TY  - JOUR
AU  - Petković, Filip
AU  - Živanović, Jasmina
AU  - Blaževski, Jana
AU  - Timotijević, G.
AU  - Momčilović, Miljana
AU  - Stanojević, Ž.
AU  - Stamenković, V.
AU  - Milošević, Verica
AU  - Stojković, M. Mostarica
AU  - Miljković, Đorđe
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1968
AB  - Experimental autoimmune encephalomyelitis (EAE) is a model of multiple
   sclerosis (MS), inflammatory, demyelinating and neurodegenerative
   disease of the central nervous system (CNS). Clinically manifested EAE
   can be induced in Dark Agouti (DA) rats, but not in Albino Oxford (AO)
   rats by immunization with spinal cord homogenate (SCH) and complete
   Freund's adjuvant (CFA). Matrix metalloproteinases (MMP) play important
   roles in various steps of MS and EAE pathogenesis. Expression of
   gelatinases MMP2 and MMP9, their activator MMP14 and their inhibitor
   tissue inhibitor of MMP (TIMP) 1 in the CNS of AO and DA rats immunized
   with SCH + CFA was determined. Expression of mRNA for MMP2, MMP9 and
   MMP14 was higher and expression of TIMP1 mRNA was lower in AO rats.
   However, gelatinase activity in spinal cords was higher in samples
   obtained from DA rats. Further, while there was no strain difference in
   MMP2 and MMP9 mRNA expression in lymph nodes of the immunized rats,
   gelatinase activity was higher in DA rats. This activity was reduced by
   antiinflammatory cytokines interleukin (IL)-10 and IL-4. Interestingly,
   gelatinase activity was detected in the nuclei of cells within the CNS,
   but not of those in lymph nodes. Our results imply that
   posttranscriptional regulation of MMP2 and MMP9 expression and/or
   function determines low gelatinase activity within the CNS and in immune
   cells of EAE-resistant AO rats. (C) 2015 IBRO. Published by Elsevier
   Ltd. All rights reserved.
T2  - Neuroscience
T1  - Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis
VL  - 292
DO  - 10.1016/j.neuroscience.2015.02.015
SP  - 1
EP  - 12
ER  - 

@article{
author = "Petković, Filip and Živanović, Jasmina and Blaževski, Jana and Timotijević, G. and Momčilović, Miljana and Stanojević, Ž. and Stamenković, V. and Milošević, Verica and Stojković, M. Mostarica and Miljković, Đorđe",
year = "2015",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is a model of multiple
   sclerosis (MS), inflammatory, demyelinating and neurodegenerative
   disease of the central nervous system (CNS). Clinically manifested EAE
   can be induced in Dark Agouti (DA) rats, but not in Albino Oxford (AO)
   rats by immunization with spinal cord homogenate (SCH) and complete
   Freund's adjuvant (CFA). Matrix metalloproteinases (MMP) play important
   roles in various steps of MS and EAE pathogenesis. Expression of
   gelatinases MMP2 and MMP9, their activator MMP14 and their inhibitor
   tissue inhibitor of MMP (TIMP) 1 in the CNS of AO and DA rats immunized
   with SCH + CFA was determined. Expression of mRNA for MMP2, MMP9 and
   MMP14 was higher and expression of TIMP1 mRNA was lower in AO rats.
   However, gelatinase activity in spinal cords was higher in samples
   obtained from DA rats. Further, while there was no strain difference in
   MMP2 and MMP9 mRNA expression in lymph nodes of the immunized rats,
   gelatinase activity was higher in DA rats. This activity was reduced by
   antiinflammatory cytokines interleukin (IL)-10 and IL-4. Interestingly,
   gelatinase activity was detected in the nuclei of cells within the CNS,
   but not of those in lymph nodes. Our results imply that
   posttranscriptional regulation of MMP2 and MMP9 expression and/or
   function determines low gelatinase activity within the CNS and in immune
   cells of EAE-resistant AO rats. (C) 2015 IBRO. Published by Elsevier
   Ltd. All rights reserved.",
journal = "Neuroscience",
title = "Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis",
volume = "292",
doi = "10.1016/j.neuroscience.2015.02.015",
pages = "1-12"
}

Petković, F., Živanović, J., Blaževski, J., Timotijević, G., Momčilović, M., Stanojević, Ž., Stamenković, V., Milošević, V., Stojković, M. M.,& Miljković, Đ.. (2015). Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis. in Neuroscience, 292, 1-12.
https://doi.org/10.1016/j.neuroscience.2015.02.015

Petković F, Živanović J, Blaževski J, Timotijević G, Momčilović M, Stanojević Ž, Stamenković V, Milošević V, Stojković MM, Miljković Đ. Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis. in Neuroscience. 2015;292:1-12.
doi:10.1016/j.neuroscience.2015.02.015 .

Petković, Filip, Živanović, Jasmina, Blaževski, Jana, Timotijević, G., Momčilović, Miljana, Stanojević, Ž., Stamenković, V., Milošević, Verica, Stojković, M. Mostarica, Miljković, Đorđe, "Activity, but not mRNA expression of gelatinases correlates with susceptibility to experimental autoimmune encephalomyelitis" in Neuroscience, 292 (2015):1-12,
https://doi.org/10.1016/j.neuroscience.2015.02.015 . .