TY  - JOUR
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9599889
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5178
AB  - A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.
PB  - Basel: MDPI
T2  - Brain Sciences
T1  - The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model
IS  - 10
VL  - 12
DO  - 10.3390/brainsci12101332
SP  - 1332
ER  - 

@article{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2-5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3-5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals' BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.",
publisher = "Basel: MDPI",
journal = "Brain Sciences",
title = "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model",
number = "10",
volume = "12",
doi = "10.3390/brainsci12101332",
pages = "1332"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences
Basel: MDPI., 12(10), 1332.
https://doi.org/10.3390/brainsci12101332

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model. in Brain Sciences. 2022;12(10):1332.
doi:10.3390/brainsci12101332 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "The Influence of Unlimited Sucrose Intake on Body Weight and Behavior-Findings from a Mouse Model" in Brain Sciences, 12, no. 10 (2022):1332,
https://doi.org/10.3390/brainsci12101332 . .

TY  - JOUR
AU  - Ivković, Sanja
AU  - Major, Tamara
AU  - Mitić, Miloš
AU  - Lončarević-Vasiljković, Nataša
AU  - Jović, Milena
AU  - Adžić, Miroslav
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0024320522001709
UR  - http://www.ncbi.nlm.nih.gov/pubmed/35283177
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4942
AB  - The brain is the softest organ in the body, and any change in the mechanical properties of the tissue induces the activation of glial cells, astrocytes and microglia. Amyloid plaques, one of the main pathological features of Alzheimer's disease (AD), are substantially harder than the surrounding brain tissue and can activate astrocytes and microglia resulting in the glial engulfment of plaques. Durotaxis, a migratory preference towards stiffer tissue, is prompting microglia to form a mechanical barrier around plaques reducing amyloid β (Aβ) induced neurotoxicity. Mechanoreceptors are highly expressed in the brain, particularly in microglia. The large increase in the expression of the mechanoreceptor Piezo1 was observed in the brains from AD animal models and AD patients in plaque encompassing glia. Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell. On the other hand, PUFAs dietary supplementation can alter microglial polarization, the envelopment of amyloid plaques, and immune response and Piezo1 activity was implicated in the similar modulations of microglia behavior. Finally, PUFAs treatment is currently in use in medical trials as the therapy for sickle cell anemia, a disease linked with the mutations in Piezo1. Further studies are needed to elucidate the connection between PUFAs, Piezo1 expression, and microglia behavior in the AD brain. These findings could open new possibilities in harnessing microglia in AD and in developing novel therapeutic strategies.
T2  - Life sciences
T1  - Fatty acids as biomodulators of Piezo1 mediated glial mechanosensitivity in Alzheimer's disease.
VL  - 297
DO  - 10.1016/j.lfs.2022.120470
SP  - 120470
ER  - 

@article{
author = "Ivković, Sanja and Major, Tamara and Mitić, Miloš and Lončarević-Vasiljković, Nataša and Jović, Milena and Adžić, Miroslav",
year = "2022",
abstract = "The brain is the softest organ in the body, and any change in the mechanical properties of the tissue induces the activation of glial cells, astrocytes and microglia. Amyloid plaques, one of the main pathological features of Alzheimer's disease (AD), are substantially harder than the surrounding brain tissue and can activate astrocytes and microglia resulting in the glial engulfment of plaques. Durotaxis, a migratory preference towards stiffer tissue, is prompting microglia to form a mechanical barrier around plaques reducing amyloid β (Aβ) induced neurotoxicity. Mechanoreceptors are highly expressed in the brain, particularly in microglia. The large increase in the expression of the mechanoreceptor Piezo1 was observed in the brains from AD animal models and AD patients in plaque encompassing glia. Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell. On the other hand, PUFAs dietary supplementation can alter microglial polarization, the envelopment of amyloid plaques, and immune response and Piezo1 activity was implicated in the similar modulations of microglia behavior. Finally, PUFAs treatment is currently in use in medical trials as the therapy for sickle cell anemia, a disease linked with the mutations in Piezo1. Further studies are needed to elucidate the connection between PUFAs, Piezo1 expression, and microglia behavior in the AD brain. These findings could open new possibilities in harnessing microglia in AD and in developing novel therapeutic strategies.",
journal = "Life sciences",
title = "Fatty acids as biomodulators of Piezo1 mediated glial mechanosensitivity in Alzheimer's disease.",
volume = "297",
doi = "10.1016/j.lfs.2022.120470",
pages = "120470"
}

Ivković, S., Major, T., Mitić, M., Lončarević-Vasiljković, N., Jović, M.,& Adžić, M.. (2022). Fatty acids as biomodulators of Piezo1 mediated glial mechanosensitivity in Alzheimer's disease.. in Life sciences, 297, 120470.
https://doi.org/10.1016/j.lfs.2022.120470

Ivković S, Major T, Mitić M, Lončarević-Vasiljković N, Jović M, Adžić M. Fatty acids as biomodulators of Piezo1 mediated glial mechanosensitivity in Alzheimer's disease.. in Life sciences. 2022;297:120470.
doi:10.1016/j.lfs.2022.120470 .

Ivković, Sanja, Major, Tamara, Mitić, Miloš, Lončarević-Vasiljković, Nataša, Jović, Milena, Adžić, Miroslav, "Fatty acids as biomodulators of Piezo1 mediated glial mechanosensitivity in Alzheimer's disease." in Life sciences, 297 (2022):120470,
https://doi.org/10.1016/j.lfs.2022.120470 . .

TY  - CONF
AU  - Dubljević, Olga
AU  - Ković, Vanja
AU  - Pavković, Željko
AU  - Mitić, Miloš
AU  - Pešić, Vesna
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5617
AB  - Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен.
AB  - Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.
PB  - Belgrade: Serbian Biological Society
C3  - Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
T1  - Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера
T1  - Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera
SP  - 384
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5617
ER  - 

@conference{
author = "Dubljević, Olga and Ković, Vanja and Pavković, Željko and Mitić, Miloš and Pešić, Vesna",
year = "2022",
abstract = "Већина доступних животињских модела зависности од шећера не укључује компоненту само-администрирања супстанце, а познато је да се код људи конзумирање шећера одвија у ad libitum условима. Како би превазишли овај проблем, у овој студији испитани су конзуматорни и бихевиорални исходи неограниченог уноса шећера, као и накнадног смањења доступности шећера код адултних мужјака C57BL/6J мишева применом модификоване парадигме „Конзуматорни сукцесивни негативни контраст“ (cSNC).1,2 Две групе животиња имале су неограничен приступ 32% раствору сахарозе 10 дана (у виду тзв. Two- Bottle-Choice протокола); 11. дана једна група добила је раствор са мањом концентрацијом сахарозе (32%→4%), док је друга група добила уобичајени 32% раствор. Контролна група је имала ad libitum приступ води. Дванаестог дана стандардизованим тестовима понашања (Тест отвореног поља, Крстасти лавиринт и Туба тест социјалне конфронтације) испитани су социјална доминација, као и новином-изазвано експлораторно и понашање слично анксиозности. Добијени резултати указују на централни утицај неограниченог уноса шећера с обзиром да је код C57BL/6J мужјака уочен анксиолитички ефекат на понашање који вероватно одражава физиолошку дисрегулацију и склоност тражењу сензација. Потенцијални простор за примену нове модификоване парадигме у испитивању патолошких последица неограниченог уноса шећера даље је размотрен., Većina dostupnih životinjskih modela zavisnosti od šećera ne uključuje komponentu samo-administriranja supstance, a poznato je da se kod ljudi konzumiranje šećera odvija u ad libitum uslovima. Kako bi prevazišli ovaj problem, u ovoj studiji ispitani su konzumatorni i bihevioralni ishodi neograničenog unosa šećera, kao i naknadnog smanjenja dostupnosti šećera kod adultnih mužjaka C57BL/6J miševa primenom modifikovane paradigme „Konzumatorni sukcesivni negativni kontrast“ (cSNC).1,2 Dve grupe životinja imale su neograničen pristup 32% rastvoru saharoze 10 dana (u vidu tzv. Two- Bottle-Choice protokola); 11. dana jedna grupa dobila je rastvor sa manjom koncentracijom saharoze (32%→4%), dok je druga grupa dobila uobičajeni 32% rastvor. Kontrolna grupa je imala ad libitum pristup vodi. Dvanaestog dana standardizovanim testovima ponašanja (Test otvorenog polja, Krstasti lavirint i Tuba test socijalne konfrontacije) ispitani su socijalna dominacija, kao i novinom-izazvano eksploratorno i ponašanje slično anksioznosti. Dobijeni rezultati ukazuju na centralni uticaj neograničenog unosa šećera s obzirom da je kod C57BL/6J mužjaka uočen anksiolitički efekat na ponašanje koji verovatno odražava fiziološku disregulaciju i sklonost traženju senzacija. Potencijalni prostor za primenu nove modifikovane paradigme u ispitivanju patoloških posledica neograničenog unosa šećera dalje je razmotren.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia",
title = "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера, Konzumatorne i bihevioralne posledice neograničenog unosa šećera i naknadnog smanjenja dostupnosti šećera",
pages = "384",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5617"
}

Dubljević, O., Ković, V., Pavković, Ž., Mitić, M.,& Pešić, V.. (2022). Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia
Belgrade: Serbian Biological Society., 384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617

Dubljević O, Ković V, Pavković Ž, Mitić M, Pešić V. Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера. in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia. 2022;:384.
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna, "Конзуматорне и бихевиоралне последице неограниченог уноса шећера и  накнадног смањења доступности шећера" in Knjiga sažetaka: Treći Kongres biologa Srbije: Osnovna i primenjena istraživanja: Metodika nastave; 2022 Sep 21-25; Zlatibor, Serbia (2022):384,
https://hdl.handle.net/21.15107/rcub_ibiss_5617 .

TY  - JOUR
AU  - Radić, Ivan
AU  - Mirić, Mirjana
AU  - Mijović, Milica
AU  - Tatalović, Nikola
AU  - Mitić, Miloš
AU  - Nestorović, Vojkan
AU  - Adžić, Miroslav
AU  - Blagojević, Duško
AU  - Popović, Ljiljana
AU  - Janićijević Hudomal, Snežana
PY  - 2021
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6170
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4181
AB  - Pumpkin seed oil (PSO) possesses a protective potential against liver injury due to the presence of biologically active ingredients. Adult male albino rats were administrated PSO (per os, 2 mL/kg b.w./day) and a 12% ethanol solution in water, ad libitum, with an average intake of 8.14 g of ethanol/kg bw/day for 6 weeks. Congestion, hepatic central vein dila-tion, portal vein branch dilation, Kupffer cell hyperplasia, fatty liver changes, hepatocyte focal necrosis were observed after daily alcohol intake. All observed changes were reduced when PSO was ingested with ethanol. PSO intake itself induced discrete cellular edema, congestion and slight dilatation of the central and portal vain branches. Chronic ethanol intake elevated catalase (CAT) activity and glutathione reductase (GR) protein expression; concomitant PSO intake had no effect on CAT activity or GR protein expression. PSO intake decreased the activities of GR, glutathione-S-transferase (GST) and xanthine oxidase (XOD) in the liver, probably due to the ingestion of antioxidants. Intake of PSO and ethanol significantly decreased cytosolic superoxide dismutase (SOD1) and increased NF-κB protein expression compared to ethanol intake, suggesting that the protective effects of PSO were mediated by the NF-κB signaling pathway. Our results reveal a therapeutic potential of PSO in alcoholic liver disease.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption
IS  - 1
VL  - 73
DO  - 10.2298/ABS201205008R
SP  - 123
EP  - 133
ER  - 

@article{
author = "Radić, Ivan and Mirić, Mirjana and Mijović, Milica and Tatalović, Nikola and Mitić, Miloš and Nestorović, Vojkan and Adžić, Miroslav and Blagojević, Duško and Popović, Ljiljana and Janićijević Hudomal, Snežana",
year = "2021",
abstract = "Pumpkin seed oil (PSO) possesses a protective potential against liver injury due to the presence of biologically active ingredients. Adult male albino rats were administrated PSO (per os, 2 mL/kg b.w./day) and a 12% ethanol solution in water, ad libitum, with an average intake of 8.14 g of ethanol/kg bw/day for 6 weeks. Congestion, hepatic central vein dila-tion, portal vein branch dilation, Kupffer cell hyperplasia, fatty liver changes, hepatocyte focal necrosis were observed after daily alcohol intake. All observed changes were reduced when PSO was ingested with ethanol. PSO intake itself induced discrete cellular edema, congestion and slight dilatation of the central and portal vain branches. Chronic ethanol intake elevated catalase (CAT) activity and glutathione reductase (GR) protein expression; concomitant PSO intake had no effect on CAT activity or GR protein expression. PSO intake decreased the activities of GR, glutathione-S-transferase (GST) and xanthine oxidase (XOD) in the liver, probably due to the ingestion of antioxidants. Intake of PSO and ethanol significantly decreased cytosolic superoxide dismutase (SOD1) and increased NF-κB protein expression compared to ethanol intake, suggesting that the protective effects of PSO were mediated by the NF-κB signaling pathway. Our results reveal a therapeutic potential of PSO in alcoholic liver disease.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption",
number = "1",
volume = "73",
doi = "10.2298/ABS201205008R",
pages = "123-133"
}

Radić, I., Mirić, M., Mijović, M., Tatalović, N., Mitić, M., Nestorović, V., Adžić, M., Blagojević, D., Popović, L.,& Janićijević Hudomal, S.. (2021). Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. in Archives of Biological Sciences
Serbian Biological Society., 73(1), 123-133.
https://doi.org/10.2298/ABS201205008R

Radić I, Mirić M, Mijović M, Tatalović N, Mitić M, Nestorović V, Adžić M, Blagojević D, Popović L, Janićijević Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. in Archives of Biological Sciences. 2021;73(1):123-133.
doi:10.2298/ABS201205008R .

Radić, Ivan, Mirić, Mirjana, Mijović, Milica, Tatalović, Nikola, Mitić, Miloš, Nestorović, Vojkan, Adžić, Miroslav, Blagojević, Duško, Popović, Ljiljana, Janićijević Hudomal, Snežana, "Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption" in Archives of Biological Sciences, 73, no. 1 (2021):123-133,
https://doi.org/10.2298/ABS201205008R . .

TY  - DATA
AU  - Radić, Ivan
AU  - Mirić, Mirjana
AU  - Mijović, Milica
AU  - Tatalović, Nikola
AU  - Mitić, Miloš
AU  - Nestorović, Vojkan
AU  - Adžić, Miroslav
AU  - Blagojević, Duško
AU  - Popović, Ljiljana
AU  - Janićijević Hudomal, Snežana
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4182
AB  - Supplementary Fig.S1. Scheme of the experimental design; Supplementary TableS2. Chemical analysis of commercialcold pressedpumpkin seed oil that was used in theexperiment.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Supplementary data for the article: Radic I, Miric M, Mijovic M, Tatalovic N, Mitic M, Nestorovic V, Adzic M, Blagojevic D, Popovic L, Janicijevic-Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. Arch Biol Sci. 2021;73(1):123–33.
IS  - 1
VL  - 73
SP  - 123
EP  - 133
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4182
ER  - 

@misc{
author = "Radić, Ivan and Mirić, Mirjana and Mijović, Milica and Tatalović, Nikola and Mitić, Miloš and Nestorović, Vojkan and Adžić, Miroslav and Blagojević, Duško and Popović, Ljiljana and Janićijević Hudomal, Snežana",
year = "2021",
abstract = "Supplementary Fig.S1. Scheme of the experimental design; Supplementary TableS2. Chemical analysis of commercialcold pressedpumpkin seed oil that was used in theexperiment.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Supplementary data for the article: Radic I, Miric M, Mijovic M, Tatalovic N, Mitic M, Nestorovic V, Adzic M, Blagojevic D, Popovic L, Janicijevic-Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. Arch Biol Sci. 2021;73(1):123–33.",
number = "1",
volume = "73",
pages = "123-133",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4182"
}

Radić, I., Mirić, M., Mijović, M., Tatalović, N., Mitić, M., Nestorović, V., Adžić, M., Blagojević, D., Popović, L.,& Janićijević Hudomal, S.. (2021). Supplementary data for the article: Radic I, Miric M, Mijovic M, Tatalovic N, Mitic M, Nestorovic V, Adzic M, Blagojevic D, Popovic L, Janicijevic-Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. Arch Biol Sci. 2021;73(1):123–33.. in Archives of Biological Sciences
Serbian Biological Society., 73(1), 123-133.
https://hdl.handle.net/21.15107/rcub_ibiss_4182

Radić I, Mirić M, Mijović M, Tatalović N, Mitić M, Nestorović V, Adžić M, Blagojević D, Popović L, Janićijević Hudomal S. Supplementary data for the article: Radic I, Miric M, Mijovic M, Tatalovic N, Mitic M, Nestorovic V, Adzic M, Blagojevic D, Popovic L, Janicijevic-Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. Arch Biol Sci. 2021;73(1):123–33.. in Archives of Biological Sciences. 2021;73(1):123-133.
https://hdl.handle.net/21.15107/rcub_ibiss_4182 .

Radić, Ivan, Mirić, Mirjana, Mijović, Milica, Tatalović, Nikola, Mitić, Miloš, Nestorović, Vojkan, Adžić, Miroslav, Blagojević, Duško, Popović, Ljiljana, Janićijević Hudomal, Snežana, "Supplementary data for the article: Radic I, Miric M, Mijovic M, Tatalovic N, Mitic M, Nestorovic V, Adzic M, Blagojevic D, Popovic L, Janicijevic-Hudomal S. Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption. Arch Biol Sci. 2021;73(1):123–33." in Archives of Biological Sciences, 73, no. 1 (2021):123-133,
https://hdl.handle.net/21.15107/rcub_ibiss_4182 .

TY  - JOUR
AU  - Radić, Ivan
AU  - Nestorović, Vojkan
AU  - Mijović, Milica
AU  - Tatalović, Nikola
AU  - Joksimović, Bojan
AU  - Lukić, Vera
AU  - Mitić, Miloš
AU  - Adžić, Miroslav
AU  - Blagojević, Duško
AU  - Veličković, Stefan
AU  - Bulajić, Sonja
AU  - Đerković, Branislav
AU  - Mirić, Mirjana
AU  - Janićijević-Hudomal, Snežana
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800014R
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3282
AB  - We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.
T2  - Archives of Biological Sciences
T1  - The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol
IS  - 3
VL  - 70
DO  - 10.2298/ABS180320014R
SP  - 531
EP  - 541
ER  - 

@article{
author = "Radić, Ivan and Nestorović, Vojkan and Mijović, Milica and Tatalović, Nikola and Joksimović, Bojan and Lukić, Vera and Mitić, Miloš and Adžić, Miroslav and Blagojević, Duško and Veličković, Stefan and Bulajić, Sonja and Đerković, Branislav and Mirić, Mirjana and Janićijević-Hudomal, Snežana",
year = "2018",
abstract = "We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.",
journal = "Archives of Biological Sciences",
title = "The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol",
number = "3",
volume = "70",
doi = "10.2298/ABS180320014R",
pages = "531-541"
}

Radić, I., Nestorović, V., Mijović, M., Tatalović, N., Joksimović, B., Lukić, V., Mitić, M., Adžić, M., Blagojević, D., Veličković, S., Bulajić, S., Đerković, B., Mirić, M.,& Janićijević-Hudomal, S.. (2018). The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol. in Archives of Biological Sciences, 70(3), 531-541.
https://doi.org/10.2298/ABS180320014R

Radić I, Nestorović V, Mijović M, Tatalović N, Joksimović B, Lukić V, Mitić M, Adžić M, Blagojević D, Veličković S, Bulajić S, Đerković B, Mirić M, Janićijević-Hudomal S. The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol. in Archives of Biological Sciences. 2018;70(3):531-541.
doi:10.2298/ABS180320014R .

Radić, Ivan, Nestorović, Vojkan, Mijović, Milica, Tatalović, Nikola, Joksimović, Bojan, Lukić, Vera, Mitić, Miloš, Adžić, Miroslav, Blagojević, Duško, Veličković, Stefan, Bulajić, Sonja, Đerković, Branislav, Mirić, Mirjana, Janićijević-Hudomal, Snežana, "The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol" in Archives of Biological Sciences, 70, no. 3 (2018):531-541,
https://doi.org/10.2298/ABS180320014R . .