TY  - JOUR
AU  - Radović, Julijana M
AU  - Maksimović-Ivanić, Danijela
AU  - Timotijević, Gordana S
AU  - Popadić, S
AU  - Ramić, Zorica D.
AU  - Trajković, Vladimir S
AU  - Miljković, Đorđe
AU  - Stošić-Grujičić, Stanislava
AU  - Mijatović, Sanja
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1135
AB  - Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments. In this context we compared the effectiveness of herbal antaquinone aloe emodin (AE) against mouse B16 melanoma and human A375, different in initial activity of ERK1/2, constitutive iNOS expression and basal level of reactive oxygen species (ROS). Both cell lines are sensitive to AE treatment. However, while the agent induces differentiation of B16 cells toward melanocytes, in A375 cells promoted massive apoptosis. Differentiation of B16 cells, characterized by enhanced melanin production and tyrosinase activity, was mediated by H2O2 production synchronized with rapid p53 accumulation and enhanced expression of cyclins D1 and D3. Caspase mediated apoptosis triggered in A375 cells was accompanied with Bcl-2 but not iNOS down-regulation. In addition, opposite regulation of Akt-ERK1/2 axis in AE treated B16 and A375 cells correlated with different outcome of the treatment. However, AE in a dose-dependent manner rescued both B16 and A375 cells from doxorubicin- or paclitaxel-induced killing. These data indicate that caution is warranted when AE is administrated to the patients with conventional chemotherapy. (C) 2012 Elsevier Ltd. All rights reserved.
T2  - Food and Chemical Toxicology
T1  - Cell-type dependent response of melanoma cells to aloe emodin
IS  - 9
VL  - 50
SP  - 911
EP  - 3189
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1135
ER  - 

@article{
author = "Radović, Julijana M and Maksimović-Ivanić, Danijela and Timotijević, Gordana S and Popadić, S and Ramić, Zorica D. and Trajković, Vladimir S and Miljković, Đorđe and Stošić-Grujičić, Stanislava and Mijatović, Sanja",
year = "2012",
abstract = "Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments. In this context we compared the effectiveness of herbal antaquinone aloe emodin (AE) against mouse B16 melanoma and human A375, different in initial activity of ERK1/2, constitutive iNOS expression and basal level of reactive oxygen species (ROS). Both cell lines are sensitive to AE treatment. However, while the agent induces differentiation of B16 cells toward melanocytes, in A375 cells promoted massive apoptosis. Differentiation of B16 cells, characterized by enhanced melanin production and tyrosinase activity, was mediated by H2O2 production synchronized with rapid p53 accumulation and enhanced expression of cyclins D1 and D3. Caspase mediated apoptosis triggered in A375 cells was accompanied with Bcl-2 but not iNOS down-regulation. In addition, opposite regulation of Akt-ERK1/2 axis in AE treated B16 and A375 cells correlated with different outcome of the treatment. However, AE in a dose-dependent manner rescued both B16 and A375 cells from doxorubicin- or paclitaxel-induced killing. These data indicate that caution is warranted when AE is administrated to the patients with conventional chemotherapy. (C) 2012 Elsevier Ltd. All rights reserved.",
journal = "Food and Chemical Toxicology",
title = "Cell-type dependent response of melanoma cells to aloe emodin",
number = "9",
volume = "50",
pages = "911-3189",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1135"
}

Radović, J. M., Maksimović-Ivanić, D., Timotijević, G. S., Popadić, S., Ramić, Z. D., Trajković, V. S., Miljković, Đ., Stošić-Grujičić, S.,& Mijatović, S.. (2012). Cell-type dependent response of melanoma cells to aloe emodin. in Food and Chemical Toxicology, 50(9), 911-3189.
https://hdl.handle.net/21.15107/rcub_ibiss_1135

Radović JM, Maksimović-Ivanić D, Timotijević GS, Popadić S, Ramić ZD, Trajković VS, Miljković Đ, Stošić-Grujičić S, Mijatović S. Cell-type dependent response of melanoma cells to aloe emodin. in Food and Chemical Toxicology. 2012;50(9):911-3189.
https://hdl.handle.net/21.15107/rcub_ibiss_1135 .

Radović, Julijana M, Maksimović-Ivanić, Danijela, Timotijević, Gordana S, Popadić, S, Ramić, Zorica D., Trajković, Vladimir S, Miljković, Đorđe, Stošić-Grujičić, Stanislava, Mijatović, Sanja, "Cell-type dependent response of melanoma cells to aloe emodin" in Food and Chemical Toxicology, 50, no. 9 (2012):911-3189,
https://hdl.handle.net/21.15107/rcub_ibiss_1135 .