TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Parabučki, Ana B.
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Dačić, Sanja
AU  - Peković, Sanja
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Nedeljković, Nadezda N
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1289
AB  - Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.
T2  - Journal of Neuroscience Research
T1  - Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury
IS  - 6
VL  - 89
EP  - 873
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1289
ER  - 

@article{
author = "Bjelobaba, Ivana and Parabučki, Ana B. and Lavrnja, Irena and Savić, Danijela and Dačić, Sanja and Peković, Sanja and Rakić, Ljubisa M and Stojiljković, Mirjana B and Nedeljković, Nadezda N",
year = "2011",
abstract = "Traumatic injury induces massive release of ATP in the extracellular space, where it influences numerous aspects of neuronal, astrocytic, and microglial responses to injury by activating P2X and P2Y receptors. The extracellular ATP actions are controlled by the ectonucleotidase enzyme pathway, which hydrolyses ATP to adenosine at all neuronal and nonneuronal cell types. Adenosine activates its P1 receptors, which have important neuroprotective roles. The rate-limiting enzyme in the ectonucleotidase pathway is ecto-5 '-nucleotidase (e-5NT), which catalyzes the final step of dephosphorylation of AMP to adenosine. The aim of the present study was to characterize the expression pattern and cellular distribution of e-5NT in the perilesioned cortex at 4 hr and 1, 2, 7, and 15 days after unilateral cortical stab injury (CSI). Immunoblot and immunohistochemical studies showed that overall e-5NT expression was lower 4 hr and 1 day postinjury and then gradually increased above the control levels. Double-immunofluorescence studies further showed in control tissue the presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes. CSI caused a rapid (after 4 hr) and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression. This was accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for up-regulation of the enzyme levels in the injured area. Thus, CSI induced dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after CSI. (C) 2011 Wiley-Liss, Inc.",
journal = "Journal of Neuroscience Research",
title = "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury",
number = "6",
volume = "89",
pages = "873",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1289"
}

Bjelobaba, I., Parabučki, A. B., Lavrnja, I., Savić, D., Dačić, S., Peković, S., Rakić, L. M., Stojiljković, M. B.,& Nedeljković, N. N.. (2011). Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research, 89(6).
https://hdl.handle.net/21.15107/rcub_ibiss_1289

Bjelobaba I, Parabučki AB, Lavrnja I, Savić D, Dačić S, Peković S, Rakić LM, Stojiljković MB, Nedeljković NN. Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury. in Journal of Neuroscience Research. 2011;89(6):null-873.
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

Bjelobaba, Ivana, Parabučki, Ana B., Lavrnja, Irena, Savić, Danijela, Dačić, Sanja, Peković, Sanja, Rakić, Ljubisa M, Stojiljković, Mirjana B, Nedeljković, Nadezda N, "Dynamic Changes in the Expression Pattern of Ecto-5 '-Nucleotidase in the Rat Model of Cortical Stab Injury" in Journal of Neuroscience Research, 89, no. 6 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1289 .

TY  - CONF
AU  - Dačić, Sanja
AU  - Stojiljković, Mirjana B
AU  - Lavrnja, Irena
AU  - Savić, Danijela
AU  - Parabučki, Ana B.
AU  - Božić, Iva D.
AU  - Bjelobaba, Ivana
AU  - Laketa, Danijela
AU  - Nedeljković, Nadezda N
AU  - Rakić, Ljubisa M
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1262
C3  - Glia
T1  - Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation
IS  - null
VL  - 59
EP  - S52
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1262
ER  - 

@conference{
author = "Dačić, Sanja and Stojiljković, Mirjana B and Lavrnja, Irena and Savić, Danijela and Parabučki, Ana B. and Božić, Iva D. and Bjelobaba, Ivana and Laketa, Danijela and Nedeljković, Nadezda N and Rakić, Ljubisa M and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation",
number = "null",
volume = "59",
pages = "S52",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1262"
}

Dačić, S., Stojiljković, M. B., Lavrnja, I., Savić, D., Parabučki, A. B., Božić, I. D., Bjelobaba, I., Laketa, D., Nedeljković, N. N., Rakić, L. M.,& Peković, S.. (2011). Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1262

Dačić S, Stojiljković MB, Lavrnja I, Savić D, Parabučki AB, Božić ID, Bjelobaba I, Laketa D, Nedeljković NN, Rakić LM, Peković S. Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation. in Glia. 2011;59(null):null-S52.
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

Dačić, Sanja, Stojiljković, Mirjana B, Lavrnja, Irena, Savić, Danijela, Parabučki, Ana B., Božić, Iva D., Bjelobaba, Ivana, Laketa, Danijela, Nedeljković, Nadezda N, Rakić, Ljubisa M, Peković, Sanja, "Treatment With Combination of B Vitamins Reduces Neurocan Expression After Cortical Ablation" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1262 .

TY  - CONF
AU  - Božić, Iva D.
AU  - Gađanski, Ivana
AU  - Lavrnja, Irena
AU  - Parabučki, Ana B.
AU  - Dačić, Sanja
AU  - Bjelobaba, Ivana
AU  - Savić, Danijela
AU  - Rakić, Ljubisa M
AU  - Stojiljković, Mirjana B
AU  - Peković, Sanja
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1261
C3  - Glia
T1  - Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury
IS  - null
VL  - 59
EP  - S101
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1261
ER  - 

@conference{
author = "Božić, Iva D. and Gađanski, Ivana and Lavrnja, Irena and Parabučki, Ana B. and Dačić, Sanja and Bjelobaba, Ivana and Savić, Danijela and Rakić, Ljubisa M and Stojiljković, Mirjana B and Peković, Sanja",
year = "2011",
journal = "Glia",
title = "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury",
number = "null",
volume = "59",
pages = "S101",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1261"
}

Božić, I. D., Gađanski, I., Lavrnja, I., Parabučki, A. B., Dačić, S., Bjelobaba, I., Savić, D., Rakić, L. M., Stojiljković, M. B.,& Peković, S.. (2011). Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia, 59(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1261

Božić ID, Gađanski I, Lavrnja I, Parabučki AB, Dačić S, Bjelobaba I, Savić D, Rakić LM, Stojiljković MB, Peković S. Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury. in Glia. 2011;59(null):null-S101.
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

Božić, Iva D., Gađanski, Ivana, Lavrnja, Irena, Parabučki, Ana B., Dačić, Sanja, Bjelobaba, Ivana, Savić, Danijela, Rakić, Ljubisa M, Stojiljković, Mirjana B, Peković, Sanja, "Temporal and Cellular Expression Pattern of Lc and N Type of Voltage-Dependent Calcium Channels After Cortical Injury" in Glia, 59, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1261 .

TY  - CONF
AU  - Podolski-Renić, Ana
AU  - Pešić, Milica
AU  - Rakić, Ljubisa M
AU  - Ruždijić, Sabera
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1432
C3  - Ejc Supplements
T1  - Purine analogs sensitize the multidrug resistant cell line (NCl-H460/R) to doxorubicin
IS  - 2
VL  - 7
EP  - 528
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1432
ER  - 

@conference{
author = "Podolski-Renić, Ana and Pešić, Milica and Rakić, Ljubisa M and Ruždijić, Sabera",
year = "2009",
journal = "Ejc Supplements",
title = "Purine analogs sensitize the multidrug resistant cell line (NCl-H460/R) to doxorubicin",
number = "2",
volume = "7",
pages = "528",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1432"
}

Podolski-Renić, A., Pešić, M., Rakić, L. M.,& Ruždijić, S.. (2009). Purine analogs sensitize the multidrug resistant cell line (NCl-H460/R) to doxorubicin. in Ejc Supplements, 7(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1432

Podolski-Renić A, Pešić M, Rakić LM, Ruždijić S. Purine analogs sensitize the multidrug resistant cell line (NCl-H460/R) to doxorubicin. in Ejc Supplements. 2009;7(2):null-528.
https://hdl.handle.net/21.15107/rcub_ibiss_1432 .

Podolski-Renić, Ana, Pešić, Milica, Rakić, Ljubisa M, Ruždijić, Sabera, "Purine analogs sensitize the multidrug resistant cell line (NCl-H460/R) to doxorubicin" in Ejc Supplements, 7, no. 2 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1432 .