TY  - JOUR
AU  - Bjekić-Macut, Jelica
AU  - Radosavljević, Vojislav
AU  - Andrić, Zoran
AU  - Ilić, Dušan
AU  - Stanojlović, Olivera
AU  - Vojnović-Milutinović, Danijela
AU  - Božić Antić, Ivana
AU  - Zdravković, Marija
AU  - Hinić, Saša
AU  - Macut, Đuro
AU  - Žarković, Miloš
PY  - 2016
UR  - http://www.degruyter.com/view/j/jomb.2016.35.issue-4/jomb-2016-0015/jomb-2016-0015.xml
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-84994910742&origin=SingleRecordEmailAlert&txGid=6CE299281CDB840158BFAC52EC5A2E1C.wsnAw8kcdt7IPYLO0V48gA:63#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2522
AB  - Background: Systemic inflammatory response syndrome (SIRS) changes cortisol dynamics and indicates dissociation between the adrenal cortex and the hypothalamo-pituitary unit. The aim of this study was to assess the cortisol response after stimulation with ACTH(1-24) in patients with SIRS at admission to the Respiratory Intensive Care Unit (RICU),and seven days later.

Methods: Fifty-four subjects were included in the study, and SIRS was defined according to the Consensus Conference criteria from 1992. Severity of the disease was determined using the APACHE II score, and organ dysfunction using the SOFA score. Low-dose (1 mu g) ACTH test (LDT) was performed in all patients, and cortisol was determined along with basal ACTH. Data were analyzed using parametric and nonparametric tests and regression analysis. The results are presented as mean +/- standard deviation, and P<0.05 was considered statistically significant.

Results: There were no differences in cortisol values between the two LDTs. Cortisol increment lower than 250 nmol/L during the LDT was found in 14/54 (25.9%) subjects at the onset of SIRS. Five out of 54 (9.6%) patients died within 7 days from the onset of SIRS. Female sex and maximal cortisol response (Delta max) on LDT predicted the duration of hospitalization in RICU, while APACHE II and SOFA scores best predicted the duration of hospitalization, mortality outcome as well as overall survival outcome.

Conclusions: A difference was found in Delta max at the diagnosis of SIRS and seven days later. Delta max, and primarily the clinical scores APACHE II and SOFA predicted the outcomes of hospitalization and overall survival.
T2  - Journal of Medical Biochemistry
T1  - Cortisol Response to Low-Dose (1 μg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome
IS  - 4
VL  - 35
DO  - 10.1515/jomb-2016-0015
SP  - 428
EP  - 435
ER  - 

@article{
author = "Bjekić-Macut, Jelica and Radosavljević, Vojislav and Andrić, Zoran and Ilić, Dušan and Stanojlović, Olivera and Vojnović-Milutinović, Danijela and Božić Antić, Ivana and Zdravković, Marija and Hinić, Saša and Macut, Đuro and Žarković, Miloš",
year = "2016",
abstract = "Background: Systemic inflammatory response syndrome (SIRS) changes cortisol dynamics and indicates dissociation between the adrenal cortex and the hypothalamo-pituitary unit. The aim of this study was to assess the cortisol response after stimulation with ACTH(1-24) in patients with SIRS at admission to the Respiratory Intensive Care Unit (RICU),and seven days later.

Methods: Fifty-four subjects were included in the study, and SIRS was defined according to the Consensus Conference criteria from 1992. Severity of the disease was determined using the APACHE II score, and organ dysfunction using the SOFA score. Low-dose (1 mu g) ACTH test (LDT) was performed in all patients, and cortisol was determined along with basal ACTH. Data were analyzed using parametric and nonparametric tests and regression analysis. The results are presented as mean +/- standard deviation, and P<0.05 was considered statistically significant.

Results: There were no differences in cortisol values between the two LDTs. Cortisol increment lower than 250 nmol/L during the LDT was found in 14/54 (25.9%) subjects at the onset of SIRS. Five out of 54 (9.6%) patients died within 7 days from the onset of SIRS. Female sex and maximal cortisol response (Delta max) on LDT predicted the duration of hospitalization in RICU, while APACHE II and SOFA scores best predicted the duration of hospitalization, mortality outcome as well as overall survival outcome.

Conclusions: A difference was found in Delta max at the diagnosis of SIRS and seven days later. Delta max, and primarily the clinical scores APACHE II and SOFA predicted the outcomes of hospitalization and overall survival.",
journal = "Journal of Medical Biochemistry",
title = "Cortisol Response to Low-Dose (1 μg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome",
number = "4",
volume = "35",
doi = "10.1515/jomb-2016-0015",
pages = "428-435"
}

Bjekić-Macut, J., Radosavljević, V., Andrić, Z., Ilić, D., Stanojlović, O., Vojnović-Milutinović, D., Božić Antić, I., Zdravković, M., Hinić, S., Macut, Đ.,& Žarković, M.. (2016). Cortisol Response to Low-Dose (1 μg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome. in Journal of Medical Biochemistry, 35(4), 428-435.
https://doi.org/10.1515/jomb-2016-0015

Bjekić-Macut J, Radosavljević V, Andrić Z, Ilić D, Stanojlović O, Vojnović-Milutinović D, Božić Antić I, Zdravković M, Hinić S, Macut Đ, Žarković M. Cortisol Response to Low-Dose (1 μg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome. in Journal of Medical Biochemistry. 2016;35(4):428-435.
doi:10.1515/jomb-2016-0015 .

Bjekić-Macut, Jelica, Radosavljević, Vojislav, Andrić, Zoran, Ilić, Dušan, Stanojlović, Olivera, Vojnović-Milutinović, Danijela, Božić Antić, Ivana, Zdravković, Marija, Hinić, Saša, Macut, Đuro, Žarković, Miloš, "Cortisol Response to Low-Dose (1 μg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome" in Journal of Medical Biochemistry, 35, no. 4 (2016):428-435,
https://doi.org/10.1515/jomb-2016-0015 . .

TY  - JOUR
AU  - Božić-Antić, Ivana
AU  - Ilić, Dušan
AU  - Bjekić-Macut, Jelica
AU  - Bogavac, Tamara
AU  - Vojnović-Milutinović, Danijela
AU  - Kastratovic-Kotlica, Biljana
AU  - Milić, Nataša
AU  - Stanojlović, Olivera
AU  - Andrić, Zoran
AU  - Macut, Djuro
PY  - 2016
UR  - http://www.eje-online.org/lookup/doi/10.1530/EJE-16-0775
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85000384361&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A9#
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2482
AB  - Objective: There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and the ability of LAP to predict MetS in different PCOS phenotypes. Design: Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls. Methods: In all subjects, LAP was determined and MetS was diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III (NCEP-ATP III), the International Diabetes Federation (IDF) and the Joint Interim Statement (JIS) criteria. Logistic regression and ROC curve analyses were used to determine predictors of MetS in each PCOS phenotype. All analyses were performed with age and BMI adjustment. Results: All PCOS phenotypes in comparison to controls had higher prevalence of MetS assessed by NCEP-ATP III criteria, and only classic phenotypes when IDF and JIS criteria were used. All phenotypes had the same prevalence of MetS irrespective of used definition. LAP and exhibited the highest diagnostic accuracy and was an independent predictor of MetS in all phenotypes. Conclusion: LAP is an independent and accurate clinical determinant of MetS in all PCOS phenotypes in our Caucasian population. All PCOS phenotypes, including non-classic ones, are metabolically challenged and with cardiovascular risk, particularly phenotype B.
T2  - European Journal of Endocrinology
T1  - Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome
IS  - 6
VL  - 175
DO  - 10.1530/EJE-16-0775
SP  - 551
EP  - 560
ER  - 

@article{
author = "Božić-Antić, Ivana and Ilić, Dušan and Bjekić-Macut, Jelica and Bogavac, Tamara and Vojnović-Milutinović, Danijela and Kastratovic-Kotlica, Biljana and Milić, Nataša and Stanojlović, Olivera and Andrić, Zoran and Macut, Djuro",
year = "2016",
abstract = "Objective: There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and the ability of LAP to predict MetS in different PCOS phenotypes. Design: Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls. Methods: In all subjects, LAP was determined and MetS was diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III (NCEP-ATP III), the International Diabetes Federation (IDF) and the Joint Interim Statement (JIS) criteria. Logistic regression and ROC curve analyses were used to determine predictors of MetS in each PCOS phenotype. All analyses were performed with age and BMI adjustment. Results: All PCOS phenotypes in comparison to controls had higher prevalence of MetS assessed by NCEP-ATP III criteria, and only classic phenotypes when IDF and JIS criteria were used. All phenotypes had the same prevalence of MetS irrespective of used definition. LAP and exhibited the highest diagnostic accuracy and was an independent predictor of MetS in all phenotypes. Conclusion: LAP is an independent and accurate clinical determinant of MetS in all PCOS phenotypes in our Caucasian population. All PCOS phenotypes, including non-classic ones, are metabolically challenged and with cardiovascular risk, particularly phenotype B.",
journal = "European Journal of Endocrinology",
title = "Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome",
number = "6",
volume = "175",
doi = "10.1530/EJE-16-0775",
pages = "551-560"
}

Božić-Antić, I., Ilić, D., Bjekić-Macut, J., Bogavac, T., Vojnović-Milutinović, D., Kastratovic-Kotlica, B., Milić, N., Stanojlović, O., Andrić, Z.,& Macut, D.. (2016). Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome. in European Journal of Endocrinology, 175(6), 551-560.
https://doi.org/10.1530/EJE-16-0775

Božić-Antić I, Ilić D, Bjekić-Macut J, Bogavac T, Vojnović-Milutinović D, Kastratovic-Kotlica B, Milić N, Stanojlović O, Andrić Z, Macut D. Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome. in European Journal of Endocrinology. 2016;175(6):551-560.
doi:10.1530/EJE-16-0775 .

Božić-Antić, Ivana, Ilić, Dušan, Bjekić-Macut, Jelica, Bogavac, Tamara, Vojnović-Milutinović, Danijela, Kastratovic-Kotlica, Biljana, Milić, Nataša, Stanojlović, Olivera, Andrić, Zoran, Macut, Djuro, "Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome" in European Journal of Endocrinology, 175, no. 6 (2016):551-560,
https://doi.org/10.1530/EJE-16-0775 . .

TY  - JOUR
AU  - Bjekić-Macut, Jelica
AU  - Božić-Antić, Ivana
AU  - Vojnović-Milutinović, Danijela
AU  - Stanojlović, Olivera
AU  - Andrić, Zoran
AU  - Ilić, Dušan
AU  - Macut, Đuro
PY  - 2015
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/493
AB  - Gojaznost se danas smatra uzrokom nastanka kardiovaskularne bolesti, tipa 2 dijabetesa, osteoartritisa, maligniteta, ali i faktorom koji doprinosi nastanku reproduktivnih poremećaja i problema plodnosti. Postoji povećan relativni rizik za nastanak anovulatornog infertiliteta u žena sa izraženom gojaznošću i produženo vreme do koncepcije. U žena u reproduktivnom periodu gojaznost je povezana sa povećanim rizikom za nastanak hiperandrogenizma i anovulacije, kao što je slučaj u sindromu policističnih jajnika (PCOS) kao najčešćem hiperandrogenom poremećaju. Postoji veliki broj dokaza u prilog postojanja bliskog odnosa adipokina, gojaznosti, metaboličkog sindroma i reproduktivnih posledica. Redukcija težine za 5-10% dovodi do poboljšanja u kliničkim, metaboličkim i reproduktivnim karakteristikama, kao što je slučaj u žena sa PCOS. Primena insulinskih senzitajzera vodi sniženju hiperinsulinemije, insulinske rezistencije, uspostavljanju normalne menstrualne cikličnosti i ovulacije kod značajnog broja žena sa PCOS. Gojaznost može uticati na stimulaciju ovulacije njenim produžavanjem, povećanjem doze gonadotropina, incidence folikularne asinhronije i prekida stimulacije. Hirurško lečenje gojaznosti predstavlja alternativni vid terapije u slučaju kada ni promena načina života ni farmakoterapijske mere ne daju povoljne rezultate. Za sada ne postoji dovoljno dokaza u prilog preporuke da se barijatrijska hirurgija koristi u lečenju gojaznih žena sa PCOS.
T2  - Medicinski glasnik Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor
T1  - Gojaznost i reproduktivna funkcija žene - mehanizmi nastanka i terapijske implikacije
IS  - 56
VL  - 20
SP  - 7
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_493
ER  - 

@article{
author = "Bjekić-Macut, Jelica and Božić-Antić, Ivana and Vojnović-Milutinović, Danijela and Stanojlović, Olivera and Andrić, Zoran and Ilić, Dušan and Macut, Đuro",
year = "2015, 2015",
abstract = "Gojaznost se danas smatra uzrokom nastanka kardiovaskularne bolesti, tipa 2 dijabetesa, osteoartritisa, maligniteta, ali i faktorom koji doprinosi nastanku reproduktivnih poremećaja i problema plodnosti. Postoji povećan relativni rizik za nastanak anovulatornog infertiliteta u žena sa izraženom gojaznošću i produženo vreme do koncepcije. U žena u reproduktivnom periodu gojaznost je povezana sa povećanim rizikom za nastanak hiperandrogenizma i anovulacije, kao što je slučaj u sindromu policističnih jajnika (PCOS) kao najčešćem hiperandrogenom poremećaju. Postoji veliki broj dokaza u prilog postojanja bliskog odnosa adipokina, gojaznosti, metaboličkog sindroma i reproduktivnih posledica. Redukcija težine za 5-10% dovodi do poboljšanja u kliničkim, metaboličkim i reproduktivnim karakteristikama, kao što je slučaj u žena sa PCOS. Primena insulinskih senzitajzera vodi sniženju hiperinsulinemije, insulinske rezistencije, uspostavljanju normalne menstrualne cikličnosti i ovulacije kod značajnog broja žena sa PCOS. Gojaznost može uticati na stimulaciju ovulacije njenim produžavanjem, povećanjem doze gonadotropina, incidence folikularne asinhronije i prekida stimulacije. Hirurško lečenje gojaznosti predstavlja alternativni vid terapije u slučaju kada ni promena načina života ni farmakoterapijske mere ne daju povoljne rezultate. Za sada ne postoji dovoljno dokaza u prilog preporuke da se barijatrijska hirurgija koristi u lečenju gojaznih žena sa PCOS.",
journal = "Medicinski glasnik Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor",
title = "Gojaznost i reproduktivna funkcija žene - mehanizmi nastanka i terapijske implikacije",
number = "56",
volume = "20",
pages = "7-14",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_493"
}

Bjekić-Macut, J., Božić-Antić, I., Vojnović-Milutinović, D., Stanojlović, O., Andrić, Z., Ilić, D.,& Macut, Đ.. (2015). Gojaznost i reproduktivna funkcija žene - mehanizmi nastanka i terapijske implikacije. in Medicinski glasnik Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor, 20(56), 7-14.
https://hdl.handle.net/21.15107/rcub_ibiss_493

Bjekić-Macut J, Božić-Antić I, Vojnović-Milutinović D, Stanojlović O, Andrić Z, Ilić D, Macut Đ. Gojaznost i reproduktivna funkcija žene - mehanizmi nastanka i terapijske implikacije. in Medicinski glasnik Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor. 2015;20(56):7-14.
https://hdl.handle.net/21.15107/rcub_ibiss_493 .

Bjekić-Macut, Jelica, Božić-Antić, Ivana, Vojnović-Milutinović, Danijela, Stanojlović, Olivera, Andrić, Zoran, Ilić, Dušan, Macut, Đuro, "Gojaznost i reproduktivna funkcija žene - mehanizmi nastanka i terapijske implikacije" in Medicinski glasnik Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor, 20, no. 56 (2015):7-14,
https://hdl.handle.net/21.15107/rcub_ibiss_493 .