TY  - JOUR
AU  - Steelman, Linda S
AU  - Fitzgerald, Timothy
AU  - Lertpiriyapong, Kvin
AU  - Cocco, Lucio
AU  - Follo, Matilde Y
AU  - Martelli, Alberto M
AU  - Neri, Luca M
AU  - Marmiroli, Sandra
AU  - Libra, Massimo
AU  - Candido, Saverio
AU  - Nicoletti, Ferdinando
AU  - Scalisi, Aurora
AU  - Fenga, Concettina
AU  - Drobot, Lyudmyla
AU  - Rakus, Dariusz
AU  - Gizak,  Agnieszka
AU  - Laidler, Piotr
AU  - Dulinska-Litewka, Joanna
AU  - Basecke,  Joerg
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Montalto, Giuseppe
AU  - Cervello, Melchiorre
AU  - Milella, Michelle
AU  - Tafuri, Agustino
AU  - Demidenko, Zoya
AU  - Abrams,  Stephen L
AU  - McCubrey, James A
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3822
AB  - The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal and other cancers have been keenly investigated since the 1980's. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about this pathway and how its deregulation can lead to cancer and how it may be differentially regulated in various cell types. Multiple inhibitors to EGFR family members have been developed and many are in clinical use. Current research often focuses on their roles and other associated pathways in cancer stem cells (CSCs), identifying sites where therapeutic resistance may develop and the mechanisms by which microRNAs (miRs) and other RNAs regulate this pathway. This review will focus on recent advances in these fields with a specific focus on breast cancer and breast CSCs. Relatively novel areas of investigation, such as treatments for other diseases (e.g., diabetes, metabolism, and intestinal parasites), have provided new information about therapeutic resistance and CSCs.
PB  - Sharjah: Bentham Science Publishers
T2  - Current Pharmaceutical Design
T1  - Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy
IS  - 16
VL  - 22
DO  - 10.2174/1381612822666160304151011
SP  - 2358
EP  - 2388
ER  - 

@article{
author = "Steelman, Linda S and Fitzgerald, Timothy and Lertpiriyapong, Kvin and Cocco, Lucio and Follo, Matilde Y and Martelli, Alberto M and Neri, Luca M and Marmiroli, Sandra and Libra, Massimo and Candido, Saverio and Nicoletti, Ferdinando and Scalisi, Aurora and Fenga, Concettina and Drobot, Lyudmyla and Rakus, Dariusz and Gizak,  Agnieszka and Laidler, Piotr and Dulinska-Litewka, Joanna and Basecke,  Joerg and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Montalto, Giuseppe and Cervello, Melchiorre and Milella, Michelle and Tafuri, Agustino and Demidenko, Zoya and Abrams,  Stephen L and McCubrey, James A",
year = "2016",
abstract = "The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal and other cancers have been keenly investigated since the 1980's. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about this pathway and how its deregulation can lead to cancer and how it may be differentially regulated in various cell types. Multiple inhibitors to EGFR family members have been developed and many are in clinical use. Current research often focuses on their roles and other associated pathways in cancer stem cells (CSCs), identifying sites where therapeutic resistance may develop and the mechanisms by which microRNAs (miRs) and other RNAs regulate this pathway. This review will focus on recent advances in these fields with a specific focus on breast cancer and breast CSCs. Relatively novel areas of investigation, such as treatments for other diseases (e.g., diabetes, metabolism, and intestinal parasites), have provided new information about therapeutic resistance and CSCs.",
publisher = "Sharjah: Bentham Science Publishers",
journal = "Current Pharmaceutical Design",
title = "Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy",
number = "16",
volume = "22",
doi = "10.2174/1381612822666160304151011",
pages = "2358-2388"
}

Steelman, L. S., Fitzgerald, T., Lertpiriyapong, K., Cocco, L., Follo, M. Y., Martelli, A. M., Neri, L. M., Marmiroli, S., Libra, M., Candido, S., Nicoletti, F., Scalisi, A., Fenga, C., Drobot, L., Rakus, D., Gizak,  ., Laidler, P., Dulinska-Litewka, J., Basecke,  ., Mijatović, S., Maksimović-Ivanić, D., Montalto, G., Cervello, M., Milella, M., Tafuri, A., Demidenko, Z., Abrams,  . L.,& McCubrey, J. A.. (2016). Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy. in Current Pharmaceutical Design
Sharjah: Bentham Science Publishers., 22(16), 2358-2388.
https://doi.org/10.2174/1381612822666160304151011

Steelman LS, Fitzgerald T, Lertpiriyapong K, Cocco L, Follo MY, Martelli AM, Neri LM, Marmiroli S, Libra M, Candido S, Nicoletti F, Scalisi A, Fenga C, Drobot L, Rakus D, Gizak  , Laidler P, Dulinska-Litewka J, Basecke  , Mijatović S, Maksimović-Ivanić D, Montalto G, Cervello M, Milella M, Tafuri A, Demidenko Z, Abrams  L, McCubrey JA. Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy. in Current Pharmaceutical Design. 2016;22(16):2358-2388.
doi:10.2174/1381612822666160304151011 .

Steelman, Linda S, Fitzgerald, Timothy, Lertpiriyapong, Kvin, Cocco, Lucio, Follo, Matilde Y, Martelli, Alberto M, Neri, Luca M, Marmiroli, Sandra, Libra, Massimo, Candido, Saverio, Nicoletti, Ferdinando, Scalisi, Aurora, Fenga, Concettina, Drobot, Lyudmyla, Rakus, Dariusz, Gizak,  Agnieszka, Laidler, Piotr, Dulinska-Litewka, Joanna, Basecke,  Joerg, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Montalto, Giuseppe, Cervello, Melchiorre, Milella, Michelle, Tafuri, Agustino, Demidenko, Zoya, Abrams,  Stephen L, McCubrey, James A, "Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy" in Current Pharmaceutical Design, 22, no. 16 (2016):2358-2388,
https://doi.org/10.2174/1381612822666160304151011 . .