TY  - JOUR
AU  - Lazic, K.
AU  - Petrovic, J.
AU  - Ciric, J.
AU  - Kalauzi, A.
AU  - Šaponjić, Jasna
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2361
AB  - Objectives: We hypothesized that the impact of distinct anesthetic
   regimens could be differently expressed during anesthesia and on
   post-anesthesia sleep in the neurodegenerative diseases. Therefore, we
   followed the impact of ketamine/diazepam and pentobarbital anesthesia in
   a rat model of the severe Parkinson's disease cholinergic neuropathology
   on the electroencephalographic (EEG) microstructure and respiratory
   pattern during anesthesia, and on the post-anesthesia sleep. Methods: We
   performed the experiments on adult, male, spontaneously breathing Wistar
   rats chronically instrumented for sleep recording. The bilateral
   pedunculopontine tegmental nucleus (PPT) lesion was done by ibotenic
   acid microinfusion. Following postoperative recovery, we recorded sleep
   for 6 h, induced anesthesia 24 h later using ketamine/diazepam or
   pentobarbital, and repeated sleep recordings sessions 48 h and 6 days
   later. During 20 min of each anesthesia we recorded both the EEG and
   respiratory movements. For sleep and EEG analysis, Fourier analysis was
   applied on 6-h recordings, and each 10-s epoch was differentiated as a
   state of wakefulness (Wake), non-rapid eye movement (NREM) or rapid eye
   movement (REM). Additionally, the group probability density
   distributions of all EEG frequency band relative amplitudes were
   calculated for each state, with particular attention during anesthesia.
   For respiratory pattern analysis we used Monotone Signal Segments
   Analysis. The PPT lesion was identified through nicotinamide adenine
   dinucleotide phosphate (NADPH) diaphorase histochemistry. Results and
   conclusions: Our data show that the ketamine/diazepam anesthetic regimen
   in the PPT-lesioned rats induces more alterations in the EEG
   microstructure and respiratory pattern than does the pentobarbital
   anesthesia. In addition, the equal time required to establish an
   anesthetized state, and the long-term effect on postanesthesia sleep in
   the PPT-lesioned vs. control rats suggest this anesthetic regimen as
   potentially more beneficial both for anesthesia induction and for
   post-anesthesia sleep in the surgical procedures of the elderly, and
   Parkinson's, and Alzheimer's patients. (C) 2015 IBRO. Published by
   Elsevier Ltd. All rights reserved.
T2  - Neuroscience
T1  - Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology
VL  - 304
DO  - 10.1016/j.neuroscience.2015.07.020
SP  - 1
EP  - 13
ER  - 

@article{
author = "Lazic, K. and Petrovic, J. and Ciric, J. and Kalauzi, A. and Šaponjić, Jasna",
year = "2015",
abstract = "Objectives: We hypothesized that the impact of distinct anesthetic
   regimens could be differently expressed during anesthesia and on
   post-anesthesia sleep in the neurodegenerative diseases. Therefore, we
   followed the impact of ketamine/diazepam and pentobarbital anesthesia in
   a rat model of the severe Parkinson's disease cholinergic neuropathology
   on the electroencephalographic (EEG) microstructure and respiratory
   pattern during anesthesia, and on the post-anesthesia sleep. Methods: We
   performed the experiments on adult, male, spontaneously breathing Wistar
   rats chronically instrumented for sleep recording. The bilateral
   pedunculopontine tegmental nucleus (PPT) lesion was done by ibotenic
   acid microinfusion. Following postoperative recovery, we recorded sleep
   for 6 h, induced anesthesia 24 h later using ketamine/diazepam or
   pentobarbital, and repeated sleep recordings sessions 48 h and 6 days
   later. During 20 min of each anesthesia we recorded both the EEG and
   respiratory movements. For sleep and EEG analysis, Fourier analysis was
   applied on 6-h recordings, and each 10-s epoch was differentiated as a
   state of wakefulness (Wake), non-rapid eye movement (NREM) or rapid eye
   movement (REM). Additionally, the group probability density
   distributions of all EEG frequency band relative amplitudes were
   calculated for each state, with particular attention during anesthesia.
   For respiratory pattern analysis we used Monotone Signal Segments
   Analysis. The PPT lesion was identified through nicotinamide adenine
   dinucleotide phosphate (NADPH) diaphorase histochemistry. Results and
   conclusions: Our data show that the ketamine/diazepam anesthetic regimen
   in the PPT-lesioned rats induces more alterations in the EEG
   microstructure and respiratory pattern than does the pentobarbital
   anesthesia. In addition, the equal time required to establish an
   anesthetized state, and the long-term effect on postanesthesia sleep in
   the PPT-lesioned vs. control rats suggest this anesthetic regimen as
   potentially more beneficial both for anesthesia induction and for
   post-anesthesia sleep in the surgical procedures of the elderly, and
   Parkinson's, and Alzheimer's patients. (C) 2015 IBRO. Published by
   Elsevier Ltd. All rights reserved.",
journal = "Neuroscience",
title = "Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology",
volume = "304",
doi = "10.1016/j.neuroscience.2015.07.020",
pages = "1-13"
}

Lazic, K., Petrovic, J., Ciric, J., Kalauzi, A.,& Šaponjić, J.. (2015). Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology. in Neuroscience, 304, 1-13.
https://doi.org/10.1016/j.neuroscience.2015.07.020

Lazic K, Petrovic J, Ciric J, Kalauzi A, Šaponjić J. Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology. in Neuroscience. 2015;304:1-13.
doi:10.1016/j.neuroscience.2015.07.020 .

Lazic, K., Petrovic, J., Ciric, J., Kalauzi, A., Šaponjić, Jasna, "Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology" in Neuroscience, 304 (2015):1-13,
https://doi.org/10.1016/j.neuroscience.2015.07.020 . .