TY  - JOUR
AU  - Babotă, Mihai
AU  - Frumuzachi, Oleg
AU  - Mocan, Andrei
AU  - Tămaș, Mircea
AU  - Dias, Maria Inês
AU  - Pinela, José
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Bădărău, Alexandru Sabin
AU  - Crișan, Gianina
AU  - Barros, Lillian
AU  - Păltinean, Ramona
PY  - 2022
UR  - https://www.mdpi.com/2223-7747/11/20/2773
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5180
AB  - Hypericum perforatum L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MSn analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of H. rochelii phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, H. rochelii was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species H. alpigenum and H. rochelii.
PB  - Basel: MDPI
T2  - Plants
T1  - Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii
IS  - 20
VL  - 11
DO  - 10.3390/plants11202773
SP  - 2773
ER  - 

@article{
author = "Babotă, Mihai and Frumuzachi, Oleg and Mocan, Andrei and Tămaș, Mircea and Dias, Maria Inês and Pinela, José and Stojković, Dejan and Soković, Marina and Bădărău, Alexandru Sabin and Crișan, Gianina and Barros, Lillian and Păltinean, Ramona",
year = "2022",
abstract = "Hypericum perforatum L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MSn analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of H. rochelii phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, H. rochelii was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species H. alpigenum and H. rochelii.",
publisher = "Basel: MDPI",
journal = "Plants",
title = "Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii",
number = "20",
volume = "11",
doi = "10.3390/plants11202773",
pages = "2773"
}

Babotă, M., Frumuzachi, O., Mocan, A., Tămaș, M., Dias, M. I., Pinela, J., Stojković, D., Soković, M., Bădărău, A. S., Crișan, G., Barros, L.,& Păltinean, R.. (2022). Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii. in Plants
Basel: MDPI., 11(20), 2773.
https://doi.org/10.3390/plants11202773

Babotă M, Frumuzachi O, Mocan A, Tămaș M, Dias MI, Pinela J, Stojković D, Soković M, Bădărău AS, Crișan G, Barros L, Păltinean R. Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii. in Plants. 2022;11(20):2773.
doi:10.3390/plants11202773 .

Babotă, Mihai, Frumuzachi, Oleg, Mocan, Andrei, Tămaș, Mircea, Dias, Maria Inês, Pinela, José, Stojković, Dejan, Soković, Marina, Bădărău, Alexandru Sabin, Crișan, Gianina, Barros, Lillian, Păltinean, Ramona, "Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii" in Plants, 11, no. 20 (2022):2773,
https://doi.org/10.3390/plants11202773 . .