TY  - JOUR
AU  - Veličković, Ivona
AU  - Živković, Jelena
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Marin, Petar D.
AU  - Grujić, Slavica
PY  - 2021
UR  - https://journals.sagepub.com/doi/10.1177/1934578X211009692
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4226
AB  - The presented study was aimed at exploring the bioactive properties (antioxidant, antimicrobial and food preserving) and chemical composition of R. discolor fruits collected from 2 geographically distinct wild-growing populations and extracted by using different solvents (methanol, ethanol, acetone and water). The total phenol (TPC), flavonoid (TFC) and anthocyanin (TAC) content varied from 52.7 to 186.8 mg GAE/g, 3.5 to 7.0 mg QE/g and 11.1 to 28.2 mg/g dry weight (dw), respectively. HPLC-DAD analysis identified cyanidin-3-glucoside (Cy-3-Glu) as the dominant anthocyanin that ranged in concentration from 18.4 to 32.2 mg/g dw. The acetone extract revealed the highest antioxidant activity through the ferric reducing antioxidant power (FRAP), total reducing power (TRC) and ß-carotene bleaching in vitro methods. The examined extracts showed antimicrobial activity, being more effective against Gram-positive (G+) than Gram-negative (G-) bacteria. Furthermore, Candida glabrata was the most susceptible among the pathogenic yeasts. The ethanol fruit extract was the most active against Listeria monocytogenes and thus chosen for incorporation in yoghurt and further analyses regarding its food preserving properties, which confirmed its efficacy towards this food-borne pathogen. Additionally, panelists gave high marks to the novel product regarding color, taste, texture flavor and overall acceptance. The obtained results indicated that R. discolor fruit extracts exhibits notable bioactivity and might therefore be considered as a good platform for the development of new preparations to be used in the food industry.
PB  - SAGE Publications Inc.
T2  - Natural Product Communications
T1  - Evaluation of Antioxidant, Antimicrobial and Potential Food Preserving Properties of Rubus Discolor (Rosaceae) Fruit Extracts
IS  - 4
VL  - 16
DO  - 10.1177/1934578X211009692
SP  - 1
EP  - 9
ER  - 

@article{
author = "Veličković, Ivona and Živković, Jelena and Stojković, Dejan and Soković, Marina and Marin, Petar D. and Grujić, Slavica",
year = "2021",
abstract = "The presented study was aimed at exploring the bioactive properties (antioxidant, antimicrobial and food preserving) and chemical composition of R. discolor fruits collected from 2 geographically distinct wild-growing populations and extracted by using different solvents (methanol, ethanol, acetone and water). The total phenol (TPC), flavonoid (TFC) and anthocyanin (TAC) content varied from 52.7 to 186.8 mg GAE/g, 3.5 to 7.0 mg QE/g and 11.1 to 28.2 mg/g dry weight (dw), respectively. HPLC-DAD analysis identified cyanidin-3-glucoside (Cy-3-Glu) as the dominant anthocyanin that ranged in concentration from 18.4 to 32.2 mg/g dw. The acetone extract revealed the highest antioxidant activity through the ferric reducing antioxidant power (FRAP), total reducing power (TRC) and ß-carotene bleaching in vitro methods. The examined extracts showed antimicrobial activity, being more effective against Gram-positive (G+) than Gram-negative (G-) bacteria. Furthermore, Candida glabrata was the most susceptible among the pathogenic yeasts. The ethanol fruit extract was the most active against Listeria monocytogenes and thus chosen for incorporation in yoghurt and further analyses regarding its food preserving properties, which confirmed its efficacy towards this food-borne pathogen. Additionally, panelists gave high marks to the novel product regarding color, taste, texture flavor and overall acceptance. The obtained results indicated that R. discolor fruit extracts exhibits notable bioactivity and might therefore be considered as a good platform for the development of new preparations to be used in the food industry.",
publisher = "SAGE Publications Inc.",
journal = "Natural Product Communications",
title = "Evaluation of Antioxidant, Antimicrobial and Potential Food Preserving Properties of Rubus Discolor (Rosaceae) Fruit Extracts",
number = "4",
volume = "16",
doi = "10.1177/1934578X211009692",
pages = "1-9"
}

Veličković, I., Živković, J., Stojković, D., Soković, M., Marin, P. D.,& Grujić, S.. (2021). Evaluation of Antioxidant, Antimicrobial and Potential Food Preserving Properties of Rubus Discolor (Rosaceae) Fruit Extracts. in Natural Product Communications
SAGE Publications Inc.., 16(4), 1-9.
https://doi.org/10.1177/1934578X211009692

Veličković I, Živković J, Stojković D, Soković M, Marin PD, Grujić S. Evaluation of Antioxidant, Antimicrobial and Potential Food Preserving Properties of Rubus Discolor (Rosaceae) Fruit Extracts. in Natural Product Communications. 2021;16(4):1-9.
doi:10.1177/1934578X211009692 .

Veličković, Ivona, Živković, Jelena, Stojković, Dejan, Soković, Marina, Marin, Petar D., Grujić, Slavica, "Evaluation of Antioxidant, Antimicrobial and Potential Food Preserving Properties of Rubus Discolor (Rosaceae) Fruit Extracts" in Natural Product Communications, 16, no. 4 (2021):1-9,
https://doi.org/10.1177/1934578X211009692 . .

TY  - JOUR
AU  - Oalđe Pavlović, Mariana
AU  - Kolarević, Stoimir
AU  - Đorđević, Jelena
AU  - Jovanović Marić, Jovana
AU  - Lunić, Tanja
AU  - Mandić, Marija
AU  - Kračun-Kolarević, Margareta
AU  - Živković, Jelena
AU  - Alimpić Aradski, Ana
AU  - Marin, Petar D.
AU  - Šavikin, Katarina
AU  - Vuković-Gačić, Branka
AU  - Božić Nedeljković, Biljana
AU  - Duletić-Laušević, Sonja
PY  - 2021
UR  - https://www.mdpi.com/2223-7747/10/11/2306
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4654
AB  - This study was designed to evaluate the genoprotective, antigenotoxic, as well as antitumor potential of methanolic, ethanolic, and aqueous extracts of Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, and Satureja montana (Lamiaceae), in different model systems. The polyphenols in these extracts were quantified both spectrophotometrically and using HPLC-DAD technique, while DPPH assay was used to assess the antioxidant activity. The genoprotective potential was tested on pUC19 Escherichia coli XL1-blue, and the antigenotoxicity on Salmonella typhimurium TA1535/pSK1002 and human lung fibroblasts, while the antitumor activity was assessed on colorectal cancer cells. Rosmarinic acid, quercetin, rutin, and luteolin-7-O-glucoside were among the identified compounds. Methanolic extracts had the best DPPH-scavenging and SOS-inducing activities, while ethanolic extracts exhibited the highest antigenotoxicity. Additionally, all extracts exhibited genoprotective potential on plasmid DNA. The antitumor effect was mediated by modulation of reactive oxygen species (ROS), nitric oxide (NO) production, and exhibition of genotoxic effects on tumor cells, especially with O. basilicum ethanolic extract. Generally, the investigated extracts were able to provide antioxidant protection for the acellular, prokaryotic, and normal human DNA, while also modulating the production of ROS and NO in tumor cells, leading to genotoxicity toward these cells and their decrease in proliferation.
PB  - Basel: MDPI
T2  - Plants
T1  - A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species
IS  - 11
VL  - 10
DO  - 10.3390/plants10112306
SP  - 2306
ER  - 

@article{
author = "Oalđe Pavlović, Mariana and Kolarević, Stoimir and Đorđević, Jelena and Jovanović Marić, Jovana and Lunić, Tanja and Mandić, Marija and Kračun-Kolarević, Margareta and Živković, Jelena and Alimpić Aradski, Ana and Marin, Petar D. and Šavikin, Katarina and Vuković-Gačić, Branka and Božić Nedeljković, Biljana and Duletić-Laušević, Sonja",
year = "2021",
abstract = "This study was designed to evaluate the genoprotective, antigenotoxic, as well as antitumor potential of methanolic, ethanolic, and aqueous extracts of Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, and Satureja montana (Lamiaceae), in different model systems. The polyphenols in these extracts were quantified both spectrophotometrically and using HPLC-DAD technique, while DPPH assay was used to assess the antioxidant activity. The genoprotective potential was tested on pUC19 Escherichia coli XL1-blue, and the antigenotoxicity on Salmonella typhimurium TA1535/pSK1002 and human lung fibroblasts, while the antitumor activity was assessed on colorectal cancer cells. Rosmarinic acid, quercetin, rutin, and luteolin-7-O-glucoside were among the identified compounds. Methanolic extracts had the best DPPH-scavenging and SOS-inducing activities, while ethanolic extracts exhibited the highest antigenotoxicity. Additionally, all extracts exhibited genoprotective potential on plasmid DNA. The antitumor effect was mediated by modulation of reactive oxygen species (ROS), nitric oxide (NO) production, and exhibition of genotoxic effects on tumor cells, especially with O. basilicum ethanolic extract. Generally, the investigated extracts were able to provide antioxidant protection for the acellular, prokaryotic, and normal human DNA, while also modulating the production of ROS and NO in tumor cells, leading to genotoxicity toward these cells and their decrease in proliferation.",
publisher = "Basel: MDPI",
journal = "Plants",
title = "A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species",
number = "11",
volume = "10",
doi = "10.3390/plants10112306",
pages = "2306"
}

Oalđe Pavlović, M., Kolarević, S., Đorđević, J., Jovanović Marić, J., Lunić, T., Mandić, M., Kračun-Kolarević, M., Živković, J., Alimpić Aradski, A., Marin, P. D., Šavikin, K., Vuković-Gačić, B., Božić Nedeljković, B.,& Duletić-Laušević, S.. (2021). A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species. in Plants
Basel: MDPI., 10(11), 2306.
https://doi.org/10.3390/plants10112306

Oalđe Pavlović M, Kolarević S, Đorđević J, Jovanović Marić J, Lunić T, Mandić M, Kračun-Kolarević M, Živković J, Alimpić Aradski A, Marin PD, Šavikin K, Vuković-Gačić B, Božić Nedeljković B, Duletić-Laušević S. A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species. in Plants. 2021;10(11):2306.
doi:10.3390/plants10112306 .

Oalđe Pavlović, Mariana, Kolarević, Stoimir, Đorđević, Jelena, Jovanović Marić, Jovana, Lunić, Tanja, Mandić, Marija, Kračun-Kolarević, Margareta, Živković, Jelena, Alimpić Aradski, Ana, Marin, Petar D., Šavikin, Katarina, Vuković-Gačić, Branka, Božić Nedeljković, Biljana, Duletić-Laušević, Sonja, "A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species" in Plants, 10, no. 11 (2021):2306,
https://doi.org/10.3390/plants10112306 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Ilić, Milan
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Ilić, Aleksandra
AU  - Stojković, Dejan
PY  - 2020
UR  - https://www.frontiersin.org/article/10.3389/fphar.2020.01020/full
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32733251
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7360817
UR  - https://radar.ibiss.bg.ac.rs/123456789/3849
AB  - Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite that, the usage of plant species in the traditional medicine of some Balkan regions remained largely unexplored in the past. This study aimed to collect and document data on the traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is among the least developed regions in Serbia. Also, comparison with data collected by Dr. Jovan Tucakov, in a book called Herbal therapy was conducted. The survey was carried out using semi-structured interviews and 113 informants were interviewed. Quantitative ethnobotany factors were calculated, allowing us discussing the results. The informants reported data on 86 medicinal plants belonging to 43 families in Pčinja district. Lamiaceae, Asteraceae, and Rosaceae were the dominant locally used families. The species with the highest number of use reports were Mentha piperita, Matricaria chamomilla, and Hypericum perforatum. Gastrointestinal ailments, respiratory problems and skin diseases were the most frequently reported indications. Usually, the administration was primarily oral followed by topical applications. Leaves were dominantly exploited plant parts and the most frequent preparation form was infusion. Medicinal plants in Pčinja district are mainly used as a mode of primary health care for treating minor health issues. After comparing our results with the ones collected half a century ago by Dr. Jovan Tucakov we can conclude that plant species mentioned in our investigation previously had a much wider spectrum of application.
PB  - Frontiers Media S.A.
T2  - Frontiers in Pharmacology
T1  - Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data.
VL  - 11
DO  - 10.3389/fphar.2020.01020
SP  - 1020
ER  - 

@article{
author = "Živković, Jelena and Ilić, Milan and Šavikin, Katarina and Zdunić, Gordana and Ilić, Aleksandra and Stojković, Dejan",
year = "2020",
abstract = "Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite that, the usage of plant species in the traditional medicine of some Balkan regions remained largely unexplored in the past. This study aimed to collect and document data on the traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is among the least developed regions in Serbia. Also, comparison with data collected by Dr. Jovan Tucakov, in a book called Herbal therapy was conducted. The survey was carried out using semi-structured interviews and 113 informants were interviewed. Quantitative ethnobotany factors were calculated, allowing us discussing the results. The informants reported data on 86 medicinal plants belonging to 43 families in Pčinja district. Lamiaceae, Asteraceae, and Rosaceae were the dominant locally used families. The species with the highest number of use reports were Mentha piperita, Matricaria chamomilla, and Hypericum perforatum. Gastrointestinal ailments, respiratory problems and skin diseases were the most frequently reported indications. Usually, the administration was primarily oral followed by topical applications. Leaves were dominantly exploited plant parts and the most frequent preparation form was infusion. Medicinal plants in Pčinja district are mainly used as a mode of primary health care for treating minor health issues. After comparing our results with the ones collected half a century ago by Dr. Jovan Tucakov we can conclude that plant species mentioned in our investigation previously had a much wider spectrum of application.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Pharmacology",
title = "Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data.",
volume = "11",
doi = "10.3389/fphar.2020.01020",
pages = "1020"
}

Živković, J., Ilić, M., Šavikin, K., Zdunić, G., Ilić, A.,& Stojković, D.. (2020). Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data.. in Frontiers in Pharmacology
Frontiers Media S.A.., 11, 1020.
https://doi.org/10.3389/fphar.2020.01020

Živković J, Ilić M, Šavikin K, Zdunić G, Ilić A, Stojković D. Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data.. in Frontiers in Pharmacology. 2020;11:1020.
doi:10.3389/fphar.2020.01020 .

Živković, Jelena, Ilić, Milan, Šavikin, Katarina, Zdunić, Gordana, Ilić, Aleksandra, Stojković, Dejan, "Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data." in Frontiers in Pharmacology, 11 (2020):1020,
https://doi.org/10.3389/fphar.2020.01020 . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Alimpić Aradski, Ana
AU  - Gođevac, Dejan
AU  - Živković, Jelena
AU  - Duletić Laušević, Sonja
AU  - Krstić Milošević, Dijana
AU  - Šavikin, Katarina
PY  - 2020
UR  - internal-pdf://Aronija 2020.pdf
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3619
AB  - Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.
T2  - Industrial Crops and Products
T1  - In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves
VL  - 148
DO  - 10.1016/j.indcrop.2020.112328
SP  - 112328
ER  - 

@article{
author = "Zdunić, Gordana and Alimpić Aradski, Ana and Gođevac, Dejan and Živković, Jelena and Duletić Laušević, Sonja and Krstić Milošević, Dijana and Šavikin, Katarina",
year = "2020",
abstract = "Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.",
journal = "Industrial Crops and Products",
title = "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves",
volume = "148",
doi = "10.1016/j.indcrop.2020.112328",
pages = "112328"
}

Zdunić, G., Alimpić Aradski, A., Gođevac, D., Živković, J., Duletić Laušević, S., Krstić Milošević, D.,& Šavikin, K.. (2020). In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products, 148, 112328.
https://doi.org/10.1016/j.indcrop.2020.112328

Zdunić G, Alimpić Aradski A, Gođevac D, Živković J, Duletić Laušević S, Krstić Milošević D, Šavikin K. In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products. 2020;148:112328.
doi:10.1016/j.indcrop.2020.112328 .

Zdunić, Gordana, Alimpić Aradski, Ana, Gođevac, Dejan, Živković, Jelena, Duletić Laušević, Sonja, Krstić Milošević, Dijana, Šavikin, Katarina, "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves" in Industrial Crops and Products, 148 (2020):112328,
https://doi.org/10.1016/j.indcrop.2020.112328 . .

TY  - CONF
AU  - Živković, Jelena
AU  - Ilić, Milan
AU  - Stojković, Dejan
AU  - Šavikin, Katarina
PY  - 2019
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4371
AB  - Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite 
that, the usage of plant species in traditional medicine of some Balkan regions remained 
largely unexplored in the past. This study aimed to collect and document data on the 
traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is 
among the least developed regions in Serbia. The survey was carried out using semi structured interviews and 113 informants were interviewed. Quantitative ethnobotany 
factors were calculated, allowing us discussing the results.
The informants reported data on 86 medicinal plants belonging to 43 families. 
The most dominant botanical families were Lamiaceae (30% of species), Asteraceae 
(26% of species) and Rosaceae (19% of species). Species with the highest number of 
use reports were Mentha piperita, Hypericum perforatum, Matricaria chamomilla, Salvia
officinalis, Urtica dioica, Thymus serpyllum and Tilia cordata. The majority of the plants 
were reported to have 1-3 different usages and the species with most diverse uses were 
Hypericum perforatum and Urtica dioica. In Pčinja district folk medicine is primarily used 
for healing minor diseases with some exceptions. The most frequent medicinal uses 
were for treating diseases of the digestive system, respiratory system and diseases of 
the skin and subcutaneous tissue, followed by general and unspecified diseases (such 
as pain, fever and health prevention). Usually, the administration was primarily oral 
followed by topical applications. Leaves were dominantly exploited plant parts and 
the most frequent preparation form was infusion. The current study represents a useful 
documentation which can contribute to preserving ethnobotanical knowledge in 
South-Eastern Serbia. For some well-known plant species new applications have been 
recorded. This can present a good starting point for new investigations
PB  - Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade
C3  - The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
T1  - Ethnobotanical study of medicinal plants traditionally used in South-East Serbia (Pčinja district)
SP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4371
ER  - 

@conference{
author = "Živković, Jelena and Ilić, Milan and Stojković, Dejan and Šavikin, Katarina",
year = "2019",
abstract = "Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite 
that, the usage of plant species in traditional medicine of some Balkan regions remained 
largely unexplored in the past. This study aimed to collect and document data on the 
traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is 
among the least developed regions in Serbia. The survey was carried out using semi structured interviews and 113 informants were interviewed. Quantitative ethnobotany 
factors were calculated, allowing us discussing the results.
The informants reported data on 86 medicinal plants belonging to 43 families. 
The most dominant botanical families were Lamiaceae (30% of species), Asteraceae 
(26% of species) and Rosaceae (19% of species). Species with the highest number of 
use reports were Mentha piperita, Hypericum perforatum, Matricaria chamomilla, Salvia
officinalis, Urtica dioica, Thymus serpyllum and Tilia cordata. The majority of the plants 
were reported to have 1-3 different usages and the species with most diverse uses were 
Hypericum perforatum and Urtica dioica. In Pčinja district folk medicine is primarily used 
for healing minor diseases with some exceptions. The most frequent medicinal uses 
were for treating diseases of the digestive system, respiratory system and diseases of 
the skin and subcutaneous tissue, followed by general and unspecified diseases (such 
as pain, fever and health prevention). Usually, the administration was primarily oral 
followed by topical applications. Leaves were dominantly exploited plant parts and 
the most frequent preparation form was infusion. The current study represents a useful 
documentation which can contribute to preserving ethnobotanical knowledge in 
South-Eastern Serbia. For some well-known plant species new applications have been 
recorded. This can present a good starting point for new investigations",
publisher = "Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade",
journal = "The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia",
title = "Ethnobotanical study of medicinal plants traditionally used in South-East Serbia (Pčinja district)",
pages = "28",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4371"
}

Živković, J., Ilić, M., Stojković, D.,& Šavikin, K.. (2019). Ethnobotanical study of medicinal plants traditionally used in South-East Serbia (Pčinja district). in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia
Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade., 28.
https://hdl.handle.net/21.15107/rcub_ibiss_4371

Živković J, Ilić M, Stojković D, Šavikin K. Ethnobotanical study of medicinal plants traditionally used in South-East Serbia (Pčinja district). in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia. 2019;:28.
https://hdl.handle.net/21.15107/rcub_ibiss_4371 .

Živković, Jelena, Ilić, Milan, Stojković, Dejan, Šavikin, Katarina, "Ethnobotanical study of medicinal plants traditionally used in South-East Serbia (Pčinja district)" in The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia (2019):28,
https://hdl.handle.net/21.15107/rcub_ibiss_4371 .

TY  - CHAP
AU  - Stojković, Dejan
AU  - Živković, Jelena
AU  - Stanisavljević, Danijela
AU  - Ivanov, Marija
AU  - Popović, Jelena
AU  - Stevanović, Milena
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2019
UR  - https://www.eurekaselect.com/176849/chapter/cytotoxicity-through-molecular-targets-involved-in-apoptosis.-where-should-we-further-search-for-mushrooms-functi
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3964
AB  - Apoptosis is considered as a classical way of programmed cell death and important control mechanism of cell homeostasis. Cancer cells acquire different instruments to circumvent programmed cell death. This promotes uncontrolled growth and frequently confers chemoresistance to tumor cells. Activation of apoptotic signaling pathway has been a target of anti-cancer drugs in an induction of cytotoxicity. The mechanism of apoptosis is complex and includes many pathways. This chapter will focus on the current knowledge of apoptosis-triggering approaches in cancer therapy, as well as on mushroom extracts and isolated compounds acting as initiators of apoptosis through regulation of genes expression involved in cancer cell death. Furthermore, we pointed out directions for novel search for mushroom functionalities in this experimental field and discuss the possible further steps for exploration on the in vitro and in vivo levels.
PB  - Bentham Science Publishers
T2  - Frontiers in Natural Product Chemistry
T1  - Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?
VL  - 5
DO  - 10.2174/9789811423772119050007
SP  - 146
EP  - 191
ER  - 

@inbook{
editor = "Atta-ur-Rahman",
author = "Stojković, Dejan and Živković, Jelena and Stanisavljević, Danijela and Ivanov, Marija and Popović, Jelena and Stevanović, Milena and Glamočlija, Jasmina and Soković, Marina",
year = "2019",
abstract = "Apoptosis is considered as a classical way of programmed cell death and important control mechanism of cell homeostasis. Cancer cells acquire different instruments to circumvent programmed cell death. This promotes uncontrolled growth and frequently confers chemoresistance to tumor cells. Activation of apoptotic signaling pathway has been a target of anti-cancer drugs in an induction of cytotoxicity. The mechanism of apoptosis is complex and includes many pathways. This chapter will focus on the current knowledge of apoptosis-triggering approaches in cancer therapy, as well as on mushroom extracts and isolated compounds acting as initiators of apoptosis through regulation of genes expression involved in cancer cell death. Furthermore, we pointed out directions for novel search for mushroom functionalities in this experimental field and discuss the possible further steps for exploration on the in vitro and in vivo levels.",
publisher = "Bentham Science Publishers",
journal = "Frontiers in Natural Product Chemistry",
booktitle = "Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?",
volume = "5",
doi = "10.2174/9789811423772119050007",
pages = "146-191"
}

Atta-ur-Rahman, Stojković, D., Živković, J., Stanisavljević, D., Ivanov, M., Popović, J., Stevanović, M., Glamočlija, J.,& Soković, M.. (2019). Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?. in Frontiers in Natural Product Chemistry
Bentham Science Publishers., 5, 146-191.
https://doi.org/10.2174/9789811423772119050007

Atta-ur-Rahman, Stojković D, Živković J, Stanisavljević D, Ivanov M, Popović J, Stevanović M, Glamočlija J, Soković M. Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?. in Frontiers in Natural Product Chemistry. 2019;5:146-191.
doi:10.2174/9789811423772119050007 .

Atta-ur-Rahman, Stojković, Dejan, Živković, Jelena, Stanisavljević, Danijela, Ivanov, Marija, Popović, Jelena, Stevanović, Milena, Glamočlija, Jasmina, Soković, Marina, "Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?" in Frontiers in Natural Product Chemistry, 5 (2019):146-191,
https://doi.org/10.2174/9789811423772119050007 . .

TY  - JOUR
AU  - Stojanović, Ivana D.
AU  - Šavikin, Katarina
AU  - Nikolovski, Neda
AU  - Živković, Jelena
AU  - Saksida, Tamara
AU  - Momčilović, Miljana
AU  - Koprivica, Ivan
AU  - Vujičić, Milica
AU  - Stanisavljević, Suzana
AU  - Miljković, Đorđe
AU  - Menković, Nebojša
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1756464617303353
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2793
AB  - Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders.
T2  - Journal of Functional Foods
T1  - Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes
VL  - 35
DO  - 10.1016/j.jff.2017.06.021
SP  - 522
EP  - 530
ER  - 

@article{
author = "Stojanović, Ivana D. and Šavikin, Katarina and Nikolovski, Neda and Živković, Jelena and Saksida, Tamara and Momčilović, Miljana and Koprivica, Ivan and Vujičić, Milica and Stanisavljević, Suzana and Miljković, Đorđe and Menković, Nebojša",
year = "2017",
abstract = "Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders.",
journal = "Journal of Functional Foods",
title = "Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes",
volume = "35",
doi = "10.1016/j.jff.2017.06.021",
pages = "522-530"
}

Stojanović, I. D., Šavikin, K., Nikolovski, N., Živković, J., Saksida, T., Momčilović, M., Koprivica, I., Vujičić, M., Stanisavljević, S., Miljković, Đ.,& Menković, N.. (2017). Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes. in Journal of Functional Foods, 35, 522-530.
https://doi.org/10.1016/j.jff.2017.06.021

Stojanović ID, Šavikin K, Nikolovski N, Živković J, Saksida T, Momčilović M, Koprivica I, Vujičić M, Stanisavljević S, Miljković Đ, Menković N. Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes. in Journal of Functional Foods. 2017;35:522-530.
doi:10.1016/j.jff.2017.06.021 .

Stojanović, Ivana D., Šavikin, Katarina, Nikolovski, Neda, Živković, Jelena, Saksida, Tamara, Momčilović, Miljana, Koprivica, Ivan, Vujičić, Milica, Stanisavljević, Suzana, Miljković, Đorđe, Menković, Nebojša, "Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes" in Journal of Functional Foods, 35 (2017):522-530,
https://doi.org/10.1016/j.jff.2017.06.021 . .

TY  - GEN
AU  - Živković, Jelena
AU  - Stojković, Dejan
AU  - Petrović, Jovana
AU  - Zdunić, Gordana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2016
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84956600634&partnerID=tZOtx3y1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2972
AB  - Correction for 'Rosa canina L. - new possibilities for an old medicinal herb' by Jelena Živkovićet al., Food Funct., 2015, DOI: 10.1039/c5fo00820d.
PB  - Royal Society of Chemistry
T2  - Food and Function
T1  - Correction: Rosa canina L. - new possibilities for an old medicinal herb.
IS  - 1
VL  - 7
DO  - 10.1039/c5fo90042e
SP  - 610
ER  - 

@misc{
author = "Živković, Jelena and Stojković, Dejan and Petrović, Jovana and Zdunić, Gordana and Glamočlija, Jasmina and Soković, Marina",
year = "2016",
abstract = "Correction for 'Rosa canina L. - new possibilities for an old medicinal herb' by Jelena Živkovićet al., Food Funct., 2015, DOI: 10.1039/c5fo00820d.",
publisher = "Royal Society of Chemistry",
journal = "Food and Function",
title = "Correction: Rosa canina L. - new possibilities for an old medicinal herb.",
number = "1",
volume = "7",
doi = "10.1039/c5fo90042e",
pages = "610"
}

Živković, J., Stojković, D., Petrović, J., Zdunić, G., Glamočlija, J.,& Soković, M.. (2016). Correction: Rosa canina L. - new possibilities for an old medicinal herb.. in Food and Function
Royal Society of Chemistry., 7(1), 610.
https://doi.org/10.1039/c5fo90042e

Živković J, Stojković D, Petrović J, Zdunić G, Glamočlija J, Soković M. Correction: Rosa canina L. - new possibilities for an old medicinal herb.. in Food and Function. 2016;7(1):610.
doi:10.1039/c5fo90042e .

Živković, Jelena, Stojković, Dejan, Petrović, Jovana, Zdunić, Gordana, Glamočlija, Jasmina, Soković, Marina, "Correction: Rosa canina L. - new possibilities for an old medicinal herb." in Food and Function, 7, no. 1 (2016):610,
https://doi.org/10.1039/c5fo90042e . .

TY  - JOUR
AU  - Mujić, Aida
AU  - Grdović, Nevena
AU  - Mujić, Ibrahim
AU  - Mihailović, Mirjana
AU  - Živković, Jelena
AU  - Poznanović, Goran
AU  - Vidaković, Melita
PY  - 2011
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-78149407400&partnerID=tZOtx3y1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3203
AB  - Oxidative stress plays a central role in the onset of diabetes which is characterised by progressive pancreatic β-cell failure. We studied the ability of phenolic extracts prepared from chestnut leaf, catkin and spiny burs to prevent oxidative stress-induced β-cell (Rin-5F) death. The Rin-5F cell death was induced by treatment with the diabetogenic agent streptozotocin (STZ) and the protective effects of the chestnut extracts were assessed after cells treatment with a STZ/extracts mixture. The chestnut extracts increased cell viability by protecting DNA from oxidative damage and by enhancing the natural antioxidant system. Moreover, the chestnut extracts had a significant impact on the cell's redox-status which was observed as an increase in the levels of reduced glutathione. Chestnut extracts were capable of inhibiting lipid peroxidation, which was manifested as a lowering of malondialdehyde levels. We concluded that chestnut extracts increased cell viability after STZ treatment as a result of their antioxidative properties. © 2010 Elsevier Ltd.
PB  - Elsevier
T2  - Food Chemistry
T1  - Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells
IS  - 3
VL  - 125
DO  - 10.1016/j.foodchem.2010.08.068
SP  - 841
EP  - 849
ER  - 

@article{
author = "Mujić, Aida and Grdović, Nevena and Mujić, Ibrahim and Mihailović, Mirjana and Živković, Jelena and Poznanović, Goran and Vidaković, Melita",
year = "2011",
abstract = "Oxidative stress plays a central role in the onset of diabetes which is characterised by progressive pancreatic β-cell failure. We studied the ability of phenolic extracts prepared from chestnut leaf, catkin and spiny burs to prevent oxidative stress-induced β-cell (Rin-5F) death. The Rin-5F cell death was induced by treatment with the diabetogenic agent streptozotocin (STZ) and the protective effects of the chestnut extracts were assessed after cells treatment with a STZ/extracts mixture. The chestnut extracts increased cell viability by protecting DNA from oxidative damage and by enhancing the natural antioxidant system. Moreover, the chestnut extracts had a significant impact on the cell's redox-status which was observed as an increase in the levels of reduced glutathione. Chestnut extracts were capable of inhibiting lipid peroxidation, which was manifested as a lowering of malondialdehyde levels. We concluded that chestnut extracts increased cell viability after STZ treatment as a result of their antioxidative properties. © 2010 Elsevier Ltd.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells",
number = "3",
volume = "125",
doi = "10.1016/j.foodchem.2010.08.068",
pages = "841-849"
}

Mujić, A., Grdović, N., Mujić, I., Mihailović, M., Živković, J., Poznanović, G.,& Vidaković, M.. (2011). Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells. in Food Chemistry
Elsevier., 125(3), 841-849.
https://doi.org/10.1016/j.foodchem.2010.08.068

Mujić A, Grdović N, Mujić I, Mihailović M, Živković J, Poznanović G, Vidaković M. Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells. in Food Chemistry. 2011;125(3):841-849.
doi:10.1016/j.foodchem.2010.08.068 .

Mujić, Aida, Grdović, Nevena, Mujić, Ibrahim, Mihailović, Mirjana, Živković, Jelena, Poznanović, Goran, Vidaković, Melita, "Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells" in Food Chemistry, 125, no. 3 (2011):841-849,
https://doi.org/10.1016/j.foodchem.2010.08.068 . .