TY  - JOUR
AU  - Babotă, Mihai
AU  - Frumuzachi, Oleg
AU  - Mocan, Andrei
AU  - Tămaș, Mircea
AU  - Dias, Maria Inês
AU  - Pinela, José
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Bădărău, Alexandru Sabin
AU  - Crișan, Gianina
AU  - Barros, Lillian
AU  - Păltinean, Ramona
PY  - 2022
UR  - https://www.mdpi.com/2223-7747/11/20/2773
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5180
AB  - Hypericum perforatum L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MSn analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of H. rochelii phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, H. rochelii was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species H. alpigenum and H. rochelii.
PB  - Basel: MDPI
T2  - Plants
T1  - Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii
IS  - 20
VL  - 11
DO  - 10.3390/plants11202773
SP  - 2773
ER  - 

@article{
author = "Babotă, Mihai and Frumuzachi, Oleg and Mocan, Andrei and Tămaș, Mircea and Dias, Maria Inês and Pinela, José and Stojković, Dejan and Soković, Marina and Bădărău, Alexandru Sabin and Crișan, Gianina and Barros, Lillian and Păltinean, Ramona",
year = "2022",
abstract = "Hypericum perforatum L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MSn analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of H. rochelii phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, H. rochelii was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species H. alpigenum and H. rochelii.",
publisher = "Basel: MDPI",
journal = "Plants",
title = "Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii",
number = "20",
volume = "11",
doi = "10.3390/plants11202773",
pages = "2773"
}

Babotă, M., Frumuzachi, O., Mocan, A., Tămaș, M., Dias, M. I., Pinela, J., Stojković, D., Soković, M., Bădărău, A. S., Crișan, G., Barros, L.,& Păltinean, R.. (2022). Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii. in Plants
Basel: MDPI., 11(20), 2773.
https://doi.org/10.3390/plants11202773

Babotă M, Frumuzachi O, Mocan A, Tămaș M, Dias MI, Pinela J, Stojković D, Soković M, Bădărău AS, Crișan G, Barros L, Păltinean R. Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii. in Plants. 2022;11(20):2773.
doi:10.3390/plants11202773 .

Babotă, Mihai, Frumuzachi, Oleg, Mocan, Andrei, Tămaș, Mircea, Dias, Maria Inês, Pinela, José, Stojković, Dejan, Soković, Marina, Bădărău, Alexandru Sabin, Crișan, Gianina, Barros, Lillian, Păltinean, Ramona, "Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii" in Plants, 11, no. 20 (2022):2773,
https://doi.org/10.3390/plants11202773 . .

TY  - JOUR
AU  - Mocan, Andrei
AU  - Babota, Mihai
AU  - Pop, Anca
AU  - Fizeșan, Ionel
AU  - Diuzheva, Alina
AU  - Locatelli, Marcello
AU  - Carradori, Simone
AU  - Campestre, Cristina
AU  - Menghini, Luigi
AU  - Sisea, Cristian R.
AU  - Soković, Marina
AU  - Zengin, Gokhan
AU  - Păltinean, Ramona
AU  - Badarau, Sabin
AU  - C Vodnar, Dan C
AU  - Crișan, Gianina
PY  - 2020
UR  - https://www.mdpi.com/2076-3921/9/6/480
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32498441
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3703
AB  - Even though Salvia genus is one of the most known and studied taxa of Lamiaceae family, the knowledge regarding the chemical composition and health-related benefits of some locally used Salvia species (mostly endemic) is still scarce. In this regard, the present work aims to evaluate the chemical profile and potential bioactivities of 70% (v/v) ethanolic extracts obtained from the less-studied S. transsylvanica and S. glutinosa in comparison with S. officinalis. HPLC-PDA analysis revealed the presence of rutin and catechin as the main compounds in the extracts of the three studied species (using the employed HPLC method), whereas the presence of naringenin was highlighted only in S. glutinosa extract. Chlorogenic acid, rutin and quercetin were identified and quantified for the first time in S. transsylvanica extracts. The in vitro antioxidant capacity of each extract was tested through complementary methods (phosphomolybdenum assay, DPPH, ABTS, CUPRAC and FRAP assays), and correlated with the presence of phenolics (especially flavonoids) in high amounts. The neuroprotective and antidiabetic abilities of S. officinalis (the most active as AChE, BChE and α-glucosidase inhibitor), S. glutinosa (the most active as α-amylase inhibitor) and S. transsylvanica were also studied. For each extract it was determined the antimicrobial, antifungal and cytotoxic effects using in vitro assays. The obtained results confirm the potential of S. transsylvanica and S. glutinosa as promising sources of bioactive compounds and as a starting point for further analyses.
PB  - MDPI AG
T2  - Antioxidants (Basel, Switzerland)
T1  - Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur.
IS  - 6
VL  - 9
DO  - 10.3390/antiox9060480
SP  - 480
ER  - 

@article{
author = "Mocan, Andrei and Babota, Mihai and Pop, Anca and Fizeșan, Ionel and Diuzheva, Alina and Locatelli, Marcello and Carradori, Simone and Campestre, Cristina and Menghini, Luigi and Sisea, Cristian R. and Soković, Marina and Zengin, Gokhan and Păltinean, Ramona and Badarau, Sabin and C Vodnar, Dan C and Crișan, Gianina",
year = "2020",
abstract = "Even though Salvia genus is one of the most known and studied taxa of Lamiaceae family, the knowledge regarding the chemical composition and health-related benefits of some locally used Salvia species (mostly endemic) is still scarce. In this regard, the present work aims to evaluate the chemical profile and potential bioactivities of 70% (v/v) ethanolic extracts obtained from the less-studied S. transsylvanica and S. glutinosa in comparison with S. officinalis. HPLC-PDA analysis revealed the presence of rutin and catechin as the main compounds in the extracts of the three studied species (using the employed HPLC method), whereas the presence of naringenin was highlighted only in S. glutinosa extract. Chlorogenic acid, rutin and quercetin were identified and quantified for the first time in S. transsylvanica extracts. The in vitro antioxidant capacity of each extract was tested through complementary methods (phosphomolybdenum assay, DPPH, ABTS, CUPRAC and FRAP assays), and correlated with the presence of phenolics (especially flavonoids) in high amounts. The neuroprotective and antidiabetic abilities of S. officinalis (the most active as AChE, BChE and α-glucosidase inhibitor), S. glutinosa (the most active as α-amylase inhibitor) and S. transsylvanica were also studied. For each extract it was determined the antimicrobial, antifungal and cytotoxic effects using in vitro assays. The obtained results confirm the potential of S. transsylvanica and S. glutinosa as promising sources of bioactive compounds and as a starting point for further analyses.",
publisher = "MDPI AG",
journal = "Antioxidants (Basel, Switzerland)",
title = "Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur.",
number = "6",
volume = "9",
doi = "10.3390/antiox9060480",
pages = "480"
}

Mocan, A., Babota, M., Pop, A., Fizeșan, I., Diuzheva, A., Locatelli, M., Carradori, S., Campestre, C., Menghini, L., Sisea, C. R., Soković, M., Zengin, G., Păltinean, R., Badarau, S., C Vodnar, D. C.,& Crișan, G.. (2020). Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur.. in Antioxidants (Basel, Switzerland)
MDPI AG., 9(6), 480.
https://doi.org/10.3390/antiox9060480

Mocan A, Babota M, Pop A, Fizeșan I, Diuzheva A, Locatelli M, Carradori S, Campestre C, Menghini L, Sisea CR, Soković M, Zengin G, Păltinean R, Badarau S, C Vodnar DC, Crișan G. Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur.. in Antioxidants (Basel, Switzerland). 2020;9(6):480.
doi:10.3390/antiox9060480 .

Mocan, Andrei, Babota, Mihai, Pop, Anca, Fizeșan, Ionel, Diuzheva, Alina, Locatelli, Marcello, Carradori, Simone, Campestre, Cristina, Menghini, Luigi, Sisea, Cristian R., Soković, Marina, Zengin, Gokhan, Păltinean, Ramona, Badarau, Sabin, C Vodnar, Dan C, Crișan, Gianina, "Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur." in Antioxidants (Basel, Switzerland), 9, no. 6 (2020):480,
https://doi.org/10.3390/antiox9060480 . .