TY  - JOUR
AU  - Pejin, Boris
AU  - Stošić-Grujičić, Stanislava
AU  - Bogdanović, Gordana M
AU  - Hegedis, Aleksandar E
AU  - Karaman, Ivo M
AU  - Stojanović, Ivana D.
AU  - Nikolić, Ivana
AU  - Kojić, Vesna V
AU  - Horvatović, Mladen
AU  - Radotić, Ksenija
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1060
AB  - The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - In Vitro Evaluation of the Immunomodulatory and Anticarcinogenic Activity of the Freshwater Bryozoan Hyalinella Punctata Methanolic Extract
IS  - 1
VL  - 8
SP  - 301
EP  - 195
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1060
ER  - 

@article{
author = "Pejin, Boris and Stošić-Grujičić, Stanislava and Bogdanović, Gordana M and Hegedis, Aleksandar E and Karaman, Ivo M and Stojanović, Ivana D. and Nikolić, Ivana and Kojić, Vesna V and Horvatović, Mladen and Radotić, Ksenija",
year = "2013",
abstract = "The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "In Vitro Evaluation of the Immunomodulatory and Anticarcinogenic Activity of the Freshwater Bryozoan Hyalinella Punctata Methanolic Extract",
number = "1",
volume = "8",
pages = "301-195",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1060"
}

Pejin, B., Stošić-Grujičić, S., Bogdanović, G. M., Hegedis, A. E., Karaman, I. M., Stojanović, I. D., Nikolić, I., Kojić, V. V., Horvatović, M.,& Radotić, K.. (2013). In Vitro Evaluation of the Immunomodulatory and Anticarcinogenic Activity of the Freshwater Bryozoan Hyalinella Punctata Methanolic Extract. in Digest Journal of Nanomaterials and Biostructures, 8(1), 301-195.
https://hdl.handle.net/21.15107/rcub_ibiss_1060

Pejin B, Stošić-Grujičić S, Bogdanović GM, Hegedis AE, Karaman IM, Stojanović ID, Nikolić I, Kojić VV, Horvatović M, Radotić K. In Vitro Evaluation of the Immunomodulatory and Anticarcinogenic Activity of the Freshwater Bryozoan Hyalinella Punctata Methanolic Extract. in Digest Journal of Nanomaterials and Biostructures. 2013;8(1):301-195.
https://hdl.handle.net/21.15107/rcub_ibiss_1060 .

Pejin, Boris, Stošić-Grujičić, Stanislava, Bogdanović, Gordana M, Hegedis, Aleksandar E, Karaman, Ivo M, Stojanović, Ivana D., Nikolić, Ivana, Kojić, Vesna V, Horvatović, Mladen, Radotić, Ksenija, "In Vitro Evaluation of the Immunomodulatory and Anticarcinogenic Activity of the Freshwater Bryozoan Hyalinella Punctata Methanolic Extract" in Digest Journal of Nanomaterials and Biostructures, 8, no. 1 (2013):301-195,
https://hdl.handle.net/21.15107/rcub_ibiss_1060 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Radotić, Ksenija
AU  - Vajs, Vlatka E
AU  - Tesević, Vele V
AU  - Hegedis, Aleksandar E
AU  - Karaman, Ivo M
AU  - Horvatović, Mladen
AU  - Soković, Marina
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1164
AB  - The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).
PB  - Bucharest: Virtual Co Physics Srl
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Antimicrobial Activity of the Freshwater Bryozoan Hyalinella Punctata (Hancock, 1850)
IS  - 3
VL  - 7
EP  - 1026
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1565
ER  - 

@article{
author = "Pejin, Boris and Glamočlija, Jasmina and Ćirić, Ana and Radotić, Ksenija and Vajs, Vlatka E and Tesević, Vele V and Hegedis, Aleksandar E and Karaman, Ivo M and Horvatović, Mladen and Soković, Marina",
year = "2012",
abstract = "The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).",
publisher = "Bucharest: Virtual Co Physics Srl",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Antimicrobial Activity of the Freshwater Bryozoan Hyalinella Punctata (Hancock, 1850)",
number = "3",
volume = "7",
pages = "1026",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1565"
}

Pejin, B., Glamočlija, J., Ćirić, A., Radotić, K., Vajs, V. E., Tesević, V. V., Hegedis, A. E., Karaman, I. M., Horvatović, M.,& Soković, M.. (2012). Antimicrobial Activity of the Freshwater Bryozoan Hyalinella Punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures
Bucharest: Virtual Co Physics Srl., 7(3).
https://hdl.handle.net/21.15107/rcub_cherry_1565

Pejin B, Glamočlija J, Ćirić A, Radotić K, Vajs VE, Tesević VV, Hegedis AE, Karaman IM, Horvatović M, Soković M. Antimicrobial Activity of the Freshwater Bryozoan Hyalinella Punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures. 2012;7(3):null-1026.
https://hdl.handle.net/21.15107/rcub_cherry_1565 .

Pejin, Boris, Glamočlija, Jasmina, Ćirić, Ana, Radotić, Ksenija, Vajs, Vlatka E, Tesević, Vele V, Hegedis, Aleksandar E, Karaman, Ivo M, Horvatović, Mladen, Soković, Marina, "Antimicrobial Activity of the Freshwater Bryozoan Hyalinella Punctata (Hancock, 1850)" in Digest Journal of Nanomaterials and Biostructures, 7, no. 3 (2012),
https://hdl.handle.net/21.15107/rcub_cherry_1565 .