TY  - JOUR
AU  - Dimkić, Ivica
AU  - Fira, Đorđe
AU  - Janakiev, Tamara
AU  - Kabić, Jovana
AU  - Stupar, Miloš
AU  - Nenadić, Marija
AU  - Unković, Nikola
AU  - Ljaljević Grbić, Milica
PY  - 2021
UR  - internal-pdf://Dimkić et al. - 2021 - The microbiome of bat guano for what is this knowledge important.pdf
UR  - https://doi.org/10.1007/s00253-021-11143-y
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4140
AB  - Abstract: Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting better understanding in preventing emerging diseases. Key points: Bat guano as reservoir and source for spreading of autochthonous and pathogenic microbiotaBat guano vs. novel zoonotic disease outbreaksDestruction of bat natural habitats urgently demands increased human awareness.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Applied Microbiology and Biotechnology
T1  - The microbiome of bat guano: for what is this knowledge important?
IS  - 4
VL  - 105
DO  - 10.1007/s00253-021-11143-y
SP  - 1407
EP  - 1419
ER  - 

@article{
author = "Dimkić, Ivica and Fira, Đorđe and Janakiev, Tamara and Kabić, Jovana and Stupar, Miloš and Nenadić, Marija and Unković, Nikola and Ljaljević Grbić, Milica",
year = "2021",
abstract = "Abstract: Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting better understanding in preventing emerging diseases. Key points: Bat guano as reservoir and source for spreading of autochthonous and pathogenic microbiotaBat guano vs. novel zoonotic disease outbreaksDestruction of bat natural habitats urgently demands increased human awareness.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Applied Microbiology and Biotechnology",
title = "The microbiome of bat guano: for what is this knowledge important?",
number = "4",
volume = "105",
doi = "10.1007/s00253-021-11143-y",
pages = "1407-1419"
}

Dimkić, I., Fira, Đ., Janakiev, T., Kabić, J., Stupar, M., Nenadić, M., Unković, N.,& Ljaljević Grbić, M.. (2021). The microbiome of bat guano: for what is this knowledge important?. in Applied Microbiology and Biotechnology
Springer Science and Business Media Deutschland GmbH., 105(4), 1407-1419.
https://doi.org/10.1007/s00253-021-11143-y

Dimkić I, Fira Đ, Janakiev T, Kabić J, Stupar M, Nenadić M, Unković N, Ljaljević Grbić M. The microbiome of bat guano: for what is this knowledge important?. in Applied Microbiology and Biotechnology. 2021;105(4):1407-1419.
doi:10.1007/s00253-021-11143-y .

Dimkić, Ivica, Fira, Đorđe, Janakiev, Tamara, Kabić, Jovana, Stupar, Miloš, Nenadić, Marija, Unković, Nikola, Ljaljević Grbić, Milica, "The microbiome of bat guano: for what is this knowledge important?" in Applied Microbiology and Biotechnology, 105, no. 4 (2021):1407-1419,
https://doi.org/10.1007/s00253-021-11143-y . .

TY  - JOUR
AU  - Ilić, Bojan
AU  - Unković, Nikola
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Ljaljević Grbić, Milica
AU  - Raspotnig, Günther
AU  - Bodner, Michaela
AU  - Vukojević, Jelena
AU  - Makarov, Slobodan
PY  - 2019
UR  - http://link.springer.com/10.1007/s00114-019-1631-z
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3389
AB  - Millipedes use an array of chemical compounds to defend themselves from predator attack. These chemical substances can have additional roles, i.e. defence against various pathogens. We evaluated the efficacy of the defensive secretion of Apfelbeckia insculpta (L. Koch, 1867) against bacteria, yeasts, and filamentous fungi. The tested secretion consisted of two compounds, p-cresol and phenol, and showed antibacterial, antibiofilm, and antifungal potential against all selected microorganisms. The most sensitive bacterium in our study was Pseudomonas aeruginosa, while the tested defensive secretion manifested the lowest activity against Escherichia coli. The defensive secretion of A. insculpta also showed an ability, albeit mild, to suppress biofilm formation by P. aeruginosa. Among the tested yeasts, Candida albicans and C. krusei were the most susceptible and most resistant species, respectively. Finally, the concentration of extracts obtained from the tested defensive secretion needed to achieve an antifungal effect was lowest in the case of Cladosporium cladosporioides. Fusarium verticillioides and Penicillium rubens were the micromycetes most resistant to the tested secretion. Our results indicate that antibacterial activity of the defensive secretion of A. insculpta is similar to or slightly weaker than that of streptomycin, while comparison with antimycotics showed that the tested millipede secretion has stronger activity than fluconazole, but weaker activity than nystatin and ketoconazole. The present study corroborates previous findings indicating that the defensive secretions of millipedes can have different roles apart from antipredator protection and are effective against pathogenic microorganisms.
T2  - Die Naturwissenschaften
T1  - Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida).
IS  - 7-8
VL  - 106
DO  - 10.1007/s00114-019-1631-z
SP  - 37
ER  - 

@article{
author = "Ilić, Bojan and Unković, Nikola and Ćirić, Ana and Glamočlija, Jasmina and Ljaljević Grbić, Milica and Raspotnig, Günther and Bodner, Michaela and Vukojević, Jelena and Makarov, Slobodan",
year = "2019",
abstract = "Millipedes use an array of chemical compounds to defend themselves from predator attack. These chemical substances can have additional roles, i.e. defence against various pathogens. We evaluated the efficacy of the defensive secretion of Apfelbeckia insculpta (L. Koch, 1867) against bacteria, yeasts, and filamentous fungi. The tested secretion consisted of two compounds, p-cresol and phenol, and showed antibacterial, antibiofilm, and antifungal potential against all selected microorganisms. The most sensitive bacterium in our study was Pseudomonas aeruginosa, while the tested defensive secretion manifested the lowest activity against Escherichia coli. The defensive secretion of A. insculpta also showed an ability, albeit mild, to suppress biofilm formation by P. aeruginosa. Among the tested yeasts, Candida albicans and C. krusei were the most susceptible and most resistant species, respectively. Finally, the concentration of extracts obtained from the tested defensive secretion needed to achieve an antifungal effect was lowest in the case of Cladosporium cladosporioides. Fusarium verticillioides and Penicillium rubens were the micromycetes most resistant to the tested secretion. Our results indicate that antibacterial activity of the defensive secretion of A. insculpta is similar to or slightly weaker than that of streptomycin, while comparison with antimycotics showed that the tested millipede secretion has stronger activity than fluconazole, but weaker activity than nystatin and ketoconazole. The present study corroborates previous findings indicating that the defensive secretions of millipedes can have different roles apart from antipredator protection and are effective against pathogenic microorganisms.",
journal = "Die Naturwissenschaften",
title = "Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida).",
number = "7-8",
volume = "106",
doi = "10.1007/s00114-019-1631-z",
pages = "37"
}

Ilić, B., Unković, N., Ćirić, A., Glamočlija, J., Ljaljević Grbić, M., Raspotnig, G., Bodner, M., Vukojević, J.,& Makarov, S.. (2019). Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida).. in Die Naturwissenschaften, 106(7-8), 37.
https://doi.org/10.1007/s00114-019-1631-z

Ilić B, Unković N, Ćirić A, Glamočlija J, Ljaljević Grbić M, Raspotnig G, Bodner M, Vukojević J, Makarov S. Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida).. in Die Naturwissenschaften. 2019;106(7-8):37.
doi:10.1007/s00114-019-1631-z .

Ilić, Bojan, Unković, Nikola, Ćirić, Ana, Glamočlija, Jasmina, Ljaljević Grbić, Milica, Raspotnig, Günther, Bodner, Michaela, Vukojević, Jelena, Makarov, Slobodan, "Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida)." in Die Naturwissenschaften, 106, no. 7-8 (2019):37,
https://doi.org/10.1007/s00114-019-1631-z . .