@article{
author = "Gerasimia, Tsasi and Soković, Marina and Ćirić, Ana and Eriotou, Effimia and Sakadani, Eleni and Samaras, Yiannis and Skaltas, Eleni",
year = "2016",
abstract = "Abstract: The essential oils (EOs) from the leaves and the flowers of Smyrnium olusatrum L., growing wild in the
island of Cephalonia (Greece), were analyzed by GC-FID and GC-MS. Fifty nine constituents, which accounted for
90.3% (fl) and 97.1% (lvs) of the oils, were identified. Furanodiene, germacrone and furanoeremophil-1-one were
the major constituents in both essential oils; they were also isolated from the flowers essential oil and identified
using spectroscopic methods, ie. 1D and 2D NMR, GC-MS. In addition -myrcene (11.7%) and -phellandrene
(5.2%) were main constituents in the essential oil of the leaves. The essential oils and the pure isolates were
evaluated for antifungal activity against Aspergillus fumigatus, A. versicolor, A. ochraceus, A. niger, Trichoderma
viride, Penicillium funiculosum, P. ochrochloron, P. verucosum var. cyclopium by using the microdilution method
and proved to possess significant antifungal effect. Among them, (+) furanoeremophil-1-one was particularly active
with MIC values in the range of 0.0008-0.125 mg/mL and MFC values of 0.025-0.050 mg/mL and proved more
effective than the commercial mycotics ketoconazole and bifonazole used as positive controls.",
publisher = "ACG Publications",
journal = "Records of Natural Products",
title = "Antifungal Compounds Isolated from Smyrnium olusatrum L. Essential Oil, Growing Wild in Cephalonia, Greece. Chemical Analysis and Structure Elucidation",
number = "1",
volume = "10",
pages = "93-102",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6749"
}