TY  - CONF
AU  - Stojković, Pavle A.
AU  - Stepanović, Ana
AU  - Lupšić, Ema
AU  - Terzić Jovanović, Nataša
AU  - Novaković, Miroslav
AU  - Pešić, Milica
AU  - Opsenica, Igor M.
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5911
AB  - Sklareol, biološki aktivan diterpen, je iskorišćen kao polazna supstanca za sintezu novih hibridnih molekula sa 1,2,4-triazolo[1,5-a]-pirimidinskim jezgrom (Slika 1). Svi derivati sklareola su testirani na ćelijsku liniju ljudskog glioblastoma U 7 i ćelijsku liniju U 7-TxR koja ispoljava višestruku rezistenciju na lekove. Jedinjenja su modifikovala aktivnost P-glikoproteina u sličnoj meri kao P-gp inhibitor treće generacije – tarikvidar. Ispitan je uticaj novih jedinjenja na različite ćelijske procese među kojima su ćelijski ciklus i ćelijska smrt, kao i na koncentraciju reaktivnih kiseoničnih i azotnih vrsta (ROS/RNS) u ćelijama glioblastoma i na potencijal membrane mitohondrija.
AB  - Sclareol, a biologically active diterpenoid, was used as the starting material for the synthesis of novel hybrid molecules containing the 1,2,4-triazolo[1,5-a]-pyrimidine moiety. All sclareol derivatives were tested on human glioblastoma U87 and multi-drug resistant U87-TxR cells. Hybrid compounds decreased P-gp activity to the same extent as a third generation P-gp inhibitor - tariquidar. We examined the effect of novel compounds on various cellular processes including the cell cycle and cell death, as well as their influence on the levels of reactive oxygen and nitrogen species (ROS/RNS) and mitochondrial membrane potential in glioblastoma cells.
PB  - Belgrade: Serbian Chemical Society
C3  - Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia
T1  - Sinteza i citotoksičnost novih derivata sklareola
T1  - Synthesis and cytotoxic activity of novel sclareol derivatives
SP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5911
ER  - 

@conference{
author = "Stojković, Pavle A. and Stepanović, Ana and Lupšić, Ema and Terzić Jovanović, Nataša and Novaković, Miroslav and Pešić, Milica and Opsenica, Igor M.",
year = "2023",
abstract = "Sklareol, biološki aktivan diterpen, je iskorišćen kao polazna supstanca za sintezu novih hibridnih molekula sa 1,2,4-triazolo[1,5-a]-pirimidinskim jezgrom (Slika 1). Svi derivati sklareola su testirani na ćelijsku liniju ljudskog glioblastoma U 7 i ćelijsku liniju U 7-TxR koja ispoljava višestruku rezistenciju na lekove. Jedinjenja su modifikovala aktivnost P-glikoproteina u sličnoj meri kao P-gp inhibitor treće generacije – tarikvidar. Ispitan je uticaj novih jedinjenja na različite ćelijske procese među kojima su ćelijski ciklus i ćelijska smrt, kao i na koncentraciju reaktivnih kiseoničnih i azotnih vrsta (ROS/RNS) u ćelijama glioblastoma i na potencijal membrane mitohondrija., Sclareol, a biologically active diterpenoid, was used as the starting material for the synthesis of novel hybrid molecules containing the 1,2,4-triazolo[1,5-a]-pyrimidine moiety. All sclareol derivatives were tested on human glioblastoma U87 and multi-drug resistant U87-TxR cells. Hybrid compounds decreased P-gp activity to the same extent as a third generation P-gp inhibitor - tariquidar. We examined the effect of novel compounds on various cellular processes including the cell cycle and cell death, as well as their influence on the levels of reactive oxygen and nitrogen species (ROS/RNS) and mitochondrial membrane potential in glioblastoma cells.",
publisher = "Belgrade: Serbian Chemical Society",
journal = "Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia",
title = "Sinteza i citotoksičnost novih derivata sklareola, Synthesis and cytotoxic activity of novel sclareol derivatives",
pages = "77",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5911"
}

Stojković, P. A., Stepanović, A., Lupšić, E., Terzić Jovanović, N., Novaković, M., Pešić, M.,& Opsenica, I. M.. (2023). Sinteza i citotoksičnost novih derivata sklareola. in Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia
Belgrade: Serbian Chemical Society., 77.
https://hdl.handle.net/21.15107/rcub_ibiss_5911

Stojković PA, Stepanović A, Lupšić E, Terzić Jovanović N, Novaković M, Pešić M, Opsenica IM. Sinteza i citotoksičnost novih derivata sklareola. in Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia. 2023;:77.
https://hdl.handle.net/21.15107/rcub_ibiss_5911 .

Stojković, Pavle A., Stepanović, Ana, Lupšić, Ema, Terzić Jovanović, Nataša, Novaković, Miroslav, Pešić, Milica, Opsenica, Igor M., "Sinteza i citotoksičnost novih derivata sklareola" in Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia (2023):77,
https://hdl.handle.net/21.15107/rcub_ibiss_5911 .