TY  - JOUR
AU  - Zengin, Gokhan
AU  - Sinan, Kouadio Ibrahime
AU  - Ak, Gunes
AU  - Mahomoodally, Mohamad Fawzi
AU  - Paksoy, Mehmet Yavuz
AU  - Picot-Allain, Carene
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Jekő, József
AU  - Cziáky, Zoltán
AU  - Rodrigues, Maria João
AU  - Pereira, Catarina G.
AU  - Custodio, Luisa
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3700
AB  - Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
PB  - Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study
VL  - 153
DO  - 10.1016/j.indcrop.2020.112572
SP  - 112572
ER  - 

@article{
author = "Zengin, Gokhan and Sinan, Kouadio Ibrahime and Ak, Gunes and Mahomoodally, Mohamad Fawzi and Paksoy, Mehmet Yavuz and Picot-Allain, Carene and Glamočlija, Jasmina and Soković, Marina and Jekő, József and Cziáky, Zoltán and Rodrigues, Maria João and Pereira, Catarina G. and Custodio, Luisa",
year = "2020",
abstract = "Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.",
publisher = "Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study",
volume = "153",
doi = "10.1016/j.indcrop.2020.112572",
pages = "112572"
}

Zengin, G., Sinan, K. I., Ak, G., Mahomoodally, M. F., Paksoy, M. Y., Picot-Allain, C., Glamočlija, J., Soković, M., Jekő, J., Cziáky, Z., Rodrigues, M. J., Pereira, C. G.,& Custodio, L.. (2020). Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study. in Industrial Crops and Products
Elsevier B.V.., 153, 112572.
https://doi.org/10.1016/j.indcrop.2020.112572

Zengin G, Sinan KI, Ak G, Mahomoodally MF, Paksoy MY, Picot-Allain C, Glamočlija J, Soković M, Jekő J, Cziáky Z, Rodrigues MJ, Pereira CG, Custodio L. Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study. in Industrial Crops and Products. 2020;153:112572.
doi:10.1016/j.indcrop.2020.112572 .

Zengin, Gokhan, Sinan, Kouadio Ibrahime, Ak, Gunes, Mahomoodally, Mohamad Fawzi, Paksoy, Mehmet Yavuz, Picot-Allain, Carene, Glamočlija, Jasmina, Soković, Marina, Jekő, József, Cziáky, Zoltán, Rodrigues, Maria João, Pereira, Catarina G., Custodio, Luisa, "Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study" in Industrial Crops and Products, 153 (2020):112572,
https://doi.org/10.1016/j.indcrop.2020.112572 . .

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Mahomoodally, Mohamad Fawzi
AU  - Paksoy, Mehmet Yavuz
AU  - Picot-Allain, Carene
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Diuzheva, Alina
AU  - Jekő, József
AU  - Cziáky, Zoltán
AU  - Rodrigues, Maria João
AU  - Sinan, Kouadio Ibrahime
AU  - Custodio, Luisa
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0926669019302833?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3337
AB  - Several species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucheri (SA), Smyrniopsis munzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (α-amylase, α-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase’s inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyl- and butyrylcholinesterase, respectively). The extracts showed higher inhibition against α-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to α-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigatus growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.
T2  - Industrial Crops and Products
T1  - Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients
VL  - 135
DO  - 10.1016/J.INDCROP.2019.04.033
SP  - 107
EP  - 121
ER  - 

@article{
author = "Zengin, Gokhan and Mahomoodally, Mohamad Fawzi and Paksoy, Mehmet Yavuz and Picot-Allain, Carene and Glamočlija, Jasmina and Soković, Marina and Diuzheva, Alina and Jekő, József and Cziáky, Zoltán and Rodrigues, Maria João and Sinan, Kouadio Ibrahime and Custodio, Luisa",
year = "2019",
abstract = "Several species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucheri (SA), Smyrniopsis munzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (α-amylase, α-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase’s inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyl- and butyrylcholinesterase, respectively). The extracts showed higher inhibition against α-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to α-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigatus growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.",
journal = "Industrial Crops and Products",
title = "Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients",
volume = "135",
doi = "10.1016/J.INDCROP.2019.04.033",
pages = "107-121"
}

Zengin, G., Mahomoodally, M. F., Paksoy, M. Y., Picot-Allain, C., Glamočlija, J., Soković, M., Diuzheva, A., Jekő, J., Cziáky, Z., Rodrigues, M. J., Sinan, K. I.,& Custodio, L.. (2019). Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients. in Industrial Crops and Products, 135, 107-121.
https://doi.org/10.1016/J.INDCROP.2019.04.033

Zengin G, Mahomoodally MF, Paksoy MY, Picot-Allain C, Glamočlija J, Soković M, Diuzheva A, Jekő J, Cziáky Z, Rodrigues MJ, Sinan KI, Custodio L. Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients. in Industrial Crops and Products. 2019;135:107-121.
doi:10.1016/J.INDCROP.2019.04.033 .

Zengin, Gokhan, Mahomoodally, Mohamad Fawzi, Paksoy, Mehmet Yavuz, Picot-Allain, Carene, Glamočlija, Jasmina, Soković, Marina, Diuzheva, Alina, Jekő, József, Cziáky, Zoltán, Rodrigues, Maria João, Sinan, Kouadio Ibrahime, Custodio, Luisa, "Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients" in Industrial Crops and Products, 135 (2019):107-121,
https://doi.org/10.1016/J.INDCROP.2019.04.033 . .

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Mahomoodally, M. Fawzi
AU  - Aktumsek, Abdurrahman
AU  - Ceylan, Ramazan
AU  - Uysal, Sengul
AU  - Mocan, Andrei
AU  - Yilmaz, Mustafa Abdullah
AU  - Picot-Allain, Carene Marie Nancy
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S2212429217305473?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3090
AB  - Six wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p-coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma). Antifungal agents, bifonazole (MIC 0.10–0.20 mg/mL and MFC 0.20–0.30 mg/mL) and ketoconazole (MIC 0.15–2.30 mg/mL and MFC 0.20–3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases.
T2  - Food Bioscience
T1  - Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
VL  - 23
DO  - 10.1016/J.FBIO.2018.03.010
SP  - 75
EP  - 82
ER  - 

@article{
author = "Zengin, Gokhan and Mahomoodally, M. Fawzi and Aktumsek, Abdurrahman and Ceylan, Ramazan and Uysal, Sengul and Mocan, Andrei and Yilmaz, Mustafa Abdullah and Picot-Allain, Carene Marie Nancy and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2018",
abstract = "Six wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p-coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma). Antifungal agents, bifonazole (MIC 0.10–0.20 mg/mL and MFC 0.20–0.30 mg/mL) and ketoconazole (MIC 0.15–2.30 mg/mL and MFC 0.20–3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases.",
journal = "Food Bioscience",
title = "Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties",
volume = "23",
doi = "10.1016/J.FBIO.2018.03.010",
pages = "75-82"
}

Zengin, G., Mahomoodally, M. F., Aktumsek, A., Ceylan, R., Uysal, S., Mocan, A., Yilmaz, M. A., Picot-Allain, C. M. N., Ćirić, A., Glamočlija, J.,& Soković, M.. (2018). Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties. in Food Bioscience, 23, 75-82.
https://doi.org/10.1016/J.FBIO.2018.03.010

Zengin G, Mahomoodally MF, Aktumsek A, Ceylan R, Uysal S, Mocan A, Yilmaz MA, Picot-Allain CMN, Ćirić A, Glamočlija J, Soković M. Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties. in Food Bioscience. 2018;23:75-82.
doi:10.1016/J.FBIO.2018.03.010 .

Zengin, Gokhan, Mahomoodally, M. Fawzi, Aktumsek, Abdurrahman, Ceylan, Ramazan, Uysal, Sengul, Mocan, Andrei, Yilmaz, Mustafa Abdullah, Picot-Allain, Carene Marie Nancy, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties" in Food Bioscience, 23 (2018):75-82,
https://doi.org/10.1016/J.FBIO.2018.03.010 . .