TY  - JOUR
AU  - Mijatović, Sanja
AU  - Savić-Radojević, Ana
AU  - Plješa-Ercegovac, Marija
AU  - Simić, Tatjana
AU  - Nicoletti, Ferdinando
AU  - Maksimović-Ivanić, Danijela
PY  - 2020
UR  - https://www.mdpi.com/2076-3921/9/5/374
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32365852
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3673
AB  - Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) are involved in regulation of proliferation and apoptosis, they may play a double-faced role in cancer, entailing protumorigenic and tumor-suppressing effects in early and later stages, respectively. In addition, ROS and RNS impact the activity and communication of all tumor constituents, mediating their reprogramming from anti- to protumorigenic phenotypes, and vice versa. An important role in this dichotomic action is played by the variable amounts of O2 in the tumor microenvironment, which dictates the ultimate outcome of the influence of ROS/RNS on carcinogenesis. Moreover, ROS/RNS levels remarkably influence the cancer response to therapy. The relevance of ROS/RNS signaling in solid tumors is witnessed by the emergence of novel targeted treatments of solid tumors with compounds that target ROS/RNS action and production, such as tyrosine kinase inhibitors and monoclonal antibodies, which might contribute to the complexity of redox regulation in cancer. Prospectively, the dual role of ROS/RNS in the different stages of tumorigenesis through different impact on oxidation and nitrosylation may also allow development of tailored diagnostic and therapeutic approaches.
PB  - MDPI AG
T2  - Antioxidants (Basel, Switzerland)
T1  - The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors.
IS  - 5
VL  - 9
DO  - 10.3390/antiox9050374
SP  - 374
ER  - 

@article{
author = "Mijatović, Sanja and Savić-Radojević, Ana and Plješa-Ercegovac, Marija and Simić, Tatjana and Nicoletti, Ferdinando and Maksimović-Ivanić, Danijela",
year = "2020",
abstract = "Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) are involved in regulation of proliferation and apoptosis, they may play a double-faced role in cancer, entailing protumorigenic and tumor-suppressing effects in early and later stages, respectively. In addition, ROS and RNS impact the activity and communication of all tumor constituents, mediating their reprogramming from anti- to protumorigenic phenotypes, and vice versa. An important role in this dichotomic action is played by the variable amounts of O2 in the tumor microenvironment, which dictates the ultimate outcome of the influence of ROS/RNS on carcinogenesis. Moreover, ROS/RNS levels remarkably influence the cancer response to therapy. The relevance of ROS/RNS signaling in solid tumors is witnessed by the emergence of novel targeted treatments of solid tumors with compounds that target ROS/RNS action and production, such as tyrosine kinase inhibitors and monoclonal antibodies, which might contribute to the complexity of redox regulation in cancer. Prospectively, the dual role of ROS/RNS in the different stages of tumorigenesis through different impact on oxidation and nitrosylation may also allow development of tailored diagnostic and therapeutic approaches.",
publisher = "MDPI AG",
journal = "Antioxidants (Basel, Switzerland)",
title = "The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors.",
number = "5",
volume = "9",
doi = "10.3390/antiox9050374",
pages = "374"
}

Mijatović, S., Savić-Radojević, A., Plješa-Ercegovac, M., Simić, T., Nicoletti, F.,& Maksimović-Ivanić, D.. (2020). The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors.. in Antioxidants (Basel, Switzerland)
MDPI AG., 9(5), 374.
https://doi.org/10.3390/antiox9050374

Mijatović S, Savić-Radojević A, Plješa-Ercegovac M, Simić T, Nicoletti F, Maksimović-Ivanić D. The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors.. in Antioxidants (Basel, Switzerland). 2020;9(5):374.
doi:10.3390/antiox9050374 .

Mijatović, Sanja, Savić-Radojević, Ana, Plješa-Ercegovac, Marija, Simić, Tatjana, Nicoletti, Ferdinando, Maksimović-Ivanić, Danijela, "The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors." in Antioxidants (Basel, Switzerland), 9, no. 5 (2020):374,
https://doi.org/10.3390/antiox9050374 . .

TY  - JOUR
AU  - Stošić-Grujičić, Stanislava
AU  - Savić-Radojević, Ana R
AU  - Maksimović-Ivanić, Danijela
AU  - Marković, Milos
AU  - Bumbaširević, Vesna D
AU  - Ramić, Zorica D.
AU  - Mostarica-Stojković, Marija B
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1788
AB  - The immunomodulatory potential of tiazofurin (TR) on experimental autoimmune encephalomyelitis (EAE) was investigated. Given continuously, TR dose-dependently suppressed the development of EAE in Dark Agouti (DA) rats immunized with either rat spinal cord homogenate (SCH) or myelin oligodendrocyte glycoprotein (MOG). Amelioration of clinical signs was also obtained when the drug was administered during the inductive phase only (day 0 to 8), or during the effector phase (day 10 to 20) of the disease. Efficacy of TR was further evaluated by adoptive transfer of the disease with myelin basic protein (MBP)-sensitized draining lymph node cells (DLNC). Cells from TR-protected rats failed to transfer the disease into naive syngeneic recipients; in addition, TR treatment of recipient rats that had received MBP-sensitized lymphoid cells diminished the adoptively transferred EAE. A reduction of clinical EAE in TR-treated rats was accompanied with the absence of mononuclear infiltration in the spinal cord and defective adhesive cell-cell interactions. The anti-MOG autoAb production was also decreased. Importantly, no evidence for a generalized impairment of the T cell activity, nor decreased in vitro proliferative antigen specific response of LNC from TR-treated animals was found. These results suggest that TR exerts its EAE protective and suppressive effects by limiting adhesive interactions involved in the autoimmune pathogenic process, and due to the lack of general immunosuppressive activity, it should be considered as a candidate drug for the treatment of neuroinflammatory diseases like multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.
T2  - Journal of Neuroimmunology
T1  - Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin
IS  - 1-2
VL  - 130
EP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1788
ER  - 

@article{
author = "Stošić-Grujičić, Stanislava and Savić-Radojević, Ana R and Maksimović-Ivanić, Danijela and Marković, Milos and Bumbaširević, Vesna D and Ramić, Zorica D. and Mostarica-Stojković, Marija B",
year = "2002",
abstract = "The immunomodulatory potential of tiazofurin (TR) on experimental autoimmune encephalomyelitis (EAE) was investigated. Given continuously, TR dose-dependently suppressed the development of EAE in Dark Agouti (DA) rats immunized with either rat spinal cord homogenate (SCH) or myelin oligodendrocyte glycoprotein (MOG). Amelioration of clinical signs was also obtained when the drug was administered during the inductive phase only (day 0 to 8), or during the effector phase (day 10 to 20) of the disease. Efficacy of TR was further evaluated by adoptive transfer of the disease with myelin basic protein (MBP)-sensitized draining lymph node cells (DLNC). Cells from TR-protected rats failed to transfer the disease into naive syngeneic recipients; in addition, TR treatment of recipient rats that had received MBP-sensitized lymphoid cells diminished the adoptively transferred EAE. A reduction of clinical EAE in TR-treated rats was accompanied with the absence of mononuclear infiltration in the spinal cord and defective adhesive cell-cell interactions. The anti-MOG autoAb production was also decreased. Importantly, no evidence for a generalized impairment of the T cell activity, nor decreased in vitro proliferative antigen specific response of LNC from TR-treated animals was found. These results suggest that TR exerts its EAE protective and suppressive effects by limiting adhesive interactions involved in the autoimmune pathogenic process, and due to the lack of general immunosuppressive activity, it should be considered as a candidate drug for the treatment of neuroinflammatory diseases like multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.",
journal = "Journal of Neuroimmunology",
title = "Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin",
number = "1-2",
volume = "130",
pages = "77",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1788"
}

Stošić-Grujičić, S., Savić-Radojević, A. R., Maksimović-Ivanić, D., Marković, M., Bumbaširević, V. D., Ramić, Z. D.,& Mostarica-Stojković, M. B.. (2002). Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin. in Journal of Neuroimmunology, 130(1-2).
https://hdl.handle.net/21.15107/rcub_ibiss_1788

Stošić-Grujičić S, Savić-Radojević AR, Maksimović-Ivanić D, Marković M, Bumbaširević VD, Ramić ZD, Mostarica-Stojković MB. Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin. in Journal of Neuroimmunology. 2002;130(1-2):null-77.
https://hdl.handle.net/21.15107/rcub_ibiss_1788 .

Stošić-Grujičić, Stanislava, Savić-Radojević, Ana R, Maksimović-Ivanić, Danijela, Marković, Milos, Bumbaširević, Vesna D, Ramić, Zorica D., Mostarica-Stojković, Marija B, "Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin" in Journal of Neuroimmunology, 130, no. 1-2 (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1788 .