TY  - JOUR
AU  - Markelić, Milica
AU  - Drača, Dijana
AU  - Krajnović, Tamara
AU  - Jović, Zorana
AU  - Vuksanović, Milica
AU  - Koruga, Djuro
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4953
AB  - (1) Background: Their unique structure and electron deficiency have brought fullerenes
into the focus of research in many fields, including medicine. The hyper-harmonized hydroxylated
fullerene water complex (3HFWC) formulation has solved the limitations of the poor solubility
and bioavailability of fullerenes. To achieve better antitumor activity, 3HFWC was combined with
short-term irradiation of cells with hyperpolarized light (HPL) generated by the application of a
nanophotonic fullerene filter in a Bioptron® device. The benefits of HPL were confirmed in the
microcirculation, wound healing and immunological function. (2) Methods: B16, B16-F10 and A375
melanoma cells were exposed to a wide spectrum of 3HFWC doses and to a single short-term HPL
irradiation. (3) Results: Apart from the differences in the redox status and level of invasiveness, the
effects of the treatments were quite similar. Decreased viability, morphological alteration, signs of
melanocytic differentiation and cellular senescence were observed upon the successful internalization
of the nanoquantum substance. (4) Conclusions: Overall, 3HFWC/HPL promoted melanoma cell
reprogramming toward a normal phenotype.
PB  - Basel: MDPI
T2  - Nanomaterials (Basel)
T1  - Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro
IS  - 8
VL  - 12
DO  - 10.3390/nano12081331
SP  - 1331
ER  - 

@article{
author = "Markelić, Milica and Drača, Dijana and Krajnović, Tamara and Jović, Zorana and Vuksanović, Milica and Koruga, Djuro and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2022",
abstract = "(1) Background: Their unique structure and electron deficiency have brought fullerenes
into the focus of research in many fields, including medicine. The hyper-harmonized hydroxylated
fullerene water complex (3HFWC) formulation has solved the limitations of the poor solubility
and bioavailability of fullerenes. To achieve better antitumor activity, 3HFWC was combined with
short-term irradiation of cells with hyperpolarized light (HPL) generated by the application of a
nanophotonic fullerene filter in a Bioptron® device. The benefits of HPL were confirmed in the
microcirculation, wound healing and immunological function. (2) Methods: B16, B16-F10 and A375
melanoma cells were exposed to a wide spectrum of 3HFWC doses and to a single short-term HPL
irradiation. (3) Results: Apart from the differences in the redox status and level of invasiveness, the
effects of the treatments were quite similar. Decreased viability, morphological alteration, signs of
melanocytic differentiation and cellular senescence were observed upon the successful internalization
of the nanoquantum substance. (4) Conclusions: Overall, 3HFWC/HPL promoted melanoma cell
reprogramming toward a normal phenotype.",
publisher = "Basel: MDPI",
journal = "Nanomaterials (Basel)",
title = "Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro",
number = "8",
volume = "12",
doi = "10.3390/nano12081331",
pages = "1331"
}

Markelić, M., Drača, D., Krajnović, T., Jović, Z., Vuksanović, M., Koruga, D., Mijatović, S.,& Maksimović-Ivanić, D.. (2022). Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro. in Nanomaterials (Basel)
Basel: MDPI., 12(8), 1331.
https://doi.org/10.3390/nano12081331

Markelić M, Drača D, Krajnović T, Jović Z, Vuksanović M, Koruga D, Mijatović S, Maksimović-Ivanić D. Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro. in Nanomaterials (Basel). 2022;12(8):1331.
doi:10.3390/nano12081331 .

Markelić, Milica, Drača, Dijana, Krajnović, Tamara, Jović, Zorana, Vuksanović, Milica, Koruga, Djuro, Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro" in Nanomaterials (Basel), 12, no. 8 (2022):1331,
https://doi.org/10.3390/nano12081331 . .