@article{
author = "Pejin, Boris and Ćirić, Ana and Karaman, Ivo and Horvatovic, Mladen and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2016",
abstract = "The antibiofilm and possible antiquorum sensing effects against
the strain Pseudomonas aeruginosa PAO1 of five crude extracts
of the freshwater bryozoan Hyalinella punctata (Hancock, 1850)
were evaluated in vitro for the first time. H. punctata ethyl acetate
extract (HpEtAc) exhibited the highest antibiofilm activity reducing
the biofilm formation of P. aeruginosa PAO1 in the range of 80.63–
88.13%. While all tested extracts reduced the twitching motility of
the aforementioned bacterial strain, HpEtAc showed to be the most
effective. Finally, at a concentration of 0.5 MIC, the same extract
mostly inhibited the production of pyocyanin by P. aeruginosa
PAO1 (71.53%). In comparison both with the positive controls used
(streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc
was found to inhibit pyocyanin in a higher extent. An extensive
chemical characterisation of this particular extract may result in
isolation and identification of novel lead compounds targeting
P. aeruginosa, an opportunistic human pathogen.",
publisher = "Abingdon: Taylor and Francis",
journal = "Natural Product Research",
title = "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1072714",
pages = "1847-1850"
}