TY  - JOUR
AU  - Krstić, Gordana
AU  - Stepanović, Ana
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Novaković, Miroslav
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4752
AB  - In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.
PB  - Belgrade : Serbian Chemical Society
T2  - The Journal of the Serbian Chemical Society
T1  - Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis
IS  - 12
VL  - 86
DO  - 10.2298/JSC210806085K
SP  - 1219
EP  - 1228
ER  - 

@article{
author = "Krstić, Gordana and Stepanović, Ana and Jadranin, Milka and Pešić, Milica and Novaković, Miroslav and Aljančić, Ivana and Vajs, Vlatka",
year = "2021",
abstract = "In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "The Journal of the Serbian Chemical Society",
title = "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis",
number = "12",
volume = "86",
doi = "10.2298/JSC210806085K",
pages = "1219-1228"
}

Krstić, G., Stepanović, A., Jadranin, M., Pešić, M., Novaković, M., Aljančić, I.,& Vajs, V.. (2021). Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(12), 1219-1228.
https://doi.org/10.2298/JSC210806085K

Krstić G, Stepanović A, Jadranin M, Pešić M, Novaković M, Aljančić I, Vajs V. Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society. 2021;86(12):1219-1228.
doi:10.2298/JSC210806085K .

Krstić, Gordana, Stepanović, Ana, Jadranin, Milka, Pešić, Milica, Novaković, Miroslav, Aljančić, Ivana, Vajs, Vlatka, "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis" in The Journal of the Serbian Chemical Society, 86, no. 12 (2021):1219-1228,
https://doi.org/10.2298/JSC210806085K . .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Jadranin, Milka
AU  - Todorović, Nina M.
AU  - Pešić, Milica
AU  - Stanković, Tijana
AU  - Aljančić, Ivana S.
AU  - Tešević, Vele V.
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0031942218300232?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3003
AB  - Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
PB  - Pergamon
T2  - Phytochemistry
T1  - Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.
VL  - 148
DO  - 10.1016/j.phytochem.2018.01.016
SP  - 104
EP  - 112
ER  - 

@article{
author = "Krstić, Gordana and Jadranin, Milka and Todorović, Nina M. and Pešić, Milica and Stanković, Tijana and Aljančić, Ivana S. and Tešević, Vele V.",
year = "2018",
abstract = "Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.",
publisher = "Pergamon",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.",
volume = "148",
doi = "10.1016/j.phytochem.2018.01.016",
pages = "104-112"
}

Krstić, G., Jadranin, M., Todorović, N. M., Pešić, M., Stanković, T., Aljančić, I. S.,& Tešević, V. V.. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.. in Phytochemistry
Pergamon., 148, 104-112.
https://doi.org/10.1016/j.phytochem.2018.01.016

Krstić G, Jadranin M, Todorović NM, Pešić M, Stanković T, Aljančić IS, Tešević VV. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.. in Phytochemistry. 2018;148:104-112.
doi:10.1016/j.phytochem.2018.01.016 .

Krstić, Gordana, Jadranin, Milka, Todorović, Nina M., Pešić, Milica, Stanković, Tijana, Aljančić, Ivana S., Tešević, Vele V., "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis." in Phytochemistry, 148 (2018):104-112,
https://doi.org/10.1016/j.phytochem.2018.01.016 . .