@article{
author = "Vojnović-Milutinović, Danijela and Radovanović, Marina and Dinic, Jovana and Đorđević, Ana and Velickovic, Natasa and Elaković, Ivana and Matić, Gordana and Brkljačić, Jelena",
year = "2014",
abstract = "Alterations in leptin and glucocorticoid signaling pathways in the
hypothalamus of male and female rats subjected to a fructose-enriched
diet were studied. The level of expression of the key components of the
leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of
cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway
(glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type
1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not
differ between fructose-fed rats and control animals of both genders.
However, in females, a fructose-enriched diet provoked increases in the
adiposity index, plasma leptin and triglyceride concentrations, and
displayed a tendency to decrease the leptin receptor (ObRb) protein and
mRNA levels. In male rats, the fructose diet caused elevations in plasma
non-esterified fatty acids and triglycerides, as well as in both plasma
and hypothalamic leptin concentrations. Our results suggest that a
fructose-enriched diet can induce hyperleptinemia in both female and
male rats, but with a more pronounced effect on hypothalamic leptin
sensitivity in females, probably contributing to the observed
development of visceral adiposity.",
journal = "Archives of Biological Sciences",
title = "Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats",
number = "2",
volume = "66",
doi = "10.2298/ABS1402829M",
pages = "829-839"
}