TY  - JOUR
AU  - Gašić, Uroš
AU  - Stojković, Dejan
AU  - Ivanov, Marija
AU  - Miletić, Milica
AU  - Mišić, Danijela
AU  - Veljić, Milan
AU  - Soković, Marina
PY  - 2021
UR  - https://scindeks.ceon.rs/Article.aspx?artid=0455-62242141028G
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4934
AB  - The following study was designed to explore antimicrobial properties of the by-product obtained in a hydro-distillation process of essential oil from Nepeta nuda L. We strived to develop a novel drink with antimicrobial self-preserving properties based on two components, N. nuda decoct and apple juice. By using 96-well plate microdilution assay it was shown that the N. nuda decoct has antimicrobial potential towards 8 bacterial and 6 fungal species, with the range of minimal inhibitory concentrations 10-300 mg/mL. By using actual food system, such as apple juice, in combination with and without short thermal treatment, we have shown that the decoct of N. nuda can inhibit the growth of food contaminant fungus Penicillium aurantiogriseum. It was determined that 3 volumes of decoct (500 mg/mL) and 22 volumes of apple juice should be mixed in order to obtain self-preserving drink resistant to P. aurantiogriseum contamination. Likewise, when thermal treatment (80 °C for 10 s) is included, self-preserving mixture of decoct and apple juice should be made in volume ratios 3:47, respectively. The designed product maintained the pleasant taste as determined by panelists during the sensorial evaluation. Chemical investigations (UHPLC-Orbitrap MS analysis) of N. nuda decoct showed that the most abundant compound was 1,5,9-epideoxyloganic acid (0.410 mg/g of dried decoct). Since N. nuda is traditionally used as a tea, we presented the novel formulation of the drink with antimicrobial properties based on the its decoct and apple juice.
PB  - Belgrade:  Institute for Medicinal Plants Research "Dr. Josif Pančić"
T2  - Lekovite sirovine
T1  - Water soluble biomolecules from Nepeta nuda regulate microbial growth: A case study of apple juice preservation
IS  - 41
DO  - 10.5937/leksir2141028G
SP  - 28
EP  - 34
ER  - 

@article{
author = "Gašić, Uroš and Stojković, Dejan and Ivanov, Marija and Miletić, Milica and Mišić, Danijela and Veljić, Milan and Soković, Marina",
year = "2021",
abstract = "The following study was designed to explore antimicrobial properties of the by-product obtained in a hydro-distillation process of essential oil from Nepeta nuda L. We strived to develop a novel drink with antimicrobial self-preserving properties based on two components, N. nuda decoct and apple juice. By using 96-well plate microdilution assay it was shown that the N. nuda decoct has antimicrobial potential towards 8 bacterial and 6 fungal species, with the range of minimal inhibitory concentrations 10-300 mg/mL. By using actual food system, such as apple juice, in combination with and without short thermal treatment, we have shown that the decoct of N. nuda can inhibit the growth of food contaminant fungus Penicillium aurantiogriseum. It was determined that 3 volumes of decoct (500 mg/mL) and 22 volumes of apple juice should be mixed in order to obtain self-preserving drink resistant to P. aurantiogriseum contamination. Likewise, when thermal treatment (80 °C for 10 s) is included, self-preserving mixture of decoct and apple juice should be made in volume ratios 3:47, respectively. The designed product maintained the pleasant taste as determined by panelists during the sensorial evaluation. Chemical investigations (UHPLC-Orbitrap MS analysis) of N. nuda decoct showed that the most abundant compound was 1,5,9-epideoxyloganic acid (0.410 mg/g of dried decoct). Since N. nuda is traditionally used as a tea, we presented the novel formulation of the drink with antimicrobial properties based on the its decoct and apple juice.",
publisher = "Belgrade:  Institute for Medicinal Plants Research "Dr. Josif Pančić"",
journal = "Lekovite sirovine",
title = "Water soluble biomolecules from Nepeta nuda regulate microbial growth: A case study of apple juice preservation",
number = "41",
doi = "10.5937/leksir2141028G",
pages = "28-34"
}

Gašić, U., Stojković, D., Ivanov, M., Miletić, M., Mišić, D., Veljić, M.,& Soković, M.. (2021). Water soluble biomolecules from Nepeta nuda regulate microbial growth: A case study of apple juice preservation. in Lekovite sirovine
Belgrade:  Institute for Medicinal Plants Research "Dr. Josif Pančić".(41), 28-34.
https://doi.org/10.5937/leksir2141028G

Gašić U, Stojković D, Ivanov M, Miletić M, Mišić D, Veljić M, Soković M. Water soluble biomolecules from Nepeta nuda regulate microbial growth: A case study of apple juice preservation. in Lekovite sirovine. 2021;(41):28-34.
doi:10.5937/leksir2141028G .

Gašić, Uroš, Stojković, Dejan, Ivanov, Marija, Miletić, Milica, Mišić, Danijela, Veljić, Milan, Soković, Marina, "Water soluble biomolecules from Nepeta nuda regulate microbial growth: A case study of apple juice preservation" in Lekovite sirovine, no. 41 (2021):28-34,
https://doi.org/10.5937/leksir2141028G . .

TY  - JOUR
AU  - Ilić-Tomić, Tatjana
AU  - Soković, Marina
AU  - Vojnović, Sandra
AU  - Ćirić, Ana
AU  - Veljić, Milan
AU  - Nikodinović-Runić, Jasmina
AU  - Novaković, Miroslav
PY  - 2017
UR  - http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-107674
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2686
AB  - Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40–70?%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)-l-HSL. On the other side, four diarylheptanoids (2–5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 µg/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.
T2  - Planta Medica
T1  - Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa
IS  - 01/02
VL  - 83
DO  - 10.1055/s-0042-107674
SP  - 117
EP  - 125
ER  - 

@article{
author = "Ilić-Tomić, Tatjana and Soković, Marina and Vojnović, Sandra and Ćirić, Ana and Veljić, Milan and Nikodinović-Runić, Jasmina and Novaković, Miroslav",
year = "2017",
abstract = "Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40–70?%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)-l-HSL. On the other side, four diarylheptanoids (2–5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 µg/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.",
journal = "Planta Medica",
title = "Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa",
number = "01/02",
volume = "83",
doi = "10.1055/s-0042-107674",
pages = "117-125"
}

Ilić-Tomić, T., Soković, M., Vojnović, S., Ćirić, A., Veljić, M., Nikodinović-Runić, J.,& Novaković, M.. (2017). Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica, 83(01/02), 117-125.
https://doi.org/10.1055/s-0042-107674

Ilić-Tomić T, Soković M, Vojnović S, Ćirić A, Veljić M, Nikodinović-Runić J, Novaković M. Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica. 2017;83(01/02):117-125.
doi:10.1055/s-0042-107674 .

Ilić-Tomić, Tatjana, Soković, Marina, Vojnović, Sandra, Ćirić, Ana, Veljić, Milan, Nikodinović-Runić, Jasmina, Novaković, Miroslav, "Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa" in Planta Medica, 83, no. 01/02 (2017):117-125,
https://doi.org/10.1055/s-0042-107674 . .