TY  - JOUR
AU  - Savić, Danka
AU  - Knežević, Goran
AU  - Matić, Gordana
AU  - Damjanović, Svetozar
PY  - 2018
UR  - http://www.psyneuen-journal.com/article/S0306-4530(18)30088-X/fulltext
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3034
AB  - BACKGROUND Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. RESULTS The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder - personality trait Disintegration. CONCLUSIONS According to our project results, DHEAS is the second putative biomarker for trauma-related disorders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.
T2  - Psychoneuroendocrinology
T1  - PTSD and depressive symptoms are linked to DHEAS via personality.
VL  - 92
DO  - 10.1016/j.psyneuen.2018.03.017
SP  - 29
EP  - 33
ER  - 

@article{
author = "Savić, Danka and Knežević, Goran and Matić, Gordana and Damjanović, Svetozar",
year = "2018",
abstract = "BACKGROUND Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. RESULTS The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder - personality trait Disintegration. CONCLUSIONS According to our project results, DHEAS is the second putative biomarker for trauma-related disorders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.",
journal = "Psychoneuroendocrinology",
title = "PTSD and depressive symptoms are linked to DHEAS via personality.",
volume = "92",
doi = "10.1016/j.psyneuen.2018.03.017",
pages = "29-33"
}

Savić, D., Knežević, G., Matić, G.,& Damjanović, S.. (2018). PTSD and depressive symptoms are linked to DHEAS via personality.. in Psychoneuroendocrinology, 92, 29-33.
https://doi.org/10.1016/j.psyneuen.2018.03.017

Savić D, Knežević G, Matić G, Damjanović S. PTSD and depressive symptoms are linked to DHEAS via personality.. in Psychoneuroendocrinology. 2018;92:29-33.
doi:10.1016/j.psyneuen.2018.03.017 .

Savić, Danka, Knežević, Goran, Matić, Gordana, Damjanović, Svetozar, "PTSD and depressive symptoms are linked to DHEAS via personality." in Psychoneuroendocrinology, 92 (2018):29-33,
https://doi.org/10.1016/j.psyneuen.2018.03.017 . .

TY  - JOUR
AU  - Matić, Gordana
AU  - Vojnović-Milutinović, Danijela
AU  - Brkljačić, Jelena
AU  - Elaković, Ivana
AU  - Manitašević-Jovanović, Sanja
AU  - Perišić, Tatjana
AU  - Dunđerski, Jadranka S.
AU  - Damjanović, Svetozar S
AU  - Knežević, Goran
AU  - Spirić, Zeljko M
AU  - Vermetten, Eric
AU  - Savić, Danka A
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/999
AB  - Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.
T2  - Progress in Neuro-Psychopharmacology & Biological Psychiatry
T1  - Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD
IS  - null
VL  - 43
SP  - 63
EP  - 245
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_999
ER  - 

@article{
author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Brkljačić, Jelena and Elaković, Ivana and Manitašević-Jovanović, Sanja and Perišić, Tatjana and Dunđerski, Jadranka S. and Damjanović, Svetozar S and Knežević, Goran and Spirić, Zeljko M and Vermetten, Eric and Savić, Danka A",
year = "2013",
abstract = "Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
title = "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD",
number = "null",
volume = "43",
pages = "63-245",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_999"
}

Matić, G., Vojnović-Milutinović, D., Brkljačić, J., Elaković, I., Manitašević-Jovanović, S., Perišić, T., Dunđerski, J. S., Damjanović, S. S., Knežević, G., Spirić, Z. M., Vermetten, E.,& Savić, D. A.. (2013). Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-Psychopharmacology & Biological Psychiatry, 43(null), 63-245.
https://hdl.handle.net/21.15107/rcub_ibiss_999

Matić G, Vojnović-Milutinović D, Brkljačić J, Elaković I, Manitašević-Jovanović S, Perišić T, Dunđerski JS, Damjanović SS, Knežević G, Spirić ZM, Vermetten E, Savić DA. Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2013;43(null):63-245.
https://hdl.handle.net/21.15107/rcub_ibiss_999 .

Matić, Gordana, Vojnović-Milutinović, Danijela, Brkljačić, Jelena, Elaković, Ivana, Manitašević-Jovanović, Sanja, Perišić, Tatjana, Dunđerski, Jadranka S., Damjanović, Svetozar S, Knežević, Goran, Spirić, Zeljko M, Vermetten, Eric, Savić, Danka A, "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD" in Progress in Neuro-Psychopharmacology & Biological Psychiatry, 43, no. null (2013):63-245,
https://hdl.handle.net/21.15107/rcub_ibiss_999 .

TY  - JOUR
AU  - Damjanović, Svetozar S
AU  - Antić, Jadranka A
AU  - Ilić, Bojana B
AU  - Beleslin-Cokić, Bojana B
AU  - Ivović, Miomira S
AU  - Ognjanović, Sanja I
AU  - Isailović, Tatjana V
AU  - Popović, Bojana M
AU  - Bozić, Ivana B
AU  - Tatić, Svetislav B
AU  - Matić, Gordana
AU  - Todorović, Vera N
AU  - Paunović, Ivan R
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1085
AB  - Glucocorticoid (GC) sensitivity depends on glucocorticoid receptor (GR) and heat shock proteins (Hsps). We investigated whether common GR genes (ER22/23EK N363S, BclI, and 9 beta) and adrenocorticotropin receptor promoter polymorphisms influence susceptibility for unilateral adrenal incidentaloma (AI), plus GR and Hsp expression in tumorous (n = 19), peritumorous (n = 13) and normal adrenocortical (n = 11) tissues. Patients (n = 112), population-matched controls (n = 100) and tumor tissues (n = 32) were genotyped for these polymorphisms. Postdexamethasone serum cortisol was higher in patients (p<0.001). GR gene variants, larger allele of BclI (odds ratio (OR) 2.9; 95% confidence interval (CI) 1.7-5.1; p < 0.001) and minor allele of 9 beta (OR 3.0; 95% CI 1.6-5.7; p < 0.001) were independent predictors of Al. In patients, the first allele is linked with larger tumors (p = 0.002) and the latter with higher postdexamethasone cortisol levels (p = 0.025). Both allele carriers had lesser waist circumference (p = 0.02), similar adrenocorticotropin and higher basal (p = 0.024) and postdexamethasone cortisol concentrations (p < 0.001). Tumorous and constitutional genotypes were similar. GR-D is the major receptor isoform in normal adrenal cortex by Western blotting. Loss of other receptor isoforms, decrease in immunostaining for GR (p < 0.0001), underexpression of chaperones (p <= 0.01) and the presence of inducible Hsp70 were found in adenomas. In conclusion, GR gene variants, C allele of BclI and minor allele of 9 beta, are associated with Als. Their concurrent presence in patients reduces GC sensitivity Normal adrenal cortex preferentially expresses GR-D. In adenomas, the lack of other GR isoforms and underexpression of heat shock proteins perhaps permanently impair GC signaling, which could promote dysregulated cortisol production and tumor growth. The innate GC sensitivity probably modifies these effects. Online address: http://www.molmed.org doi: 10.2119/molmed.2012.00261
T2  - Molecular Medicine
T1  - Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids
IS  - 11
VL  - 18
SP  - 189
EP  - 1465
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1085
ER  - 

@article{
author = "Damjanović, Svetozar S and Antić, Jadranka A and Ilić, Bojana B and Beleslin-Cokić, Bojana B and Ivović, Miomira S and Ognjanović, Sanja I and Isailović, Tatjana V and Popović, Bojana M and Bozić, Ivana B and Tatić, Svetislav B and Matić, Gordana and Todorović, Vera N and Paunović, Ivan R",
year = "2012",
abstract = "Glucocorticoid (GC) sensitivity depends on glucocorticoid receptor (GR) and heat shock proteins (Hsps). We investigated whether common GR genes (ER22/23EK N363S, BclI, and 9 beta) and adrenocorticotropin receptor promoter polymorphisms influence susceptibility for unilateral adrenal incidentaloma (AI), plus GR and Hsp expression in tumorous (n = 19), peritumorous (n = 13) and normal adrenocortical (n = 11) tissues. Patients (n = 112), population-matched controls (n = 100) and tumor tissues (n = 32) were genotyped for these polymorphisms. Postdexamethasone serum cortisol was higher in patients (p<0.001). GR gene variants, larger allele of BclI (odds ratio (OR) 2.9; 95% confidence interval (CI) 1.7-5.1; p < 0.001) and minor allele of 9 beta (OR 3.0; 95% CI 1.6-5.7; p < 0.001) were independent predictors of Al. In patients, the first allele is linked with larger tumors (p = 0.002) and the latter with higher postdexamethasone cortisol levels (p = 0.025). Both allele carriers had lesser waist circumference (p = 0.02), similar adrenocorticotropin and higher basal (p = 0.024) and postdexamethasone cortisol concentrations (p < 0.001). Tumorous and constitutional genotypes were similar. GR-D is the major receptor isoform in normal adrenal cortex by Western blotting. Loss of other receptor isoforms, decrease in immunostaining for GR (p < 0.0001), underexpression of chaperones (p <= 0.01) and the presence of inducible Hsp70 were found in adenomas. In conclusion, GR gene variants, C allele of BclI and minor allele of 9 beta, are associated with Als. Their concurrent presence in patients reduces GC sensitivity Normal adrenal cortex preferentially expresses GR-D. In adenomas, the lack of other GR isoforms and underexpression of heat shock proteins perhaps permanently impair GC signaling, which could promote dysregulated cortisol production and tumor growth. The innate GC sensitivity probably modifies these effects. Online address: http://www.molmed.org doi: 10.2119/molmed.2012.00261",
journal = "Molecular Medicine",
title = "Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids",
number = "11",
volume = "18",
pages = "189-1465",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1085"
}

Damjanović, S. S., Antić, J. A., Ilić, B. B., Beleslin-Cokić, B. B., Ivović, M. S., Ognjanović, S. I., Isailović, T. V., Popović, B. M., Bozić, I. B., Tatić, S. B., Matić, G., Todorović, V. N.,& Paunović, I. R.. (2012). Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids. in Molecular Medicine, 18(11), 189-1465.
https://hdl.handle.net/21.15107/rcub_ibiss_1085

Damjanović SS, Antić JA, Ilić BB, Beleslin-Cokić BB, Ivović MS, Ognjanović SI, Isailović TV, Popović BM, Bozić IB, Tatić SB, Matić G, Todorović VN, Paunović IR. Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids. in Molecular Medicine. 2012;18(11):189-1465.
https://hdl.handle.net/21.15107/rcub_ibiss_1085 .

Damjanović, Svetozar S, Antić, Jadranka A, Ilić, Bojana B, Beleslin-Cokić, Bojana B, Ivović, Miomira S, Ognjanović, Sanja I, Isailović, Tatjana V, Popović, Bojana M, Bozić, Ivana B, Tatić, Svetislav B, Matić, Gordana, Todorović, Vera N, Paunović, Ivan R, "Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids" in Molecular Medicine, 18, no. 11 (2012):189-1465,
https://hdl.handle.net/21.15107/rcub_ibiss_1085 .

TY  - JOUR
AU  - Savić, Danka A
AU  - Knežević, Goran
AU  - Damjanović, Svetozar S
AU  - Spirić, Zeljko M
AU  - Matić, Gordana
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1145
AB  - The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences. (C) 2012 Elsevier Ltd. All rights reserved.
T2  - Psychoneuroendocrinology
T1  - Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'
IS  - 9
VL  - 37
SP  - 1045
EP  - 1520
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1145
ER  - 

@article{
author = "Savić, Danka A and Knežević, Goran and Damjanović, Svetozar S and Spirić, Zeljko M and Matić, Gordana",
year = "2012",
abstract = "The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences. (C) 2012 Elsevier Ltd. All rights reserved.",
journal = "Psychoneuroendocrinology",
title = "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'",
number = "9",
volume = "37",
pages = "1045-1520",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1145"
}

Savić, D. A., Knežević, G., Damjanović, S. S., Spirić, Z. M.,& Matić, G.. (2012). Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology, 37(9), 1045-1520.
https://hdl.handle.net/21.15107/rcub_ibiss_1145

Savić DA, Knežević G, Damjanović SS, Spirić ZM, Matić G. Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology. 2012;37(9):1045-1520.
https://hdl.handle.net/21.15107/rcub_ibiss_1145 .

Savić, Danka A, Knežević, Goran, Damjanović, Svetozar S, Spirić, Zeljko M, Matić, Gordana, "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'" in Psychoneuroendocrinology, 37, no. 9 (2012):1045-1520,
https://hdl.handle.net/21.15107/rcub_ibiss_1145 .

TY  - JOUR
AU  - Savić, Danka A
AU  - Knežević, Goran
AU  - Damjanović, Svetozar S
AU  - Spirić, Zeljko M
AU  - Matić, Gordana
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1169
AB  - Background: Studies of cortisol in post-traumatic stress disorder (PTSD) have yielded mixed results. We hypothesize that personality traits and traumatic experiences could be the confounders of cortisol measures and disease symptoms. Method: This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 400 male participants categorized by four groups: (A) 133 with current PTSD, (B) 66 with lifetime PTSD, (C) 102 trauma controls, and (D) 99 healthy controls (matched by age and education). Cortisol and ACTH were measured in blood samples taken hourly from 22:00 h to 09:00 h, with an additional sample at 07:30 h (resting state and morning rise). The next night, dexamethasone (0.5 mg) suppression test was performed. Results: No significant differences in basal cortisol and ACTH were found between study groups. The trait Conscientiousness, negatively modulated by Extraversion (assessed by NEO Personality Inventory-Revised) was found to correlate with cortisol (but not with ACTH). Group differences are found on suppression. Structural equation modeling shows excellent fit only when the paths (influences) from Conscientiousness to basal cortisol and from traumatic events to suppression are present. The paths connecting suppression and PTSD symptoms do not contribute. Conclusions: Two sources of differences of hypothalamo-pituitary-adrenocortical axis functioning are implied, both only indirectly connected to PTSD. It seems that basal cortisol secretion is associated more tightly with personality (introvertively modulated Conscientiousness), while the regulation by glucocorticoid receptor system is sensitized by repeated traumatic situations. (c) 2011 Elsevier Ltd. All rights reserved.
T2  - Psychoneuroendocrinology
T1  - The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?
IS  - 7
VL  - 37
EP  - 947
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1169
ER  - 

@article{
author = "Savić, Danka A and Knežević, Goran and Damjanović, Svetozar S and Spirić, Zeljko M and Matić, Gordana",
year = "2012",
abstract = "Background: Studies of cortisol in post-traumatic stress disorder (PTSD) have yielded mixed results. We hypothesize that personality traits and traumatic experiences could be the confounders of cortisol measures and disease symptoms. Method: This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 400 male participants categorized by four groups: (A) 133 with current PTSD, (B) 66 with lifetime PTSD, (C) 102 trauma controls, and (D) 99 healthy controls (matched by age and education). Cortisol and ACTH were measured in blood samples taken hourly from 22:00 h to 09:00 h, with an additional sample at 07:30 h (resting state and morning rise). The next night, dexamethasone (0.5 mg) suppression test was performed. Results: No significant differences in basal cortisol and ACTH were found between study groups. The trait Conscientiousness, negatively modulated by Extraversion (assessed by NEO Personality Inventory-Revised) was found to correlate with cortisol (but not with ACTH). Group differences are found on suppression. Structural equation modeling shows excellent fit only when the paths (influences) from Conscientiousness to basal cortisol and from traumatic events to suppression are present. The paths connecting suppression and PTSD symptoms do not contribute. Conclusions: Two sources of differences of hypothalamo-pituitary-adrenocortical axis functioning are implied, both only indirectly connected to PTSD. It seems that basal cortisol secretion is associated more tightly with personality (introvertively modulated Conscientiousness), while the regulation by glucocorticoid receptor system is sensitized by repeated traumatic situations. (c) 2011 Elsevier Ltd. All rights reserved.",
journal = "Psychoneuroendocrinology",
title = "The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?",
number = "7",
volume = "37",
pages = "947",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1169"
}

Savić, D. A., Knežević, G., Damjanović, S. S., Spirić, Z. M.,& Matić, G.. (2012). The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?. in Psychoneuroendocrinology, 37(7).
https://hdl.handle.net/21.15107/rcub_ibiss_1169

Savić DA, Knežević G, Damjanović SS, Spirić ZM, Matić G. The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?. in Psychoneuroendocrinology. 2012;37(7):null-947.
https://hdl.handle.net/21.15107/rcub_ibiss_1169 .

Savić, Danka A, Knežević, Goran, Damjanović, Svetozar S, Spirić, Zeljko M, Matić, Gordana, "The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?" in Psychoneuroendocrinology, 37, no. 7 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1169 .

TY  - JOUR
AU  - Vojnović-Milutinović, Danijela
AU  - Macut, Đuro P
AU  - Bozić, Ivana B
AU  - Brkljačić, Jelena
AU  - Damjanović, Svetozar S
AU  - Matić, Gordana
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1248
AB  - Introduction: Molecular mechanisms underlying pathophysiology of polycystic ovary syndrome (PCOS), especially those related to cortisol signaling, are poorly understood. We hypothesized that modulation of glucocorticoid receptor (GR) expression and function, may underlie possible PCOS-related impairment of feedback inhibition of hypothalamic-pituitary-adrenocortical (HPA) axis activity and thus contribute to increased adrenal androgen production in women with PCOS. Materials and Methods: 24 normal-weight and 31 obese women with PCOS were compared to 25 normal-weight controls. Fasting blood samples were collected for measurements of serum concentrations of dehydroepiandrosterone sulfate, testosterone, sex hormone-binding globulin, insulin, basal cortisol and cortisol after oral administration of 0.5 mg dexamethasone. Concentrations of GR mRNA, GR protein, mineralocorticoid receptor (MR) protein and heat shock proteins (Hsps), as well as the number of GR per cell (B(max)) and its equilibrium dissociation constant (K(D)) were measured in isolated peripheral blood mononuclear cells. Results: An increase in HPA axis sensitivity to dexamethasone, an elevation of the GR protein concentration, and unaltered receptor functional status were found in both normal-weight and obese women with PCOS vs. healthy controls. Lymphocyte MR, Hsp90 and Hsp70 concentrations, and MR/GR ratio were similar in all groups. Correlation between B(max) and K(D) was weaker in the group of obese women with PCOS than in the other 2 groups. Conclusions: The results did not confirm the initial hypothesis, but imply that PCOS is associated with increased GR protein concentration and HPA axis sensitivity to dexamethasone.
T2  - Experimental and Clinical Endocrinology & Diabetes
T1  - Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome
IS  - 10
VL  - 119
EP  - 643
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1248
ER  - 

@article{
author = "Vojnović-Milutinović, Danijela and Macut, Đuro P and Bozić, Ivana B and Brkljačić, Jelena and Damjanović, Svetozar S and Matić, Gordana",
year = "2011",
abstract = "Introduction: Molecular mechanisms underlying pathophysiology of polycystic ovary syndrome (PCOS), especially those related to cortisol signaling, are poorly understood. We hypothesized that modulation of glucocorticoid receptor (GR) expression and function, may underlie possible PCOS-related impairment of feedback inhibition of hypothalamic-pituitary-adrenocortical (HPA) axis activity and thus contribute to increased adrenal androgen production in women with PCOS. Materials and Methods: 24 normal-weight and 31 obese women with PCOS were compared to 25 normal-weight controls. Fasting blood samples were collected for measurements of serum concentrations of dehydroepiandrosterone sulfate, testosterone, sex hormone-binding globulin, insulin, basal cortisol and cortisol after oral administration of 0.5 mg dexamethasone. Concentrations of GR mRNA, GR protein, mineralocorticoid receptor (MR) protein and heat shock proteins (Hsps), as well as the number of GR per cell (B(max)) and its equilibrium dissociation constant (K(D)) were measured in isolated peripheral blood mononuclear cells. Results: An increase in HPA axis sensitivity to dexamethasone, an elevation of the GR protein concentration, and unaltered receptor functional status were found in both normal-weight and obese women with PCOS vs. healthy controls. Lymphocyte MR, Hsp90 and Hsp70 concentrations, and MR/GR ratio were similar in all groups. Correlation between B(max) and K(D) was weaker in the group of obese women with PCOS than in the other 2 groups. Conclusions: The results did not confirm the initial hypothesis, but imply that PCOS is associated with increased GR protein concentration and HPA axis sensitivity to dexamethasone.",
journal = "Experimental and Clinical Endocrinology & Diabetes",
title = "Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome",
number = "10",
volume = "119",
pages = "643",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1248"
}

Vojnović-Milutinović, D., Macut, Đ. P., Bozić, I. B., Brkljačić, J., Damjanović, S. S.,& Matić, G.. (2011). Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome. in Experimental and Clinical Endocrinology & Diabetes, 119(10).
https://hdl.handle.net/21.15107/rcub_ibiss_1248

Vojnović-Milutinović D, Macut ĐP, Bozić IB, Brkljačić J, Damjanović SS, Matić G. Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome. in Experimental and Clinical Endocrinology & Diabetes. 2011;119(10):null-643.
https://hdl.handle.net/21.15107/rcub_ibiss_1248 .

Vojnović-Milutinović, Danijela, Macut, Đuro P, Bozić, Ivana B, Brkljačić, Jelena, Damjanović, Svetozar S, Matić, Gordana, "Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome" in Experimental and Clinical Endocrinology & Diabetes, 119, no. 10 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1248 .

TY  - JOUR
AU  - Macut, Đuro P
AU  - Vojnović-Milutinović, Danijela
AU  - Bozić, Ivana B
AU  - Matić, Gordana
AU  - Brkljačić, Jelena
AU  - Panidis, Dimitrios
AU  - Petakov, Milan S
AU  - Spanos, Nikolaos
AU  - Bjekić, Jelica
AU  - Stanojlović, Olivera P
AU  - Petrović-Milinković, Anđela
AU  - Radojicić, Zoran A
AU  - Damjanović, Svetozar S
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1402
AB  - Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 +/- A 5.1 years, mean body mass index (BMI) 24.5 +/- A 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P < 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.
T2  - Endocrine
T1  - Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome
IS  - 1
VL  - 37
EP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1402
ER  - 

@article{
author = "Macut, Đuro P and Vojnović-Milutinović, Danijela and Bozić, Ivana B and Matić, Gordana and Brkljačić, Jelena and Panidis, Dimitrios and Petakov, Milan S and Spanos, Nikolaos and Bjekić, Jelica and Stanojlović, Olivera P and Petrović-Milinković, Anđela and Radojicić, Zoran A and Damjanović, Svetozar S",
year = "2010",
abstract = "Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 +/- A 5.1 years, mean body mass index (BMI) 24.5 +/- A 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P < 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.",
journal = "Endocrine",
title = "Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome",
number = "1",
volume = "37",
pages = "134",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1402"
}

Macut, Đ. P., Vojnović-Milutinović, D., Bozić, I. B., Matić, G., Brkljačić, J., Panidis, D., Petakov, M. S., Spanos, N., Bjekić, J., Stanojlović, O. P., Petrović-Milinković, A., Radojicić, Z. A.,& Damjanović, S. S.. (2010). Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome. in Endocrine, 37(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1402

Macut ĐP, Vojnović-Milutinović D, Bozić IB, Matić G, Brkljačić J, Panidis D, Petakov MS, Spanos N, Bjekić J, Stanojlović OP, Petrović-Milinković A, Radojicić ZA, Damjanović SS. Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome. in Endocrine. 2010;37(1):null-134.
https://hdl.handle.net/21.15107/rcub_ibiss_1402 .

Macut, Đuro P, Vojnović-Milutinović, Danijela, Bozić, Ivana B, Matić, Gordana, Brkljačić, Jelena, Panidis, Dimitrios, Petakov, Milan S, Spanos, Nikolaos, Bjekić, Jelica, Stanojlović, Olivera P, Petrović-Milinković, Anđela, Radojicić, Zoran A, Damjanović, Svetozar S, "Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome" in Endocrine, 37, no. 1 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1402 .