TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Snežana D.
AU  - Mačvanin, Mirjana T.
AU  - Nikolić, Milan R.
AU  - Mandić, Ljuba M.
AU  - Jovanović, Vesna B.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0009279719310257?via%3Dihub
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31400341
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3454
AB  - Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.
T2  - Chemico-Biological Interactions
T1  - Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.
VL  - 311
DO  - 10.1016/j.cbi.2019.108787
SP  - 108787
ER  - 

@article{
author = "Uzelac, Tamara N. and Nikolić-Kokić, Aleksandra and Spasić, Snežana D. and Mačvanin, Mirjana T. and Nikolić, Milan R. and Mandić, Ljuba M. and Jovanović, Vesna B.",
year = "2019",
abstract = "Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.",
journal = "Chemico-Biological Interactions",
title = "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.",
volume = "311",
doi = "10.1016/j.cbi.2019.108787",
pages = "108787"
}

Uzelac, T. N., Nikolić-Kokić, A., Spasić, S. D., Mačvanin, M. T., Nikolić, M. R., Mandić, L. M.,& Jovanović, V. B.. (2019). Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.. in Chemico-Biological Interactions, 311, 108787.
https://doi.org/10.1016/j.cbi.2019.108787

Uzelac TN, Nikolić-Kokić A, Spasić SD, Mačvanin MT, Nikolić MR, Mandić LM, Jovanović VB. Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.. in Chemico-Biological Interactions. 2019;311:108787.
doi:10.1016/j.cbi.2019.108787 .

Uzelac, Tamara N., Nikolić-Kokić, Aleksandra, Spasić, Snežana D., Mačvanin, Mirjana T., Nikolić, Milan R., Mandić, Ljuba M., Jovanović, Vesna B., "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content." in Chemico-Biological Interactions, 311 (2019):108787,
https://doi.org/10.1016/j.cbi.2019.108787 . .

TY  - JOUR
AU  - Milanović, Miško
AU  - Tomić, Milisav
AU  - Perović, Veljko
AU  - Radovanović, Milan
AU  - Mukherjee, Saumitra
AU  - Jakšić, Darko
AU  - Petrović, Marko
AU  - 
AU  - Radovanović, Ana
PY  - 2017
UR  - http://link.springer.com/10.1007/s12665-017-6896-y
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2844
AB  - This paper presents the effect of land-use changes on land degradation by utilization of remote sensing methods and the Gavrilović erosion potential method, due to surface mining activities in the period 2001–2011. Studied area includes the zone of influence of the Rudarski basen Kolubara, which covers the exploitation area of the Kolubara coal basin in the Republic of Serbia. The analysis is based on the processing of Landsat 5 satellite images from 2001 and 2011. In the analysis of satellite images, the supervised classification method was used. The results suggest that the observed spatial–temporal area is exposed to erosion as a result of land-use changes. Preliminary conclusion is that the dominant anthropogenic factor, responsible for changes in land use, is pronounced through the mining activity, industrialization, construction as well as agricultural activities. Very small changes in land use that occurred in the period 2001–2010 have led to relatively small amount of change from the aspect of land degradation. Also, due to the planned exploitation of the mine which included into account the sustainability of ecosystems, primarily through appropriate conservation measures, RB Kolubara is not in danger of a possible erosion processes that could undermine the stability of the basin.
T2  - Environmental Earth Sciences
T1  - Land degradation analysis of mine-impacted zone of Kolubara in Serbia
IS  - 16
VL  - 76
DO  - 10.1007/s12665-017-6896-y
SP  - 580
EP  - 580
ER  - 

@article{
author = "Milanović, Miško and Tomić, Milisav and Perović, Veljko and Radovanović, Milan and Mukherjee, Saumitra and Jakšić, Darko and Petrović, Marko and  and Radovanović, Ana",
year = "2017",
abstract = "This paper presents the effect of land-use changes on land degradation by utilization of remote sensing methods and the Gavrilović erosion potential method, due to surface mining activities in the period 2001–2011. Studied area includes the zone of influence of the Rudarski basen Kolubara, which covers the exploitation area of the Kolubara coal basin in the Republic of Serbia. The analysis is based on the processing of Landsat 5 satellite images from 2001 and 2011. In the analysis of satellite images, the supervised classification method was used. The results suggest that the observed spatial–temporal area is exposed to erosion as a result of land-use changes. Preliminary conclusion is that the dominant anthropogenic factor, responsible for changes in land use, is pronounced through the mining activity, industrialization, construction as well as agricultural activities. Very small changes in land use that occurred in the period 2001–2010 have led to relatively small amount of change from the aspect of land degradation. Also, due to the planned exploitation of the mine which included into account the sustainability of ecosystems, primarily through appropriate conservation measures, RB Kolubara is not in danger of a possible erosion processes that could undermine the stability of the basin.",
journal = "Environmental Earth Sciences",
title = "Land degradation analysis of mine-impacted zone of Kolubara in Serbia",
number = "16",
volume = "76",
doi = "10.1007/s12665-017-6896-y",
pages = "580-580"
}

Milanović, M., Tomić, M., Perović, V., Radovanović, M., Mukherjee, S., Jakšić, D., Petrović, M., ,& Radovanović, A.. (2017). Land degradation analysis of mine-impacted zone of Kolubara in Serbia. in Environmental Earth Sciences, 76(16), 580-580.
https://doi.org/10.1007/s12665-017-6896-y

Milanović M, Tomić M, Perović V, Radovanović M, Mukherjee S, Jakšić D, Petrović M, , Radovanović A. Land degradation analysis of mine-impacted zone of Kolubara in Serbia. in Environmental Earth Sciences. 2017;76(16):580-580.
doi:10.1007/s12665-017-6896-y .

Milanović, Miško, Tomić, Milisav, Perović, Veljko, Radovanović, Milan, Mukherjee, Saumitra, Jakšić, Darko, Petrović, Marko, , Radovanović, Ana, "Land degradation analysis of mine-impacted zone of Kolubara in Serbia" in Environmental Earth Sciences, 76, no. 16 (2017):580-580,
https://doi.org/10.1007/s12665-017-6896-y . .