - Faggio, Caterina
AU  - Prokić, Marko
PY  - 2021
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1532045621002180
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4484
AB  - Global warming represents a severe threat to existing ecosystems, especially for anuran tadpoles who encounter significant fluctuations in their habitats. Decreasing water levels in permanent and temporary water bodies is a significant risk for larval survival or fitness. On the other hand, the natural environment of amphibians is extremely polluted by various xenobiotics. This study evaluated how pre-exposure of Bombina variegata tadpoles to chronic environmental stress (desiccation) modulates the biochemical response of juvenile individuals to following acute chemical stressor (pesticide deltamethrin). Our results demonstrated that individually applied pesticide changed the thiol and lipid status of the treated juveniles but animals subjected solely to desiccation pressure were more tolerant to free radicals and showed no induction of lipid peroxidation. Comparison of juveniles exposed to deltamethrin revealed that desiccation pretreatment during the larval stage of development modified cellular protection in the juveniles. Higher activities of CAT, GSH-Px and GR were recorded in the pre-exposed group, as well as a lower degree of lipid peroxidation relative to the group that was not pre-exposed to low water stress. Pre-desiccated groups displayed the greatest range of coordination of investigated antioxidant parameters, supported by Pearson's correlations. Activation of the GSH-redox system is a significant marker in juveniles against stress caused by desiccation and a chemical stressor. The stressful environment experienced during tadpole development produced an adaptive reaction to subsequent exposure to another stressor in juveniles. To develop relevant management and conservation strategies, more studies of the interactive effects of environmental and chemical stressors are necessary.
PB  - New York: Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
T1  - Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles.
VL  - 250
DO  - 10.1016/j.cbpc.2021.109191
SP  - 109191
ER  - 

@article{
author = "Radovanović, Tijana and Gavrilović, Branka and Petrović, Tamara and Despotović, Svetlana and Gavrić, Jelena and Kijanović, Ana and Mirč, Marko and Tomašević Kolarov, Nataša and Faggio, Caterina and Prokić, Marko",
year = "2021",
abstract = "Global warming represents a severe threat to existing ecosystems, especially for anuran tadpoles who encounter significant fluctuations in their habitats. Decreasing water levels in permanent and temporary water bodies is a significant risk for larval survival or fitness. On the other hand, the natural environment of amphibians is extremely polluted by various xenobiotics. This study evaluated how pre-exposure of Bombina variegata tadpoles to chronic environmental stress (desiccation) modulates the biochemical response of juvenile individuals to following acute chemical stressor (pesticide deltamethrin). Our results demonstrated that individually applied pesticide changed the thiol and lipid status of the treated juveniles but animals subjected solely to desiccation pressure were more tolerant to free radicals and showed no induction of lipid peroxidation. Comparison of juveniles exposed to deltamethrin revealed that desiccation pretreatment during the larval stage of development modified cellular protection in the juveniles. Higher activities of CAT, GSH-Px and GR were recorded in the pre-exposed group, as well as a lower degree of lipid peroxidation relative to the group that was not pre-exposed to low water stress. Pre-desiccated groups displayed the greatest range of coordination of investigated antioxidant parameters, supported by Pearson's correlations. Activation of the GSH-redox system is a significant marker in juveniles against stress caused by desiccation and a chemical stressor. The stressful environment experienced during tadpole development produced an adaptive reaction to subsequent exposure to another stressor in juveniles. To develop relevant management and conservation strategies, more studies of the interactive effects of environmental and chemical stressors are necessary.",
publisher = "New York: Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology",
title = "Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles.",
volume = "250",
doi = "10.1016/j.cbpc.2021.109191",
pages = "109191"
}

Radovanović, T., Gavrilović, B., Petrović, T., Despotović, S., Gavrić, J., Kijanović, A., Mirč, M., Tomašević Kolarov, N., Faggio, C.,& Prokić, M.. (2021). Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles.. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
New York: Elsevier Inc.., 250, 109191.
https://doi.org/10.1016/j.cbpc.2021.109191

Radovanović T, Gavrilović B, Petrović T, Despotović S, Gavrić J, Kijanović A, Mirč M, Tomašević Kolarov N, Faggio C, Prokić M. Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles.. in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2021;250:109191.
doi:10.1016/j.cbpc.2021.109191 .

Radovanović, Tijana, Gavrilović, Branka, Petrović, Tamara, Despotović, Svetlana, Gavrić, Jelena, Kijanović, Ana, Mirč, Marko, Tomašević Kolarov, Nataša, Faggio, Caterina, Prokić, Marko, "Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles." in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 250 (2021):109191,
https://doi.org/10.1016/j.cbpc.2021.109191 . .