TY  - JOUR
AU  - Filipović, Milos R
AU  - Eberhardt, Mirjam
AU  - Prokopović, Vladimir
AU  - Mijušković, Ana
AU  - Reeh, Peter
AU  - Oreščanin Dušić, Zorana
AU  - Ivanović-Burmazović, Ivana S
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1041
AB  - Hydrogen sulfide (H2S) has been increasingly recognized as an important signaling molecule that regulates both blood pressure and neuronal activity. Attention has been drawn to its interactions with another gasotransmitter, nitric oxide (NO). Here, we provide evidence that the physiological effects observed upon the application of sodium nitroprusside (SNP) and H2S can be ascribed to the generation of nitroxyl (HNO), which is a direct product of the reaction between SNP and H2S, not a consequence of released NO subsequently reacting with H2S. Intracellular HNO formation has been confirmed, and the subsequent release of calcitonin gene related peptide from a mouse heart has been demonstrated. Unlike with other thiols, SNP reacts with H2S in the same way as rhodanese, i.e, the cyanide transforms into a thiocyanate. These findings shed new light on how H2S is understood to interact with nitroprusside. Additionally, they offer a new and convenient pharmacological source of HNO for therapeutic purposes.
T2  - Journal of Medicinal Chemistry
T1  - Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO
IS  - 4
VL  - 56
DO  - 10.1021/jm3012036
SP  - 793
EP  - 1508
ER  - 

@article{
author = "Filipović, Milos R and Eberhardt, Mirjam and Prokopović, Vladimir and Mijušković, Ana and Reeh, Peter and Oreščanin Dušić, Zorana and Ivanović-Burmazović, Ivana S",
year = "2013",
abstract = "Hydrogen sulfide (H2S) has been increasingly recognized as an important signaling molecule that regulates both blood pressure and neuronal activity. Attention has been drawn to its interactions with another gasotransmitter, nitric oxide (NO). Here, we provide evidence that the physiological effects observed upon the application of sodium nitroprusside (SNP) and H2S can be ascribed to the generation of nitroxyl (HNO), which is a direct product of the reaction between SNP and H2S, not a consequence of released NO subsequently reacting with H2S. Intracellular HNO formation has been confirmed, and the subsequent release of calcitonin gene related peptide from a mouse heart has been demonstrated. Unlike with other thiols, SNP reacts with H2S in the same way as rhodanese, i.e, the cyanide transforms into a thiocyanate. These findings shed new light on how H2S is understood to interact with nitroprusside. Additionally, they offer a new and convenient pharmacological source of HNO for therapeutic purposes.",
journal = "Journal of Medicinal Chemistry",
title = "Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO",
number = "4",
volume = "56",
doi = "10.1021/jm3012036",
pages = "793-1508"
}

Filipović, M. R., Eberhardt, M., Prokopović, V., Mijušković, A., Reeh, P., Oreščanin Dušić, Z.,& Ivanović-Burmazović, I. S.. (2013). Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO. in Journal of Medicinal Chemistry, 56(4), 793-1508.
https://doi.org/10.1021/jm3012036

Filipović MR, Eberhardt M, Prokopović V, Mijušković A, Reeh P, Oreščanin Dušić Z, Ivanović-Burmazović IS. Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO. in Journal of Medicinal Chemistry. 2013;56(4):793-1508.
doi:10.1021/jm3012036 .

Filipović, Milos R, Eberhardt, Mirjam, Prokopović, Vladimir, Mijušković, Ana, Reeh, Peter, Oreščanin Dušić, Zorana, Ivanović-Burmazović, Ivana S, "Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNO" in Journal of Medicinal Chemistry, 56, no. 4 (2013):793-1508,
https://doi.org/10.1021/jm3012036 . .

TY  - JOUR
AU  - Otašević, Vesna
AU  - Korac, Aleksandra B
AU  - Vučetić, Milica
AU  - Macanović, Biljana
AU  - Garalejić, Eliana
AU  - Ivanović-Burmazović, Ivana S
AU  - Filipović, Milos R
AU  - Buzadžić, Biljana J.
AU  - Stančić, Ana
AU  - Janković, Aleksandra
AU  - Velicković, Ksenija D
AU  - Golić, Igor
AU  - Markelić, Milica B
AU  - Korać, Bato
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1067
AB  - Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide ((NO)-N-center dot), the number of MitoTracker (R) Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as (NO)-N-center dot might be involved in the observed effects of the mimic. Antioxid. Redox Signal. 18, 170-178.
T2  - Antioxidants & Redox Signaling
T1  - Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?
IS  - 2
VL  - 18
SP  - 23
EP  - 178
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1067
ER  - 

@article{
author = "Otašević, Vesna and Korac, Aleksandra B and Vučetić, Milica and Macanović, Biljana and Garalejić, Eliana and Ivanović-Burmazović, Ivana S and Filipović, Milos R and Buzadžić, Biljana J. and Stančić, Ana and Janković, Aleksandra and Velicković, Ksenija D and Golić, Igor and Markelić, Milica B and Korać, Bato",
year = "2013",
abstract = "Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide ((NO)-N-center dot), the number of MitoTracker (R) Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as (NO)-N-center dot might be involved in the observed effects of the mimic. Antioxid. Redox Signal. 18, 170-178.",
journal = "Antioxidants & Redox Signaling",
title = "Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?",
number = "2",
volume = "18",
pages = "23-178",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1067"
}

Otašević, V., Korac, A. B., Vučetić, M., Macanović, B., Garalejić, E., Ivanović-Burmazović, I. S., Filipović, M. R., Buzadžić, B. J., Stančić, A., Janković, A., Velicković, K. D., Golić, I., Markelić, M. B.,& Korać, B.. (2013). Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?. in Antioxidants & Redox Signaling, 18(2), 23-178.
https://hdl.handle.net/21.15107/rcub_ibiss_1067

Otašević V, Korac AB, Vučetić M, Macanović B, Garalejić E, Ivanović-Burmazović IS, Filipović MR, Buzadžić BJ, Stančić A, Janković A, Velicković KD, Golić I, Markelić MB, Korać B. Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?. in Antioxidants & Redox Signaling. 2013;18(2):23-178.
https://hdl.handle.net/21.15107/rcub_ibiss_1067 .

Otašević, Vesna, Korac, Aleksandra B, Vučetić, Milica, Macanović, Biljana, Garalejić, Eliana, Ivanović-Burmazović, Ivana S, Filipović, Milos R, Buzadžić, Biljana J., Stančić, Ana, Janković, Aleksandra, Velicković, Ksenija D, Golić, Igor, Markelić, Milica B, Korać, Bato, "Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?" in Antioxidants & Redox Signaling, 18, no. 2 (2013):23-178,
https://hdl.handle.net/21.15107/rcub_ibiss_1067 .

TY  - JOUR
AU  - Stančić, Ana
AU  - Otašević, Vesna
AU  - Janković, Aleksandra
AU  - Vučetić, Milica
AU  - Ivanović-Burmazović, Ivana S
AU  - Filipović, Milos R
AU  - Korac, Aleksandra B
AU  - Markelić, Milica B
AU  - Velicković, Ksenija D
AU  - Golić, Igor
AU  - Buzadžić, Biljana J.
AU  - Korać, Bato
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/960
AB  - Hippocampal structural changes associated with diabetes-related cognitive impairments are well described, but their molecular background remained vague. We examined whether/how diabetes alters molecular basis of energy metabolism in hippocampus readily after diabetes onset, with special emphasis on its redox-sensitivity. To induce diabetes, adult Mill Hill hybrid hooded rats received a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were further divided in two subgroups receiving (i) or not (ii) superoxide dismutase (SOD) mimic, [Mn(II)(pyane)Cl-2] for 7 days, i.p. Treatment of the diabetic animals started after blood glucose level >= 12 mM. Diabetes decreased protein levels of oxidative phosphorylation components: complex III and ATP synthase. In contrast, protein amounts of glyceraldehyde-3-phosphate dehydrogenase, pyruvate dehydrogenase, and hypoxia-inducible factor-1 alpha - the key regulator of energy metabolism in stress conditions, were higher in diabetic animals. Treatment with SOD mimic restored/increased the levels of oxidative phosphorylation components and returned hypoxia-inducible factor-1 alpha to control level, while diabetes-induced up-regulation of glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase, was additionally stimulated. To conclude, our results provide insight into the earliest molecular changes of energy-producing pathways in diabetes that may account for structural/functional disturbance of hippocampus, seen during disease progression. Also, data suggest [Mn(II)(pyane)Cl-2] as potential therapeutic agent in cutting-edge approaches to threat this widespread metabolic disorder. (C) 2013 Elsevier Inc. All rights reserved.
T2  - Brain Research Bulletin
T1  - Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic
IS  - null
VL  - 99
SP  - 153
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_960
ER  - 

@article{
author = "Stančić, Ana and Otašević, Vesna and Janković, Aleksandra and Vučetić, Milica and Ivanović-Burmazović, Ivana S and Filipović, Milos R and Korac, Aleksandra B and Markelić, Milica B and Velicković, Ksenija D and Golić, Igor and Buzadžić, Biljana J. and Korać, Bato",
year = "2013",
abstract = "Hippocampal structural changes associated with diabetes-related cognitive impairments are well described, but their molecular background remained vague. We examined whether/how diabetes alters molecular basis of energy metabolism in hippocampus readily after diabetes onset, with special emphasis on its redox-sensitivity. To induce diabetes, adult Mill Hill hybrid hooded rats received a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were further divided in two subgroups receiving (i) or not (ii) superoxide dismutase (SOD) mimic, [Mn(II)(pyane)Cl-2] for 7 days, i.p. Treatment of the diabetic animals started after blood glucose level >= 12 mM. Diabetes decreased protein levels of oxidative phosphorylation components: complex III and ATP synthase. In contrast, protein amounts of glyceraldehyde-3-phosphate dehydrogenase, pyruvate dehydrogenase, and hypoxia-inducible factor-1 alpha - the key regulator of energy metabolism in stress conditions, were higher in diabetic animals. Treatment with SOD mimic restored/increased the levels of oxidative phosphorylation components and returned hypoxia-inducible factor-1 alpha to control level, while diabetes-induced up-regulation of glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase, was additionally stimulated. To conclude, our results provide insight into the earliest molecular changes of energy-producing pathways in diabetes that may account for structural/functional disturbance of hippocampus, seen during disease progression. Also, data suggest [Mn(II)(pyane)Cl-2] as potential therapeutic agent in cutting-edge approaches to threat this widespread metabolic disorder. (C) 2013 Elsevier Inc. All rights reserved.",
journal = "Brain Research Bulletin",
title = "Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic",
number = "null",
volume = "99",
pages = "153-33",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_960"
}

Stančić, A., Otašević, V., Janković, A., Vučetić, M., Ivanović-Burmazović, I. S., Filipović, M. R., Korac, A. B., Markelić, M. B., Velicković, K. D., Golić, I., Buzadžić, B. J.,& Korać, B.. (2013). Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic. in Brain Research Bulletin, 99(null), 153-33.
https://hdl.handle.net/21.15107/rcub_ibiss_960

Stančić A, Otašević V, Janković A, Vučetić M, Ivanović-Burmazović IS, Filipović MR, Korac AB, Markelić MB, Velicković KD, Golić I, Buzadžić BJ, Korać B. Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic. in Brain Research Bulletin. 2013;99(null):153-33.
https://hdl.handle.net/21.15107/rcub_ibiss_960 .

Stančić, Ana, Otašević, Vesna, Janković, Aleksandra, Vučetić, Milica, Ivanović-Burmazović, Ivana S, Filipović, Milos R, Korac, Aleksandra B, Markelić, Milica B, Velicković, Ksenija D, Golić, Igor, Buzadžić, Biljana J., Korać, Bato, "Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic" in Brain Research Bulletin, 99, no. null (2013):153-33,
https://hdl.handle.net/21.15107/rcub_ibiss_960 .

TY  - CONF
AU  - Vučetić, Milica
AU  - Stančić, Ana
AU  - Filipović, Milos R
AU  - Ivanović-Burmazović, Ivana S
AU  - Otašević, Vesna
AU  - Korac, Aleksandra B
AU  - Janković, Aleksandra
AU  - Buzadžić, Biljana J.
AU  - Velicković, Ksenija D
AU  - Markelić, Milica B
AU  - Golić, Igor
AU  - Korać, Bato
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1137
C3  - European Journal of Clinical Investigation
T1  - The effects of superoxide dismutase mimic on energy metabolism in hippocampus of diabetic rats
IS  - null
VL  - 42
SP  - 969
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1137
ER  - 

@conference{
author = "Vučetić, Milica and Stančić, Ana and Filipović, Milos R and Ivanović-Burmazović, Ivana S and Otašević, Vesna and Korac, Aleksandra B and Janković, Aleksandra and Buzadžić, Biljana J. and Velicković, Ksenija D and Markelić, Milica B and Golić, Igor and Korać, Bato",
year = "2012",
journal = "European Journal of Clinical Investigation",
title = "The effects of superoxide dismutase mimic on energy metabolism in hippocampus of diabetic rats",
number = "null",
volume = "42",
pages = "969-76",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1137"
}

Vučetić, M., Stančić, A., Filipović, M. R., Ivanović-Burmazović, I. S., Otašević, V., Korac, A. B., Janković, A., Buzadžić, B. J., Velicković, K. D., Markelić, M. B., Golić, I.,& Korać, B.. (2012). The effects of superoxide dismutase mimic on energy metabolism in hippocampus of diabetic rats. in European Journal of Clinical Investigation, 42(null), 969-76.
https://hdl.handle.net/21.15107/rcub_ibiss_1137

Vučetić M, Stančić A, Filipović MR, Ivanović-Burmazović IS, Otašević V, Korac AB, Janković A, Buzadžić BJ, Velicković KD, Markelić MB, Golić I, Korać B. The effects of superoxide dismutase mimic on energy metabolism in hippocampus of diabetic rats. in European Journal of Clinical Investigation. 2012;42(null):969-76.
https://hdl.handle.net/21.15107/rcub_ibiss_1137 .

Vučetić, Milica, Stančić, Ana, Filipović, Milos R, Ivanović-Burmazović, Ivana S, Otašević, Vesna, Korac, Aleksandra B, Janković, Aleksandra, Buzadžić, Biljana J., Velicković, Ksenija D, Markelić, Milica B, Golić, Igor, Korać, Bato, "The effects of superoxide dismutase mimic on energy metabolism in hippocampus of diabetic rats" in European Journal of Clinical Investigation, 42, no. null (2012):969-76,
https://hdl.handle.net/21.15107/rcub_ibiss_1137 .

TY  - CONF
AU  - Macanović, Biljana
AU  - Otašević, Vesna
AU  - Korac, Aleksandra B
AU  - Vučetić, Milica
AU  - Garalejić, Eliana
AU  - Ivanović-Burmazović, Ivana S
AU  - Filipović, Milos R
AU  - Buzadžić, Biljana J.
AU  - Stančić, Ana
AU  - Janković, Aleksandra
AU  - Velicković, Ksenija D
AU  - Golić, Igor
AU  - Markelić, Milica B
AU  - Korać, Bato
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1212
C3  - Human Reproduction
T1  - Manganese (II) pentaazamacrocyclic SOD mimic improves functional status of human sperm mitochondria: involvement of iNO
IS  - null
VL  - 27
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1212
ER  - 

@conference{
author = "Macanović, Biljana and Otašević, Vesna and Korac, Aleksandra B and Vučetić, Milica and Garalejić, Eliana and Ivanović-Burmazović, Ivana S and Filipović, Milos R and Buzadžić, Biljana J. and Stančić, Ana and Janković, Aleksandra and Velicković, Ksenija D and Golić, Igor and Markelić, Milica B and Korać, Bato",
year = "2012",
journal = "Human Reproduction",
title = "Manganese (II) pentaazamacrocyclic SOD mimic improves functional status of human sperm mitochondria: involvement of iNO",
number = "null",
volume = "27",
pages = "na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1212"
}

Macanović, B., Otašević, V., Korac, A. B., Vučetić, M., Garalejić, E., Ivanović-Burmazović, I. S., Filipović, M. R., Buzadžić, B. J., Stančić, A., Janković, A., Velicković, K. D., Golić, I., Markelić, M. B.,& Korać, B.. (2012). Manganese (II) pentaazamacrocyclic SOD mimic improves functional status of human sperm mitochondria: involvement of iNO. in Human Reproduction, 27(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1212

Macanović B, Otašević V, Korac AB, Vučetić M, Garalejić E, Ivanović-Burmazović IS, Filipović MR, Buzadžić BJ, Stančić A, Janković A, Velicković KD, Golić I, Markelić MB, Korać B. Manganese (II) pentaazamacrocyclic SOD mimic improves functional status of human sperm mitochondria: involvement of iNO. in Human Reproduction. 2012;27(null):null-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1212 .

Macanović, Biljana, Otašević, Vesna, Korac, Aleksandra B, Vučetić, Milica, Garalejić, Eliana, Ivanović-Burmazović, Ivana S, Filipović, Milos R, Buzadžić, Biljana J., Stančić, Ana, Janković, Aleksandra, Velicković, Ksenija D, Golić, Igor, Markelić, Milica B, Korać, Bato, "Manganese (II) pentaazamacrocyclic SOD mimic improves functional status of human sperm mitochondria: involvement of iNO" in Human Reproduction, 27, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1212 .