TY  - JOUR
AU  - Gašić, Uroš
AU  - Ćirić, Ivanka
AU  - Pejčić, Tomislav
AU  - Radenković, Dejan
AU  - Đorđević, Vladimir
AU  - Radulović, Siniša
AU  - Tešić, Živoslav
PY  - 2020
UR  - https://www.mdpi.com/2076-3921/9/6/547
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32585831
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7346180
UR  - https://radar.ibiss.bg.ac.rs/123456789/3891
AB  - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
PB  - MDPI AG
T2  - Antioxidants (Basel, Switzerland)
T1  - Polyphenols as Possible Agents for Pancreatic Diseases.
IS  - 6
VL  - 9
DO  - 10.3390/antiox9060547
SP  - 547
ER  - 

@article{
author = "Gašić, Uroš and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav",
year = "2020",
abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.",
publisher = "MDPI AG",
journal = "Antioxidants (Basel, Switzerland)",
title = "Polyphenols as Possible Agents for Pancreatic Diseases.",
number = "6",
volume = "9",
doi = "10.3390/antiox9060547",
pages = "547"
}

Gašić, U., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland)
MDPI AG., 9(6), 547.
https://doi.org/10.3390/antiox9060547

Gašić U, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić Ž. Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland). 2020;9(6):547.
doi:10.3390/antiox9060547 .

Gašić, Uroš, Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav, "Polyphenols as Possible Agents for Pancreatic Diseases." in Antioxidants (Basel, Switzerland), 9, no. 6 (2020):547,
https://doi.org/10.3390/antiox9060547 . .

TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Tosti, Tomislav
AU  - Džamić, Zoran
AU  - Gašić, Uroš
AU  - Vuksanović, Aleksandar
AU  - Dolićanin, Zana
AU  - Tešić, Živoslav
PY  - 2019
UR  - https://www.mdpi.com/1420-3049/24/21/3982
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3521
AB  - In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight represent measures that greatly reduce the risk of various diseases. The type of diet is very important for disease development. Numerous epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of polyphenols, and their protective effects against the development of prostate diseases.
T2  - Molecules (Basel, Switzerland)
T1  - The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.
IS  - 21
VL  - 24
DO  - 10.3390/molecules24213982
SP  - 3982
ER  - 

@article{
author = "Pejčić, Tomislav and Tosti, Tomislav and Džamić, Zoran and Gašić, Uroš and Vuksanović, Aleksandar and Dolićanin, Zana and Tešić, Živoslav",
year = "2019",
abstract = "In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight represent measures that greatly reduce the risk of various diseases. The type of diet is very important for disease development. Numerous epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of polyphenols, and their protective effects against the development of prostate diseases.",
journal = "Molecules (Basel, Switzerland)",
title = "The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.",
number = "21",
volume = "24",
doi = "10.3390/molecules24213982",
pages = "3982"
}

Pejčić, T., Tosti, T., Džamić, Z., Gašić, U., Vuksanović, A., Dolićanin, Z.,& Tešić, Ž.. (2019). The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.. in Molecules (Basel, Switzerland), 24(21), 3982.
https://doi.org/10.3390/molecules24213982

Pejčić T, Tosti T, Džamić Z, Gašić U, Vuksanović A, Dolićanin Z, Tešić Ž. The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.. in Molecules (Basel, Switzerland). 2019;24(21):3982.
doi:10.3390/molecules24213982 .

Pejčić, Tomislav, Tosti, Tomislav, Džamić, Zoran, Gašić, Uroš, Vuksanović, Aleksandar, Dolićanin, Zana, Tešić, Živoslav, "The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases." in Molecules (Basel, Switzerland), 24, no. 21 (2019):3982,
https://doi.org/10.3390/molecules24213982 . .