TY  - JOUR
AU  - Cvetanović Kljakić, Aleksandra
AU  - Stupar, Alena
AU  - Terzić, Milena
AU  - Božunović, Jelena
AU  - Gašić, Uroš
AU  - Zengin, Gokhan
AU  - Yildiztugay, Evren
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6468
AB  - The plant species Opopanax hispidus is known in traditional Turkish medicine and nutrition. In addition to all the advantages that are known by the traditions of old generations, O. hispidus has been insufficiently examined, and its potential could be used in treatment in modern medicine and diet. In this paper, O. hispidus extracts obtained by conventional (maceration (MAC), and Soxhlet (SOX)) and contemporary (accelerated solvent extraction (ASE), homogenizer assisted extraction (HAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), supercritical fluid extraction (SFE)) methods were examined in terms of their chemical composition and biological potential. The extract obtained by HAE extraction had the highest content of total phenolics and flavonoids (36.98 mg GAE/g and 15.04 mg RE/g, respectively). The highest antioxidant activity was recorded for HAE and ASE extracts. O. hispidus extracts achieved inhibitory activity against acetylcholinesterase (4.12–6.44 mg GALAE/g), tyrosinase (44.78–76.72 mg KAE/g), α-amylase (0.35–0.46 mmol ACAE/g), and α-glucosidase (1.67–1.77 mmol ACAE/g) enzymes. LC-MS technique was used for the quantitative analysis of the extracts, allowing the quantification of chlorogenic acid, neochlorogenic acid, and p-coumaric acid, rutin, luteolin, and kaempferol 3-O-glucoside as the most abundant phenolic components. Results suggested that the green extraction techniques for obtaining extracts that are rich in bioactive compounds have advantages compared to conventional extraction. Therefore, these extracts can be used as antioxidants, neuroprotective, antityrosinase, and antidiabetic agents while respecting the principles of sustainable development and green chemistry.
PB  - Elsevier
T2  - Sustainable Chemistry and Pharmacy
T1  - Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies
VL  - 33
DO  - 10.1016/j.scp.2023.101122
SP  - 101122
ER  - 

@article{
author = "Cvetanović Kljakić, Aleksandra and Stupar, Alena and Terzić, Milena and Božunović, Jelena and Gašić, Uroš and Zengin, Gokhan and Yildiztugay, Evren",
year = "2023",
abstract = "The plant species Opopanax hispidus is known in traditional Turkish medicine and nutrition. In addition to all the advantages that are known by the traditions of old generations, O. hispidus has been insufficiently examined, and its potential could be used in treatment in modern medicine and diet. In this paper, O. hispidus extracts obtained by conventional (maceration (MAC), and Soxhlet (SOX)) and contemporary (accelerated solvent extraction (ASE), homogenizer assisted extraction (HAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), supercritical fluid extraction (SFE)) methods were examined in terms of their chemical composition and biological potential. The extract obtained by HAE extraction had the highest content of total phenolics and flavonoids (36.98 mg GAE/g and 15.04 mg RE/g, respectively). The highest antioxidant activity was recorded for HAE and ASE extracts. O. hispidus extracts achieved inhibitory activity against acetylcholinesterase (4.12–6.44 mg GALAE/g), tyrosinase (44.78–76.72 mg KAE/g), α-amylase (0.35–0.46 mmol ACAE/g), and α-glucosidase (1.67–1.77 mmol ACAE/g) enzymes. LC-MS technique was used for the quantitative analysis of the extracts, allowing the quantification of chlorogenic acid, neochlorogenic acid, and p-coumaric acid, rutin, luteolin, and kaempferol 3-O-glucoside as the most abundant phenolic components. Results suggested that the green extraction techniques for obtaining extracts that are rich in bioactive compounds have advantages compared to conventional extraction. Therefore, these extracts can be used as antioxidants, neuroprotective, antityrosinase, and antidiabetic agents while respecting the principles of sustainable development and green chemistry.",
publisher = "Elsevier",
journal = "Sustainable Chemistry and Pharmacy",
title = "Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies",
volume = "33",
doi = "10.1016/j.scp.2023.101122",
pages = "101122"
}

Cvetanović Kljakić, A., Stupar, A., Terzić, M., Božunović, J., Gašić, U., Zengin, G.,& Yildiztugay, E.. (2023). Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies. in Sustainable Chemistry and Pharmacy
Elsevier., 33, 101122.
https://doi.org/10.1016/j.scp.2023.101122

Cvetanović Kljakić A, Stupar A, Terzić M, Božunović J, Gašić U, Zengin G, Yildiztugay E. Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies. in Sustainable Chemistry and Pharmacy. 2023;33:101122.
doi:10.1016/j.scp.2023.101122 .

Cvetanović Kljakić, Aleksandra, Stupar, Alena, Terzić, Milena, Božunović, Jelena, Gašić, Uroš, Zengin, Gokhan, Yildiztugay, Evren, "Chemical profiling and biological activities of Opopanax hispidus extracts: A comparative insight on conventional and green extraction technologies" in Sustainable Chemistry and Pharmacy, 33 (2023):101122,
https://doi.org/10.1016/j.scp.2023.101122 . .