TY  - JOUR
AU  - Dujmović, Irena
AU  - Pekmezović, Tatjana D
AU  - Obrenović, Radmila Z
AU  - Nikolić, Aleksandra L.
AU  - Spasić, Mihajlo
AU  - Mostarica-Stojković, Marija B
AU  - Drulović, Jelena S
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1442
AB  - Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009; 47: 848-53.
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis
IS  - 7
VL  - 47
EP  - 853
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1442
ER  - 

@article{
author = "Dujmović, Irena and Pekmezović, Tatjana D and Obrenović, Radmila Z and Nikolić, Aleksandra L. and Spasić, Mihajlo and Mostarica-Stojković, Marija B and Drulović, Jelena S",
year = "2009",
abstract = "Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009; 47: 848-53.",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis",
number = "7",
volume = "47",
pages = "853",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1442"
}

Dujmović, I., Pekmezović, T. D., Obrenović, R. Z., Nikolić, A. L., Spasić, M., Mostarica-Stojković, M. B.,& Drulović, J. S.. (2009). Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis. in Clinical Chemistry and Laboratory Medicine, 47(7).
https://hdl.handle.net/21.15107/rcub_ibiss_1442

Dujmović I, Pekmezović TD, Obrenović RZ, Nikolić AL, Spasić M, Mostarica-Stojković MB, Drulović JS. Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis. in Clinical Chemistry and Laboratory Medicine. 2009;47(7):null-853.
https://hdl.handle.net/21.15107/rcub_ibiss_1442 .

Dujmović, Irena, Pekmezović, Tatjana D, Obrenović, Radmila Z, Nikolić, Aleksandra L., Spasić, Mihajlo, Mostarica-Stojković, Marija B, Drulović, Jelena S, "Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis" in Clinical Chemistry and Laboratory Medicine, 47, no. 7 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1442 .

TY  - JOUR
AU  - Bogdanović, Visnja V
AU  - Stankov, Karmen
AU  - Icević, Ivana D
AU  - Zikić, Dragan R
AU  - Nikolić, Aleksandra L.
AU  - Solajić, Slavica V
AU  - Đorđević, Aleksandar N
AU  - Bogdanović, Gordana M
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1532
AB  - Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pretreatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismulase and glutathione peroxidase in irradiated K562 cells.
T2  - Journal of Radiation Research
T1  - Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line
IS  - 3
VL  - 49
EP  - 327
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1532
ER  - 

@article{
author = "Bogdanović, Visnja V and Stankov, Karmen and Icević, Ivana D and Zikić, Dragan R and Nikolić, Aleksandra L. and Solajić, Slavica V and Đorđević, Aleksandar N and Bogdanović, Gordana M",
year = "2008",
abstract = "Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pretreatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismulase and glutathione peroxidase in irradiated K562 cells.",
journal = "Journal of Radiation Research",
title = "Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line",
number = "3",
volume = "49",
pages = "327",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1532"
}

Bogdanović, V. V., Stankov, K., Icević, I. D., Zikić, D. R., Nikolić, A. L., Solajić, S. V., Đorđević, A. N.,& Bogdanović, G. M.. (2008). Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. in Journal of Radiation Research, 49(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1532

Bogdanović VV, Stankov K, Icević ID, Zikić DR, Nikolić AL, Solajić SV, Đorđević AN, Bogdanović GM. Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. in Journal of Radiation Research. 2008;49(3):null-327.
https://hdl.handle.net/21.15107/rcub_ibiss_1532 .

Bogdanović, Visnja V, Stankov, Karmen, Icević, Ivana D, Zikić, Dragan R, Nikolić, Aleksandra L., Solajić, Slavica V, Đorđević, Aleksandar N, Bogdanović, Gordana M, "Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line" in Journal of Radiation Research, 49, no. 3 (2008),
https://hdl.handle.net/21.15107/rcub_ibiss_1532 .

TY  - JOUR
AU  - Saičić, Zorica
AU  - Mijalković, Dejan N.
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Spasić, Mihajlo
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1671
AB  - The effects of altered thyroid state on the antioxidant defence system in the liver of differently aged rats were examined. Male rats aged 15, 45 and 75 days were treated with L-thyroxine, T-4 (40 mu g/100 g body mass, s.c., one dose per day) for 14 days (finally aged 30, 60 and 90 days, respectively). The following antioxidant defense enzymes were measured: superoxide dismutases (both copper zinc, CuZn-SOD and manganese containing. Mn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), gluthione-S-transferase (GST), glutathione reductase (GR), as well as the content of low molecular mass antioxidant glutathione (GSH). The effect of T-4 on antioxidant defense system in the liver differs with respect to age. T-4 treatment decreased CAT and GST activities, as well as the content of GSH in animals aged 60 and 90 days. The same treatment elevated GR activity in rats at 30 days of age, this phenomenon was not observed in older animals. The different response of immature rats to thyroxine compared to older animals could be attributed to the differences in thyroxine metabolism and the developmental pattern. Direct effect of T-4 on mature rats can be considered as a part of its overall catabolic action.
T2  - Physiological Research
T1  - Effect of thyroxine on antioxidant defense system in the liver of rats of different age
IS  - 5
VL  - 55
EP  - 568
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1671
ER  - 

@article{
author = "Saičić, Zorica and Mijalković, Dejan N. and Nikolić, Aleksandra L. and Blagojević, Duško and Spasić, Mihajlo",
year = "2006",
abstract = "The effects of altered thyroid state on the antioxidant defence system in the liver of differently aged rats were examined. Male rats aged 15, 45 and 75 days were treated with L-thyroxine, T-4 (40 mu g/100 g body mass, s.c., one dose per day) for 14 days (finally aged 30, 60 and 90 days, respectively). The following antioxidant defense enzymes were measured: superoxide dismutases (both copper zinc, CuZn-SOD and manganese containing. Mn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), gluthione-S-transferase (GST), glutathione reductase (GR), as well as the content of low molecular mass antioxidant glutathione (GSH). The effect of T-4 on antioxidant defense system in the liver differs with respect to age. T-4 treatment decreased CAT and GST activities, as well as the content of GSH in animals aged 60 and 90 days. The same treatment elevated GR activity in rats at 30 days of age, this phenomenon was not observed in older animals. The different response of immature rats to thyroxine compared to older animals could be attributed to the differences in thyroxine metabolism and the developmental pattern. Direct effect of T-4 on mature rats can be considered as a part of its overall catabolic action.",
journal = "Physiological Research",
title = "Effect of thyroxine on antioxidant defense system in the liver of rats of different age",
number = "5",
volume = "55",
pages = "568",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1671"
}

Saičić, Z., Mijalković, D. N., Nikolić, A. L., Blagojević, D.,& Spasić, M.. (2006). Effect of thyroxine on antioxidant defense system in the liver of rats of different age. in Physiological Research, 55(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1671

Saičić Z, Mijalković DN, Nikolić AL, Blagojević D, Spasić M. Effect of thyroxine on antioxidant defense system in the liver of rats of different age. in Physiological Research. 2006;55(5):null-568.
https://hdl.handle.net/21.15107/rcub_ibiss_1671 .

Saičić, Zorica, Mijalković, Dejan N., Nikolić, Aleksandra L., Blagojević, Duško, Spasić, Mihajlo, "Effect of thyroxine on antioxidant defense system in the liver of rats of different age" in Physiological Research, 55, no. 5 (2006),
https://hdl.handle.net/21.15107/rcub_ibiss_1671 .

TY  - JOUR
AU  - Saičić, Zorica
AU  - Mijalković, Dejan N.
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Spasić, Mihajlo
AU  - Petrović, Vojislav M.
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/123
AB  - Effect of thyroxine on antioxidant enzyme activities and GSH content in brain (cortex and rest of the brain) of different maturated rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 μg/100 g body mass), s.c, one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on antioxidant defense (AD) enzyme activities and GSH content in brain differs with respect to age. T4 treatment decrease activities of Mn SOD and CuZn SOD in the rest of the brain of 60 days old rats in comparison to controls and CAT activity in cortex of 30 and 60 day old rats. GSH-Px activity in cortex of 90 days old rats was decreased in T4 treated group in respect to controls, while activity remains unchanged in 30 and 60 day old rats. The activity of GSH-Px in the rest of the brain was unaffected by the treatment in all groups. GSH content in cortex of animals of 30 and 60 days old rats were higher in comparison with corresponding controls, while in 90 days old rats effects were opposite. L- thyroxine treatment significantly decrease GSH content in rest of the brain of 30 days old rats in respect with corresponding controls, while in 60 and 90 days old animals such changes were not detected.
AB  - U ovom radu ispitivan je efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutatationa (GSH) u mozgu (moždana kora i ostatak mozga) pacova različite starosti. Mužjaci pacova soja Mili Hill hybrid hooded starosti 15, 45 and 75 dana tretirani su sa L-tiroksinom, T4 (40 μg/100 g telesne mase), s.c, jedna doza dnevno, 14 dana (do finalne starosti 30, 60 i 90 dana). Efekat T4 na aktivnost antioksidacionih zaštitnih enzima i količinu GSH u mozgu razlikuje se sa starošću pacova. Tretman sa T4 smanjuje aktivnost Mn SOD i CuZn SOD u ostatku mozga pacova starih 60 dana u poređenju sa kontrolama i aktivnost CAT u moždanoj kori pacova starih 30 i 60 dana. GSH-Px aktivnost u moždanoj kori pacova starih 90 dana je smanjena kod pacova tretiranih sa T4 u odnosu na kontrole, dok je aktivnost nepromenjena kod pacova starih 30 i 60 dana. Aktivnost GSH-Px u moždanoj kori pacova je nepromenjena u svim ispitivanim grupama. Količina GSH u moždanoj kori pacova starih 30 i 60 dana je povećana u poređenju sa kontrolama, dok je kod pacova starih 90 dana smanjena. Tretman sa L-tiroksinom značajno smanjuje količinu GSH u ostatku mozga pacova starih 30 dana u poređenju sa kontrolama, dok kod pacova starosti 60 i 90 dana promene nisu detektovane.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti
T1  - Effect of thyroxine on antioxidant defense enzyme activities and glutathione content in brain of different maturated rats
IS  - 1
VL  - 41
SP  - 1
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_123
ER  - 

@article{
author = "Saičić, Zorica and Mijalković, Dejan N. and Nikolić, Aleksandra L. and Blagojević, Duško and Spasić, Mihajlo and Petrović, Vojislav M.",
year = "2005, 2005",
abstract = "Effect of thyroxine on antioxidant enzyme activities and GSH content in brain (cortex and rest of the brain) of different maturated rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 μg/100 g body mass), s.c, one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on antioxidant defense (AD) enzyme activities and GSH content in brain differs with respect to age. T4 treatment decrease activities of Mn SOD and CuZn SOD in the rest of the brain of 60 days old rats in comparison to controls and CAT activity in cortex of 30 and 60 day old rats. GSH-Px activity in cortex of 90 days old rats was decreased in T4 treated group in respect to controls, while activity remains unchanged in 30 and 60 day old rats. The activity of GSH-Px in the rest of the brain was unaffected by the treatment in all groups. GSH content in cortex of animals of 30 and 60 days old rats were higher in comparison with corresponding controls, while in 90 days old rats effects were opposite. L- thyroxine treatment significantly decrease GSH content in rest of the brain of 30 days old rats in respect with corresponding controls, while in 60 and 90 days old animals such changes were not detected., U ovom radu ispitivan je efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutatationa (GSH) u mozgu (moždana kora i ostatak mozga) pacova različite starosti. Mužjaci pacova soja Mili Hill hybrid hooded starosti 15, 45 and 75 dana tretirani su sa L-tiroksinom, T4 (40 μg/100 g telesne mase), s.c, jedna doza dnevno, 14 dana (do finalne starosti 30, 60 i 90 dana). Efekat T4 na aktivnost antioksidacionih zaštitnih enzima i količinu GSH u mozgu razlikuje se sa starošću pacova. Tretman sa T4 smanjuje aktivnost Mn SOD i CuZn SOD u ostatku mozga pacova starih 60 dana u poređenju sa kontrolama i aktivnost CAT u moždanoj kori pacova starih 30 i 60 dana. GSH-Px aktivnost u moždanoj kori pacova starih 90 dana je smanjena kod pacova tretiranih sa T4 u odnosu na kontrole, dok je aktivnost nepromenjena kod pacova starih 30 i 60 dana. Aktivnost GSH-Px u moždanoj kori pacova je nepromenjena u svim ispitivanim grupama. Količina GSH u moždanoj kori pacova starih 30 i 60 dana je povećana u poređenju sa kontrolama, dok je kod pacova starih 90 dana smanjena. Tretman sa L-tiroksinom značajno smanjuje količinu GSH u ostatku mozga pacova starih 30 dana u poređenju sa kontrolama, dok kod pacova starosti 60 i 90 dana promene nisu detektovane.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti, Effect of thyroxine on antioxidant defense enzyme activities and glutathione content in brain of different maturated rats",
number = "1",
volume = "41",
pages = "1-12",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_123"
}

Saičić, Z., Mijalković, D. N., Nikolić, A. L., Blagojević, D., Spasić, M.,& Petrović, V. M.. (2005). Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41(1), 1-12.
https://hdl.handle.net/21.15107/rcub_ibiss_123

Saičić Z, Mijalković DN, Nikolić AL, Blagojević D, Spasić M, Petrović VM. Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2005;41(1):1-12.
https://hdl.handle.net/21.15107/rcub_ibiss_123 .

Saičić, Zorica, Mijalković, Dejan N., Nikolić, Aleksandra L., Blagojević, Duško, Spasić, Mihajlo, Petrović, Vojislav M., "Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41, no. 1 (2005):1-12,
https://hdl.handle.net/21.15107/rcub_ibiss_123 .

TY  - JOUR
AU  - Nikolić, Aleksandra L.
AU  - Stević, Zorica
AU  - Blagojević, Duško
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/38
AB  - Activities of cooper zinc superoxide dismutase (Cu,Zn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST) in the blood of familial amyotrophic lateral sclerosis patients with Leu144Phe mutation (FALS), asimptomatic carriers with Leu144Phe mutation and controls were studied. Activity of Cu,Zn SOD was significantly lower in the FALS patients and asimptomatic carriers than in controls (p<0.001). In the FALS patients GSH-Px activity was lower (p<0.01) and activity of GR was higher (p<0.001) in comparison with controls. Canonical discriminant analyses provide statistical evidence that examined groups are different in the composition of antioxidant enzymes in blood and revealed that each component confers to observed difference. Our results suggests that oxidative stress is involved in pathogenesis of FALS and the activities of antioxidant enzymes are exposed to different kind of oxidative pressure in FALS patients, asymptomatic carriers and controls.
AB  - U ovom radu ispitivana je aktivnost: bakar cink sadržavajuće superoksid dismutaze (Cu, Zn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px), glutation reduktaze (GR) i glutation-S-transferaze (GST) u krvi pacijenata sa familijarnim oblikom amiotrofične lateralne skleroze (FALS) sa mutacijom Leu144Phe, asimptomskim nosiocima mutacije Leu144Phe i kontrola. Aktivnost Cu,Zn SOD je statistički značajno niža kod FALS pacijenata i asimptomskih nosioca mutacije Leu144Phe nego kod kontrola (p < 0,001). Kod FALS pacijenata aktivnost GSH-Px je niža (p < 0,01), a aktivnost GR je veća (p < 0,001) u poređenju sa kontrolnom grupom. Kanonijska diskriminantna analiza obezbeđuje statističku podršku uočene razlike u sastavu antioksidacionih zaštitnih enzima u krvi ispitivanih grupa i pokazuje nam da svaka komponenta značajno doprinosi toj razlici. Naši rezultati sugerišu da je oksidacioni stres uključen u patogenezu FALS i da su antioksidacioni zaštitni enzimi izloženi različitom oksidacionom pritisku kod FALS, asimptomskih nosioca mutacije Leu144Phe i kontrola.
T2  - Jugoslovenska medicinska biohemija
T1  - Aktivnost antioksidacionih zaštitnih enzima u krvi ljudi sa Leu144Phe mutacijom
T1  - Activities of antioxidant defense enzymes in the blood of individuals with Leu144Phe mutation
IS  - 2
VL  - 24
SP  - 111
EP  - 114
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_38
ER  - 

@article{
author = "Nikolić, Aleksandra L. and Stević, Zorica and Blagojević, Duško and Saičić, Zorica and Spasić, Mihajlo",
year = "2005, 2005",
abstract = "Activities of cooper zinc superoxide dismutase (Cu,Zn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST) in the blood of familial amyotrophic lateral sclerosis patients with Leu144Phe mutation (FALS), asimptomatic carriers with Leu144Phe mutation and controls were studied. Activity of Cu,Zn SOD was significantly lower in the FALS patients and asimptomatic carriers than in controls (p<0.001). In the FALS patients GSH-Px activity was lower (p<0.01) and activity of GR was higher (p<0.001) in comparison with controls. Canonical discriminant analyses provide statistical evidence that examined groups are different in the composition of antioxidant enzymes in blood and revealed that each component confers to observed difference. Our results suggests that oxidative stress is involved in pathogenesis of FALS and the activities of antioxidant enzymes are exposed to different kind of oxidative pressure in FALS patients, asymptomatic carriers and controls., U ovom radu ispitivana je aktivnost: bakar cink sadržavajuće superoksid dismutaze (Cu, Zn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px), glutation reduktaze (GR) i glutation-S-transferaze (GST) u krvi pacijenata sa familijarnim oblikom amiotrofične lateralne skleroze (FALS) sa mutacijom Leu144Phe, asimptomskim nosiocima mutacije Leu144Phe i kontrola. Aktivnost Cu,Zn SOD je statistički značajno niža kod FALS pacijenata i asimptomskih nosioca mutacije Leu144Phe nego kod kontrola (p < 0,001). Kod FALS pacijenata aktivnost GSH-Px je niža (p < 0,01), a aktivnost GR je veća (p < 0,001) u poređenju sa kontrolnom grupom. Kanonijska diskriminantna analiza obezbeđuje statističku podršku uočene razlike u sastavu antioksidacionih zaštitnih enzima u krvi ispitivanih grupa i pokazuje nam da svaka komponenta značajno doprinosi toj razlici. Naši rezultati sugerišu da je oksidacioni stres uključen u patogenezu FALS i da su antioksidacioni zaštitni enzimi izloženi različitom oksidacionom pritisku kod FALS, asimptomskih nosioca mutacije Leu144Phe i kontrola.",
journal = "Jugoslovenska medicinska biohemija",
title = "Aktivnost antioksidacionih zaštitnih enzima u krvi ljudi sa Leu144Phe mutacijom, Activities of antioxidant defense enzymes in the blood of individuals with Leu144Phe mutation",
number = "2",
volume = "24",
pages = "111-114",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_38"
}

Nikolić, A. L., Stević, Z., Blagojević, D., Saičić, Z.,& Spasić, M.. (2005). Aktivnost antioksidacionih zaštitnih enzima u krvi ljudi sa Leu144Phe mutacijom. in Jugoslovenska medicinska biohemija, 24(2), 111-114.
https://hdl.handle.net/21.15107/rcub_ibiss_38

Nikolić AL, Stević Z, Blagojević D, Saičić Z, Spasić M. Aktivnost antioksidacionih zaštitnih enzima u krvi ljudi sa Leu144Phe mutacijom. in Jugoslovenska medicinska biohemija. 2005;24(2):111-114.
https://hdl.handle.net/21.15107/rcub_ibiss_38 .

Nikolić, Aleksandra L., Stević, Zorica, Blagojević, Duško, Saičić, Zorica, Spasić, Mihajlo, "Aktivnost antioksidacionih zaštitnih enzima u krvi ljudi sa Leu144Phe mutacijom" in Jugoslovenska medicinska biohemija, 24, no. 2 (2005):111-114,
https://hdl.handle.net/21.15107/rcub_ibiss_38 .

TY  - JOUR
AU  - Saičić, Zorica
AU  - Mijalković, Dejan N.
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Spasić, Mihajlo
AU  - Petrović, Vojislav M.
PY  - 2004
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/35
AB  - Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione (GSH) content in the interscapular brown adipose tissue (IBAT) of different aged rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 mg/100 g body mass), s.c., one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on GSH-dependent antioxidant enzyme activities in the IBAT differs with respect to age. T4 treatment gradually decrease activities of all GSH-dependent antioxidant enzymes in 60 and 90 days old rats in comparison to young ones. GSH content in animals of 30 and 60 days old rats are lower in comparison with 90 days old rats, but the effects are oppposite. L-thyroxine treatment significantly increase GSH content in 30 days old rats (p<0.001) in respect with coresponding controls, while decrease in 60 and 90 days old animals were detected (p<0.01). Different response of non-mature rats to thyroxine comparing to older rats could be attributed to the difference in thyroxine metabolism and developmental phase of regulatory physiological systems maturation including antioxidative.
AB  - Ispitivan je efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količ inu glutationa (GSH) u interskapularnom mrkom masnom tkivu (IBAT) pacova različite starosti. Mužjaci Mill Hill hybrid hooded pacova starih 15, 45 i 75 dana tretirani su sa L-tiroksinom, T4 (40 mg/100 g telesne mase), s.c., jedna doza dnevno, tokom 14 dana (do finalne starosti 30, 60 i 90 dana). Efekat T4 na aktivnost GSH-zavisnih antioksidacionih enzima u IBAT-u se razlikuje u odnosu na starost.Tretman sa T4 smanjuje aktivnost svih GSH-zavisnih antioksidacionih enzima kod pacova 60 i 90 dana starosti u poređenju sa mladim jedinkama. Količina GSH kod životinja starih 30 i 60 dana je niža u poređenju sa pacovima starih 90 dana. Tretman tiroksinom značajno povećava količinu GSH kod pacova starih 30 dana (p<0,001) u odnosu na odgovarajuće kontrole, dok kod pacova starosti 60 i 90 dana izaziva smanjenje (p<0,01). Različit odgovor ne-maturiranih pacova na tiroksin u odnosu na maturirane životinje može se pripisati razlikama u metabolizmu tiroksina i razvojnoj fazi regulatornih fizioloških sistema uključujući i antioksidacioni.
T2  - Jugoslovenska medicinska biohemija
T1  - Efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količinu glutationa u interskapularnom mrkom masnom tkivu pacova različite starosti
T1  - Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione content in the interscapular brown adipose tissue of different maturated rats
IS  - 4
VL  - 23
SP  - 367
EP  - 373
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_35
ER  - 

@article{
author = "Saičić, Zorica and Mijalković, Dejan N. and Nikolić, Aleksandra L. and Blagojević, Duško and Spasić, Mihajlo and Petrović, Vojislav M.",
year = "2004, 2004",
abstract = "Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione (GSH) content in the interscapular brown adipose tissue (IBAT) of different aged rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 mg/100 g body mass), s.c., one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on GSH-dependent antioxidant enzyme activities in the IBAT differs with respect to age. T4 treatment gradually decrease activities of all GSH-dependent antioxidant enzymes in 60 and 90 days old rats in comparison to young ones. GSH content in animals of 30 and 60 days old rats are lower in comparison with 90 days old rats, but the effects are oppposite. L-thyroxine treatment significantly increase GSH content in 30 days old rats (p<0.001) in respect with coresponding controls, while decrease in 60 and 90 days old animals were detected (p<0.01). Different response of non-mature rats to thyroxine comparing to older rats could be attributed to the difference in thyroxine metabolism and developmental phase of regulatory physiological systems maturation including antioxidative., Ispitivan je efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količ inu glutationa (GSH) u interskapularnom mrkom masnom tkivu (IBAT) pacova različite starosti. Mužjaci Mill Hill hybrid hooded pacova starih 15, 45 i 75 dana tretirani su sa L-tiroksinom, T4 (40 mg/100 g telesne mase), s.c., jedna doza dnevno, tokom 14 dana (do finalne starosti 30, 60 i 90 dana). Efekat T4 na aktivnost GSH-zavisnih antioksidacionih enzima u IBAT-u se razlikuje u odnosu na starost.Tretman sa T4 smanjuje aktivnost svih GSH-zavisnih antioksidacionih enzima kod pacova 60 i 90 dana starosti u poređenju sa mladim jedinkama. Količina GSH kod životinja starih 30 i 60 dana je niža u poređenju sa pacovima starih 90 dana. Tretman tiroksinom značajno povećava količinu GSH kod pacova starih 30 dana (p<0,001) u odnosu na odgovarajuće kontrole, dok kod pacova starosti 60 i 90 dana izaziva smanjenje (p<0,01). Različit odgovor ne-maturiranih pacova na tiroksin u odnosu na maturirane životinje može se pripisati razlikama u metabolizmu tiroksina i razvojnoj fazi regulatornih fizioloških sistema uključujući i antioksidacioni.",
journal = "Jugoslovenska medicinska biohemija",
title = "Efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količinu glutationa u interskapularnom mrkom masnom tkivu pacova različite starosti, Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione content in the interscapular brown adipose tissue of different maturated rats",
number = "4",
volume = "23",
pages = "367-373",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_35"
}

Saičić, Z., Mijalković, D. N., Nikolić, A. L., Blagojević, D., Spasić, M.,& Petrović, V. M.. (2004). Efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količinu glutationa u interskapularnom mrkom masnom tkivu pacova različite starosti. in Jugoslovenska medicinska biohemija, 23(4), 367-373.
https://hdl.handle.net/21.15107/rcub_ibiss_35

Saičić Z, Mijalković DN, Nikolić AL, Blagojević D, Spasić M, Petrović VM. Efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količinu glutationa u interskapularnom mrkom masnom tkivu pacova različite starosti. in Jugoslovenska medicinska biohemija. 2004;23(4):367-373.
https://hdl.handle.net/21.15107/rcub_ibiss_35 .

Saičić, Zorica, Mijalković, Dejan N., Nikolić, Aleksandra L., Blagojević, Duško, Spasić, Mihajlo, Petrović, Vojislav M., "Efekat tiroksina na aktivnost antioksidacionih glutation-zavisnih enzima i količinu glutationa u interskapularnom mrkom masnom tkivu pacova različite starosti" in Jugoslovenska medicinska biohemija, 23, no. 4 (2004):367-373,
https://hdl.handle.net/21.15107/rcub_ibiss_35 .

TY  - JOUR
AU  - Spasić, Mihajlo
AU  - Davidović, Biljana
AU  - Kastratović, Dragana A.
AU  - Nikolić, Aleksandra L.
AU  - Mijalković, Dejan N.
AU  - Saničanin, Živko
PY  - 2002
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/546
AB  - Increased amount of reactive oxygen and nitrogen species were detected during myocardial ischemia after acute myocardial infarction (AMI). Decreased activity of some antioxidative defense enzymes in erythrocytes creates conditions for oxidative stress and propagation of thus induced damages. In this study, we tried to detect changes in antioxidative defense enzyme activities in erythrocytes of patients with AMI and to determine a nature of this changes. Activity of copper zinc super oxide dismutase (CuZn SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione peroxidase (GSH-Px, EC 1.11.1.9) and glutathione reductase (GR, EC 2.5.1.18) were determined in AMI patiens and compared with controls. Activities of CuZn SOD (p<0.005) and CAT (p<0.05), as well as, GSH-Px (p<0.02) were significantly lower comparing with controls. Activity of GR was significantly higher (p<0.005) with respect to controls. Activity of CuZn SOD in patients with AMI were more inhibited (47 ± 5 %) with 6 mM diethyldithiocarbamate (DDC) than corresponding controls (32 ± 3 %). In vitro inhibition of control samples with hydrogen peroxide (H2O2) and electrophoretic analysis indicate H2O2 as potential inhibitor of CuZn SOD in patient with AMI.
AB  - Povećana količina reaktivnih vrsta kiseonika i azota i snižena aktivnost prirodnih odbrambenih sistema detektovana je tokom srčane ishemije. Enzimske komponente antioksidacione zaštite u eritrocitima smanjuju aktivnost stvarajući uslove za propagaciju oštećenja izazvanih oksidacionim stresom. U ovom radu, pokušali smo da detektujemo promene u aktivnosti antioksidacionih enzima u eritrocitima pacijenata obolelih od AIM-a i utvrdimo prirodu promena. Određivana je aktivnost bakar cink sadržavajuće superoksid dismutaze (CuZn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px) i glutation reduktaze (GR) kod pacijenata obolelih od AIM-a i upoređivana sa aktivnošću kod kontrola. Aktivnosti SOD (p<0.005) i CAT (p<0.05), kao i GSH-Px (p<0.02) bile su značajno niže u odnosu na kontrole. Aktivnost GR (p<0.005) bila je značajno viša u odnosu na kontrolu. Aktivnost CuZn SOD bila je inhibirana 6 mM dietilditiokarbamatom (DDC-om) više kod pacijenata obolelih od akutnog infarkta miokarda (47 ± 5 %) nego kod kontrola (32 ± 3 %). In vitro inhibicija kontrolnih uzoraka sa vodonik peroksidom i elektroforetska analiza ukazuju na vodonik peroksid kao mogući inhibitor CuZn SOD kod AIM-a.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Inhibicija aktivnosti antioksidativnih enzima u eritrocitima pacijenata sa akutnim infarktom miokarda
T1  - Antioxidative defense enzyme inhibition in erythrocytes of patients with acute myocardial infarction
IS  - 3
VL  - 38
SP  - 77
EP  - 83
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_546
ER  - 

@article{
author = "Spasić, Mihajlo and Davidović, Biljana and Kastratović, Dragana A. and Nikolić, Aleksandra L. and Mijalković, Dejan N. and Saničanin, Živko",
year = "2002, 2002",
abstract = "Increased amount of reactive oxygen and nitrogen species were detected during myocardial ischemia after acute myocardial infarction (AMI). Decreased activity of some antioxidative defense enzymes in erythrocytes creates conditions for oxidative stress and propagation of thus induced damages. In this study, we tried to detect changes in antioxidative defense enzyme activities in erythrocytes of patients with AMI and to determine a nature of this changes. Activity of copper zinc super oxide dismutase (CuZn SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione peroxidase (GSH-Px, EC 1.11.1.9) and glutathione reductase (GR, EC 2.5.1.18) were determined in AMI patiens and compared with controls. Activities of CuZn SOD (p<0.005) and CAT (p<0.05), as well as, GSH-Px (p<0.02) were significantly lower comparing with controls. Activity of GR was significantly higher (p<0.005) with respect to controls. Activity of CuZn SOD in patients with AMI were more inhibited (47 ± 5 %) with 6 mM diethyldithiocarbamate (DDC) than corresponding controls (32 ± 3 %). In vitro inhibition of control samples with hydrogen peroxide (H2O2) and electrophoretic analysis indicate H2O2 as potential inhibitor of CuZn SOD in patient with AMI., Povećana količina reaktivnih vrsta kiseonika i azota i snižena aktivnost prirodnih odbrambenih sistema detektovana je tokom srčane ishemije. Enzimske komponente antioksidacione zaštite u eritrocitima smanjuju aktivnost stvarajući uslove za propagaciju oštećenja izazvanih oksidacionim stresom. U ovom radu, pokušali smo da detektujemo promene u aktivnosti antioksidacionih enzima u eritrocitima pacijenata obolelih od AIM-a i utvrdimo prirodu promena. Određivana je aktivnost bakar cink sadržavajuće superoksid dismutaze (CuZn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px) i glutation reduktaze (GR) kod pacijenata obolelih od AIM-a i upoređivana sa aktivnošću kod kontrola. Aktivnosti SOD (p<0.005) i CAT (p<0.05), kao i GSH-Px (p<0.02) bile su značajno niže u odnosu na kontrole. Aktivnost GR (p<0.005) bila je značajno viša u odnosu na kontrolu. Aktivnost CuZn SOD bila je inhibirana 6 mM dietilditiokarbamatom (DDC-om) više kod pacijenata obolelih od akutnog infarkta miokarda (47 ± 5 %) nego kod kontrola (32 ± 3 %). In vitro inhibicija kontrolnih uzoraka sa vodonik peroksidom i elektroforetska analiza ukazuju na vodonik peroksid kao mogući inhibitor CuZn SOD kod AIM-a.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Inhibicija aktivnosti antioksidativnih enzima u eritrocitima pacijenata sa akutnim infarktom miokarda, Antioxidative defense enzyme inhibition in erythrocytes of patients with acute myocardial infarction",
number = "3",
volume = "38",
pages = "77-83",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_546"
}

Spasić, M., Davidović, B., Kastratović, D. A., Nikolić, A. L., Mijalković, D. N.,& Saničanin, Ž.. (2002). Inhibicija aktivnosti antioksidativnih enzima u eritrocitima pacijenata sa akutnim infarktom miokarda. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38(3), 77-83.
https://hdl.handle.net/21.15107/rcub_ibiss_546

Spasić M, Davidović B, Kastratović DA, Nikolić AL, Mijalković DN, Saničanin Ž. Inhibicija aktivnosti antioksidativnih enzima u eritrocitima pacijenata sa akutnim infarktom miokarda. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2002;38(3):77-83.
https://hdl.handle.net/21.15107/rcub_ibiss_546 .

Spasić, Mihajlo, Davidović, Biljana, Kastratović, Dragana A., Nikolić, Aleksandra L., Mijalković, Dejan N., Saničanin, Živko, "Inhibicija aktivnosti antioksidativnih enzima u eritrocitima pacijenata sa akutnim infarktom miokarda" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38, no. 3 (2002):77-83,
https://hdl.handle.net/21.15107/rcub_ibiss_546 .

TY  - JOUR
AU  - Radojičić, Ratko M.
AU  - Borković Mitić, Slavica
AU  - Pavlović, Slađan
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2002
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/463
AB  - Diethyldithiocarbamate (DDC) exhibits a variety of effects including neurotoxic, radio-protective and sensitizing activity. It is a potent copper chelating agent used for the treatment of oxygen toxicity, as an imunomodulator in cancer therapy, as well as in HIV infected patients. In this study we examined the effect of DDC, a superoxide dismutase (SOD) inhibitor, on the activities of copper-zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Three hours after diethyldithiocar-bamate treatment (1 g/kg b.m, i.p) a significant decrease of SOD and increase of GR and GST activities were found in the blood of rats. A negative correlation between SOD and GR and a positive correlation between GR and GST activities were also obtained. DDC induced a concentration dependent increase of GR activity and NADPH consumption in an enzymatic assay in vitro. The obtained results may be interpreted to indicate that a decrease in SOD activity in the blood of rats, after DDC administration, may be compensated for by changes in the activity of some other compounds suggesting that regulation of antioxidative defence is very complex.
AB  - Dietilditiokarbamat (DDC) ispoljava različite uticaje kao što su neurotoksičnost, radioprotekcija i senzibilizacja. On je snažan helirajući agens za bakar i koristi se u tretiranju kiseonične toksičnosti imunomodulaciji kao i kod pacijenata zaraženih HIV virusom. U ovom radu smo proučavali uticaj DDC, inhibitora superoksid dismutaze (SOD), na aktivnost bakar cink sadržavajuće superoksid dismutaze (CuZn SOD), katalaze (CAT) glutation peroksidaze (GSH-Px), glutation reduktaze (GR) i glutation-S-transferaze (GST).Tretiranje pacova dietilditiokarbamatom u trajanju od tri časa (1g/kgt.m, i.p) dovodi do značajnogsmanjenja aktivnosti CuZn SOD i povećanja aktivnosti GR i GST u krvi pacova. Takodje je dobijena negativna korelacija izmedju SOD i GR aktivnosti. DDC indukuje povećanje GR aktivnosti koje je koncentraciono zavisno kao i NADPH potrošnju u in vitro enzimatskom eseju. Dobijeni rezultati ukazuju na činjenicu da smanjivanje aktivnosti SOD u krvi pacova posle tretiranja DDCom može biti kompenzovano promenom aktivnosti drugih komponenti što dalje sugeriše da je regulacija antioksidacione zaštite veoma kompleksna.
T2  - Acta veterinaria
T1  - Uticaj dietilditiokarbanata na aktivnostanti oksidacionih enzima u krvi pacova
T1  - The effect of diethyldithicarbarnate on antioxidant enzyme activities in the blood of rats
IS  - 5-6
VL  - 52
SP  - 329
EP  - 335
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_463
ER  - 

@article{
author = "Radojičić, Ratko M. and Borković Mitić, Slavica and Pavlović, Slađan and Nikolić, Aleksandra L. and Blagojević, Duško and Saičić, Zorica and Spasić, Mihajlo",
year = "2002, 2002",
abstract = "Diethyldithiocarbamate (DDC) exhibits a variety of effects including neurotoxic, radio-protective and sensitizing activity. It is a potent copper chelating agent used for the treatment of oxygen toxicity, as an imunomodulator in cancer therapy, as well as in HIV infected patients. In this study we examined the effect of DDC, a superoxide dismutase (SOD) inhibitor, on the activities of copper-zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Three hours after diethyldithiocar-bamate treatment (1 g/kg b.m, i.p) a significant decrease of SOD and increase of GR and GST activities were found in the blood of rats. A negative correlation between SOD and GR and a positive correlation between GR and GST activities were also obtained. DDC induced a concentration dependent increase of GR activity and NADPH consumption in an enzymatic assay in vitro. The obtained results may be interpreted to indicate that a decrease in SOD activity in the blood of rats, after DDC administration, may be compensated for by changes in the activity of some other compounds suggesting that regulation of antioxidative defence is very complex., Dietilditiokarbamat (DDC) ispoljava različite uticaje kao što su neurotoksičnost, radioprotekcija i senzibilizacja. On je snažan helirajući agens za bakar i koristi se u tretiranju kiseonične toksičnosti imunomodulaciji kao i kod pacijenata zaraženih HIV virusom. U ovom radu smo proučavali uticaj DDC, inhibitora superoksid dismutaze (SOD), na aktivnost bakar cink sadržavajuće superoksid dismutaze (CuZn SOD), katalaze (CAT) glutation peroksidaze (GSH-Px), glutation reduktaze (GR) i glutation-S-transferaze (GST).Tretiranje pacova dietilditiokarbamatom u trajanju od tri časa (1g/kgt.m, i.p) dovodi do značajnogsmanjenja aktivnosti CuZn SOD i povećanja aktivnosti GR i GST u krvi pacova. Takodje je dobijena negativna korelacija izmedju SOD i GR aktivnosti. DDC indukuje povećanje GR aktivnosti koje je koncentraciono zavisno kao i NADPH potrošnju u in vitro enzimatskom eseju. Dobijeni rezultati ukazuju na činjenicu da smanjivanje aktivnosti SOD u krvi pacova posle tretiranja DDCom može biti kompenzovano promenom aktivnosti drugih komponenti što dalje sugeriše da je regulacija antioksidacione zaštite veoma kompleksna.",
journal = "Acta veterinaria",
title = "Uticaj dietilditiokarbanata na aktivnostanti oksidacionih enzima u krvi pacova, The effect of diethyldithicarbarnate on antioxidant enzyme activities in the blood of rats",
number = "5-6",
volume = "52",
pages = "329-335",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_463"
}

Radojičić, R. M., Borković Mitić, S., Pavlović, S., Nikolić, A. L., Blagojević, D., Saičić, Z.,& Spasić, M.. (2002). Uticaj dietilditiokarbanata na aktivnostanti oksidacionih enzima u krvi pacova. in Acta veterinaria, 52(5-6), 329-335.
https://hdl.handle.net/21.15107/rcub_ibiss_463

Radojičić RM, Borković Mitić S, Pavlović S, Nikolić AL, Blagojević D, Saičić Z, Spasić M. Uticaj dietilditiokarbanata na aktivnostanti oksidacionih enzima u krvi pacova. in Acta veterinaria. 2002;52(5-6):329-335.
https://hdl.handle.net/21.15107/rcub_ibiss_463 .

Radojičić, Ratko M., Borković Mitić, Slavica, Pavlović, Slađan, Nikolić, Aleksandra L., Blagojević, Duško, Saičić, Zorica, Spasić, Mihajlo, "Uticaj dietilditiokarbanata na aktivnostanti oksidacionih enzima u krvi pacova" in Acta veterinaria, 52, no. 5-6 (2002):329-335,
https://hdl.handle.net/21.15107/rcub_ibiss_463 .

TY  - CONF
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Stević, Zorica D
AU  - Niketić, Vesna P
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1804
C3  - Free Radical Biology and Medicine
T1  - Activities of antioxidative defence enzymes in the blood of patients with amyotrophic lateral sclerosis - Base for controled trial of antioxidants combination
IS  - null
VL  - 33
EP  - S126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1804
ER  - 

@conference{
author = "Nikolić, Aleksandra L. and Blagojević, Duško and Stević, Zorica D and Niketić, Vesna P and Saičić, Zorica and Spasić, Mihajlo",
year = "2002",
journal = "Free Radical Biology and Medicine",
title = "Activities of antioxidative defence enzymes in the blood of patients with amyotrophic lateral sclerosis - Base for controled trial of antioxidants combination",
number = "null",
volume = "33",
pages = "S126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1804"
}

Nikolić, A. L., Blagojević, D., Stević, Z. D., Niketić, V. P., Saičić, Z.,& Spasić, M.. (2002). Activities of antioxidative defence enzymes in the blood of patients with amyotrophic lateral sclerosis - Base for controled trial of antioxidants combination. in Free Radical Biology and Medicine, 33(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1804

Nikolić AL, Blagojević D, Stević ZD, Niketić VP, Saičić Z, Spasić M. Activities of antioxidative defence enzymes in the blood of patients with amyotrophic lateral sclerosis - Base for controled trial of antioxidants combination. in Free Radical Biology and Medicine. 2002;33(null):null-S126.
https://hdl.handle.net/21.15107/rcub_ibiss_1804 .

Nikolić, Aleksandra L., Blagojević, Duško, Stević, Zorica D, Niketić, Vesna P, Saičić, Zorica, Spasić, Mihajlo, "Activities of antioxidative defence enzymes in the blood of patients with amyotrophic lateral sclerosis - Base for controled trial of antioxidants combination" in Free Radical Biology and Medicine, 33, no. null (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1804 .

TY  - JOUR
AU  - Stević, Zorica D
AU  - Nikolić, Aleksandra L.
AU  - Blagojević, Duško
AU  - Saičić, Zorica
AU  - Kocev, Nikola I
AU  - Apostolski, Slobodan A
AU  - Spasić, Mihajlo
PY  - 2001
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1811
AB  - We assessed a combination of methionine, vitamin E and selenium, as Alsemet(R) in a double blind, placebo controlled trial in 28 out patients with amyotrophic lateral sclerosis. After 12 months, 50% of patients in the placebo group were still alive as compared to 81.3% in the Alsemet(R) group (p<0.05). The rate of deterioration, limb and bulbar-function scores (p<0.05) and muscle-testing score (p<0.025) were significantly lower in the Alsemet(R) group than in the placebo group at the end of a sixth month treatment. We noted a significant increase in GSH-Px activity (p<0.05), as well as an increase in the amount of Vit E (p<0.05) in the Alsemet(R) group in comparison to the placebo group during the clinical trial.
T2  - Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry
T1  - A controlled trial of combination of methionine and antioxidants in ALS patients
IS  - 4
VL  - 20
EP  - 228
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1811
ER  - 

@article{
author = "Stević, Zorica D and Nikolić, Aleksandra L. and Blagojević, Duško and Saičić, Zorica and Kocev, Nikola I and Apostolski, Slobodan A and Spasić, Mihajlo",
year = "2001",
abstract = "We assessed a combination of methionine, vitamin E and selenium, as Alsemet(R) in a double blind, placebo controlled trial in 28 out patients with amyotrophic lateral sclerosis. After 12 months, 50% of patients in the placebo group were still alive as compared to 81.3% in the Alsemet(R) group (p<0.05). The rate of deterioration, limb and bulbar-function scores (p<0.05) and muscle-testing score (p<0.025) were significantly lower in the Alsemet(R) group than in the placebo group at the end of a sixth month treatment. We noted a significant increase in GSH-Px activity (p<0.05), as well as an increase in the amount of Vit E (p<0.05) in the Alsemet(R) group in comparison to the placebo group during the clinical trial.",
journal = "Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry",
title = "A controlled trial of combination of methionine and antioxidants in ALS patients",
number = "4",
volume = "20",
pages = "228",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1811"
}

Stević, Z. D., Nikolić, A. L., Blagojević, D., Saičić, Z., Kocev, N. I., Apostolski, S. A.,& Spasić, M.. (2001). A controlled trial of combination of methionine and antioxidants in ALS patients. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 20(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1811

Stević ZD, Nikolić AL, Blagojević D, Saičić Z, Kocev NI, Apostolski SA, Spasić M. A controlled trial of combination of methionine and antioxidants in ALS patients. in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry. 2001;20(4):null-228.
https://hdl.handle.net/21.15107/rcub_ibiss_1811 .

Stević, Zorica D, Nikolić, Aleksandra L., Blagojević, Duško, Saičić, Zorica, Kocev, Nikola I, Apostolski, Slobodan A, Spasić, Mihajlo, "A controlled trial of combination of methionine and antioxidants in ALS patients" in Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry, 20, no. 4 (2001),
https://hdl.handle.net/21.15107/rcub_ibiss_1811 .