TY  - JOUR
AU  - Petković, Branka
AU  - Pešić, Vesna
AU  - Veskov, Rosica
AU  - Ristić, Slavica
AU  - Tasić, Jelena
AU  - Piperski, Vesna
AU  - Ruždijić, Sabera
AU  - Jokanović, Milan
AU  - Stukalov, Petar
AU  - Rakić, Ljubiša
PY  - 2004
UR  - https://www.sciencedirect.com/science/article/pii/S0091305704000073?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3804
AB  - The effects of tiazofurin (TR; 2-β-D-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.
PB  - Pergamon-Elsevier Science Ltd
T2  - Pharmacology Biochemistry and Behavior
T1  - The effects of tiazofurin on basal and amphetamine-induced motor activity in rats
IS  - 3
VL  - 77
DO  - 10.1016/j.pbb.2003.12.025
SP  - 575
EP  - 582
ER  - 

@article{
author = "Petković, Branka and Pešić, Vesna and Veskov, Rosica and Ristić, Slavica and Tasić, Jelena and Piperski, Vesna and Ruždijić, Sabera and Jokanović, Milan and Stukalov, Petar and Rakić, Ljubiša",
year = "2004",
abstract = "The effects of tiazofurin (TR; 2-β-D-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Pharmacology Biochemistry and Behavior",
title = "The effects of tiazofurin on basal and amphetamine-induced motor activity in rats",
number = "3",
volume = "77",
doi = "10.1016/j.pbb.2003.12.025",
pages = "575-582"
}

Petković, B., Pešić, V., Veskov, R., Ristić, S., Tasić, J., Piperski, V., Ruždijić, S., Jokanović, M., Stukalov, P.,& Rakić, L.. (2004). The effects of tiazofurin on basal and amphetamine-induced motor activity in rats. in Pharmacology Biochemistry and Behavior
Pergamon-Elsevier Science Ltd., 77(3), 575-582.
https://doi.org/10.1016/j.pbb.2003.12.025

Petković B, Pešić V, Veskov R, Ristić S, Tasić J, Piperski V, Ruždijić S, Jokanović M, Stukalov P, Rakić L. The effects of tiazofurin on basal and amphetamine-induced motor activity in rats. in Pharmacology Biochemistry and Behavior. 2004;77(3):575-582.
doi:10.1016/j.pbb.2003.12.025 .

Petković, Branka, Pešić, Vesna, Veskov, Rosica, Ristić, Slavica, Tasić, Jelena, Piperski, Vesna, Ruždijić, Sabera, Jokanović, Milan, Stukalov, Petar, Rakić, Ljubiša, "The effects of tiazofurin on basal and amphetamine-induced motor activity in rats" in Pharmacology Biochemistry and Behavior, 77, no. 3 (2004):575-582,
https://doi.org/10.1016/j.pbb.2003.12.025 . .