@article{
author = "Sekulić, Slobodan and Jakovljević, Branislava and Korovljev, Darinka and Simić, Svetlana and Čapo, Ivan and Podgorac, Jelena and Martać, Ljiljana and Kesić, Srđan and Rakić, Srđan and Petković, Branka",
year = "2022",
abstract = "Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid
in the third trimester of pregnancy and it can be acute and chronic depending on
the duration. Published data suggest that during muscle development, in the stage
of late histochemical differentiation decreased mechanical loading cause decreased
expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the
case of chronic polyhydramnios, histochemical muscle differentiation could be affected
as a consequence of permanent decreased physical loading. Most affected would
be muscles which are the most active i.e., spine extensor muscles and muscles of
legs. Long-lasting decreased mechanical loading on muscle should cause decreased
expression of MHC type 1 leading to slow-to-fast transition, decreased number of
muscle fiber type I especially in extensor muscles of spine and legs. Additionally,
because MHC type 1 is present in all skeletal muscles it could lead to various degrees
of hypotrophy depending on constituting a percentage of MHC type 1 in affected
muscles. These changes in the case of preexisting muscle disorders have the potential
to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic
polyhydramnios is a rare opportunity to study the influence of reduced physical loading
on muscle development in the human fetus. Also, it could be a medical entity to examine
the influence of micro- and hypogravity conditions on the development of the fetal
muscular system during the last trimester of gestation.",
publisher = "Switzerland: Frontiers Media SA",
journal = "Frontiers in Physiology",
title = "Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition",
volume = "12",
doi = "10.3389/fphys.2021.810391",
pages = "810391"
}
