TY  - JOUR
AU  - Tambur, Zoran
AU  - Aleksić, Ema
AU  - Čabrilo Lazić, Milana
AU  - Opačić, Dolores
AU  - Kalevski, Katarina
AU  - Puletić, Miljan
AU  - Avramov, Stevan
AU  - Biočanin, Vladimir
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6653
AB  - This study aimed to investigate the possibility of applying the hyperlight fluid fusion essential complex in dental plaque control, and to evaluate the effectiveness of new and modern agents used for the prevention and early treatment of gingivitis. Methodology:  The  study  included  60  subjects  randomly  divided  into  two  groups.  The  control  group  was  assigned  to  0.12%  chlorhexidine  (CHX) mouth rinse, whereas the test group used a solution based on hyper-harmonized hydroxylated fullerene water complex (3HFWC), twice daily for 2 weeks. The plaque, gingivitis and bleeding scores were evaluated and recorded. Collected plaque samples were seeded on blood agar  and  incubated  aerobically  at  a  temperature  of  37  °C  for  24-48  hours.  In  order  to  isolate  anaerobic  bacteria,  samples  were  seeded  on  Schaedler Agar and incubated anaerobically at 37 °C for seven days. Serial dilutions in saline from 101 - 106 were made, and grown colonies were counted and identified using the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) system. Results: The reduction in the number of bacteria was significant in both control and test groups. The reduction was greater in the control group compared to the experimental group, but without statistically significant difference.Conclusions: 3HFWC treatment causes significant reduction in the number of dental plaque microorganisms. Since 3HFWC solution exhibited a  bacteriostatic  effect  similar  to  chlorhexidine  it  could  be  an  adequate  addition  to  solution  of  a  growing  problem  in  prevention  and  early treatment of gingivitis and periodontitis.
PB  - Tramaniglio, Italy: The Journal of Infection in Developing Countries Non-Profit organization
T2  - The Journal of Infection in Developing Countries
T1  - The investigation of antibacterial activity of hyperlight fluid fusion subcellular essential complex
IS  - 5
VL  - 17
DO  - 10.3855/jidc.17740
SP  - 643
EP  - 648
ER  - 

@article{
author = "Tambur, Zoran and Aleksić, Ema and Čabrilo Lazić, Milana and Opačić, Dolores and Kalevski, Katarina and Puletić, Miljan and Avramov, Stevan and Biočanin, Vladimir",
year = "2023",
abstract = "This study aimed to investigate the possibility of applying the hyperlight fluid fusion essential complex in dental plaque control, and to evaluate the effectiveness of new and modern agents used for the prevention and early treatment of gingivitis. Methodology:  The  study  included  60  subjects  randomly  divided  into  two  groups.  The  control  group  was  assigned  to  0.12%  chlorhexidine  (CHX) mouth rinse, whereas the test group used a solution based on hyper-harmonized hydroxylated fullerene water complex (3HFWC), twice daily for 2 weeks. The plaque, gingivitis and bleeding scores were evaluated and recorded. Collected plaque samples were seeded on blood agar  and  incubated  aerobically  at  a  temperature  of  37  °C  for  24-48  hours.  In  order  to  isolate  anaerobic  bacteria,  samples  were  seeded  on  Schaedler Agar and incubated anaerobically at 37 °C for seven days. Serial dilutions in saline from 101 - 106 were made, and grown colonies were counted and identified using the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) system. Results: The reduction in the number of bacteria was significant in both control and test groups. The reduction was greater in the control group compared to the experimental group, but without statistically significant difference.Conclusions: 3HFWC treatment causes significant reduction in the number of dental plaque microorganisms. Since 3HFWC solution exhibited a  bacteriostatic  effect  similar  to  chlorhexidine  it  could  be  an  adequate  addition  to  solution  of  a  growing  problem  in  prevention  and  early treatment of gingivitis and periodontitis.",
publisher = "Tramaniglio, Italy: The Journal of Infection in Developing Countries Non-Profit organization",
journal = "The Journal of Infection in Developing Countries",
title = "The investigation of antibacterial activity of hyperlight fluid fusion subcellular essential complex",
number = "5",
volume = "17",
doi = "10.3855/jidc.17740",
pages = "643-648"
}

Tambur, Z., Aleksić, E., Čabrilo Lazić, M., Opačić, D., Kalevski, K., Puletić, M., Avramov, S.,& Biočanin, V.. (2023). The investigation of antibacterial activity of hyperlight fluid fusion subcellular essential complex. in The Journal of Infection in Developing Countries
Tramaniglio, Italy: The Journal of Infection in Developing Countries Non-Profit organization., 17(5), 643-648.
https://doi.org/10.3855/jidc.17740

Tambur Z, Aleksić E, Čabrilo Lazić M, Opačić D, Kalevski K, Puletić M, Avramov S, Biočanin V. The investigation of antibacterial activity of hyperlight fluid fusion subcellular essential complex. in The Journal of Infection in Developing Countries. 2023;17(5):643-648.
doi:10.3855/jidc.17740 .

Tambur, Zoran, Aleksić, Ema, Čabrilo Lazić, Milana, Opačić, Dolores, Kalevski, Katarina, Puletić, Miljan, Avramov, Stevan, Biočanin, Vladimir, "The investigation of antibacterial activity of hyperlight fluid fusion subcellular essential complex" in The Journal of Infection in Developing Countries, 17, no. 5 (2023):643-648,
https://doi.org/10.3855/jidc.17740 . .

TY  - CONF
AU  - Tambur, Zoran
AU  - Aleksić, Ema
AU  - Milutinović, Jovana
AU  - Avramov, Stevan
AU  - Malešević, Adam
AU  - Biočanin, Vladimir
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6655
AB  - Izbor antibiotika se zasniva na principu “najbolje pretpostavke“, uz poznavanje
infektivnog oboljenja, najverovatnijeg uzročnika i njegovog uobičajenog profila
osetljivosti na antibiotike. Ovakva empirijska antibiotska terapija se najčešće primenjuje
u stomatologiji jer je većina infekcija uzrokovana sa više uzročnika, u ovim infekcijama
najčešće su uključene anaerobne Gram-negativne bakterije i prilikom uzimanja uzoraka
teško je izbeći kontaminaciju uzorka sa kolonizujućom mikroflorom. Potrebno je
pridržavati se osnovnih principa pravilne primene antibiotika. Potrebno je utvrditi da li je
oboljenje infektivne etiologije, i ako jeste pre primene antibiotika uzeti uzorak za
mikrobiološki pregled. Više faktora može da utiče na izbor antibiotika: istorija bolesti,
alergijske reakcije, toksični efekti leka i prethodne antimikrobne terapije. Dozu je
potrebno odrediti unapred, pre primene, da bi se postigla dovoljna koncentracija
antibiotika na mestu infekcije. Pri tome je potrebno voditi računa o postojećim oštećenjima
organa. Način primene antibiotika zavisi od težine oboljenja pa se kod teških infekcija bira
parenteralni, intravenski put primene. Sve češće se zapažaju interakcije antibiotika sa
drugim lekovima, zbog uvođenja novih lekova u kliničku praksu, pa je neophodno i ovaj
faktor uzeti u obzir prilikom određivanja antimikrobne terapije. Odstupanja od ovih
principa mogu dovesti do raznih nepravilnosti i neželjenih reakcija u terapiji. Preterana
empirijska upotreba antibiotika dovela je do enormnog razvoja rezistencije bakterija na
ove agense pa je danas sužen izbor terapijskih mogućnosti za lečenje mnogih infekcija i
moraju se koristiti često manje efikasni agensi.
AB  - Antibiotics are chosen on a "best guess" basis, with knowledge of the
infectious disease, the most likely pathogen and its usual antibiotic susceptibility profile.
This type of empirical antibiotic therapy is used in most situations in dentistry because
most infections are caused by multiple pathogens, anaerobic gramme-negative bacteria
are most commonly involved in these infections, and it's difficult to avoid contamination
of the specimen with the colonising microflora when taking samples. It's important to
follow the basic principles of the correct use of antibiotics. It must be determined whether
the disease has an infectious cause and if so, a sample must be taken for microbiological
examination before antibiotics are administered. Several factors may influence the choice
of antibiotic: medical history, allergic reactions, toxic effects of the drug and previous
antimicrobial therapy. Existing organ damage must be taken into account. The way
antibiotics are administered depends on the severity of the disease. For example, the
parenteral, intravenous route of administration is chosen for severe infections.
Interactions of antibiotics with other drugs are becoming more common due to the
introduction of new drugs into clinical practise, so this factor must be considered when
determining antimicrobial therapy. The over-empirical use of antibiotics has led to a
tremendous development of bacterial resistance to these agents, so that today the choice
of therapeutic options for the treatment of many infections is limited to less effective
agents.
PB  - Herceg Novi: Faculty of management Herceg Novi, Montenegro
C3  - Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro
T1  - Research on the correct use of antibiotics in dentistry
T1  - Istraživanje pravilne primene antibiotika u stomatologij
SP  - 492
EP  - 514
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6655
ER  - 

@conference{
author = "Tambur, Zoran and Aleksić, Ema and Milutinović, Jovana and Avramov, Stevan and Malešević, Adam and Biočanin, Vladimir",
year = "2023",
abstract = "Izbor antibiotika se zasniva na principu “najbolje pretpostavke“, uz poznavanje
infektivnog oboljenja, najverovatnijeg uzročnika i njegovog uobičajenog profila
osetljivosti na antibiotike. Ovakva empirijska antibiotska terapija se najčešće primenjuje
u stomatologiji jer je većina infekcija uzrokovana sa više uzročnika, u ovim infekcijama
najčešće su uključene anaerobne Gram-negativne bakterije i prilikom uzimanja uzoraka
teško je izbeći kontaminaciju uzorka sa kolonizujućom mikroflorom. Potrebno je
pridržavati se osnovnih principa pravilne primene antibiotika. Potrebno je utvrditi da li je
oboljenje infektivne etiologije, i ako jeste pre primene antibiotika uzeti uzorak za
mikrobiološki pregled. Više faktora može da utiče na izbor antibiotika: istorija bolesti,
alergijske reakcije, toksični efekti leka i prethodne antimikrobne terapije. Dozu je
potrebno odrediti unapred, pre primene, da bi se postigla dovoljna koncentracija
antibiotika na mestu infekcije. Pri tome je potrebno voditi računa o postojećim oštećenjima
organa. Način primene antibiotika zavisi od težine oboljenja pa se kod teških infekcija bira
parenteralni, intravenski put primene. Sve češće se zapažaju interakcije antibiotika sa
drugim lekovima, zbog uvođenja novih lekova u kliničku praksu, pa je neophodno i ovaj
faktor uzeti u obzir prilikom određivanja antimikrobne terapije. Odstupanja od ovih
principa mogu dovesti do raznih nepravilnosti i neželjenih reakcija u terapiji. Preterana
empirijska upotreba antibiotika dovela je do enormnog razvoja rezistencije bakterija na
ove agense pa je danas sužen izbor terapijskih mogućnosti za lečenje mnogih infekcija i
moraju se koristiti često manje efikasni agensi., Antibiotics are chosen on a "best guess" basis, with knowledge of the
infectious disease, the most likely pathogen and its usual antibiotic susceptibility profile.
This type of empirical antibiotic therapy is used in most situations in dentistry because
most infections are caused by multiple pathogens, anaerobic gramme-negative bacteria
are most commonly involved in these infections, and it's difficult to avoid contamination
of the specimen with the colonising microflora when taking samples. It's important to
follow the basic principles of the correct use of antibiotics. It must be determined whether
the disease has an infectious cause and if so, a sample must be taken for microbiological
examination before antibiotics are administered. Several factors may influence the choice
of antibiotic: medical history, allergic reactions, toxic effects of the drug and previous
antimicrobial therapy. Existing organ damage must be taken into account. The way
antibiotics are administered depends on the severity of the disease. For example, the
parenteral, intravenous route of administration is chosen for severe infections.
Interactions of antibiotics with other drugs are becoming more common due to the
introduction of new drugs into clinical practise, so this factor must be considered when
determining antimicrobial therapy. The over-empirical use of antibiotics has led to a
tremendous development of bacterial resistance to these agents, so that today the choice
of therapeutic options for the treatment of many infections is limited to less effective
agents.",
publisher = "Herceg Novi: Faculty of management Herceg Novi, Montenegro",
journal = "Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro",
title = "Research on the correct use of antibiotics in dentistry, Istraživanje pravilne primene antibiotika u stomatologij",
pages = "492-514",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6655"
}

Tambur, Z., Aleksić, E., Milutinović, J., Avramov, S., Malešević, A.,& Biočanin, V.. (2023). Research on the correct use of antibiotics in dentistry. in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro
Herceg Novi: Faculty of management Herceg Novi, Montenegro., 492-514.
https://hdl.handle.net/21.15107/rcub_ibiss_6655

Tambur Z, Aleksić E, Milutinović J, Avramov S, Malešević A, Biočanin V. Research on the correct use of antibiotics in dentistry. in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro. 2023;:492-514.
https://hdl.handle.net/21.15107/rcub_ibiss_6655 .

Tambur, Zoran, Aleksić, Ema, Milutinović, Jovana, Avramov, Stevan, Malešević, Adam, Biočanin, Vladimir, "Research on the correct use of antibiotics in dentistry" in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro (2023):492-514,
https://hdl.handle.net/21.15107/rcub_ibiss_6655 .