TY  - JOUR
AU  - Gašić, Uroš
AU  - Ćirić, Ivanka
AU  - Pejčić, Tomislav
AU  - Radenković, Dejan
AU  - Đorđević, Vladimir
AU  - Radulović, Siniša
AU  - Tešić, Živoslav
PY  - 2020
UR  - https://www.mdpi.com/2076-3921/9/6/547
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32585831
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7346180
UR  - https://radar.ibiss.bg.ac.rs/123456789/3891
AB  - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
PB  - MDPI AG
T2  - Antioxidants (Basel, Switzerland)
T1  - Polyphenols as Possible Agents for Pancreatic Diseases.
IS  - 6
VL  - 9
DO  - 10.3390/antiox9060547
SP  - 547
ER  - 

@article{
author = "Gašić, Uroš and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav",
year = "2020",
abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.",
publisher = "MDPI AG",
journal = "Antioxidants (Basel, Switzerland)",
title = "Polyphenols as Possible Agents for Pancreatic Diseases.",
number = "6",
volume = "9",
doi = "10.3390/antiox9060547",
pages = "547"
}

Gašić, U., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland)
MDPI AG., 9(6), 547.
https://doi.org/10.3390/antiox9060547

Gašić U, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić Ž. Polyphenols as Possible Agents for Pancreatic Diseases.. in Antioxidants (Basel, Switzerland). 2020;9(6):547.
doi:10.3390/antiox9060547 .

Gašić, Uroš, Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav, "Polyphenols as Possible Agents for Pancreatic Diseases." in Antioxidants (Basel, Switzerland), 9, no. 6 (2020):547,
https://doi.org/10.3390/antiox9060547 . .

TY  - CONF
AU  - Đorđević, Vladimir
AU  - Prokić, Marko
AU  - Pavlović, Slađan
AU  - Radovanović, Tijana
AU  - Gavrilović, Branka
AU  - Mutić, Jelena
AU  - Buha, Aleksandra
AU  - Knežević, Djordje
AU  - Jovanović, Sanja
AU  - Borković Mitić, Slavica
PY  - 2016
UR  - https://www.imi.hr/en/2016/03/10/crotox-2016-book-of-abstracts/
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3507
AB  - Pancreatic cancer (PC) is one of the most aggressive types of cancer and a worldwide health treat. However, it is rather unclear which environmental pollutants can be linked to PC development. Exposure to toxic metals through various sources can be one of the risk factors, especially having in mind that some toxic metals can induce oxidative stress, which has already been associated with the pathogenesis of PC. The aim of this study was to investigate the levels of cadmium (Cd) and lead (Pb), toxic metals of great environmental concern known to induce oxidative stress, in the blood of PC patients and healthy control subjects, as well as to examine the following biomarkers of oxidative stress: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), glutathione (GSH), sulfhydrylgroups (SH), and lipid peroxides (TBARS) in blood. Blood samples were obtained from 15 PC patients and 7 healthy subjects. The present study demonstrated a significant increase in Pb concentrations in patients with carcinoma when compared to healthy subjects (p<0.05), while no significant differences were observed in Cd levels. The activities of SOD and CAT, as well as the concentration of SH groups, were significantly higher in people with PC compared with controls (p<0.05) proving oxidative stress induction in the blood of PC patients. This work contributes to a better understanding of the potential role of metal-induced oxidative stress in PC aetiology. However, confirmation of these pilot findings in a larger study is needed.
PB  - Croatian Society of Toxicology
C3  - Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)
T1  - The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.
SP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3507
ER  - 

@conference{
author = "Đorđević, Vladimir and Prokić, Marko and Pavlović, Slađan and Radovanović, Tijana and Gavrilović, Branka and Mutić, Jelena and Buha, Aleksandra and Knežević, Djordje and Jovanović, Sanja and Borković Mitić, Slavica",
year = "2016",
abstract = "Pancreatic cancer (PC) is one of the most aggressive types of cancer and a worldwide health treat. However, it is rather unclear which environmental pollutants can be linked to PC development. Exposure to toxic metals through various sources can be one of the risk factors, especially having in mind that some toxic metals can induce oxidative stress, which has already been associated with the pathogenesis of PC. The aim of this study was to investigate the levels of cadmium (Cd) and lead (Pb), toxic metals of great environmental concern known to induce oxidative stress, in the blood of PC patients and healthy control subjects, as well as to examine the following biomarkers of oxidative stress: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), glutathione (GSH), sulfhydrylgroups (SH), and lipid peroxides (TBARS) in blood. Blood samples were obtained from 15 PC patients and 7 healthy subjects. The present study demonstrated a significant increase in Pb concentrations in patients with carcinoma when compared to healthy subjects (p<0.05), while no significant differences were observed in Cd levels. The activities of SOD and CAT, as well as the concentration of SH groups, were significantly higher in people with PC compared with controls (p<0.05) proving oxidative stress induction in the blood of PC patients. This work contributes to a better understanding of the potential role of metal-induced oxidative stress in PC aetiology. However, confirmation of these pilot findings in a larger study is needed.",
publisher = "Croatian Society of Toxicology",
journal = "Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)",
title = "The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.",
pages = "47",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3507"
}

Đorđević, V., Prokić, M., Pavlović, S., Radovanović, T., Gavrilović, B., Mutić, J., Buha, A., Knežević, D., Jovanović, S.,& Borković Mitić, S.. (2016). The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.. in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1)
Croatian Society of Toxicology., 47.
https://hdl.handle.net/21.15107/rcub_ibiss_3507

Đorđević V, Prokić M, Pavlović S, Radovanović T, Gavrilović B, Mutić J, Buha A, Knežević D, Jovanović S, Borković Mitić S. The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results.. in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1). 2016;:47.
https://hdl.handle.net/21.15107/rcub_ibiss_3507 .

Đorđević, Vladimir, Prokić, Marko, Pavlović, Slađan, Radovanović, Tijana, Gavrilović, Branka, Mutić, Jelena, Buha, Aleksandra, Knežević, Djordje, Jovanović, Sanja, Borković Mitić, Slavica, "The potential role of metal-induced oxidative stress in human pancreatic cancer: Preliminary results." in Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016; 2016 Oct 9-12; Poreč, Croatia. (Archives of Industrial Hygiene and Toxicology; Vol. 67; No. Suppl.1) (2016):47,
https://hdl.handle.net/21.15107/rcub_ibiss_3507 .