TY  - JOUR
AU  - Oreščanin Dušić, Zorana
AU  - Cutura, Neđo D
AU  - Soldo, Vesna
AU  - Milovanović, SR
AU  - Curković, Aleksandar
AU  - Tomović, Branislav
AU  - Janković-Raznatović, Svetlana D
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1322
AB  - This study examined the factors that influence the optimal dose of epidural anesthesia (EA), its effect on labor duration, and the frequency of vacuum and forceps administration at the end of delivery. The study group included 100 women who underwent vaginal delivery with EA with administration of 0.125% bupivacaine. A control group included 100 vaginally delivered women, without EA administration. In both groups delivery was stimulated by syntocinon. The level of labor pain influenced the optimal bolus dose of EA more than the body mass. However, the maintenance dose was influenced by both of these factors equally. Labor in the study group was somewhat shorter. In the group with EA the percentage of forceps and vacuum extractor application was twice that in the control group. There was no difference in average value of 5-minute Apgar scor in newborns.
T2  - Clinical and Experimental Obstetrics & Gynecology
T1  - Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps
IS  - 3
VL  - 38
EP  - 250
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1322
ER  - 

@article{
author = "Oreščanin Dušić, Zorana and Cutura, Neđo D and Soldo, Vesna and Milovanović, SR and Curković, Aleksandar and Tomović, Branislav and Janković-Raznatović, Svetlana D",
year = "2011",
abstract = "This study examined the factors that influence the optimal dose of epidural anesthesia (EA), its effect on labor duration, and the frequency of vacuum and forceps administration at the end of delivery. The study group included 100 women who underwent vaginal delivery with EA with administration of 0.125% bupivacaine. A control group included 100 vaginally delivered women, without EA administration. In both groups delivery was stimulated by syntocinon. The level of labor pain influenced the optimal bolus dose of EA more than the body mass. However, the maintenance dose was influenced by both of these factors equally. Labor in the study group was somewhat shorter. In the group with EA the percentage of forceps and vacuum extractor application was twice that in the control group. There was no difference in average value of 5-minute Apgar scor in newborns.",
journal = "Clinical and Experimental Obstetrics & Gynecology",
title = "Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps",
number = "3",
volume = "38",
pages = "250",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1322"
}

Oreščanin Dušić, Z., Cutura, N. D., Soldo, V., Milovanović, S., Curković, A., Tomović, B.,& Janković-Raznatović, S. D.. (2011). Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps. in Clinical and Experimental Obstetrics & Gynecology, 38(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1322

Oreščanin Dušić Z, Cutura ND, Soldo V, Milovanović S, Curković A, Tomović B, Janković-Raznatović SD. Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps. in Clinical and Experimental Obstetrics & Gynecology. 2011;38(3):null-250.
https://hdl.handle.net/21.15107/rcub_ibiss_1322 .

Oreščanin Dušić, Zorana, Cutura, Neđo D, Soldo, Vesna, Milovanović, SR, Curković, Aleksandar, Tomović, Branislav, Janković-Raznatović, Svetlana D, "Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps" in Clinical and Experimental Obstetrics & Gynecology, 38, no. 3 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1322 .

TY  - JOUR
AU  - Blagojević, Duško
AU  - Oreščanin Dušić, Zorana
AU  - Milovanović, Slobodan R
AU  - Radojičić, Ratko M.
AU  - Nikolić-Kokić, Aleksandra
AU  - Appiah, Isabella
AU  - Slavić, Marija
AU  - Cutura, Neđo D
AU  - Trbojević, Stevan
AU  - Spasić, Mihajlo
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1475
AB  - Protamine sulphate (PS) effect on spontaneous and calcium-induced rhythmic contractions of isolated virgin rat uteri was studied. PS caused dose-dependent relaxation of both types of contractions (two-way ANOVA, significant dose effects). Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 10(-5) mol/l), methylene blue (MB; 0.9 x 10(-6) mol/l) or propranolol (1.7 x 10(-5) mol/l) enhanced PS-mediated uterine muscle relaxation of spontaneous contractions. Dose-dependent relaxation of spontaneous active isolated rat uterus with PS was lower in uteri pretreated with single dose of tetraethylammonium (TEA; 6 x 10(-3) mol/l), glibenclamide (2 x 10(-6) mol/l) and 4-aminopyridine (4-AP; 10(-3) mol/l). Calcium-induced activity of the isolated rat uterus pretreated with the same concentration of L-NAME, MB, or propranolol modified the kinetic of PS-induced relaxation without changes in EC(50) values. Pre-treatment with glibenclamide, TEA and 4-AP significantly reduce PS relaxing effect of calcium-induced activity and according to EC(50) values the order of magnitude was glibenclamide > TEA > 4-AP. PS is mixture of polyamines and may activate different signal-transduction pathways. Our results cleary demonstrate that in uterine smooth muscle PS act dominantly through potassium chanels and marginaly through beta-adrenergic receptos or nitric oxide-dependent pathways.
T2  - General Physiology and Biophysics
T1  - Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated
IS  - null
VL  - 28
EP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1475
ER  - 

@article{
author = "Blagojević, Duško and Oreščanin Dušić, Zorana and Milovanović, Slobodan R and Radojičić, Ratko M. and Nikolić-Kokić, Aleksandra and Appiah, Isabella and Slavić, Marija and Cutura, Neđo D and Trbojević, Stevan and Spasić, Mihajlo",
year = "2009",
abstract = "Protamine sulphate (PS) effect on spontaneous and calcium-induced rhythmic contractions of isolated virgin rat uteri was studied. PS caused dose-dependent relaxation of both types of contractions (two-way ANOVA, significant dose effects). Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 10(-5) mol/l), methylene blue (MB; 0.9 x 10(-6) mol/l) or propranolol (1.7 x 10(-5) mol/l) enhanced PS-mediated uterine muscle relaxation of spontaneous contractions. Dose-dependent relaxation of spontaneous active isolated rat uterus with PS was lower in uteri pretreated with single dose of tetraethylammonium (TEA; 6 x 10(-3) mol/l), glibenclamide (2 x 10(-6) mol/l) and 4-aminopyridine (4-AP; 10(-3) mol/l). Calcium-induced activity of the isolated rat uterus pretreated with the same concentration of L-NAME, MB, or propranolol modified the kinetic of PS-induced relaxation without changes in EC(50) values. Pre-treatment with glibenclamide, TEA and 4-AP significantly reduce PS relaxing effect of calcium-induced activity and according to EC(50) values the order of magnitude was glibenclamide > TEA > 4-AP. PS is mixture of polyamines and may activate different signal-transduction pathways. Our results cleary demonstrate that in uterine smooth muscle PS act dominantly through potassium chanels and marginaly through beta-adrenergic receptos or nitric oxide-dependent pathways.",
journal = "General Physiology and Biophysics",
title = "Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated",
number = "null",
volume = "28",
pages = "148",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1475"
}

Blagojević, D., Oreščanin Dušić, Z., Milovanović, S. R., Radojičić, R. M., Nikolić-Kokić, A., Appiah, I., Slavić, M., Cutura, N. D., Trbojević, S.,& Spasić, M.. (2009). Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated. in General Physiology and Biophysics, 28(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1475

Blagojević D, Oreščanin Dušić Z, Milovanović SR, Radojičić RM, Nikolić-Kokić A, Appiah I, Slavić M, Cutura ND, Trbojević S, Spasić M. Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated. in General Physiology and Biophysics. 2009;28(null):null-148.
https://hdl.handle.net/21.15107/rcub_ibiss_1475 .

Blagojević, Duško, Oreščanin Dušić, Zorana, Milovanović, Slobodan R, Radojičić, Ratko M., Nikolić-Kokić, Aleksandra, Appiah, Isabella, Slavić, Marija, Cutura, Neđo D, Trbojević, Stevan, Spasić, Mihajlo, "Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated" in General Physiology and Biophysics, 28, no. null (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1475 .