TY  - JOUR
AU  - Vujičić, Milica
AU  - Saksida, Tamara
AU  - Despotović, Sanja
AU  - Soković Bajić, Svetlana
AU  - Lalić, Ivana
AU  - Koprivica, Ivan
AU  - Mićanović, Dragica
AU  - Golić, Natasa
AU  - Tolinački, Maja
AU  - Stojanović, Ivana D.
PY  - 2018
UR  - http://www.nature.com/articles/s41598-018-24706-3
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5910418
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3049
AB  - Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability. In these circumstances the diversity and content of gut microbiota in MIF-KO mice was considerably different compared to wild type mice. This change in microbiota was accompanied by an increased intestinal IgA concentration and a higher production of pro-inflammatory cytokines TNF and IFN-γ in mesenteric lymph nodes of MIF-KO mice. The forced changes of microbiota executed by antibiotics prevented the "leakage" of the barrier in MIF-KO mice, probably through up-regulation of occludin expression and normalization of cellular pore diameters. In addition, cytokine secretion was normalized after the treatment with antibiotics. These results suggest that MIF participates in the maintenance of physiological microbiota diversity and immunosurveillance, which in turn enables the proper intestinal barrier function.
T2  - Scientific Reports
T1  - The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier.
IS  - 1
VL  - 8
DO  - 10.1038/s41598-018-24706-3
SP  - 6337
ER  - 

@article{
author = "Vujičić, Milica and Saksida, Tamara and Despotović, Sanja and Soković Bajić, Svetlana and Lalić, Ivana and Koprivica, Ivan and Mićanović, Dragica and Golić, Natasa and Tolinački, Maja and Stojanović, Ivana D.",
year = "2018",
abstract = "Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability. In these circumstances the diversity and content of gut microbiota in MIF-KO mice was considerably different compared to wild type mice. This change in microbiota was accompanied by an increased intestinal IgA concentration and a higher production of pro-inflammatory cytokines TNF and IFN-γ in mesenteric lymph nodes of MIF-KO mice. The forced changes of microbiota executed by antibiotics prevented the "leakage" of the barrier in MIF-KO mice, probably through up-regulation of occludin expression and normalization of cellular pore diameters. In addition, cytokine secretion was normalized after the treatment with antibiotics. These results suggest that MIF participates in the maintenance of physiological microbiota diversity and immunosurveillance, which in turn enables the proper intestinal barrier function.",
journal = "Scientific Reports",
title = "The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier.",
number = "1",
volume = "8",
doi = "10.1038/s41598-018-24706-3",
pages = "6337"
}

Vujičić, M., Saksida, T., Despotović, S., Soković Bajić, S., Lalić, I., Koprivica, I., Mićanović, D., Golić, N., Tolinački, M.,& Stojanović, I. D.. (2018). The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier.. in Scientific Reports, 8(1), 6337.
https://doi.org/10.1038/s41598-018-24706-3

Vujičić M, Saksida T, Despotović S, Soković Bajić S, Lalić I, Koprivica I, Mićanović D, Golić N, Tolinački M, Stojanović ID. The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier.. in Scientific Reports. 2018;8(1):6337.
doi:10.1038/s41598-018-24706-3 .

Vujičić, Milica, Saksida, Tamara, Despotović, Sanja, Soković Bajić, Svetlana, Lalić, Ivana, Koprivica, Ivan, Mićanović, Dragica, Golić, Natasa, Tolinački, Maja, Stojanović, Ivana D., "The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier." in Scientific Reports, 8, no. 1 (2018):6337,
https://doi.org/10.1038/s41598-018-24706-3 . .