TY  - JOUR
AU  - Ntungwe, Epole N.
AU  - Jovanović Stojanov, Sofija
AU  - Duarte, Noélia M.
AU  - Candeias, Nuno R.
AU  - Díaz-Lanza, Ana M.
AU  - Vágvölgyi, Máté
AU  - Hunyadi, Attila
AU  - Pešić, Milica
AU  - Rijo, Patrícia
PY  - 2022
UR  - https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00711
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9014510
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4945
AB  - In this study, a bioguided fractionation of Plectranthus mutabilis extract was performed by chromatographic methods. It yielded one new nor-abietane diterpene, mutabilol (1), and three known abietanes, coleon-U-quinone (2), 8α,9α-epoxycoleon-U-quinone (3), and coleon U (4). The abietane diterpenoid 5 was also tentatively identified using HPLC-MS/MS. Moreover, the extract profile and quantification of each isolated compound were determined by HPLC-DAD. Compound 4 was the major compound in the extract. Compounds 2-4 were found to be selective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longer exposure of 72 h and consequently revert doxorubicin (DOX) resistance in subsequent combined treatment. None of the compounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it.
T2  - ACS Medicinal Chemistry Letters
T1  - C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.
IS  - 4
VL  - 13
DO  - 10.1021/acsmedchemlett.1c00711
SP  - 674
EP  - 680
ER  - 

@article{
author = "Ntungwe, Epole N. and Jovanović Stojanov, Sofija and Duarte, Noélia M. and Candeias, Nuno R. and Díaz-Lanza, Ana M. and Vágvölgyi, Máté and Hunyadi, Attila and Pešić, Milica and Rijo, Patrícia",
year = "2022",
abstract = "In this study, a bioguided fractionation of Plectranthus mutabilis extract was performed by chromatographic methods. It yielded one new nor-abietane diterpene, mutabilol (1), and three known abietanes, coleon-U-quinone (2), 8α,9α-epoxycoleon-U-quinone (3), and coleon U (4). The abietane diterpenoid 5 was also tentatively identified using HPLC-MS/MS. Moreover, the extract profile and quantification of each isolated compound were determined by HPLC-DAD. Compound 4 was the major compound in the extract. Compounds 2-4 were found to be selective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longer exposure of 72 h and consequently revert doxorubicin (DOX) resistance in subsequent combined treatment. None of the compounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it.",
journal = "ACS Medicinal Chemistry Letters",
title = "C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.",
number = "4",
volume = "13",
doi = "10.1021/acsmedchemlett.1c00711",
pages = "674-680"
}

Ntungwe, E. N., Jovanović Stojanov, S., Duarte, N. M., Candeias, N. R., Díaz-Lanza, A. M., Vágvölgyi, M., Hunyadi, A., Pešić, M.,& Rijo, P.. (2022). C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.. in ACS Medicinal Chemistry Letters, 13(4), 674-680.
https://doi.org/10.1021/acsmedchemlett.1c00711

Ntungwe EN, Jovanović Stojanov S, Duarte NM, Candeias NR, Díaz-Lanza AM, Vágvölgyi M, Hunyadi A, Pešić M, Rijo P. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.. in ACS Medicinal Chemistry Letters. 2022;13(4):674-680.
doi:10.1021/acsmedchemlett.1c00711 .

Ntungwe, Epole N., Jovanović Stojanov, Sofija, Duarte, Noélia M., Candeias, Nuno R., Díaz-Lanza, Ana M., Vágvölgyi, Máté, Hunyadi, Attila, Pešić, Milica, Rijo, Patrícia, "C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators." in ACS Medicinal Chemistry Letters, 13, no. 4 (2022):674-680,
https://doi.org/10.1021/acsmedchemlett.1c00711 . .