TY  - JOUR
AU  - Lalić, Ivana M.
AU  - Bichele, Rudolf
AU  - Repar, Anja
AU  - Despotović, Sanja Z.
AU  - Petričević, Saša
AU  - Laan, Martti
AU  - Peterson, Pärt
AU  - Westermann, Jürgen
AU  - Milićević, Živana
AU  - Mirkov, Ivana
AU  - Milićević, Novica M.
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0940960217301553?via%3Dihub
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29289711
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3020
AB  - It is well known that bacterial lipopolysaccharide (LPS) induces migration of several cellular populations within the spleen. However, there are no data about the impact of LPS on B and T lymphocytes present in the red pulp. Therefore, we used an experimental model in which we tested the effects of intravenously injected LPS on the molecular, cellular and structural changes of the spleen, with special reference to the red pulp lymphocytes. We discovered that LPS induced a massive relocation of B and T lymphocytes from the splenic red pulp, which was independent of the tumor necrosis factor receptor-1 signaling axis. Early after LPS treatment, quantitative real-time PCR analysis revealed the elevated levels of mRNA encoding numerous chemokines and proinflammatory cytokines (XCL1, CXCL9, CXCL10, CCL3, CCL4, CCL5, CCL17, CCL20, CCL22, TNFα and LTα) which affect the navigation and activities of B and T lymphocytes in the lymphoid tissues. An extreme increase in mRNA levels for CCL20 was detected in the white pulp of the LPS-treated mice. The CCL20-expressing cells were localized in the PALS. Some smaller CCL20-expressing cells were evenly dispersed in the B cell zone. Thus, our study provides new knowledge of how microbial products could be involved in shaping the structure of lymphatic organs.
T2  - Annals of anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
T1  - Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen
VL  - 216
DO  - 10.1016/j.aanat.2017.12.002
SP  - 125
EP  - 134
ER  - 

@article{
author = "Lalić, Ivana M. and Bichele, Rudolf and Repar, Anja and Despotović, Sanja Z. and Petričević, Saša and Laan, Martti and Peterson, Pärt and Westermann, Jürgen and Milićević, Živana and Mirkov, Ivana and Milićević, Novica M.",
year = "2018",
abstract = "It is well known that bacterial lipopolysaccharide (LPS) induces migration of several cellular populations within the spleen. However, there are no data about the impact of LPS on B and T lymphocytes present in the red pulp. Therefore, we used an experimental model in which we tested the effects of intravenously injected LPS on the molecular, cellular and structural changes of the spleen, with special reference to the red pulp lymphocytes. We discovered that LPS induced a massive relocation of B and T lymphocytes from the splenic red pulp, which was independent of the tumor necrosis factor receptor-1 signaling axis. Early after LPS treatment, quantitative real-time PCR analysis revealed the elevated levels of mRNA encoding numerous chemokines and proinflammatory cytokines (XCL1, CXCL9, CXCL10, CCL3, CCL4, CCL5, CCL17, CCL20, CCL22, TNFα and LTα) which affect the navigation and activities of B and T lymphocytes in the lymphoid tissues. An extreme increase in mRNA levels for CCL20 was detected in the white pulp of the LPS-treated mice. The CCL20-expressing cells were localized in the PALS. Some smaller CCL20-expressing cells were evenly dispersed in the B cell zone. Thus, our study provides new knowledge of how microbial products could be involved in shaping the structure of lymphatic organs.",
journal = "Annals of anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft",
title = "Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen",
volume = "216",
doi = "10.1016/j.aanat.2017.12.002",
pages = "125-134"
}

Lalić, I. M., Bichele, R., Repar, A., Despotović, S. Z., Petričević, S., Laan, M., Peterson, P., Westermann, J., Milićević, Ž., Mirkov, I.,& Milićević, N. M.. (2018). Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen. in Annals of anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft, 216, 125-134.
https://doi.org/10.1016/j.aanat.2017.12.002

Lalić IM, Bichele R, Repar A, Despotović SZ, Petričević S, Laan M, Peterson P, Westermann J, Milićević Ž, Mirkov I, Milićević NM. Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen. in Annals of anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft. 2018;216:125-134.
doi:10.1016/j.aanat.2017.12.002 .

Lalić, Ivana M., Bichele, Rudolf, Repar, Anja, Despotović, Sanja Z., Petričević, Saša, Laan, Martti, Peterson, Pärt, Westermann, Jürgen, Milićević, Živana, Mirkov, Ivana, Milićević, Novica M., "Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen" in Annals of anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft, 216 (2018):125-134,
https://doi.org/10.1016/j.aanat.2017.12.002 . .