TY  - JOUR
AU  - Stevanović, Ivana
AU  - Čolić, Miodrag
AU  - Jovanović, Marina
AU  - Jelenković, Ankica V.
AU  - Ninković, Milica I.
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/558
AB  - The present study was aimed at determining the effectiveness of nitric oxide synthase (NOS) inhibitors: N-nitro-L-arginine methyl ester, 7-nitroindazole and aminoguanidine in modulating the toxicity of AlCl3 on superoxide production and the malondialdehyde concentration of Wistar rats. The animals were sacrificed 10 min and 3 days after the treatment and the forebrain cortex was removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in the neuronal tissues show that aluminum acts as pro-oxidant, while NOS inhibitors exert an anti-oxidant action in AlCl3-treated animals.
AB  - U eksperimentu je određivana efikasnost inhibitora azot-oksid-sintaze (NOS): metil-estra N-nitro-L-arginina, 7-nitroindazola i aminogvanidina u modulaciji toksičnosti AlCl3 na stvaranje superoksidnog anjona i koncentraciju malondialdehida kod Wistar pacova. Životinje su žrtvovane 10 min i 3 dana nakon tretmana i izolovana je kora velikog mozga. Rezultati pokazuju da izlaganje AlCl3 pokreće oksidativni stres u različitim moždanim regionima. Biohemijske promene opisane u neuronskom tkivu pokazuju da aluminijum deluje kao pro-oksidant, dok inhibitori NOS imaju antioksidativno dejstvo kod životinja tretiranih AlCl3.
T2  - Journal of the Serbian Chemical Society
T1  - Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3
T1  - Effects of various nitric oxide synthase inhibitors on AlCl3-induced neuronal injury in rats
IS  - 5
VL  - 74
SP  - 503
EP  - 511
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_558
ER  - 

@article{
author = "Stevanović, Ivana and Čolić, Miodrag and Jovanović, Marina and Jelenković, Ankica V. and Ninković, Milica I.",
year = "2009, 2009",
abstract = "The present study was aimed at determining the effectiveness of nitric oxide synthase (NOS) inhibitors: N-nitro-L-arginine methyl ester, 7-nitroindazole and aminoguanidine in modulating the toxicity of AlCl3 on superoxide production and the malondialdehyde concentration of Wistar rats. The animals were sacrificed 10 min and 3 days after the treatment and the forebrain cortex was removed. The results show that AlCl3 exposure promotes oxidative stress in different neural areas. The biochemical changes observed in the neuronal tissues show that aluminum acts as pro-oxidant, while NOS inhibitors exert an anti-oxidant action in AlCl3-treated animals., U eksperimentu je određivana efikasnost inhibitora azot-oksid-sintaze (NOS): metil-estra N-nitro-L-arginina, 7-nitroindazola i aminogvanidina u modulaciji toksičnosti AlCl3 na stvaranje superoksidnog anjona i koncentraciju malondialdehida kod Wistar pacova. Životinje su žrtvovane 10 min i 3 dana nakon tretmana i izolovana je kora velikog mozga. Rezultati pokazuju da izlaganje AlCl3 pokreće oksidativni stres u različitim moždanim regionima. Biohemijske promene opisane u neuronskom tkivu pokazuju da aluminijum deluje kao pro-oksidant, dok inhibitori NOS imaju antioksidativno dejstvo kod životinja tretiranih AlCl3.",
journal = "Journal of the Serbian Chemical Society",
title = "Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3, Effects of various nitric oxide synthase inhibitors on AlCl3-induced neuronal injury in rats",
number = "5",
volume = "74",
pages = "503-511",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_558"
}

Stevanović, I., Čolić, M., Jovanović, M., Jelenković, A. V.,& Ninković, M. I.. (2009). Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3. in Journal of the Serbian Chemical Society, 74(5), 503-511.
https://hdl.handle.net/21.15107/rcub_ibiss_558

Stevanović I, Čolić M, Jovanović M, Jelenković AV, Ninković MI. Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3. in Journal of the Serbian Chemical Society. 2009;74(5):503-511.
https://hdl.handle.net/21.15107/rcub_ibiss_558 .

Stevanović, Ivana, Čolić, Miodrag, Jovanović, Marina, Jelenković, Ankica V., Ninković, Milica I., "Efekti različitih inhibitora azot-oksid-sintaze na oštećenje neurona izazvano AlCl3" in Journal of the Serbian Chemical Society, 74, no. 5 (2009):503-511,
https://hdl.handle.net/21.15107/rcub_ibiss_558 .

TY  - JOUR
AU  - Cerović, Aleksandra
AU  - Miletić, Ivanka
AU  - Blagojević, Duško
AU  - Šobajić, Slađana
AU  - Čolić, Miodrag
AU  - Vasiljevska, Milijana
AU  - Poznanić, Milica
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/37
AB  - The effect of dietary zinc on the distribution of fatty acids in blood plasma chylomicrons was studied. The experiment was performed on male Mongolian Gerbils, fed ad libitum for 3 weeks with standard diet, containing 8 or 38 mg of Zn per kg of food (low zinc diet group, LZ, and saturated zinc diet group, SZ, respectivelly). At the 21st day gerbils were given sunflower oil by gavage. After 2.5 hours, blood was collected from abdominal vein, and samples were pooled (five animals per one sample). Chylomicron fractions were isolated by ultracentrifugation and mass of dried chylomicrons was measured. Fatty acid composition was analyzed by gas-liquid chromatography. Significantly higher amount of chylomicrons in blood plasma of SZ than in LZ group was found. In chylomicrons, following fatty acids were found: 16:0, 16:1, 17:0, 17:1, 18:0, 18:1, 18:2, 18:3, 20:0, 21:0 and 20:4. The amount of individual fatty acids in chylomicrons in both groups was similar, except 20:4 where lower amount in SZ group was found. Zinc diet did not affect fatty acid distribution in chylomicrons of both groups. Animals fed with zinc saturated diet had higher amount of fatty acids in blood plasma. Observed results suggest that dietary zinc influences the quantity of fatty acids absorption but not its distribution in chylomicrons.
AB  - Ispitivan je efekat unosa dijetarnog cinka na distribuciju masnih kiselina u hilomikronima plazme. Eksperiment je rađen na mužjacima gerbila, hranjenim standardnom dijetom, ad libitum, u toku 3 nedelje hrana je sadržala 8 ili 38 mg cinka po kg hrane (grupa sa smanjenim unosom cinka, LZ i grupa sa povećanim unosom cinka, SZ, respektivno). Dvadeset prvog dana, životinjama je dato suncokretovo ulje sondom. Nakon 2,5 časa, krv je uzimana iz abdominalne vene i uzorci su pulovani (5 životinja za jedan uzorak). Hilomikronske frakcije su izolovane ultracentrifugiranjem i merena je masa suvih hilomikrona. Masnokiselinski sastav lipida u hilomikronima je određivan gasno-tečnom hromatografijom. Nađena je značajno veća količina hilomikrona u plazmi SZ grupe nego u LZ grupi. U hilomikronima su nađene sledeće masne kiseline: 16:0, 16:1, 17:0, 17:1, 18:0, 18:1, 18:2, 18:3, 20:0, 21:0 i 20:4. Zastupljenost pojedinačnih masnih kiselina u hilomikronima obe grupe bila je slična, izuzev za 20:4 gde je izmerena niža količina u SZ grupi. Ishrana cinkom ne utiče na distribuciju većine masnih kiselina u hilomikronima. Dobijeni rezultati ukazuju da cink utiče na metabolizam masti i to u delu formiranja hilomikrona, ali je uticaj ograničen na količinu formiranih hilomikrona, ali ne i distribuciju pojedinih masnih kiselina u hilomikronima.
T2  - Jugoslovenska medicinska biohemija
T1  - Efekat ishrane cinkom na distribuciju masnih kiselina u hilomikronima plazme
T1  - The effect of zinc diet on distribution of fatty acid in blood plasma chylomicrons
IS  - 1
VL  - 24
SP  - 15
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_37
ER  - 

@article{
author = "Cerović, Aleksandra and Miletić, Ivanka and Blagojević, Duško and Šobajić, Slađana and Čolić, Miodrag and Vasiljevska, Milijana and Poznanić, Milica",
year = "2005, 2005",
abstract = "The effect of dietary zinc on the distribution of fatty acids in blood plasma chylomicrons was studied. The experiment was performed on male Mongolian Gerbils, fed ad libitum for 3 weeks with standard diet, containing 8 or 38 mg of Zn per kg of food (low zinc diet group, LZ, and saturated zinc diet group, SZ, respectivelly). At the 21st day gerbils were given sunflower oil by gavage. After 2.5 hours, blood was collected from abdominal vein, and samples were pooled (five animals per one sample). Chylomicron fractions were isolated by ultracentrifugation and mass of dried chylomicrons was measured. Fatty acid composition was analyzed by gas-liquid chromatography. Significantly higher amount of chylomicrons in blood plasma of SZ than in LZ group was found. In chylomicrons, following fatty acids were found: 16:0, 16:1, 17:0, 17:1, 18:0, 18:1, 18:2, 18:3, 20:0, 21:0 and 20:4. The amount of individual fatty acids in chylomicrons in both groups was similar, except 20:4 where lower amount in SZ group was found. Zinc diet did not affect fatty acid distribution in chylomicrons of both groups. Animals fed with zinc saturated diet had higher amount of fatty acids in blood plasma. Observed results suggest that dietary zinc influences the quantity of fatty acids absorption but not its distribution in chylomicrons., Ispitivan je efekat unosa dijetarnog cinka na distribuciju masnih kiselina u hilomikronima plazme. Eksperiment je rađen na mužjacima gerbila, hranjenim standardnom dijetom, ad libitum, u toku 3 nedelje hrana je sadržala 8 ili 38 mg cinka po kg hrane (grupa sa smanjenim unosom cinka, LZ i grupa sa povećanim unosom cinka, SZ, respektivno). Dvadeset prvog dana, životinjama je dato suncokretovo ulje sondom. Nakon 2,5 časa, krv je uzimana iz abdominalne vene i uzorci su pulovani (5 životinja za jedan uzorak). Hilomikronske frakcije su izolovane ultracentrifugiranjem i merena je masa suvih hilomikrona. Masnokiselinski sastav lipida u hilomikronima je određivan gasno-tečnom hromatografijom. Nađena je značajno veća količina hilomikrona u plazmi SZ grupe nego u LZ grupi. U hilomikronima su nađene sledeće masne kiseline: 16:0, 16:1, 17:0, 17:1, 18:0, 18:1, 18:2, 18:3, 20:0, 21:0 i 20:4. Zastupljenost pojedinačnih masnih kiselina u hilomikronima obe grupe bila je slična, izuzev za 20:4 gde je izmerena niža količina u SZ grupi. Ishrana cinkom ne utiče na distribuciju većine masnih kiselina u hilomikronima. Dobijeni rezultati ukazuju da cink utiče na metabolizam masti i to u delu formiranja hilomikrona, ali je uticaj ograničen na količinu formiranih hilomikrona, ali ne i distribuciju pojedinih masnih kiselina u hilomikronima.",
journal = "Jugoslovenska medicinska biohemija",
title = "Efekat ishrane cinkom na distribuciju masnih kiselina u hilomikronima plazme, The effect of zinc diet on distribution of fatty acid in blood plasma chylomicrons",
number = "1",
volume = "24",
pages = "15-20",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_37"
}

Cerović, A., Miletić, I., Blagojević, D., Šobajić, S., Čolić, M., Vasiljevska, M.,& Poznanić, M.. (2005). Efekat ishrane cinkom na distribuciju masnih kiselina u hilomikronima plazme. in Jugoslovenska medicinska biohemija, 24(1), 15-20.
https://hdl.handle.net/21.15107/rcub_ibiss_37

Cerović A, Miletić I, Blagojević D, Šobajić S, Čolić M, Vasiljevska M, Poznanić M. Efekat ishrane cinkom na distribuciju masnih kiselina u hilomikronima plazme. in Jugoslovenska medicinska biohemija. 2005;24(1):15-20.
https://hdl.handle.net/21.15107/rcub_ibiss_37 .

Cerović, Aleksandra, Miletić, Ivanka, Blagojević, Duško, Šobajić, Slađana, Čolić, Miodrag, Vasiljevska, Milijana, Poznanić, Milica, "Efekat ishrane cinkom na distribuciju masnih kiselina u hilomikronima plazme" in Jugoslovenska medicinska biohemija, 24, no. 1 (2005):15-20,
https://hdl.handle.net/21.15107/rcub_ibiss_37 .