TY  - JOUR
AU  - Mangano, Katia
AU  - Fagone, Paolo
AU  - Di Mauro, M
AU  - Ascione, E
AU  - Maiello, V
AU  - Milicić, Tanja
AU  - Jotić, Aleksandra Z
AU  - Lalić, Nebojsa M
AU  - Saksida, Tamara
AU  - Stojanović, Ivana D.
AU  - Selmi, C
AU  - Farina, C
AU  - Stošić-Grujičić, Stanislava
AU  - Meroni, P
AU  - Nicoletti, Ferdinando
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1119
AB  - The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases. To define more clearly the role of apotransferrin (apoTf) in type 1 diabetes we determined the impact of this protein on type 1 diabetes as investigated in islet cells, animal models and patient sera. First, we demonstrated that recombinant apoTf counteracts the cytokine-induced death of murine pancreatic islet cells. Secondly, human apoTf administration favourably influences the course of type 1 diabetes in animal models, resulting in protection against disease development that was associated with reduction of insulitis and reduced levels of proinflammatory cytokines. Finally, we confirmed that patients with newly diagnosed type 1 diabetes manifest significantly lower apoTf serum levels compared to healthy controls and patients with long-lasting disease. In conclusion, our data suggest the apoTf pivotal role in the perpetuation of type 1 diabetes pathology.
T2  - Clinical and Experimental Immunology
T1  - The immunobiology of apotransferrin in type 1 diabetes
IS  - 3
VL  - 169
SP  - 5
EP  - 252
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1119
ER  - 

@article{
author = "Mangano, Katia and Fagone, Paolo and Di Mauro, M and Ascione, E and Maiello, V and Milicić, Tanja and Jotić, Aleksandra Z and Lalić, Nebojsa M and Saksida, Tamara and Stojanović, Ivana D. and Selmi, C and Farina, C and Stošić-Grujičić, Stanislava and Meroni, P and Nicoletti, Ferdinando",
year = "2012",
abstract = "The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases. To define more clearly the role of apotransferrin (apoTf) in type 1 diabetes we determined the impact of this protein on type 1 diabetes as investigated in islet cells, animal models and patient sera. First, we demonstrated that recombinant apoTf counteracts the cytokine-induced death of murine pancreatic islet cells. Secondly, human apoTf administration favourably influences the course of type 1 diabetes in animal models, resulting in protection against disease development that was associated with reduction of insulitis and reduced levels of proinflammatory cytokines. Finally, we confirmed that patients with newly diagnosed type 1 diabetes manifest significantly lower apoTf serum levels compared to healthy controls and patients with long-lasting disease. In conclusion, our data suggest the apoTf pivotal role in the perpetuation of type 1 diabetes pathology.",
journal = "Clinical and Experimental Immunology",
title = "The immunobiology of apotransferrin in type 1 diabetes",
number = "3",
volume = "169",
pages = "5-252",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1119"
}

Mangano, K., Fagone, P., Di Mauro, M., Ascione, E., Maiello, V., Milicić, T., Jotić, A. Z., Lalić, N. M., Saksida, T., Stojanović, I. D., Selmi, C., Farina, C., Stošić-Grujičić, S., Meroni, P.,& Nicoletti, F.. (2012). The immunobiology of apotransferrin in type 1 diabetes. in Clinical and Experimental Immunology, 169(3), 5-252.
https://hdl.handle.net/21.15107/rcub_ibiss_1119

Mangano K, Fagone P, Di Mauro M, Ascione E, Maiello V, Milicić T, Jotić AZ, Lalić NM, Saksida T, Stojanović ID, Selmi C, Farina C, Stošić-Grujičić S, Meroni P, Nicoletti F. The immunobiology of apotransferrin in type 1 diabetes. in Clinical and Experimental Immunology. 2012;169(3):5-252.
https://hdl.handle.net/21.15107/rcub_ibiss_1119 .

Mangano, Katia, Fagone, Paolo, Di Mauro, M, Ascione, E, Maiello, V, Milicić, Tanja, Jotić, Aleksandra Z, Lalić, Nebojsa M, Saksida, Tamara, Stojanović, Ivana D., Selmi, C, Farina, C, Stošić-Grujičić, Stanislava, Meroni, P, Nicoletti, Ferdinando, "The immunobiology of apotransferrin in type 1 diabetes" in Clinical and Experimental Immunology, 169, no. 3 (2012):5-252,
https://hdl.handle.net/21.15107/rcub_ibiss_1119 .