@article{
author = "Ignjatović, Đurđica and Živković, Jelena and Tovilović-Kovačević, Gordana and Savikin, Katarina and Tomić, Mirko and Maksimović, Zoran and Jankovic, Teodora",
year = "2015",
abstract = "Methanol and 70\% acetone extracts from Veronica jacquinii, Veronica
urticifolia and Veronica teucrium were evaluated regarding their
neuroprotective/antioxidant effects on the human neuroblastoma SH-SY5Y
cell line. All extracts exhibited modest protective activity by
increasing cell survival in cells stressed with sodium nitroprusside
(9-12\%) and hydrogen peroxide (16-21\%) compared to non-treated cells.
These activities were accompanied by reductions in the amount of
superoxide radicals and index of lipid peroxidation. Extracts were
further analysed for the content of total phenolics, phenylpropanoid
glycosides and iridoids, and the major compounds acteoside and aucubin.
The highest amount of total phenolics was observed in V. jacquinii,
while V. teucrium was richest in total iridoids, acteoside and aucubin.
Angiogenic properties on EA.hy926 human endothelial cells were also
examined. At the highest non-toxic concentration (25 mu g/ml), the
tested extracts inhibited spontaneous tube formation of endothelial
cells on the extracellular matrix, implying their possible
antiangiogenic activity. The most potent inhibitory effects were shown
by methanol extract of V. jacquinii and aqueous acetone extract of V.
teucrium. The extracts did not significantly change the adhesive or
migratory capacity of EA.hy926 cells. Considering the traditional use of
Veronica species, these results suggest a need for further assessment of
their supposed wound-healing properties.",
journal = "Frontiers in Life Science",
title = "Evaluation of angiogenic and neuroprotective potential of different
extracts from three Veronica species",
number = "2",
volume = "8",
doi = "10.1080/21553769.2014.998297",
pages = "107-116"
}
